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INHIBITOR GENE [4 records]
Record 1 - internal organization data 2025-09-11
Record 1, English
Record 1, Subject field(s)
- Visual Disorders
Record 1, Main entry term, English
- Sorsby’s macular dystrophy
1, record 1, English, Sorsby%26rsquo%3Bs%20macular%20dystrophy
correct, noun
Record 1, Abbreviations, English
Record 1, Synonyms, English
- Sorsby’s fundus dystrophy 2, record 1, English, Sorsby%26rsquo%3Bs%20fundus%20dystrophy
correct, noun
- Sorsby’s dystrophy 3, record 1, English, Sorsby%26rsquo%3Bs%20dystrophy
correct, noun
Record 1, Textual support, English
Record number: 1, Textual support number: 1 CONT
Sorsby's macular dystrophy.... This is an extremely rare, dominantly inherited disorder, with many clinical similarities to age-related macular degeneration. A gene for Sorsby's dystrophy that codes for a tissue inhibitor metalloproteinase, TIMP-3, has been identified.... Several mutations of TIMP-3 have been identified in patients with Sorsby's dystrophy.... Early in the disease process, several very fine drusen or a large confluent plaque or yellowish material may be noted beneath the central RPE [retinal pigment epithelium]. Then, typically around 40 years of age, patients develop bilateral exudative maculopathy, which leaves heavily pigmented macular scars and areas of geographical atrophy. 4, record 1, English, - Sorsby%26rsquo%3Bs%20macular%20dystrophy
Record 1, Key term(s)
- Sorsby macular dystrophy
- Sorsby fundus dystrophy
- Sorsby dystrophy
Record 1, French
Record 1, Domaine(s)
- Troubles de la vision
Record 1, Main entry term, French
- dystrophie maculaire de Sorsby
1, record 1, French, dystrophie%20maculaire%20de%20Sorsby
correct, feminine noun
Record 1, Abbreviations, French
Record 1, Synonyms, French
- dystrophie de Sorsby 2, record 1, French, dystrophie%20de%20Sorsby
correct, feminine noun
Record 1, Textual support, French
Record number: 1, Textual support number: 1 CONT
La dystrophie de Sorsby est une dystrophie maculaire de transmission autosomique dominante liée à une mutation sur le gène TIMP3. Le phénotype est caractérisé par l'apparition de drusen et de néovaisseaux et une atrophie rétinienne survenant entre la 3e et 6e décennie. La pathologie est progressive et cécitante. 3, record 1, French, - dystrophie%20maculaire%20de%20Sorsby
Record 1, Spanish
Record 1, Textual support, Spanish
Record 2 - internal organization data 2018-02-21
Record 2, English
Record 2, Subject field(s)
- Biotechnology
- Genetics
Record 2, Main entry term, English
- transgenesis
1, record 2, English, transgenesis
correct
Record 2, Abbreviations, English
Record 2, Synonyms, English
Record 2, Textual support, English
Record number: 2, Textual support number: 1 DEF
The transfer of genetic material from one organism to another. 2, record 2, English, - transgenesis
Record number: 2, Textual support number: 1 CONT
We determined the expression pattern of the tissue inhibitor of metalloproteinase(TIMP) in the development of the mouse embryo using in situ hybridization and transgenesis. To define the sequences regulating TIMP expression, we generated transgenic mice that expressed the Escherichia coli beta-galactosidase gene under control of a 5’ region of the mouse TIMP gene containing-2158 to-58 by upstream of the initiator ATG. 3, record 2, English, - transgenesis
Record 2, French
Record 2, Domaine(s)
- Biotechnologie
- Génétique
Record 2, Main entry term, French
- transgénèse
1, record 2, French, transg%C3%A9n%C3%A8se
correct, feminine noun
Record 2, Abbreviations, French
Record 2, Synonyms, French
Record 2, Textual support, French
Record number: 2, Textual support number: 1 DEF
Transfert de matériel génétique d'un organisme à un autre. 2, record 2, French, - transg%C3%A9n%C3%A8se
Record number: 2, Textual support number: 1 CONT
L'introduction d'un gène étranger dans le patrimoine héréditaire d'un individu définit la transgénèse. Différentes techniques sont utilisées chez les mammifères pour y parvenir. Les deux premières ne permettent pas, à elles seules, de choisir l'endroit où le transgène s'intégrera. Il s'agit : (1) de la micro-injection dans l'œuf, qui permet d'introduire de grands fragments d'ADN exogène; (2) des rétrovirus recombinants défectifs qui permettent d'intégrer avec une fréquence élevée des fragments d'ADN dont la taille est cependant limitée par la place disponible dans la capside du rétrovirus. 3, record 2, French, - transg%C3%A9n%C3%A8se
Record 2, Spanish
Record 2, Campo(s) temático(s)
- Biotecnología
- Genética
Record 2, Main entry term, Spanish
- transgénesis
1, record 2, Spanish, transg%C3%A9nesis
correct, feminine noun
Record 2, Abbreviations, Spanish
Record 2, Synonyms, Spanish
Record 2, Textual support, Spanish
Record number: 2, Textual support number: 1 DEF
Transferencia de un gen (que se convierte en transgén) a un organismo receptor (llamado transgénico), que generalmente puede transmitirlo a su descendencia. 2, record 2, Spanish, - transg%C3%A9nesis
Record 3 - internal organization data 2003-05-15
Record 3, English
Record 3, Subject field(s)
- Genetics
- Molecular Biology
Record 3, Main entry term, English
- inhibitor gene
1, record 3, English, inhibitor%20gene
correct
Record 3, Abbreviations, English
Record 3, Synonyms, English
- inhibiting gene 2, record 3, English, inhibiting%20gene
correct
Record 3, Textual support, English
Record number: 3, Textual support number: 1 DEF
One which masks or inhibits the effect of a gene at another locus. 1, record 3, English, - inhibitor%20gene
Record 3, French
Record 3, Domaine(s)
- Génétique
- Biologie moléculaire
Record 3, Main entry term, French
- gène inhibiteur
1, record 3, French, g%C3%A8ne%20inhibiteur
correct, masculine noun
Record 3, Abbreviations, French
Record 3, Synonyms, French
Record 3, Textual support, French
Record number: 3, Textual support number: 1 CONT
[...] des chercheurs de Rhône Poulenc Rorer de Vitry s/Seine ont utilisé un gène inhibiteur de la croissance cellulaire pour arrêter la prolifération des cellules musculaires du muscle lisse vasculaire responsable de la resténose qui apparaît souvent après une intervention par ballonnets sur les artères [...]. 2, record 3, French, - g%C3%A8ne%20inhibiteur
Record 3, Spanish
Record 3, Campo(s) temático(s)
- Genética
- Biología molecular
Record 3, Main entry term, Spanish
- gen inhibidor
1, record 3, Spanish, gen%20inhibidor
correct, masculine noun
Record 3, Abbreviations, Spanish
Record 3, Synonyms, Spanish
Record 3, Textual support, Spanish
Record 4 - internal organization data 1995-04-07
Record 4, English
Record 4, Subject field(s)
- Genetics
- Biochemistry
Record 4, Main entry term, English
- neuronal apoptotic inhibitor protein
1, record 4, English, neuronal%20apoptotic%20inhibitor%20protein
correct
Record 4, Abbreviations, English
- NAIP 2, record 4, English, NAIP
correct
Record 4, Synonyms, English
Record 4, Textual support, English
Record number: 4, Textual support number: 1 CONT
The product of this gene is called neuronal apoptotic inhibitor protein(NAIP) may cause SMA(spinal muscular atrophy) 1, record 4, English, - neuronal%20apoptotic%20inhibitor%20protein
Record 4, French
Record 4, Domaine(s)
- Génétique
- Biochimie
Record 4, Main entry term, French
- protéine inhibitrice de l'apoptose neuronale
1, record 4, French, prot%C3%A9ine%20inhibitrice%20de%20l%27apoptose%20neuronale
proposal, feminine noun
Record 4, Abbreviations, French
- PIAN 1, record 4, French, PIAN
proposal, feminine noun
Record 4, Synonyms, French
Record 4, Textual support, French
Record number: 4, Textual support number: 1 OBS
Équivalent français et son abréviation proposés par un médecin de l'Hôpital Sainte-Justine, à Montréal. 1, record 4, French, - prot%C3%A9ine%20inhibitrice%20de%20l%27apoptose%20neuronale
Record 4, Spanish
Record 4, Textual support, Spanish
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