TERMIUM Plus^®

Record 1,  Textual support,  English

Record number: 1, Textual support number: 1 DEF

Technique for separating molecules based on their differential mobility in an electric field.  3, record 1, English, - electrophoresis

Record number: 1, Textual support number: 1 CONT

The principles of electrophoresis ... can be simply stated as the acceleration of charged particles in an electric field; this is opposed by friction due to passage through the surrounding medium such that the particles move at a constant speed proportional to their charge.  4, record 1, English, - electrophoresis

Record number: 1, Textual support number: 1 OBS

[Electrophoresis] is used routinely to separate the protein fractions of serum, urine, or cerebrospinal fluid; to separate serum lipoproteins; to separate the lactate dehydrogenase and creatine kinase isoenzymes; and to detect hemoglobin variants. It is also used in conjunction with immunodiffusion to separate proteins and identify them by antigenic differences.  3, record 1, English, - electrophoresis

Record number: 1, Textual support number: 1 PHR

Agarose gel, gel, paper, polyacrylamide gel electrophoresis.  5, record 1, English, - electrophoresis

Record 1,  Textual support,  French

Record number: 1, Textual support number: 1 DEF

Technique physicochimique permettant la séparation de diverses substances contenues dans un mélange, grâce à leur différence de mobilité sous l'influence d'un champ électrique (courant continu) [...]  3, record 1, French, - %C3%A9lectrophor%C3%A8se

Record number: 1, Textual support number: 1 OBS

[La] mobilité [des molécules], en présence d'une solution tampon de pH déterminé, est fonction, suivant le support utilisé, de la taille, de la forme, et surtout de la charge électrique de ces molécules.  3, record 1, French, - %C3%A9lectrophor%C3%A8se

Record number: 1, Textual support number: 1 PHR

Électrophorèse continue, sur gel, sur gel d'agarose, sur gel de polyacrylamide, sur papier, sur support.  4, record 1, French, - %C3%A9lectrophor%C3%A8se

Record 1,  Textual support,  Spanish

Record number: 1, Textual support number: 1 DEF

Método de fraccionamiento molecular basado en diferencias de movilidad en un campo eléctrico que es función de la carga de la molécula.  2, record 1, Spanish, - electroforesis

Record 2,  Textual support,  English

Record number: 2, Textual support number: 1 CONT

Cyclin-dependent kinase(Cdks) is a family of serine-threonine protein kinase which plays a pivotal role in the eucaryote cell cycle regulation.  1, record 2, English, - cyclin%2Ddependent%20kinase

Record number: 2, Textual support number: 1 OBS

The term "dependent," when used as an adjective as is the case here, is more frequently written with an "e." "Dependant" with an "a" represents the noun form.  4, record 2, English, - cyclin%2Ddependent%20kinase

Record 2,  Textual support,  French

Record number: 2, Textual support number: 1 CONT

Le déroulement correct des phases successives du cycle mitotique des cellules eucaryotes est assuré, en grande partie, par une famille de kinases sérine-thréonine, dites kinases dépendantes des cyclines (cyclin-dependent kinases, Cdks). Leur structure primaire montre une homologie entre les espèces tout au long de l'échelle de l'évolution.  1, record 2, French, - kinase%20d%C3%A9pendante%20des%20cyclines

Record number: 2, Textual support number: 1 OBS

La plus connue, la Cdk2, associée à la cycline B, est indispensable à la mitose.  2, record 2, French, - kinase%20d%C3%A9pendante%20des%20cyclines

Record 2,  Textual support,  Spanish

Record 3,  Textual support,  English

Record number: 3, Textual support number: 1 CONT

Finally, a discussion of the signal transduction pathways involved in survival factor-signaling will review the roles played by PI-3 kinase and AKT and speculate on how activation of these kinases by survival factors might regulate the apoptotic pathway.  2, record 3, English, - survival%20factor

Record 3,  Textual support,  French

Record number: 3, Textual support number: 1 DEF

Molécule de signalisation extracellulaire qui empêche l’apoptose.  1, record 3, French, - facteur%20de%20survie

Record number: 3, Textual support number: 1 OBS

facteur de survie : terme et définition publiés au Journal officiel de la République française le 31 janvier 2016.  2, record 3, French, - facteur%20de%20survie

Record 3,  Textual support,  Spanish

Record 4,  Textual support,  English

Record number: 4, Textual support number: 1 DEF

An enzyme which is induced in cells affected with DNA viruses and which catalyses the phosphorylation of thymidine to thymidylic acid, in the process of DNA synthesis.  3, record 4, English, - thymidine%20kinase

Record number: 4, Textual support number: 1 CONT

In papovavirus-infected cells the induced enzyme is cellular in origin, but the thymidine kinase induced by Herpesvirus is specified by the virus Genome, and differs in several properties from the cell enzyme.  3, record 4, English, - thymidine%20kinase

Record 4,  Textual support,  French

Record number: 4, Textual support number: 1 CONT

Cette enzyme virale, la thymidine kinase, n'est présente que dans les cellules infectées.  1, record 4, French, - thymidine%20kinase

Record 4,  Textual support,  Spanish

Record number: 4, Textual support number: 1 DEF

Enzima que permite a una célula utilizar una vía metabólica alternativa para incorporar timidina en el ADN.  1, record 4, Spanish, - timidina%20quinasa

Record number: 4, Textual support number: 1 OBS

Se utiliza como marcador seleccionable para identificar las células eucarióticas transfectadas.  1, record 4, Spanish, - timidina%20quinasa

Record 5,  Textual support,  English

Record number: 5, Textual support number: 1 DEF

Enzyme that catalyzes the transfer of the [gamma] -phosphate of ATP to a 5’-OH terminus in DNA or RNA.  2, record 5, English, - polynucleotide%20kinase

Record number: 5, Textual support number: 1 OBS

It is used for labeling 5’ termini in DNA for sequencing by the Maxam-Gilbert technique.  2, record 5, English, - polynucleotide%20kinase

Record 5,  Textual support,  French

Record number: 5, Textual support number: 1 DEF

Enzyme phosphorylant la partie terminale d'un polynucléotide. [Définition normalisée par l'AFNOR et reproduite avec son autorisation.]  2, record 5, French, - polynucl%C3%A9otide%20kinase

Record number: 5, Textual support number: 1 OBS

polynucléotide kinase : terme normalisé par l'AFNOR et publié au Journal officiel de la République française le 22 septembre 2000.  3, record 5, French, - polynucl%C3%A9otide%20kinase

Record 5,  Textual support,  Spanish

Record 6,  Textual support,  English

Record number: 6, Textual support number: 1 DEF

Enzyme of skeletal muscle and the myocardium and of brain tissue that catalyzes the transfer of a phosphate group from phosphocreatine to ADP, producing creatine and ATP. It occurs as three isoenzymes each having two components labeled M and B: the form in brain tissue is BB, in skeletal muscle MM, and in myocardial tissue both MM and MB. The form normally found in serum is virtually all MM isoenzyme.  1, record 6, English, - creatine%20kinase

Record number: 6, Textual support number: 1 OBS

The recommended name of this enzyme, that normally used, is creatine kinase, and the systematic name, based on the reaction catalyzed, is ATP : creatine phosphotransferase.  4, record 6, English, - creatine%20kinase

Record 6,  Textual support,  French

Record number: 6, Textual support number: 1 DEF

Enzyme musculaire catalysant la phosphorylation de la créatine en présence d'ATP. La créatine phosphate ainsi formée possède une liaison riche en énergie et constitue la forme de stockage de l'énergie au niveau du muscle.  1, record 6, French, - cr%C3%A9atine%20kinase

Record 6,  Textual support,  Spanish

Record 7,  Textual support,  English

Record number: 7, Textual support number: 1 DEF

Enzyme which converts a zymogen to the active enzyme form.  2, record 7, English, - kinase

Record number: 7, Textual support number: 1 CONT

A somewhat different type of regulation of enzyme activity is the enzyme-catalyzed activation of inactive precursors of enzymes(zymogens) to yield the catalytically active forms. The classical examples are the digestive enzymes pepsin, trypsin, and chymotrypsin which are synthesized as the inactive zymogens pepsinogen, trypsinogen, and chymotrypsinogen, respectively. When these enzymes are secreted into the gastrointestinal tract, they are converted into their active forms by the selective hydrolytic cleavage of one or more specific peptide bonds in the zymogen molecule.... Trypsinogen is converted into active trypsin by removal of a hexapeptide from the N-terminal end, through the action of... kinase.  3, record 7, English, - kinase

Record 7,  Textual support,  French

Record number: 7, Textual support number: 1 DEF

Nom d'ensemble des enzymes dont la présence est nécessaire pour rendre active une autre enzyme. Ex.: l'entérokinase pancréatique permet la transformation du trypsinogène en trypsine.  2, record 7, French, - kinase

Record 7,  Textual support,  Spanish

Record 8,  Textual support,  French

Record 8,  Textual support,  Spanish

Record 9,  Textual support,  English

Record number: 9, Textual support number: 1 DEF

Positively charged resin used in ion-exchange chromatography to which diethylaminoethyl groups have been attached.  2, record 9, English, - DEAE%2Dcellulose

Record number: 9, Textual support number: 1 CONT

Although some of the earliest reports on immobilising enzymes refer to inorganic supports, in the next phase of development organic polymers were favoured. This was probably due both to the rapid development of interest in enzyme structure and the chemical modification of enzymes, and to the ease with which enzymes could be attached to organic polymers such as cellulose. This was achieved by adsorption(to DEAE-cellulose), and by covalent bonding.... Glucose isomerase has been immobilized through sorption from water solutions by anion exchange celluloses such as diethylaminoethyl(DEAE) cellulose and... pyruvate kinase bound to diethylaminoethylcellulose(DEAE-cellulose) via cyanuric chloride.  3, record 9, English, - DEAE%2Dcellulose

Record 9,  Textual support,  French

Record number: 9, Textual support number: 1 DEF

Cellulose chargée positivement utilisée comme échangeuse d'anions dans la séparation chromatographique des protéines.  1, record 9, French, - DEAE%20cellulose

Record number: 9, Textual support number: 1 CONT

Les protéines peuvent être fractionnées grâce à la chromatographie par échange d'ions. On utilise souvent dans ce but des celluloses modifiées qui sont, soit des échangeurs d'anion comme la diéthylaminoéthyl-cellulose (DEAE-cellulose), soit des échangeurs de cations comme la carboxyméthyl-cellulose (CM-cellulose).  3, record 9, French, - DEAE%20cellulose

Record 9,  Textual support,  Spanish

Record 10,  Textual support,  English

Record number: 10, Textual support number: 1 CONT

Tyrosine kinase oncogenes and growth-regulatory signal transduction. Research in our laboratory is focused on the molecular mechanisms regulating cellular growth and differentiation in both normal and tumor cells. Using hematopoietic differentiation and fibroblast transformation as model systems, we are investigating the roles of non-receptor protein-tyrosine kinases and small G-proteins in these processes. Tyrosine kinase activity is associated with many proteins involved in growth-regulatory signal transduction, including growth hormone receptors and transforming oncogene products.  1, record 10, English, - small%20G%2DProtein

Record 10,  Textual support,  French

Record number: 10, Textual support number: 1 CONT

Les petites protéines G de la famille Rho (sous-groupe de la vaste famille Ras) jouent ainsi un rôle déterminant dans le contrôle de la réorganisation du cytosquelette d'actine. Elles agissent les unes sur les autres, en cascade, et collaborent avec de nombreux partenaires auxquels elles se lient par des domaines protéiques conservés, en un système dont nous avons déjà souligné la complexité.  1, record 10, French, - petite%20prot%C3%A9ine%20G

Record 10,  Textual support,  Spanish

Record number: 10, Textual support number: 1 CONT

Una clase principal de proteína G, denominada proteínas G pequeñas, es la familia ras, que fueron inicialmente identificadas como los productos de oncogenes de virus de sarcoma de rata.  2, record 10, Spanish, - prote%C3%ADna%20G%20peque%C3%B1a

Record 11,  Textual support,  English

Record number: 11, Textual support number: 1 DEF

Usually short and appropriate name assigned to each enzyme for everyday use. An example is creatine kinase : the systematic name of this enzyme, based on the reaction catalyzed, is ATP : creatine phosphotransferase.  2, record 11, English, - recommended%20name

Record 11,  Textual support,  French

Record number: 11, Textual support number: 1 DEF

Pour les enzymes, appellation simple consacrée par l'usage.  2, record 11, French, - nom%20commun%20recommand%C3%A9

Record number: 11, Textual support number: 1 OBS

Le nom commun recommandé est, la plupart du temps, formé par celui du substrat auquel on ajoute le suffixe "ase".  3, record 11, French, - nom%20commun%20recommand%C3%A9

Record 11,  Textual support,  Spanish

Record 12,  Textual support,  English

Record number: 12, Textual support number: 1 CONT

Triggered conformational changes ... are the motions of groups of atoms (i.e. individual side-chains) or whole sections of a protein (i.e. loops of chain, domains of secondary and tertiary structure, or subunit), which occur as a response to a specific stimulus. The distance moved can be as much as 10 [angstrom unit] or more. The time scale can be estimated by studies of the rate of binding or turnover reactions. The energy for triggered conformational change comes from specific interactions, such as electrostatic attractions or hydrogen bonding interactions. The best-known example of a triggered conformational change is the transition in tertiary structure that occurs when ligands bind to the iron atoms of hemoglobin.  1, record 12, English, - triggered%20conformational%20change

Record number: 12, Textual support number: 1 OBS

The types of substances whose binding can trigger a specific conformational change include substrates(dihydroxyacetone phosphate in triose phosphate isomerase), coenzymes(NAD binding to lactate dehydrogenase), allosteric effectors(CTP and ATP in aspartic transcarbamylase), inhibitors(statine-containing polypeptide inhibitors of acid proteases) and even protons(the Bohr effect in hemoglobin; pH-dependent conformational changes in adenylate kinase).  1, record 12, English, - triggered%20conformational%20change

Record 12,  Textual support,  French

Record number: 12, Textual support number: 1 DEF

Modification de la conformation des protéines provoquée par la fixation de ligands à leur surface. Parmi ces ligands, notons les substrats, activateurs, inhibiteurs et coenzymes.  2, record 12, French, - changement%20de%20conformation%20prot%C3%A9ique%20induit

Record 12,  Textual support,  Spanish

Record 13,  Textual support,  English

Record number: 13, Textual support number: 1 CONT

In another application of gene therapy we have used an adenoviral vector that carries the gene for herpes simplex virus thymidine kinase(HSV-tk). Cells expressing HSV-tk will convert the anti-viral drug ganciclovir(GCV) to a form that is toxic to rapidly dividing cells. Using this adenoviral vector we have repeatedly shown robust tumoricidal effects in a variety of animal models of CNS tumor and will soon take this treatment to phase I clinical trials. We are extending this work to the manipulation of the CNSs immune response to tumors using adenoviral vectors that carry several cytokine genes.  1, record 13, English, - herpes%20simplex%20virus%20thymidine%20kinase

Record 13,  Textual support,  French

Record number: 13, Textual support number: 1 CONT

Traitement du glioblastome multiforme - une tumeur létale du cerveau - par transduction tumorale in vivo du gène codant la thymidine kinase du virus herpès simplex (HSV-TK), suivie par l'administration de ganciclovir, tel est l'intitulé des essais cliniques de phase II qui ont débuté en juin dernier en Belgique.  1, record 13, French, - thimidine%20kinase%20du%20virus%20herp%C3%A8s%20simplex

Record 13,  Textual support,  Spanish

Record 14,  Textual support,  English

Record number: 14, Textual support number: 1 DEF

[An enzyme that] phosphorylates tyrosine residues in some proteins.  1, record 14, English, - protein%20tyrosine%20kinase

Record 14,  Textual support,  French

Record number: 14, Textual support number: 1 CONT

[L']activation se traduit souvent par la mise en jeu d'une activité protéine tyrosine kinase (c'est-à-dire une activité de phosphorylation de protéines sur une tyrosine) portée par le récepteur ou simplement couplée au récepteur.  1, record 14, French, - prot%C3%A9ine%20tyrosine%20kinase

Record 14,  Textual support,  Spanish

Record 15,  Textual support,  English

Record number: 15, Textual support number: 1 DEF

[A receptor that] binds protein tyrosine kinase enzymes such as the receptors for epidermal growth factor, insulin, insulin-like growth factor-1, platelet-derived growth factor, fibroblast growth factor...  1, record 15, English, - receptor%20tyrosine%20kinase

Record 15,  Textual support,  French

Record number: 15, Textual support number: 1 CONT

Le récepteur de l'insuline est un récepteur tyrosine kinase. C'est une protéine enzymatique, une protéine tyrosine kinase, sur laquelle se fixe l'insuline : cette enzyme a pour fonction de phosphoryler des résidus tyrosine spécifiques appartenant à d'autres protéines.  1, record 15, French, - r%C3%A9cepteur%20tyrosine%20kinase

Record 15,  Textual support,  Spanish

Record 16,  Textual support,  English

Record number: 16, Textual support number: 1 DEF

A protein kinase [that transduces] the cellular signals [promoting] lipid hydrolysis.  1, record 16, English, - protein%20kinase%20C

Record number: 16, Textual support number: 1 OBS

[Protein kinase C is a] 80kDa [kilodaltons] enzyme... recruited to the plasma membrane by diacylglycerol and, in many cases, by calcium. The enzyme is activated by diacylglycerol and phospholipid(usually PS [phosphatidylserine]) and is thought to undergo a conformational change upon binding to the membrane. PKC [protein kinase C] phosphorylates a variety of target proteins which control growth and cellular differentiation.  1, record 16, English, - protein%20kinase%20C

Record 16,  Textual support,  French

Record number: 16, Textual support number: 1 CONT

Après activation, la protéine kinase C est transférée du cytoplasme vers la membrane où elle phosphoryle des protéines sur les résidus sérine et thréonine.  1, record 16, French, - prot%C3%A9ine%20kinase%20C

Record 16,  Textual support,  Spanish

Record 17,  Textual support,  English

Record number: 17, Textual support number: 1 CONT

Tectorigenin and tectoridin, isolated from the rhizomes of Korean Belamcanda chinensis(Iridaceae) which are used as Chinese traditional medicine for the treatment of inflammation, suppressed prostaglandin E2 production by rat peritoneal macrophages stimulated by the protein kinase C activator...  2, record 17, English, - tectorigenin

Record 17,  Textual support,  French

Record number: 17, Textual support number: 1 OBS

La tectorigénine est un isoflavonoïde.  2, record 17, French, - tectorig%C3%A9nine

Record 17,  Textual support,  Spanish

Record 18,  Textual support,  English

Record number: 18, Textual support number: 1 DEF

A tissue culture medium containing hypoxanthine, aminopterin, and thymidine, used in somatic cell fusion experiments. Aminopterin(an antifolate) blocks de novo synthesis of purine and thymine nucleotides, but these compounds can be produced from hypoxanthine and thymidine by normal cells possessing the enzymes hypoxanthine phosphoribosyltransferase(HPRT) and thymidine kinase(TK).  1, record 18, English, - HAT%20medium

Record 18,  Textual support,  French

Record number: 18, Textual support number: 1 DEF

Milieu sélectif contenant de l'hypoxanthine, de l'aminoptérine et de la thymidine. La synthèse de l'ADN à partir des sucres et des acides aminés est bloquée par l'aminoptérine. Une autre voie de biosynthèse possible utilise des nucléotides préformés (les précurseurs de l'ADN) et deux enzymes : la thymidine-kinase (TK) et l'hypoxanthine guanine phosphoriboxyl transférase (HGPRT). Les cellules qui possèdent ces enzymes peuvent croître sur un milieu contenant l'aminoptérine et les nucléosides.  2, record 18, French, - milieu%20HAT

Record 18,  Textual support,  Spanish

Record 19,  Textual support,  English

Record number: 19, Textual support number: 1 CONT

the EGF receptor tyrosine kinase is an enzyme commonly studied for functions it performs as an internal cell communicator.  2, record 19, English, - tyrosine%20kinase

Record 19,  Textual support,  French

Record number: 19, Textual support number: 1 CONT

Les récepteurs de croissance possédant une activité intrinsèque de tyrosine kinase s'associent au niveau de leur domaine cytoplasmique à d'autres protéines participant au transfert de signaux mitogéniques.  4, record 19, French, - tyrosine%2Dkinase

Record number: 19, Textual support number: 1 OBS

Tyrosine : acide aminé  5, record 19, French, - tyrosine%2Dkinase

Record number: 19, Textual support number: 2 OBS

terme français formulé d'après les règles généralement suivies dans la nomenclature des enzymes.  1, record 19, French, - tyrosine%2Dkinase

Record 19,  Textual support,  Spanish

Record 20,  Textual support,  English

Record number: 20, Textual support number: 1 CONT

While all AKAPs contain a conserved RII binding domain, a second motif unique to each anchoring protein allows it to sequester the kinase to specific intracellular locations.  1, record 20, English, - anchoring%20protein

Record number: 20, Textual support number: 2 CONT

There are several endocytic pathways that can mediate the internalization of many different cargo proteins.  2, record 20, English, - anchoring%20protein

Record 20,  Textual support,  French

Record number: 20, Textual support number: 1 CONT

Nous avons ensuite montré que la myosine VIIa est une protéine d'ancrage de la protéine kinase A.  1, record 20, French, - prot%C3%A9ine%20d%27ancrage

Record 20,  Textual support,  Spanish

Record 21,  Textual support,  English

Record number: 21, Textual support number: 1 CONT

The G-protein-coupled receptor kinases (GRKs) are protein kinases that phosphorylate only active G-protein-coupled receptors.  2, record 21, English, - G%20protein%2Dcoupled%20receptor%20kinase

Record 21,  Textual support,  French

Record number: 21, Textual support number: 1 CONT

La phosphorylation du récepteur intervient dès la fixation du ligand. Deux classes principales de protéines kinases sont impliquées dans ce phénomène : la PKA et les GRK.  1, record 21, French, - kinase%20associ%C3%A9e%20au%20r%C3%A9cepteur%20coupl%C3%A9%20%C3%A0%20une%20prot%C3%A9ine%20G

Record number: 21, Textual support number: 2 CONT

Les kinases associées aux récepteurs couplés aux protéines G (GRK) : Le rôle des GRK a été montré par un certain nombre de moyens comme la surexpression, ou l'utilisation d'anticorps inhibant leur fonction.  1, record 21, French, - kinase%20associ%C3%A9e%20au%20r%C3%A9cepteur%20coupl%C3%A9%20%C3%A0%20une%20prot%C3%A9ine%20G

Record 21,  Textual support,  Spanish

Record 22,  Textual support,  English

Record number: 22, Textual support number: 1 CONT

We hope to elucidate the role of adenosine kinase(ADK) and that of the adenine salvage pathway in plant systems by isolating and characterizing ADK-deficient mutants from Arabidopsis thaliana. To achieve this goal, both a direct selection, previously employed for mammalian systems, and gene silencing are being used.  2, record 22, English, - adenosine%20kinase

Record 22,  Textual support,  French

Record 22,  Textual support,  Spanish

Record 23,  Textual support,  English

Record number: 23, Textual support number: 1 DEF

The transforming (sarcoma inducing) gene of Rous sarcoma virus.  1, record 23, English, - Src

Record number: 23, Textual support number: 1 CONT

A strong link between Src activity and the progression of breast cancer has been established. This work should prove very useful in defining the signaling pathways through which hyperactive Src signaling leads to cancerous transformations. It will also help to identify new targets for molecular therapeutics designed to inhibit the tumor-producing effects of altered Src kinase activity.  2, record 23, English, - Src

Record number: 23, Textual support number: 1 PHR

Src activity, signaling.  2, record 23, English, - Src

Record 23,  Textual support,  French

Record number: 23, Textual support number: 1 CONT

On distingue les oncogènes par un symbole à trois lettres s'inspirant du type de tumeur produite ou du nom du virus, par exemple src pour sarcome, abl pour virus d'Abelson.  2, record 23, French, - src

Record number: 23, Textual support number: 2 CONT

Des études préliminaires effectuées en laboratoire ont apporté la démonstration du rôle de certaines molécules de signalisation (Src, MAPK et RAC) dans l'induction de la transition épithélium-mésenchyme (TEM).  3, record 23, French, - src

Record 23,  Textual support,  Spanish

Record 24,  Textual support,  English

Record number: 24, Textual support number: 1 CONT

Study of the recognition-sites of nucleotides on the contractile proteins myosin and actinomyosin as well as their associated kinases, arginine kinase and creatine kinase, involving a synthetic, photolabile derivative of ATP : ATPgamma-(p-azido-aniline). Study of the structure-activity relations of the globular heads of myosin by chemical and photochemical methods(synthesis and interaction of an ATP analogue, substituted on the gamma-phosphorus atom with an azide radical).(Cited in PASCAL data base.)  2, record 24, English, - contractile%20protein

Record 24,  Textual support,  French

Record number: 24, Textual support number: 1 CONT

Étude des sites de reconnaissance des nucléotides au niveau des protéines contractiles, myosine [...] ainsi que des kinases qui leur sont associées : arginine kinase et créatine kinase, à l'aide d'un dérivé photolabile synthétique de l'ATP [...]. Étude des relations structure-activité au niveau des têtes globulaires de la myosine par approches chimique et photochimique (synthèse et interaction d'un analogue de l'ATP substitué sur l'atome de phosphore-gamma par le radical azide). (Cité dans la base de données PASCAL.)  2, record 24, French, - prot%C3%A9ine%20contractile

Record 24,  Textual support,  Spanish

Record 25,  Textual support,  English

Record number: 25, Textual support number: 1 DEF

An enzyme of the transferase class that catalyses the realteen ATP + protein = ADP + phosphoprotein.  2, record 25, English, - protein%20kinase

Record 25,  Textual support,  French

Record number: 25, Textual support number: 1 DEF

Enzyme qui assure le transfert d'une liaison phosphate riche en énergie, provenant de l'adénosine triphosphate (ATP), sur une protéine acceptrice qui est ainsi activée.  3, record 25, French, - prot%C3%A9ine%20kinase

Record number: 25, Textual support number: 1 CONT

L'analyse de la séquence en acides aminés n'a pas permis de déduire une quelconque activité de la protéine (protéine kinase, facteur de croissance, etc.). Grâce à leur homologie, l'ADNc murin a pu servir de sonde pour isoler l'ADNc humain.  4, record 25, French, - prot%C3%A9ine%20kinase

Record 25,  Textual support,  Spanish

Record 26,  Textual support,  French

Record 26,  Textual support,  Spanish

Record 27,  Textual support,  French

Record 27,  Textual support,  Spanish

Record 28,  Textual support,  English

Record number: 28, Textual support number: 1 CONT

Aspartate kinase(AK) catalyzes the first reaction of common biosynthetic pathway of threonine, lysine and methionine in plants and bacteria.  2, record 28, English, - aspartate%20kinase

Record 28,  Textual support,  French

Record number: 28, Textual support number: 1 OBS

L'aspartate kinase (AK) catalyse la première étape de la biosynthèse commune à la thréonine, à la lysine et à la méthionine chez les plantes et les bactéries.  3, record 28, French, - aspartate%20kinase

Record 28,  Textual support,  Spanish

Record 29,  Textual support,  English

Record number: 29, Textual support number: 1 CONT

The protein kinase PKR is a component of the interferon-induced anti-viral defense mechanism in mammalian cells. Upon activation by binding double-stranded RNA in infected cells, the kinase down-regulates the cellular translational apparatus, and thus impairs viral protein expression. To overcome the inhibitory effects of PKR, viruses have developed efficient methods to prevent the activation or function of the kinase. A potential site of therapeutic intervention is to block viral inhibition of PKR.  2, record 29, English, - protein%20kinase%20PKR

Record 29,  Textual support,  French

Record number: 29, Textual support number: 1 CONT

Récemment, Michael Lai et son équipe de l'université de Los Angeles ont décrit un mécanisme expliquant la plus grande résistance de certaines souches de VHC à l'interféron. Ces chercheurs travaillent sur une enzyme, la protéine kinase PKR, qui fait avorter les virus en inhibant leur synthèse protéique. L'interféron accélère la production de la PKR par les cellules.  1, record 29, French, - prot%C3%A9ine%20kinase%20PKR

Record 29,  Textual support,  Spanish

Record 30,  Textual support,  English

Record number: 30, Textual support number: 1 DEF

An enzyme that catalyzes the phosphorylation of glycerol to glycerophosphate during microbial fermentation of propionic acid.  1, record 30, English, - glycerokinase

Record 30,  Textual support,  French

Record number: 30, Textual support number: 1 CONT

Les taux de phosphorylation du glycérol et d'oxydation du glycérol-3-phosphate sont moins rapides chez les rats consommant de l'éthanol que chez les rats témoins, ce qui indique une diminution de l'activité de la glycérol kinase et de la glycérol-3-phosphate déshydrogénase, donc, une utilisation plus lente du glycérol. Le taux d'utilisation du glycérol est fonction de la dose de glycérol et de la concentration d'oxygène.  1, record 30, French, - glyc%C3%A9rol%2Dkinase

Record 30,  Textual support,  Spanish

Record 31,  Textual support,  English

Record number: 31, Textual support number: 1 CONT

Oncogene abnormalities and the microenvironment of the cells, including the extracellular matrix and hormonal milieu, are now understood to be critical determinants of tumorigenesis and metastasis. The molecules we are targeting that participate in tumorigenesis include estrogen, the HER-2/neu tyrosine kinase, and the extracellular matrix protein fibulin-1, thought to function during embryogenesis in the conversion of epithelial cells to migratory mesenchymal cells.  1, record 31, English, - fibulin

Record 31,  Textual support,  French

Record number: 31, Textual support number: 1 CONT

Les fibulines du latin fibul «étreinte, boucle» sont des protéines de la matrice extracellulaire que l'on retrouve aussi en très faibles concentrations dans le plasma. Elles comprennent trois protéines différentes.  1, record 31, French, - fibuline

Record 31,  Textual support,  Spanish

Record 32,  Textual support,  English

Record number: 32, Textual support number: 1 CONT

Hypersecretory diseases have been untreatable because the trigger causing the uncontrolled flow of mucus was unknown. The chemical cascade that activates the mucous gene "EGF receptor tyrosine kinase" has just been discovered.  1, record 32, English, - hypersecretory%20disease

Record number: 32, Textual support number: 1 OBS

Such as acute asthma, chronic bronchitis, and cystic fibrosis.  1, record 32, English, - hypersecretory%20disease

Record 32,  Textual support,  French

Record 32,  Textual support,  Spanish

Record 33,  Textual support,  English

Record number: 33, Textual support number: 1 CONT

Invasion and angiogenesis are the newest therapeutic targets to yield agents for phase I clinical trials. Three general strategies for anti-invasive/anti-angiogenic therapy have been proposed :(1) inhibition of the production of stimulatory factors by tumor cells,(2) blockade of invasive activity, and(3) interdiction of the signal directing the proliferative or invasive command. Growth factor antagonists, such as suramin, tyrphostins, 78, 79 and signal transduction inhibitors such as CAI(see below) and protein kinase C(PKC) inhibitors are all in clinical development.  1, record 33, English, - angiogenic%20therapy

Record 33,  Textual support,  French

Record number: 33, Textual support number: 1 CONT

Les tumeurs cancéreuses solides ne peuvent se développer sans «recruter» de nouveaux vaisseaux sanguins et ce processus d'angiogénèse est responsable d'un problème majeur dans le traitement des cancers: la résistance acquise aux médicaments. Une étude expérimentale conforte des espoirs suscités depuis quelques temps par la thérapie angiogénique. En traitant des souris atteintes de divers cancers par un inhibiteur spécifique de l'angiogenèse, l'endostatine, on peut véritablement «endormir» les tumeurs de façon prolongée.  1, record 33, French, - th%C3%A9rapie%20angiog%C3%A9nique

Record 33,  Textual support,  Spanish

Record 34,  Textual support,  French

Record 34,  Textual support,  Spanish

Record 35,  Textual support,  English

Record number: 35, Textual support number: 1 CONT

Cystic fibrosis(CF) is a common lethal genetic disease that manifests itself in airway and other epithelial cells as defective chloride ion absorption and secretion. The gene responsible for CF has been identified and predicted to encode a membrane protein termed the CF transmembrane conductance regulator(CFTR). Here we demonstrate that CFTR is a membrane-associated glycoprotein that can be phosphorylated in vitro by cAMP-dependent protein kinase.  2, record 35, English, - cystic%20fibrosis%20transmembrane%20conductance%20regulator

Record number: 35, Textual support number: 1 OBS

Tiré du périodique "Nature", 1990, 347 (6291), 382-386.  2, record 35, English, - cystic%20fibrosis%20transmembrane%20conductance%20regulator

Record 35,  Textual support,  French

Record number: 35, Textual support number: 1 OBS

Protéine transmembranaire intervenant dans la perméabilité de la membrane plasmique au chlore (canal chlore)  1, record 35, French, - r%C3%A9gulateur%20de%20la%20perm%C3%A9abilit%C3%A9%20transmembranaire%20de%20la%20fibrose%20kystique

Record 35,  Textual support,  Spanish

Record 36,  Textual support,  English

Record number: 36, Textual support number: 1 CONT

Here we describe changes in dNTP metabolism that precede DNA fragmentation in a model of apoptosis driven by deprivation of the cytokine interleukin 3(IL-3). In haemopoietic BAF3 cells, IL-3 withdrawal leads to a rapid decrease in the size of dATP, dTTP and dGTP pools without affecting dCTP levels. This imbalance in dNTP pools precedes DNA fragmentation and is accompanied by down-regulation of enzymes controlling the de novo and salvage pathways of dNTP synthesis, ribonucleotide reductase and thymidine kinase(TK) respectively.  2, record 36, English, - dNTP

Record number: 36, Textual support number: 1 OBS

Biochemical Journal, Biochem. J. (1996) 316, 421 425 (Printed in Great Britain).  3, record 36, English, - dNTP

Record 36,  Textual support,  French

Record number: 36, Textual support number: 1 OBS

Précurseur utilisé pour la synthèse de l'ADN.  3, record 36, French, - 2%2Dd%C3%A9soxyribonucl%C3%A9otide%20triphosphate

Record 36,  Textual support,  Spanish

Record 37,  Textual support,  English

Record number: 37, Textual support number: 1 CONT

Activation of macrophages by bacterial lipopolysaccharide(LPS) induces transcription of genes that encode for proinflammatory regulators of the immune response. Previous work has suggested that activation of the transcription factor activator protein 1(AP-1) is one LPS-induced event that mediates this response. Consistent with this notion, we found that LPS stimulated AP-1-mediated transcription of a transfected reporter gene in the murine macrophage cell line RAW 264. 7. As AP-1 activity is regulated in part by activation of the c-Jun N-terminal kinase(JNK), which phosphorylates and subsequently increases the transcriptional activity of c-Jun, we examined whether LPS treatment of macrophages resulted in activation of this kinase.  3, record 37, English, - jun%20N%2Dterminal%20kinase

Record number: 37, Textual support number: 1 OBS

PNAS Activation of c-Jun N-terminal kinase in bacterial lipopolysaccharide-sti. Proceedings of the National Academy of Sciences Volume 93, Number 07; Pages : 2774-2778 Immunology.  4, record 37, English, - jun%20N%2Dterminal%20kinase

Record 37,  Textual support,  French

Record number: 37, Textual support number: 1 OBS

JNK  2, record 37, French, - prot%C3%A9ine%20JNK

Record 37,  Textual support,  Spanish

Record 38,  Textual support,  English

Record number: 38, Textual support number: 1 CONT

Rabbits immunized with a synthetic peptide corresponding to N-terminal amino acid residues 1-12 of rat p21-Activated Kinase(PAK) conjugated to KLH; sequence-MSNNGLDVQDKP-C(C-terminal cysteinyl residue added for conjugation).  3, record 38, English, - p21%2Dactivated%20kinase

Record number: 38, Textual support number: 1 OBS

Manser et al., Nature 367:40, 1994; Martin et al., EMBO J. 14:1971, 1995; Manser et al., J. Biol. Chem. 270:25070, 1995  4, record 38, English, - p21%2Dactivated%20kinase

Record 38,  Textual support,  French

Record 38,  Textual support,  Spanish

Record 39,  Textual support,  English

Record number: 39, Textual support number: 1 CONT

Insoluble peptidoglycan (PGN) from staphylococcal cell walls as well as soluble PGN (sPGN) secreted by staphylococci in the presence of beta-lactam antibiotics induced TNF- alpha mRNA and secretion of bioactive TNF-alpha in the murine RAW264.7 macrophage cell line. PGN and sPGN also induced rapid and dose-dependent tyrosine phosphorylation of several cellular proteins, including lyn and mitogen-activated protein kinases (extracellular signal-regulated kinases; but not hck, fgr, or vav) and increased the activities of mitogen-activated protein and rsk kinases. These PGN- and sPGN-induced effects were qualitatively similar to the effects induced by ReLPS, but higher concentrations of PGN and sPGN than ReLPS were required.  3, record 39, English, - extracellular%20signal%2Dregulated%20kinase

Record number: 39, Textual support number: 1 OBS

The Journal of Immunology: Volume: 155 Number: 05 Pages: 2620 - 2630 September 1, 1995.  4, record 39, English, - extracellular%20signal%2Dregulated%20kinase

Record 39,  Textual support,  French

Record 39,  Textual support,  Spanish

Record 40,  Textual support,  English

Record number: 40, Textual support number: 1 CONT

Egr-1 expression WAS protein kinase C(PKC)-dependent because staurosporine and calphostin C abrogated the urea effect, and down-regulation of PKC through chronic TPA treatment inhibited both urea-inducible Egr-1 protein expression and gene transcription.  4, record 40, English, - Wiskott%2DAldrich%20syndrome%20protein

Record number: 40, Textual support number: 1 OBS

The Journal of Clinical Investigation. April 15, 1996, Volume 97, Number 8 - abstracts. Categories. Molecular Medicine / Genetic Disorders. Infection /...  5, record 40, English, - Wiskott%2DAldrich%20syndrome%20protein

Record 40,  Textual support,  French

Record number: 40, Textual support number: 1 CONT

Par une analyse moléculaire approfondie, l'équipe de Uta Francke du Howard Hughes Medical Institute a cloné un gène directement impliqué [dans le syndrome de Wiskott-Aldrich (WAS) codant la protéine WASP (WAS protein). Des mutations ponctuelles sont observées chez trois familles atteintes de ce syndrome.  1, record 40, French, - prot%C3%A9ine%20WAS

Record 40,  Textual support,  Spanish

Record 41,  Textual support,  English

Record number: 41, Textual support number: 1 CONT

We describe here the cloning and characterization of a cDNA encoding a protein kinase that has high sequence homology to members of the mitogen-activated protein kinase(MAPK) kinase kinase(MAPKKK or MEKK) family; this cDNA is named cATMEKK1(Arabidopsis thaliana MAP kinase or ERK kinase kinase 1).  4, record 41, English, - MAP%20kinase%2Fextracellular%20signal%2Dregulated%20kinase%2Fkinase

Record number: 41, Textual support number: 1 OBS

Proceedings of the National Academy of Sciences Volume 93, Number 02; Pages: 765-769 Plant Biology.  5, record 41, English, - MAP%20kinase%2Fextracellular%20signal%2Dregulated%20kinase%2Fkinase

Record 41,  Textual support,  French

Record 41,  Textual support,  Spanish

Record 42,  Textual support,  English

Record number: 42, Textual support number: 1 CONT

The stress-activated protein kinases(SAPKs), which are distantly related to the MAP kinases, are the dominant c-Jun amino-terminal protein kinases activated in response to a variety of cellular stresses, including treatment with tumour-necrosis factor-alpha and interleukin-beta[...] We have now identified a novel protein kinase, called SAPK/ERK kinase-1(SEK1), which is structurally related to the MAP kinase kinases(MEKs). SEK1 is a potent activator of the SAPKs in vitro and in vivo.  3, record 42, English, - SAPK%2FERK%20kinase%2D1

Record number: 42, Textual support number: 1 OBS

Role of SAPK/ERK kinase-1 in the stress-activated pathway regulating transcription factor c-Jun. Excerpt from Nature 372, 794-8, 1994.  4, record 42, English, - SAPK%2FERK%20kinase%2D1

Record 42,  Textual support,  French

Record 42,  Textual support,  Spanish

Record 43,  Textual support,  English

Record number: 43, Textual support number: 1 CONT

We describe here the cloning and characterization of a cDNA encoding a protein kinase that has high sequence homology to members of the mitogen-activated protein kinase(MAPK) kinase kinase(MAPKKK or MEKK) family; this cDNA is named cATMEKK1 Arabidopsis thaliana MAP kinase or ERK kinase kinase.  1, record 43, English, - mitogen%2Dactivated%20protein%20kinase%20kinase%20kinase

Record number: 43, Textual support number: 1 OBS

Proceedings of the National Academy of Sciences Volume 93, Number 02; Pages : 765-769 Plant Biology. A gene encoding a mitogen-activated protein kinase.  3, record 43, English, - mitogen%2Dactivated%20protein%20kinase%20kinase%20kinase

Record 43,  Textual support,  French

Record 43,  Textual support,  Spanish

Record 44,  Textual support,  English

Record number: 44, Textual support number: 1 CONT

Genetic studies have revealed one gene that causes Alzheimer’s disease in very rare families, on chromosome 21, and two other chromosome regions that probably also include Alzheimer’s-associated genes, on chromosomes 14 and 19.  3, record 44, English, - chromosome%20region

Record number: 44, Textual support number: 2 CONT

... DNA cloning and physical mapping techniques have been used to characterize the AS/PWS chromosome region in the vicinity of D15S10... Is the chromosomal region 9q34 always involved in variants of the Ph SUP 1 translocation?... Cloning and characterization of the Escherichia coli chromosomal region surrounding the DNAG gene... Localization of a human receptor tyrosine kinase(ETK1) to chromosome region... The first chromosomic region of human major histocompatibility... [Source : PASCAL database].  2, record 44, English, - chromosome%20region

Record number: 44, Textual support number: 1 OBS

Restructuring the phase is often a viable alternative: The HLA region on the chromosome (la région chromosomique HLA).  2, record 44, English, - chromosome%20region

Record 44,  Textual support,  French

Record number: 44, Textual support number: 1 CONT

Gène marqueur : gène connu [...] qui [...] est forcément situé sur la même région chromosomique que le gène recherché.  1, record 44, French, - r%C3%A9gion%20chromosomique

Record number: 44, Textual support number: 2 CONT

[...] Le locus d'un gène de prédisposition a été identifié dans la région chromosomique 17q21 [...] Clonage et caractérisation de la région chromosomique d'E.C. entourant le gène DND [...]. Organisation de la région chromosomique du complexe majeur d'histocompatibilité humain (Source : base de données PASCAL).  2, record 44, French, - r%C3%A9gion%20chromosomique

Record 44,  Textual support,  Spanish

Record 45,  Textual support,  French

Record 45,  Textual support,  Spanish

Record 46,  Textual support,  English

Record number: 46, Textual support number: 1 CONT

There are some questions as to methodology [concerning research in molecular and developmental genetics] Things such as possible difficulties with interpretation of data from using heterologous biochemical assays and correlating in vitro protein phosphorylation sites with in vivo sites of phosphorylation could have been better addressed ....  1, record 46, English, - protein%20phosphorylation

Record number: 46, Textual support number: 2 CONT

Protein kinase C-mediated bidirectional regulation of DNA synthesis, RB protein phosphorylation, and cyclin-dependent kinases in human vascular endothelial cells... Agents which activate protein kinase C or otherwise enhance protein phosphorylation caused a substantial decrease in A beta production in vitro... The muscarinic inhibition of cyclic AMP(cAMP) mediated contractile effects may not only be the result of a reduction in cAMP levels, but may also involve cAMP linked protein phosphorylation in the heart... Recent studies in Alzheimer brains have shown aberrant protein phosphorylation, suggesting an alteration in protein kinases and/or phosphoprotein phosphatases... [Source : PASCAL database].  2, record 46, English, - protein%20phosphorylation

Record 46,  Textual support,  French

Record number: 46, Textual support number: 1 CONT

L'exemple le plus ancien et le plus célèbre des régulations par phosphorylation de protéines est celui de la glycogène phosphorylase, déjà rencontrée comme protéine allostérique. Nous savons qu'un 2e mécanisme règle l'activité de la protéine puisqu'elle peut passer par phosphorylation d'une forme b peu active à une forme a très active. Une seule phosphorylation sur chaque sous-unité du dimère suffit [...]  1, record 46, French, - phosphorylation%20de%20prot%C3%A9ines

Record 46,  Textual support,  Spanish

Record 47,  Textual support,  English

Record number: 47, Textual support number: 1 CONT

Study of the recognition-sites of nucleotides on the contractile proteins myosin and actinomyosin as well as their associated kinases, arginine kinase and creatine kinase, involving a synthetic, photolabile derivative of ATP : ATPgamma-(p-azido-aniline). Study of the structure-activity relations of the globular heads of myosin by chemical and photochemical methods(synthesis and interaction of an ATP analogue, substituted on the gamma-phosphorus atom with an azide radical).(Cited in PASCAL data base.)  1, record 47, English, - photolabile%20derivative

Record 47,  Textual support,  French

Record number: 47, Textual support number: 1 CONT

Étude des sites de reconnaissance des nucléotides au niveau des protéines contractiles, myosine [...] ainsi que des kinases qui leur sont associées : arginine kinase et créatine kinase, à l'aide d'un dérivé photolabile synthétique de l'ATP [...]. Étude des relations structure-activité au niveau des têtes globulaires de la myosine par approches chimique et photochimique (synthèse et interaction d'un analogue de l'ATP substitué sur l'atome de phosphore-gamma par le radical azide). (Cité dans la base de données PASCAL.)  1, record 47, French, - d%C3%A9riv%C3%A9%20photolabile

Record 47,  Textual support,  Spanish

Record 48,  Textual support,  English

Record number: 48, Textual support number: 1 CONT

Study of the recognition-sites of nucleotides on the contractile proteins myosin and actinomyosin as well as their associated kinases, arginine kinase and creatine kinase, involving a synthetic, photolabile derivative of ATP : ATPgamma-(p-azido-aniline). Study of the structure-activity relations of the globular heads of myosin by chemical and photochemical methods(synthesis and interaction of an ATP analogue, substituted on the gamma-phosphorus atom with an azide radical).(Cited in PASCAL data base.)  1, record 48, English, - ATP%20analogue

Record 48,  Textual support,  French

Record number: 48, Textual support number: 1 CONT

Étude des sites de reconnaissance des nucléotides au niveau des protéines contractiles, myosine et actomyosine ainsi que des kinases qui leur sont associées : arginine kinase et créatine kinase, à l'aide d'un dérivé photolabile synthétique de l'ATP : l'ATPgamma -(p-azidoanilide). Étude des relations structure-activité au niveau des têtes globulaires de la myosine par approches chimique et photochimique (synthèse et interaction d'un analogue de l'ATP substitué sur l'atome de phosphore-gamma par le radical azide). (Cité dans la base de données PASCAL.)  1, record 48, French, - analogue%20de%20l%27ATP

Record 48,  Textual support,  Spanish

Record 49,  Textual support,  English

Record number: 49, Textual support number: 1 CONT

Study of the recognition-sites of nucleotides on the contractile proteins myosin and actinomyosin as well as their associated kinases, arginine kinase and creatine kinase, involving a synthetic, photolabile derivative of ATP : ATPgamma-(p-azido-aniline). Study of the structure-activity relations of the globular heads of myosin by chemical and photochemical methods(synthesis and interaction of an ATP analogue, substituted on the gamma-phosphorus atom with an azide radical).(Cited in PASCAL data base.)  1, record 49, English, - arginine%20kinase

Record 49,  Textual support,  French

Record number: 49, Textual support number: 1 CONT

Étude des sites de reconnaissance des nucléotides au niveau des protéines contractiles, myosine [...] ainsi que des kinases qui leur sont associées : arginine kinase et créatine kinase, à l'aide d'un dérivé photolabile synthétique de l'ATP [...]. Étude des relations structure-activité au niveau des têtes globulaires de la myosine par approches chimique et photochimique (synthèse et interaction d'un analogue de l'ATP substitué sur l'atome de phosphore-gamma par le radical azide). (Cité dans la base de données PASCAL.)  1, record 49, French, - arginine%20kinase

Record 49,  Textual support,  Spanish

Record 50,  Textual support,  English

Record number: 50, Textual support number: 1 CONT

Study of the recognition-sites of nucleotides on the contractile proteins myosin and actinomyosin as well as their associated kinases, arginine kinase and creatine kinase, involving a synthetic, photolabile derivative of ATP : ATPgamma-(p-azido-aniline). Study of the structure-activity relations of the globular heads of myosin by chemical and photochemical methods(synthesis and interaction of an ATP analogue, substituted on the gamma-phosphorus atom with an azide radical).(Cited in PASCAL data base.)  1, record 50, English, - gamma%2Dphosphorus%20atom

Record 50,  Textual support,  French

Record number: 50, Textual support number: 1 CONT

Étude des sites de reconnaissance des nucléotides au niveau des protéines contractiles, myosine [...] ainsi que des kinases qui leur sont associées : arginine kinase et créatine kinase, à l'aide d'un dérivé photolabile synthétique de l'ATP [...]. Étude des relations structure-activité au niveau des têtes globulaires de la myosine par approches chimique et photochimique (synthèse et interaction d'un analogue de l'ATP substitué sur l'atome de phosphore-gamma par le radical azide). (Cité dans la base de données PASCAL.)  1, record 50, French, - atome%20de%20phosphore%2Dgamma

Record 50,  Textual support,  Spanish

Record 51,  Textual support,  English

Record number: 51, Textual support number: 1 CONT

Study of the recognition-sites of nucleotides on the contractile proteins myosin and actinomyosin as well as their associated kinases, arginine kinase and creatine kinase, involving a synthetic, photolabile derivative of ATP : ATPgamma-(p-azido-aniline). Study of the structure-activity relations of the globular heads of myosin by chemical and photochemical methods(synthesis and interaction of an ATP analogue, substituted on the gamma-phosphorus atom with an azide radical).(Cited in PASCAL data base.)  1, record 51, English, - globular%20head%20of%20myosin

Record 51,  Textual support,  French

Record number: 51, Textual support number: 1 CONT

Étude des sites de reconnaissance des nucléotides au niveau des protéines contractiles, myosine [...] ainsi que des kinases qui leur sont associées : arginine kinase et créatine kinase, à l'aide d'un dérivé photolabile synthétique de l'ATP [...]. Étude des relations structure-activité au niveau des têtes globulaires de la myosine par approches chimique et photochimique (synthèse et interaction d'un analogue de l'ATP substitué sur l'atome de phosphore-gamma par le radical azide). (Cité dans la base de données PASCAL.)  1, record 51, French, - t%C3%AAte%20globulaire%20de%20la%20myosine

Record 51,  Textual support,  Spanish

Record 52,  Textual support,  English

Record number: 52, Textual support number: 1 CONT

Aland Island eye disease (Forsius-Eriksson syndrome) associated with contiguous deletion syndrome at Xp21. Similarity to incomplete congenital stationary night blindness. (In Archives of Ophthalmology, 1989, 107 (8) 1170-1179, cited in PASCAL data base.)  1, record 52, English, - Aland%20Island%20eye%20disease

Record number: 52, Textual support number: 2 CONT

Aland island eye disease(forsius-eriksson ocular albinism) and Xp21 deletion in a patient with duchenne muscular dystrophy, glycerol kinase deficiency, and congenital adrenal hypoplasia.(In American journal of medical genetics, 1990, 36(1) 23-28, cited in PASCAL data base.)  1, record 52, English, - Aland%20Island%20eye%20disease

Record 52,  Textual support,  French

Record number: 52, Textual support number: 1 CONT

Différents types d'albinisme - [...] Albinisme oculaire [...] Syndrome de Forsins-Eriksson - Maladie des yeux d'Aland (variété allélique ou pseudo-allélique du précédent)  1, record 52, French, - maladie%20des%20yeux%20d%27Aland

Record 52,  Textual support,  Spanish

Record 53,  Textual support,  English

Record number: 53, Textual support number: 1 CONT

Identification of a developmentally regulated protein-tyrosine kinase by using anti-phosphotyrosine antibodies to screen a cDNA expression library.  1, record 53, English, - screen

Record number: 53, Textual support number: 1 OBS

Tiré de: Proceedings of the Naturial Academy of Sciences of the United States of America, 1989, 86 (14), 5449-5453.  1, record 53, English, - screen

Record 53,  Textual support,  French

Record number: 53, Textual support number: 1 CONT

Un clone secondaire B4D10 a été obtenu sur les mêmes bases. Il a servi à construire une banque génomique et une banque d'ADNc. La première a été criblée avec des séquences Alu humaine. Un fragment génomique, ainsi isolé, a permis d'isoler un clone d'ADNc qui a lui-même été utilisé comme sonde pour cribler une banque d'ADNc de lymphoblastes humains. C'est de cette banque qu'a été isolé un clone contenant toute la séquence codante du récepteur d'IFNa humain.  1, record 53, French, - cribler

Record 53,  Textual support,  Spanish

Record 54,  Textual support,  English

Record 54,  Textual support,  French

Record number: 54, Textual support number: 1 OBS

kinase : Enzyme assurant le transfert d'un phosphate provenant de l'adénosine triphosphate (ATP) sur un accepteur qui est ainsi activé (...).  2, record 54, French, - prot%C3%A9ine%2Dkinase%20intracellulaire

Record 54,  Textual support,  Spanish

Record 55,  Textual support,  French

Record 55,  Textual support,  Spanish

Record 56,  Textual support,  English

Record number: 56, Textual support number: 1 OBS

creatine kinase. Enzyme of skeletal muscle and the myocardium and of brain tissue that catalyzes the transfer of a phosphate group from phosphocreatine to ADP, producing creatine and ATP. It occurs as three isoenzymes each having two components labeled M and B : the form in brain tissue is BB, in skeletal muscle MM, and in myocardial tissue both MM, and in myocardial tissue both MM and MB. The form normally found in serum is virtually all MM isoenzyme.  3, record 56, English, - MB%20creatine%20kinase

Record 56,  Textual support,  French

Record number: 56, Textual support number: 1 CONT

Le taux sanguin de la créatine-kinase s'élève dans tous les cas d'atteinte musculaire : myopathies, ischémies aiguës des membres, infarctus du myocarde, dans ce dernier cas, l'élévation du taux sérique de la CK atteint son maximum vers la 20e heure. [...] Une variété de cette enzyme (isozyme), la créatine-kinase MB (CK-MB : M = muscle; B = brain, cerveau) n'apparaît dans le sérum qu'en cas de lésion du myocarde.  1, record 56, French, - cr%C3%A9atine%20%2D%20kinase%20MB

Record 56,  Textual support,  Spanish

Record 57,  Textual support,  English

Record number: 57, Textual support number: 1 CONT

The mitochondrial enzymes show a definite compartmentation. The outer membrane contains NADH-cytochrome-c-reductase, which consists of a flavoprotein and cytochrome b₃. Monoamine oxidase is the specific enzyme marker of this membrane. The outer compartment contains adenylate kinase and other soluble enzymes. The inner membrane carries all the components of the respiratory chain and of oxidative phosphorylation.  1, record 57, English, - enzyme%20marker

Record number: 57, Textual support number: 1 OBS

See "enzyme label".  2, record 57, English, - enzyme%20marker

Record 57,  Textual support,  French

Record number: 57, Textual support number: 1 DEF

Enzyme dont la localisation est préférentielle dans tel ou tel organite subcellulaire de tel ou tel tissu. Sa présence, mieux même, l'augmentation de sa concentration (mesurée par l'intermédiaire de son activité enzymatique) est un signe de l'enrichissement progressif des fractions subcellulaires successivement obtenues, en l'organite recherché (noyaux, mitochondries, lysosomes, etc.).  1, record 57, French, - enzyme%20marqueur

Record number: 57, Textual support number: 1 CONT

On a parfois abusivement étendu au cerveau, à la rate, au poumon, etc. de l'Homme, des résultats d'enzymes marqueurs dont l'affectation n'est réelle à tel ou tel organite subcellulaire que dans le foie du rat mâle de souche Wistar! Malgré tout, le bilan de l'usage des enzymes marqueurs demeure largement positif pour une meilleure connaissance des relations structure-fonction au niveau cellulaire.  1, record 57, French, - enzyme%20marqueur

Record number: 57, Textual support number: 1 OBS

Ne pas confondre avec "enzyme marqueur", voir "enzyme label".  2, record 57, French, - enzyme%20marqueur

Record 57,  Textual support,  Spanish

Record 58,  Textual support,  English

Record number: 58, Textual support number: 1 DEF

The act or process of rendering active, as in the transformation of pre-enzyme into an active enzyme by the action of a kinase or another pre-enzyme,...  1, record 58, English, - activation

Record 58,  Textual support,  French

Record number: 58, Textual support number: 1 CONT

Les activateurs des enzymes sont les substances qui exaltent de façon plus ou moins spécifique l'activité du biocatalyseur. (...) L'activation enzymatique par des ions est bien différente de l'activation des proenzymes ou zymogènes, (...), et qui implique une modification de la protéine enzymatique, souvent accompagnées d'une variation du poids moléculaire (...)  1, record 58, French, - activation

Record 58,  Textual support,  Spanish

Record 59,  Textual support,  English

Record number: 59, Textual support number: 1 CONT

[A few] mutants could be selected because they are resistant to a compound called AEC, which resembles lysine so closely that it mimics its regulatory effect, inhibiting aspartate kinase even if no lysine is being synthesized. In the presence of AEC, wild strains die as a result of lysine starvation, whereas the mutants proliferate and form colonies.  1, record 59, English, - AEC

Record 59,  Textual support,  French

Record number: 59, Textual support number: 1 CONT

[Certains] mutants ont pu être isolés parce qu'ils sont résistants à un composé appelé AEC, lequel ressemble tellement à la lysine qu'il reproduit son action régulatrice en inhibant l'aspartate kinase, même en l'absence de lysine : aussi, en présence d'AEC, les souches sauvages meurent par privation de lysine, alors que les mutants prolifèrent et forment des colonies.  1, record 59, French, - AEC

Record 59,  Textual support,  Spanish

Record 60,  Textual support,  French

Record 60,  Textual support,  Spanish