TERMIUM Plus^®

Record 1,  Textual support,  English

Record number: 1, Textual support number: 1 CONT

Targeted alpha-particle therapy(or TAT) is an investigational method of targeted radionuclide therapy for various cancers and infectious diseases. It employs radioactive alpha-emitting substances which undergo decay to treat diseased tissue at close proximity. TAT has the potential to provide highly targeted treatment, especially to microscopic tumor cells. Targets include leukemias, lymphomas, gliomas, melanoma, peritoneal carcinomatosis and HIV.  2, record 1, English, - targeted%20alpha%20therapy

Record number: 1, Textual support number: 2 CONT

Targeted alpha therapy (TAT) delivers high-energy alpha particles to cancer cells and the tumour microenvironment to treat metastatic castration-resistant prostate cancer (mCRPC) and other cancers.  3, record 1, English, - targeted%20alpha%20therapy

Record 1,  Textual support,  French

Record number: 1, Textual support number: 1 CONT

Les thérapies alpha ciblées utilisent des isotopes médicaux liés à une biomolécule qui peut cibler les cellules cancéreuses avec précision sans endommager les zones environnantes.  1, record 1, French, - th%C3%A9rapie%20alpha%20cibl%C3%A9e

Record 1,  Textual support,  Spanish

Record 2,  Textual support,  English

Record number: 2, Textual support number: 1 OBS

The Canadian Melanoma Foundation is a non-profit organization working with the public, melanoma patients and their families to raise awareness of melanoma and to build financial support for Canadian scientists throughout the country who are conducting cutting edge research for the better understanding and better treatment of melanoma.  2, record 2, English, - Canadian%20Melanoma%20Foundation

Record 2,  Textual support,  French

Record number: 2, Textual support number: 1 OBS

La fondation Canadian Melanoma Foundation est une organisation sans but lucratif. Elle compte sur les dons généreux de ceux qui se soucient de l'amélioration des méthodes prévention et de la guérison du cancer.  2, record 2, French, - Canadian%20Melanoma%20Foundation

Record 2,  Textual support,  Spanish

Record 3,  Textual support,  English

Record number: 3, Textual support number: 1 DEF

A mole usually greater than 5 mm, that has an irregular border and the color of which is variable within a single lesion.  2, record 3, English, - dysplastic%20nevus

Record number: 3, Textual support number: 1 OBS

Dysplastic nevus may turn into melanoma.  2, record 3, English, - dysplastic%20nevus

Record 3,  Textual support,  French

Record number: 3, Textual support number: 1 DEF

Nævus nævomélanocytaire caractérisé par un aspect clinique et histologique très particulier de dysplasie mélanocytaire, et précurseur de mélanomes malins.  2, record 3, French, - n%C3%A6vus%20dysplasique

Record number: 3, Textual support number: 1 OBS

Chaque lésion possède une bordure irrégulière et (ou) une couleur non homogène ainsi qu'un diamètre dépassant généralement 6 mm.  2, record 3, French, - n%C3%A6vus%20dysplasique

Record 3,  Textual support,  Spanish

Record 4,  Textual support,  English

Record number: 4, Textual support number: 1 DEF

The occurrence of dysplastic nevi in persons with or at risk for familial or nonfamilial malignant melanoma.  5, record 4, English, - dysplastic%20nevus%20syndrome

Record number: 4, Textual support number: 1 CONT

Some families have an inherited predisposition to develop melanomas. This condition is referred to as the dysplastic nevus syndrome(DNS) or the familial atypical mole melanoma(FAMM) syndrome.  3, record 4, English, - dysplastic%20nevus%20syndrome

Record 4,  Textual support,  French

Record number: 4, Textual support number: 1 CONT

Le syndrome du nævus dysplasique, appelé encore «FAMMM syndrome» (familial atypical multiple mole melanoma) représente près de 95 % des mélanomes familiaux. Les nævi dysplasiques seraient des précurseurs vrais du mélanome malin (MM) et 40 % des mélanomes superficiels extensifs (superficial spreading melanoma - S.S.M.) surviendraient sur nævus dysplasique. Leur présence permet d'identifier dans les familles de mélanomes les sujets à haut risque (ce risque approche 100 %).  2, record 4, French, - syndrome%20du%20n%C3%A6vus%20dysplasique

Record 4,  Textual support,  Spanish

Record number: 4, Textual support number: 1 DEF

Presencia familiar de nuevus displásicos.  1, record 4, Spanish, - s%C3%ADndrome%20de%20nevus%20displ%C3%A1sico

Record number: 4, Textual support number: 1 OBS

Las personas que tienen este síndrome tienen un mayor riesgo de desarrollar melanoma.  1, record 4, Spanish, - s%C3%ADndrome%20de%20nevus%20displ%C3%A1sico

Record 5,  Textual support,  English

Record number: 5, Textual support number: 1 OBS

8740/3: International Classification of Diseases code.  2, record 5, English, - malignant%20melanoma%20in%20junctional%20nevus

Record 5,  Textual support,  French

Record number: 5, Textual support number: 1 OBS

8740/3 : Code de la Classification internationale des maladies.  2, record 5, French, - m%C3%A9lanome%20malin%20sur%20n%C3%A6vus%20de%20jonction

Record 5,  Textual support,  Spanish

Record 6,  Textual support,  English

Record number: 6, Textual support number: 1 OBS

8761/3: International Classification of Diseases code.  2, record 6, English, - malignant%20melanoma%20in%20giant%20pigmented%20nevus

Record 6,  Textual support,  French

Record number: 6, Textual support number: 1 OBS

8761/3 : Code de la Classification internationale des maladies.  2, record 6, French, - m%C3%A9lanome%20malin%20sur%20n%C3%A6vus%20pigmentaire%20g%C3%A9ant

Record 6,  Textual support,  Spanish

Record 7,  Textual support,  English

Record number: 7, Textual support number: 1 DEF

The most serious type of skin cancer, [malignant tumor] which originates in the cells that produce melanin (the dark protective pigment of the skin).  2, record 7, English, - melanoma

Record number: 7, Textual support number: 1 OBS

melanoma : When used alone the term refers to malignant melanoma.  3, record 7, English, - melanoma

Record 7,  Textual support,  French

Record number: 7, Textual support number: 1 DEF

Tumeur maligne, pigmentée ou non, constituée d'une prolifération de cellules mélaniques.  3, record 7, French, - m%C3%A9lanome

Record number: 7, Textual support number: 1 OBS

Les proliférations mélaniques bénignes sont des nævus nævocellulaires. Le terme «mélanome» pour une tumeur nævique bénigne est à proscrire formellement (par exemple, dire nævus de Spitz au lieu de mélanome de Spitz ou mélanome juvénile).  1, record 7, French, - m%C3%A9lanome

Record 7,  Textual support,  Spanish

Record 8,  Textual support,  English

Record number: 8, Textual support number: 1 OBS

Objectives. To provide emotional and financial assistance to those battling melanoma; to promote education and awareness of skin cancer [and] to raise funds to further research treatment options.  2, record 8, English, - Save%20Your%20Skin%20Foundation

Record 8,  Textual support,  French

Record number: 8, Textual support number: 1 OBS

Objectifs : Fournir une aide morale et financière à ceux touchés par le cancer de la peau; faire de la prévention et sensibiliser au cancer de la peau [et] lever des fonds pour soutenir la recherche.  1, record 8, French, - Fondation%20Sauve%20Ta%20Peau

Record 8,  Textual support,  Spanish

Record 9,  Textual support,  English

Record number: 9, Textual support number: 1 CONT

The traditional identification of physicians as either clinician or researcher is challenged by the emergence of randomised clinical trials(RCTs) where research and clinical care are performed simultaneously. A mail survey using a self-administered questionnaire, the Physician Orientation Profile, was conducted of 101 physicians from the Collaborative Ocular Melanoma Study(COMS), a set of trials which compares surgical removal of the eye with radiation in the treatment of medium sized eye cancers. A 95 % response rate was obtained; follow-up telephone interviews were conducted with 87 % of respondents.  2, record 9, English, - surgical%20removal%20of%20the%20eye

Record 9,  Textual support,  French

Record number: 9, Textual support number: 1 CONT

Bourgeonnement des axones dans la voie optique ipsilatérale après ablation de l'œil du côté opposé.  1, record 9, French, - ablation%20de%20l%27%26oelig%3Bil

Record 9,  Textual support,  Spanish

Record 10,  Textual support,  English

Record 10,  Textual support,  French

Record number: 10, Textual support number: 1 DEF

Mélanome qui se situe au niveau de la peau.  1, record 10, French, - m%C3%A9lanome%20cutan%C3%A9

Record number: 10, Textual support number: 1 OBS

Certains mélanomes se situent au niveau de l'œil. Un mélanome peut être bénin, comme les nævi, ou malin, comme les nævo-carcinomes.  1, record 10, French, - m%C3%A9lanome%20cutan%C3%A9

Record 10,  Textual support,  Spanish

Record 11,  Textual support,  English

Record number: 11, Textual support number: 1 OBS

CSPA is a patient-centred organization serving patient needs to enhance care, to promote skin health and to find cures for Canadian skin patients.  3, record 11, English, - Canadian%20Skin%20Patient%20Alliance

Record number: 11, Textual support number: 2 OBS

The mission of the CSPA is to promote skin health and improve the quality of life of Canadians living with dermatological conditions. [CSPA is] a national non-profit organization dedicated to advocate, educate and support Canadians living with skin diseases, conditions and traumas. [The Alliance] advocates for best treatment options for all skin patients;... educates on a variety of issues affecting these patients; and... supports the members of... affiliate organizations who work specifically on their disease areas such as acne, scleroderma, melanoma and psoriasis.  4, record 11, English, - Canadian%20Skin%20Patient%20Alliance

Record 11,  Textual support,  French

Record number: 11, Textual support number: 1 OBS

L'ACPD est un organisme qui dessert les besoins des patients atteints de maladies cutanées avec une orientation vers l'amélioration des soins, la promotion de la santé de la peau et la recherche en matière de guérison pour les patients canadiens.  2, record 11, French, - Alliance%20canadienne%20des%20patients%20en%20dermatologie

Record number: 11, Textual support number: 2 OBS

L'Alliance canadienne des patients en dermatologie créée par les patients pour les patients offre de l'information et du support pour les patients en dermatologie et leur famille.  3, record 11, French, - Alliance%20canadienne%20des%20patients%20en%20dermatologie

Record 11,  Textual support,  Spanish

Record 12,  Textual support,  English

Record number: 12, Textual support number: 1 DEF

A monoclonal antibody binding to the CTLA-4 expressed in activated T cells ...  2, record 12, English, - ipilimumab

Record number: 12, Textual support number: 1 OBS

[Ipilimumab] was recently approved by the U. S. Food and Drug Administration(FDA) for the treatment of metastatic melanoma.  3, record 12, English, - ipilimumab

Record 12,  Textual support,  French

Record number: 12, Textual support number: 1 DEF

Anticorps monoclonal se liant à la protéine CTLA-4 (cytotoxic T-lymphocyte antigen 4) [...]  2, record 12, French, - ipilimumab

Record number: 12, Textual support number: 1 CONT

[...] l'ipilimumab a reçu l'autorisation de la Commission européenne pour être administré en première ligne du traitement du mélanome avancé - non opérable ou métastatique.  2, record 12, French, - ipilimumab

Record number: 12, Textual support number: 2 CONT

En cas de mélanome, le récepteur lymphocytaire CTLA-4 est inhibé par les cellules cancéreuses, ce qui empêche les lymphocytes T de détruire les cellules tumorales au niveau ganglionnaire. L'ipilimumab fonctionne en débloquant ce mécanisme inhibiteur.  3, record 12, French, - ipilimumab

Record 12,  Textual support,  Spanish

Record 13,  Textual support,  English

Record number: 13, Textual support number: 1 DEF

A malignant tumor (of the lung), usually developing from a nevus and consisting of black masses of cells with a marked tendency to metastasis.  2, record 13, English, - malignant%20melanoma%20of%20the%20lung

Record 13,  Textual support,  French

Record number: 13, Textual support number: 1 DEF

Mélanome malin prenant naissance dans une grosse bronche sous forme d'un lésion sessile infiltrante, pigmentée ou non.  1, record 13, French, - m%C3%A9lanome%20malin%20du%20poumon

Record 13,  Textual support,  Spanish

Record 14,  Textual support,  English

Record number: 14, Textual support number: 1 DEF

A slow growing type [of melanoma] characterized by macular onset and lateral spread within the epidermis; usually occurring on the hands, feet and mucous membranes.  1, record 14, English, - acral%2Dlentiginous%20melanoma

Record 14,  Textual support,  French

Record number: 14, Textual support number: 1 DEF

Mélanome caractérisé par une macule pigmentée s'élargissant au fil des ans et qui touche les extrémités distales, régions palmoplantaires en particulier, avec contours polycycliques et encoches, et polychromie très évocatrice.  2, record 14, French, - m%C3%A9lanome%20lentigineux%20des%20extr%C3%A9mit%C3%A9s

Record 14,  Textual support,  Spanish

Record number: 14, Textual support number: 1 DEF

Cáncer cutáneo que se manifiesta con una mancha oscura en la palma de la mano, en la planta del pie o en las uñas.  1, record 14, Spanish, - melanoma%20acral%20lentiginoso

Record 15,  Textual support,  English

Record number: 15, Textual support number: 1 CONT

ERGAMISOL. Janssen. Levamisole HCl. Immunomodulator used as adjuvant therapy in poor prognosis malignant melanoma following complete surgical excision and exclusion of metastatic disease. Also indicated as adjuvant therapy, in combination with 5-fluorouracil, in patients with completely resected Dukes’ stage C colon cancer. Evidence of metastatic disease must be excluded before initiating therapy. In patients with Dukes’ stage C carcinoma of the colon. Children : Also recommended for use in high-dose steroid-dependent nephrotic syndrome in children : As adjuvant therapy following relapse on corticosteroids such as prednisone; or as an alternative to the use of an alkylating agent or cyclosporin. Supplied : Tablets.  3, record 15, English, - levamisole%20hydrochloride

Record number: 15, Textual support number: 1 OBS

Active ingredient sold under the name Ergamisol.  4, record 15, English, - levamisole%20hydrochloride

Record 15,  Textual support,  French

Record number: 15, Textual support number: 1 DEF

Agent immunomodulateur présenté sous forme de comprimé.  2, record 15, French, - chlorhydrate%20de%20l%C3%A9vamisole

Record number: 15, Textual support number: 1 OBS

Indiqué comme traitement d'appoint dans le mélanome malin à mauvais pronostic, après l'exérèse chirurgicale complète et l'exclusion de métastase, le lévamisole est également indiqué en association avec le 5-fluorouracile, dans le carcinome du côlon du stade Dukes C, après une résection complète. En pédiatrie, le lévamisole est recommandé pour traiter le syndrome néphrotique répondant aux stéroïdes à posologies élevées, comme traitement avec des corticostéroïdes comme la prednisone, ou pour remplacer un agent alkylant ou le cyclosporine.  1, record 15, French, - chlorhydrate%20de%20l%C3%A9vamisole

Record number: 15, Textual support number: 2 OBS

Principe actif commercialisé sous le nom de Ergamisol.  3, record 15, French, - chlorhydrate%20de%20l%C3%A9vamisole

Record 15,  Textual support,  Spanish

Record number: 15, Textual support number: 1 CONT

El medicamento "clorhidrato de levamisol" queda declarado como medicamento huérfano para la siguiente indicación: tratamiento del síndrome refrótico.  1, record 15, Spanish, - clorhidrato%20de%20levamisol

Record 16,  Textual support,  English

Record number: 16, Textual support number: 1 DEF

A dibasic acid, slightly soluble in water, ethyl alcohol, and acetone.  3, record 16, English, - betulinic%20acid

Record number: 16, Textual support number: 1 CONT

Betulinic acid is a pentacyclic triterpene. It has several botanical sources, but can also be chemically derived from betulin, a substance found in abundance in the outer bark of white birch trees(Betula alba). Betulinic acid has been found to selectively kill human melanoma cells while leaving healthy cells alive.  4, record 16, English, - betulinic%20acid

Record number: 16, Textual support number: 1 OBS

Chemical formula : C₃₀H₄₈O₃  5, record 16, English, - betulinic%20acid

Record 16,  Textual support,  French

Record number: 16, Textual support number: 1 CONT

L'acide bétulinique est cytotoxique in vitro et in vivo : il inhibe sélectivement, en induisant l'apoptose, la croissance de mélanomes humains développés sur souris. Certains amides de l'acide bétulinique (amide de l'acide 11-amino-undécanoïque et RPR 103611) sont des inhibiteurs puissants et sélectifs de la réplication du virus HIV-1.  2, record 16, French, - acide%20b%C3%A9tulinique

Record number: 16, Textual support number: 1 OBS

Formule chimique : C₃₀H₄₈O₃  3, record 16, French, - acide%20b%C3%A9tulinique

Record 16,  Textual support,  Spanish

Record 17,  Textual support,  English

Record number: 17, Textual support number: 1 DEF

A centrifugally expanding type [of melanoma] characterized by lateral spread within the epidermis, irregular borders and variable coloration(red, pink, blue, white, brown and black).  1, record 17, English, - superficial%20spreading%20melanoma

Record number: 17, Textual support number: 1 OBS

It occurs most commonly on the legs of women and the chest and back of men.  1, record 17, English, - superficial%20spreading%20melanoma

Record 17,  Textual support,  French

Record number: 17, Textual support number: 1 CONT

Mélanome. [...] Mélanome superficiel extensif (dit SSM) : tache pigmentée à contours irréguliers. L'évolution horizontale est plus prolongée avant l'évolution verticale.  1, record 17, French, - m%C3%A9lanome%20superficiel%20extensif

Record 17,  Textual support,  Spanish

Record number: 17, Textual support number: 1 DEF

Uno de los cuatro tipos de melanoma. Puede surgir de un lunar existente o ser un nuevo crecimiento.  1, record 17, Spanish, - melanoma%20de%20extensi%C3%B3n%20superficial

Record 18,  Textual support,  English

Record number: 18, Textual support number: 1 OBS

8774/3: International Classification of Diseases code.  2, record 18, English, - type%20B%20spindle%20cell%20melanoma

Record 18,  Textual support,  French

Record number: 18, Textual support number: 1 CONT

8774/3 : Code de la Classification internationale des maladies.  2, record 18, French, - m%C3%A9lanome%20%C3%A0%20cellules%20fusiformes%20de%20type%20B

Record 18,  Textual support,  Spanish

Record 19,  Textual support,  English

Record number: 19, Textual support number: 1 CONT

8772/3: International Classification of Diseases code.  2, record 19, English, - spindle%20cell%20melanoma

Record 19,  Textual support,  French

Record number: 19, Textual support number: 1 OBS

8772/3 : Code de la Classification internationale des maladies.  2, record 19, French, - m%C3%A9lanome%20%C3%A0%20cellules%20fusiformes

Record 19,  Textual support,  Spanish

Record 20,  Textual support,  English

Record number: 20, Textual support number: 1 CONT

8773/3: International Classification of Diseases code.  2, record 20, English, - type%20A%20spindle%20cell%20melanoma

Record 20,  Textual support,  French

Record number: 20, Textual support number: 1 OBS

8773/3 : Code de la Classification internationale des maladies.  2, record 20, French, - m%C3%A9lanome%20%C3%A0%20cellules%20fusiformes%20de%20type%20A

Record 20,  Textual support,  Spanish

Record 21,  Textual support,  English

Record number: 21, Textual support number: 1 OBS

8741/3: International Classification of Diseases code.  2, record 21, English, - malignant%20melanoma%20in%20precancerous%20melanosis

Record 21,  Textual support,  French

Record number: 21, Textual support number: 1 OBS

8741/3 : Code de la Classification internationale des maladies.  2, record 21, French, - m%C3%A9lanome%20malin%20sur%20m%C3%A9lanose%20pr%C3%A9canc%C3%A9reuse

Record 21,  Textual support,  Spanish

Record 22,  Textual support,  English

Record number: 22, Textual support number: 1 OBS

8775/3: International Classification of Diseases code.  2, record 22, English, - mixed%20epithelioid%20and%20spindle%20cell%20melanoma

Record 22,  Textual support,  French

Record number: 22, Textual support number: 1 CONT

8775/3 : Code de la Classification internationale des maladies.  2, record 22, French, - m%C3%A9lanome%20%C3%A0%20cellules%20%C3%A9pith%C3%A9lo%C3%AFdes%20et%20%C3%A0%20cellules%20fusiformes

Record 22,  Textual support,  Spanish

Record 23,  Textual support,  English

Record number: 23, Textual support number: 1 OBS

8742/3: International Classification of Diseases code.  2, record 23, English, - malignant%20melanoma%20in%20Hutchinson%27s%20melanotic%20freckle

Record 23,  Textual support,  French

Record number: 23, Textual support number: 1 OBS

8742/3 : Code de la Classification internationale des maladies.  2, record 23, French, - m%C3%A9lanome%20malin%20sur%20m%C3%A9lanose%20circonscrite%20de%20Dubreuilh

Record 23,  Textual support,  Spanish

Record 24,  Textual support,  English

Record number: 24, Textual support number: 1 DEF

A rare virus that normally causes only minor flu-like infections in people, but has the ability to kill human cancer cells leaving non-cancerous cells intact. It sometimes infects cattle, causing temporary blisters on the lip such as cold sores, but does no lasting damage.  3, record 24, English, - vesicular%20stomatitis%20virus

Record number: 24, Textual support number: 1 CONT

In the laboratory, the VSV has destroyed a wide variety of cancer cells :melanoma, lung, colon, breast and protate cancers and leukemia.  3, record 24, English, - vesicular%20stomatitis%20virus

Record number: 24, Textual support number: 2 CONT

We have been studying effects on vesicular stomatitis virus (VSV), an RNA virus, and on human immunodeficiency virus (HIV), a retrovirus. With VSV we have shown that transcription of the infecting RNA molecule, the primary transcription step, is inhibited, thus amplification of viral RNA is prevented.  4, record 24, English, - vesicular%20stomatitis%20virus

Record 24,  Textual support,  French

Record number: 24, Textual support number: 1 CONT

L'enveloppe du virus de la stomatite vésiculaire (VSV), également utilisée, permet quant à elle le transfert de gènes vers des cellules d'une origine autre que mammifère, comme les cellules de poisson ou d'insecte.  1, record 24, French, - virus%20de%20la%20stomatite%20v%C3%A9siculaire

Record 24,  Textual support,  Spanish

Record number: 24, Textual support number: 1 DEF

Virus de la familia Rhabdoviridae, del género vesiculovirus, del que se reconocen dos serotipos [...] New Jersey (NJ) e Indiana (I), de acuerdo con el lugar de origen de los primeros aislamientos caracterizados inmunológicamente.  2, record 24, Spanish, - virus%20de%20estomatitis%20vesicular

Record number: 24, Textual support number: 1 CONT

El virus infecta en forma natural a mamiferos domésticos y silvestres. [...] principalmente a cerdos, caballos y bovinos, produciendo vesículas y erosiones en la boca, rodete coronario y pezones, especialmente en vacas en producción.  3, record 24, Spanish, - virus%20de%20estomatitis%20vesicular

Record number: 24, Textual support number: 1 OBS

La presencia del virus de la estomatitis vesicular (VEV), parece limitada al hemisferio occidental, especialmente a países que bordean el mar Caribe como México, Costa Rica, Colombia y Venezuela.  2, record 24, Spanish, - virus%20de%20estomatitis%20vesicular

Record 25,  Textual support,  English

Record number: 25, Textual support number: 1 DEF

An inhibitor of the enzyme ribonucleoside diphosphate reductase, which catalyzes the conversion of ribonucleotides to deoxyribonucleotides, an essential step in DNA synthesis.  1, record 25, English, - hydroxyurea

Record number: 25, Textual support number: 1 OBS

[Hydroxyurea] is used as an antineoplastic agent primarily for treatment of busulfan-resistant chronic granulocytic leukemia, and also for the treatment of carcinoma of the head and neck, ovary, and cervix, malignant melanoma, and polycythemia vera; administered orally.  1, record 25, English, - hydroxyurea

Record 25,  Textual support,  French

Record number: 25, Textual support number: 1 CONT

L'Hydroxyurée est une molécule utilisée habituellement dans les maladies du sang (leucémies). Elle est prescrite avec la ddI [dideoxyinosine] dont elle renforce l'action anti-VIH. Elle agit en freinant la synthèse de l'ADN. Sa place dans le traitement du VIH est mal évaluée et controversée.  2, record 25, French, - hydroxyur%C3%A9e

Record 25,  Textual support,  Spanish

Record 26,  Textual support,  English

Record number: 26, Textual support number: 1 DEF

A melanoma developing from a freckle-like lesion(pigmented patches) mostly on the face or other exposed surfaces of the skin.  2, record 26, English, - Hutchinson%26rsquo%3Bs%20melanotic%20freckle

Record number: 26, Textual support number: 1 OBS

Flat, tan or brown, with irregular darker spots, it causes no symptoms.  2, record 26, English, - Hutchinson%26rsquo%3Bs%20melanotic%20freckle

Record number: 26, Textual support number: 2 OBS

Lentigo maligna is also called Hutchinson's melanotic freckle. When the lesion is confined to the epidermis, it is called lentigo maligna; when it becomes invasive, it is called lentigo maligna melanoma.  2, record 26, English, - Hutchinson%26rsquo%3Bs%20melanotic%20freckle

Record 26,  Textual support,  French

Record number: 26, Textual support number: 1 CONT

Le mélanome malin à type de lentigo (LMM : «lentigo malignant melanoma») débute par une lésion strictement épidermique de mélanose précancéreuse de Dubreuilh (ou «Hutchinson melanotic freckle» des Anglo-Saxons).  2, record 26, French, - m%C3%A9lanose%20circonscrite%20pr%C3%A9canc%C3%A9reuse%20de%20Dubreuilh

Record 26,  Textual support,  Spanish

Record number: 26, Textual support number: 1 DEF

Neoplasia maligna de piel presentada como una mácula irregular con aspecto de mancha de tinta.  1, record 26, Spanish, - melanoma%20lentigo%20maligno

Record number: 26, Textual support number: 1 OBS

Las lesiones tienen lugar en piel dañada por el sol, frecuentemente en la población anciana.  1, record 26, Spanish, - melanoma%20lentigo%20maligno

Record 27,  Textual support,  English

Record number: 27, Textual support number: 1 CONT

Nodular melanoma appears as a rapidly growing, blue-black, smooth or eroded nodule. It invades dermis early in its evolution, making premetastatic diagnosis difficult.  1, record 27, English, - nodular%20melanoma

Record number: 27, Textual support number: 1 OBS

Melanoma is a malignant skin tumor.  2, record 27, English, - nodular%20melanoma

Record 27,  Textual support,  French

Record number: 27, Textual support number: 1 OBS

Tumeur mélanique maligne.  4, record 27, French, - m%C3%A9lanome%20nodulaire

Record number: 27, Textual support number: 1 CONT

Mélanome nodulaire [...] Macroscopie : Il constitue une lésion tumorale en saillie, monochrome, noire bleutée ou gris rose, parfois achromique, qui va s'accompagner d'un halo inflammatoire et s'ulcérer.  1, record 27, French, - m%C3%A9lanome%20nodulaire

Record 27,  Textual support,  Spanish

Record number: 27, Textual support number: 1 DEF

Tipo de melanoma que surge de un nevus preexistente o como un nuevo crecimiento.  1, record 27, Spanish, - melanoma%20nodular

Record number: 27, Textual support number: 1 OBS

Es el tipo de melanoma maligno más agresivo.  1, record 27, Spanish, - melanoma%20nodular

Record 28,  Textual support,  English

Record 28,  Textual support,  French

Record number: 28, Textual support number: 1 OBS

Le gène suppresseur de tumeur, p53 est considéré comme une molécule absolument essentielle à la régulation des réactions cellulaires à divers agents agresseurs de l'ADN [acide désoxyribonucléique]. Très peu de temps après l'apparition des cancers non mélaniques, p53 est muté ou perdu, ce qui donne à croire que ce gène est essentiel à la protection des kératinocytes normaux contre les effets destructeurs du rayonnement ultraviolet (UV).  1, record 28, French, - cancer%20non%20m%C3%A9lanique

Record 28,  Textual support,  Spanish

Record 29,  Textual support,  English

Record number: 29, Textual support number: 1 DEF

The capacity of producing metastases more or less rapidly.  1, record 29, English, - metastatic%20potential

Record number: 29, Textual support number: 1 OBS

It varies highly depending on the type of cancer : malignant melanoma may spread very rapidly to the lungs and bones, whereas basal cell epithelioma never produces any metastase.  1, record 29, English, - metastatic%20potential

Record 29,  Textual support,  French

Record number: 29, Textual support number: 1 DEF

Capacité à produire plus ou moins rapidement de métastases.  1, record 29, French, - potentiel%20m%C3%A9tastatique

Record number: 29, Textual support number: 1 OBS

Cette capacité varie fortement suivant le type de cancer : le mélanome malin peut se propager très rapidement aux poumons et aux os tandis que l'épithélioma basocellulaire ne provoque jamais de métastases.  1, record 29, French, - potentiel%20m%C3%A9tastatique

Record 29,  Textual support,  Spanish

Record 30,  Textual support,  French

Record 30,  Textual support,  Spanish

Record 31,  Textual support,  French

Record 31,  Textual support,  Spanish

Record 32,  Textual support,  English

Record number: 32, Textual support number: 1 CONT

The products of cell fusions hybridomas, are selected for their ability to grow in a medium containing aminopepterin, which poisons the unfused melanoma cells.  3, record 32, English, - aminopterin

Record number: 32, Textual support number: 1 OBS

4-amino-pteroylglutamic acid.  3, record 32, English, - aminopterin

Record 32,  Textual support,  French

Record number: 32, Textual support number: 1 OBS

Médicament antagoniste de l'acide folique.  2, record 32, French, - aminopt%C3%A9rine

Record number: 32, Textual support number: 2 OBS

acide 4-amino-pteroylglutamate aminoptérine sodique: amino -4 ptéroylglutamate de sodium.  3, record 32, French, - aminopt%C3%A9rine

Record 32,  Textual support,  Spanish

Record number: 32, Textual support number: 1 DEF

Racimos de agujas amarillas solubles en soluciones acuosas de hidróxido sódico. Tóxico por ingestión. Difiere en estructura ligeramente del ácido fólico y antagoniza la utilización de éste por el organismo.  2, record 32, Spanish, - aminopterina

Record 33,  Textual support,  French

Record 33,  Textual support,  Spanish

Record 34,  Textual support,  English

Record number: 34, Textual support number: 1 OBS

Most susceptible to melanoma and non-melanoma skin cancers.  1, record 34, English, - lightly%20pigmented%20skin

Record 34,  Textual support,  French

Record 34,  Textual support,  Spanish

Record 35,  Textual support,  English

Record number: 35, Textual support number: 1 CONT

Marine compounds acting on microtubules-Until this decade natural microtubule poisons were obtained mainly from plants(and also to a lesser extent from fungi and bacteria). However, it has been suggested that marine organisms could be a very suitable source of antimicrotubular compounds. Among them, isohomohalichondrin B has been described. Isohomohalichondrin B has activity against lung cancer or melanoma cell lines, and it prevents the binding of GTP to tubulin. Additionally there are other compounds like Ecteinascidin 743(from the tunicate Ecteinascidin turbinata), with activity in lung cancer, breast cancer and melanoma cells lines; or lamellarin N(from the tunicate Didemnum sp.) also with activity in lung cancer cell lines. These compounds promote a different rearrangment of the cell microtubule network and cause cell death.  1, record 35, English, - ecteinascidin

Record 35,  Textual support,  French

Record number: 35, Textual support number: 1 OBS

Substance d'origine marine présentant des propriétés antitumorales,isolée chez Ecteinascidia turbinata (ascidie) qu'on retrouve dans la Mer des Caraïbes.  2, record 35, French, - ecteinascidine

Record 35,  Textual support,  Spanish

Record 36,  Textual support,  English

Record number: 36, Textual support number: 1 CONT

An assessment of the occurrence rate of periungual hyperpigmentation with subungual melanoma(Hutchinson's sign) and periungual hyperpigmentation with other subungual lesions has not been published, although periungual hyperpigmentation with a pigmented streak or other pigmented lesion of the nail has been considered pathognomonic for subungual melanoma for a century.(In J Dermatol Surg Oncol(UNITED STATES) 1988, 14(9) p1011-3, cited in MEDLINE data base.)  1, record 36, English, - Hutchinson%26rsquo%3Bs%20sign

Record 36,  Textual support,  French

Record number: 36, Textual support number: 1 CONT

Formes cliniques du mélanome malin - MM sous-unguéal - Panaris mélanique -- Appartenant au groupe du MM acral lentigineux, il en partage les caractères épidémiologiques, histologiques et pronostiques. Dans trois quarts des cas, il siège au gros orteil ou au pouce; c'est au début une macule brune ou noire du lit de l'ongle et du repli sous-unguéal (signe de Hutchinson), simulant volontiers un hématome.  1, record 36, French, - signe%20de%20Hutchinson

Record 36,  Textual support,  Spanish

Record 37,  Textual support,  English

Record number: 37, Textual support number: 1 CONT

The balloon cell melanoma is deceptively benign-appearing, consisting of a mass of clear foam cells with little atypia and rare mitotic figures. The presence of a transition zone of spindle or epitheloid tumor cells can clarify the diagnosis. In the absence of a transition zone, balloon cell melanoma may be difficult to distinguish from a balloon cell nevus, xanthoma, granular cell tumor, hypernephroma, or liposarcoma.  2, record 37, English, - balloon%20cell%20melanoma

Record 37,  Textual support,  French

Record 37,  Textual support,  Spanish

Record 38,  Textual support,  English

Record number: 38, Textual support number: 1 OBS

European Melanoma Group is not an official english translation  1, record 38, English, - Groupe%20europ%C3%A9en%20du%20m%C3%A9lanome

Record 38,  Textual support,  French

Record 38,  Textual support,  Spanish

Record 39,  Textual support,  English

Record 39,  Textual support,  French

Record number: 39, Textual support number: 1 DEF

Tumeur, généralement maligne, non pigmentée.  1, record 39, French, - m%C3%A9lanome%20am%C3%A9lanique

Record 39,  Textual support,  Spanish

Record 40,  Textual support,  English

Record number: 40, Textual support number: 1 CONT

The choice of fraction size is determined by the relative radiosensitivity of the tumor. Less sensitive tumors, such as malignant melanoma or sarcomas, are usually treated with larger individual fractions.  1, record 40, English, - fraction

Record 40,  Textual support,  French

Record number: 40, Textual support number: 1 CONT

Il a reçu 3400 cGy en dix-sept fractions au niveau des régions cervicales.  1, record 40, French, - fraction

Record 40,  Textual support,  Spanish

Record 41,  Textual support,  French

Record 41,  Textual support,  Spanish