TERMIUM Plus^®

Record 1,  Textual support,  English

Record number: 1, Textual support number: 1 CONT

The concept that chronic hyperglycemia induces a deterioration of beta-cell function was developed on observing that any hypoglycemic strategy can improve plasma insulin levels after OGTT [oral glucose tolerance test] in diabetes... The deleterious effect of hyperglycemia was subsequently named glucotoxicity and encompasses glucose utilization by skeletal muscle.  3, record 1, English, - glucotoxicity

Record 1,  Textual support,  French

Record number: 1, Textual support number: 1 CONT

L'excès chronique de glucose et de lipides circulants est pathogène avec des effets peut-être synergiques. L'hyperglycémie chronique, la dyslipidémie et l'excès d'acides gras et de triglycérides circulants, ainsi que des taux élevés de cytokines pro-inflammatoires, associés à l'insulinorésistance, sont les caractéristiques biologiques du sujet diabétique obèse. L'hyperglycémie chronique est toxique pour de nombreux tissus et organes, cellules β comprises (glucotoxicité) [...]  2, record 1, French, - glucotoxicit%C3%A9

Record 1,  Textual support,  Spanish

Record 2,  Textual support,  English

Record number: 2, Textual support number: 1 CONT

As the name suggests, a multiple-compartment PK [pharmacokinetic] model consists of a central compartment and one or several peripheral compartments, though the compartments do not represent specific anatomical or physiological structures. In general, the central compartment represents plasma(or blood) with or without richly perfused tissues, such as heart, liver, brain, etc.,... and the peripheral compartments represent slowly or less perfused tissues, such as skin, muscle, bone and fat.... In a two-compartment model... upon administration, a substance is introduced into the central compartment that is followed by its distribution between the central and a peripheral compartment; however, equilibration of the concentration of the substance between the two compartments is not anticipated to be achieved instantaneously. Once equilibration is reached, the elimination of the substance is assumed to occur from the central compartment.  4, record 2, English, - two%2Dcompartment%20pharmacokinetic%20model

Record 2,  Textual support,  French

Record 2,  Textual support,  Spanish

Record 3,  Textual support,  English

Record number: 3, Textual support number: 1 DEF

The delicate plasma membrane which invests every striated muscle fiber.  2, record 3, English, - sarcolemma

Record 3,  Textual support,  French

Record number: 3, Textual support number: 1 DEF

Membrane mince, de nature conjonctive, qui entoure chaque fibre musculaire striée.  2, record 3, French, - sarcolemme

Record 3,  Textual support,  Spanish

Record 4,  Textual support,  English

Record number: 4, Textual support number: 1 CONT

Cystatin C is an endogenous cysteine proteinase inhibitor of low molecular weight that possesses many ideal features for use as a surrogate marker of kidney function and an estimate of GFR [glomerular filtration rate]. Cystatin C is synthesized at a relatively constant rate and is released into plasma by all nucleated cells in the body. Cystatin C levels reportedly are not affected by patient age, sex, muscle mass, or changes in diet.  2, record 4, English, - cystatin%20C

Record 4,  Textual support,  French

Record number: 4, Textual support number: 1 CONT

La cystatine C est une protéine de 122 acides aminés impliquée [...] dans la modulation du système immunitaire. Elle est produite de façon constante par les cellules nucléées de l’organisme, librement filtrée au niveau glomérulaire et entièrement réabsorbée et dégradée dans le tubule proximal, sans clairance urinaire. Étant sans rapport avec la masse musculaire, la concentration plasmatique de la cystatine C ne semble dépendre que du débit de filtration glomérulaire (DFG). Elle s’est donc présentée [...] comme un nouveau marqueur biologique permettant d’évaluer la fonction rénale, en particulier dans les cas où les formules basées sur la créatinine étaient limitées, c'est-à-dire dans les situations où le rapport entre le poids et la masse musculaire est modifié.  2, record 4, French, - cystatine%20C

Record 4,  Textual support,  Spanish

Record 5,  Textual support,  French

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Record 6,  Textual support,  English

Record number: 6, Textual support number: 1 CONT

Succinylcholine is rapidly hydrolyzed by plasma pseudocholinesterase to succinylmonocholine(which is a nondepolarizing type of muscle relaxant), and then more slowly to succinic acid and choline.  1, record 6, English, - succinylmonocholine

Record 6,  Textual support,  French

Record number: 6, Textual support number: 1 CONT

La succinylcholine est rapidement hydrolysée par la pseudocholinestérase plasmatique en succinylmonocholine (myorelaxant non dépolarisant) puis, plus lentement, en acide succinique et en choline.  1, record 6, French, - succinylmonocholine

Record 6,  Textual support,  Spanish

Record 7,  Textual support,  English

Record number: 7, Textual support number: 1 CONT

Succinylcholine is rapidly hydrolyzed by plasma pseudocholinesterase to succinylmonocholine(which is a nondepolarizing type of muscle relaxant), and then more slowly to succinic acid and choline.  1, record 7, English, - plasma%20pseudocholinesterase

Record 7,  Textual support,  French

Record number: 7, Textual support number: 1 CONT

La succinylcholine est rapidement hydrolysée par la pseudocholinestérase plasmatique en succinylmonocholine (myorelaxant non dépolarisant) puis, plus lentement, en acide succinique et en choline.  1, record 7, French, - pseudocholinest%C3%A9rase%20plasmatique

Record 7,  Textual support,  Spanish