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Record 1,  Textual support,  English

Record number: 1, Textual support number: 1 CONT

There are too few of at least two types of blood cells(red blood cells, platelets, or white blood cells) ;less than 5% of the cells in the bone marrow are blasts and less than 1% of the cells in the blood are blasts; if red blood cells are affected, they may have extra iron; refractory cytopenia may progress to acute myeloid leukemia(AML).  3, record 1, English, - refractory%20cytopenia%20with%20multilineage%20dysplasia

Record 1,  Textual support,  French

Record number: 1, Textual support number: 1 CONT

Il y a trop peu d'au moins 2 types de cellules sanguines (globules rouges, globules blancs, plaquettes) dans le sang; si les globules rouges sont affectés, ils pourraient contenir trop de fer; moins de 1 % des cellules dans le sang et moins de 5 % des cellules dans la moelle osseuse sont des blastes; la CRDM peut évoluer en LAM [leucémie aiguë myéloblastique].  2, record 1, French, - cytop%C3%A9nie%20r%C3%A9fractaire%20avec%20dysplasie%20multilign%C3%A9e

Record 1,  Textual support,  Spanish

Record 2,  Textual support,  French

Record 2,  Textual support,  Spanish

Record 3,  Textual support,  English

Record number: 3, Textual support number: 1 CONT

Refractory anemia with excess blasts (RAEB) is an MDS [myelodysplastic syndrome] characterized by increased myeloblasts in the bone marrow and/or blood or the presence of Auer rods. The thresholds of what constitutes an increase in blasts differ in the blood and bone marrow.  3, record 3, English, - refractory%20anemia%20with%20excess%20blasts

Record number: 3, Textual support number: 2 CONT

There are too few red blood cells in the blood and the patient has anemia; five percent to 19% of the cells in the bone marrow are blasts; there also may be changes to the white blood cells and platelets; refractory anemia with excess blasts may progress to acute myeloid leukemia(AML).  4, record 3, English, - refractory%20anemia%20with%20excess%20blasts

Record 3,  Textual support,  French

Record number: 3, Textual support number: 1 CONT

Il y a trop peu de globules rouges dans le sang et présence d'anémie; des changements peuvent avoir affecté les globules blancs et les plaquettes; le nombre de blastes dans le sang est normal (moins de 5 %); l'AREB est divisée en 2 catégories qui se basent sur le pourcentage de blastes dans la moelle osseuse : AREB-1 – de 5 à 9 % des cellules dans la moelle osseuse sont des blastes; AREB-2 – de 10 à 19 % des cellules dans la moelle osseuse sont des blastes. Environ 25 % des cas d'AREB-1 et 33 % des cas d'AREB-2 évoluent en LAM [leucémie aiguë myéloblastique].  2, record 3, French, - an%C3%A9mie%20r%C3%A9fractaire%20avec%20exc%C3%A8s%20de%20blastes

Record 3,  Textual support,  Spanish

Record 4,  Textual support,  English

Record number: 4, Textual support number: 1 DEF

A form of acute myeloid leukemia(AML) involving the cells that give rise to the erythrocytes(the red blood cells).  4, record 4, English, - erythroleukemia

Record number: 4, Textual support number: 1 OBS

In this type of leukemia, the body produces large numbers of abnormal, immature red blood cells.  4, record 4, English, - erythroleukemia

Record 4,  Textual support,  French

Record number: 4, Textual support number: 1 DEF

Affection sanguine caractérisée par l'apparition dans le sang périphérique d'érythroblastes et de myéloblastes atypiques.  1, record 4, French, - %C3%A9rythroleuc%C3%A9mie

Record number: 4, Textual support number: 1 CONT

Les caractères cytologiques de l'érythroleucoblastose sont à la fois ceux d'une leucose aiguë et ceux d'une érythroblastose maligne.  1, record 4, French, - %C3%A9rythroleuc%C3%A9mie

Record 4,  Textual support,  Spanish

Record number: 4, Textual support number: 1 DEF

Extraño tipo de leucemia no linfocítica aguda que afecta tanto a los glóbulos rojos como a los blancos.  1, record 4, Spanish, - eritroleucemia

Record 5,  Textual support,  English

Record number: 5, Textual support number: 1 DEF

A bifunctional cytotoxic alkylating agent, 1, 4-butanediol dimethanesulfonate, an antineoplastic agent unrelated to the nitrogen mustards; used primarily for treatment of chronic granulocytic leukemia and also polycythemia vera and myeloid metaplasia; the major side effect is bone marrow depression.  4, record 5, English, - busulfan

Record number: 5, Textual support number: 1 OBS

Chemical formula: C₆H₁₄O₆S₂ or C₆H₁₄S₂O₆  5, record 5, English, - busulfan

Record 5,  Textual support,  French

Record number: 5, Textual support number: 1 DEF

Poudre cristalline, insoluble dans l'eau, peu soluble dans l'alcool utilisé entre autres dans le traitement de la leucémie myéloïde.  5, record 5, French, - busulfan

Record number: 5, Textual support number: 1 OBS

Formule chimique : C₆H₁₄S₂O₆ ou C₆H₁₄O₆S₂  6, record 5, French, - busulfan

Record 5,  Textual support,  Spanish

Record number: 5, Textual support number: 1 DEF

Fármaco alquilante antineoplásico.  2, record 5, Spanish, - busulfano

Record number: 5, Textual support number: 1 OBS

[...] utilizado para el tratamiento de la leucemia mielógena crónica, y neoplasia de la médula ósea.  2, record 5, Spanish, - busulfano

Record number: 5, Textual support number: 2 OBS

Fórmula química: C₆H₁₄O₆S₂ o C₆H₁₄S₂O₆  3, record 5, Spanish, - busulfano

Record 6,  Textual support,  English

Record number: 6, Textual support number: 1 DEF

A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow.  3, record 6, English, - leukemia

Record number: 6, Textual support number: 1 CONT

leukemia... is classified according to degree of cell differentiation as acute or chronic(terms no longer referring to duration of disease), and according to predominant type of cell involved as myelogenous [myeloid] or lymphocytic [lymphoid].  3, record 6, English, - leukemia

Record 6,  Textual support,  French

Record number: 6, Textual support number: 1 DEF

Maladie maligne et évolutive affectant les organes hémapoïétiques, marquée par une prolifération et un développement anormaux des leucocytes et de leurs précurseurs dans le sang et la moelle osseuse.  2, record 6, French, - leuc%C3%A9mie

Record number: 6, Textual support number: 1 CONT

[...] la leucémie [...] peut être aiguë ou chronique, myéloïde ou lymphoïde (en fonction du type de prolifération cellulaire).  3, record 6, French, - leuc%C3%A9mie

Record 6,  Textual support,  Spanish

Record number: 6, Textual support number: 1 DEF

Enfermedad consistente en la producción excesiva de leucocitos por los órganos encargados de ello.  2, record 6, Spanish, - leucemia

Record number: 6, Textual support number: 1 OBS

Cáncer de las células precursoras de los glóbulos blancos.  3, record 6, Spanish, - leucemia

Record 7,  Textual support,  English

Record 7,  Textual support,  French

Record 7,  Textual support,  Spanish

Record number: 7, Textual support number: 1 DEF

Leucemia caracterizada por la proliferación incontrolada de los mielocitos y sus precursores en la médula espinal y otras localizaciones.  1, record 7, Spanish, - leucemia%20mieloide

Record number: 7, Textual support number: 1 CONT

El síndrome mielodisplásico y la leucemia mieloide son complicaciones tardías de la terapia mieloablativa con apoyo autólogo de médula ósea o de células madres de la sangre periférica.  1, record 7, Spanish, - leucemia%20mieloide

Record 8,  Textual support,  French

Record 8,  Textual support,  Spanish

Record 9,  Textual support,  English

Record number: 9, Textual support number: 1 DEF

A cancer of blood cells, characterized by replacement of the bone marrow with malignant leukemic cells.  1, record 9, English, - chronic%20myeloid%20leukemia

Record number: 9, Textual support number: 1 OBS

Many of these leukemic cells can be found circulating in the blood and can cause enlargement of the spleen, liver and other organs.  1, record 9, English, - chronic%20myeloid%20leukemia

Record 9,  Textual support,  French

Record number: 9, Textual support number: 1 DEF

Affection néoplasique, appartenant au groupe des syndromes myéloprolifératifs, se traduisant par une accumulation de cellules myéloides.  1, record 9, French, - leuc%C3%A9mie%20my%C3%A9lo%C3%AFde%20chronique

Record 9,  Textual support,  Spanish

Record number: 9, Textual support number: 1 DEF

Uno de los cuatro tipos más importantes de leucemia, caracterizado por un aumento de la producción de leucocitos que se acumulan en el torrente sanguíneo y en la médula ósea.  1, record 9, Spanish, - leucemia%20mieloide%20cr%C3%B3nica

Record number: 9, Textual support number: 1 CONT

La leucemia mieloide crónica se asocia a la anomalía cromosómica denominada cromosoma Filadelfia.  1, record 9, Spanish, - leucemia%20mieloide%20cr%C3%B3nica

Record 10,  Textual support,  English

Record number: 10, Textual support number: 1 CONT

The cost-effectiveness of idarubicin/cytosine arabinoside versus daunorubicin/ccytosine arabinoside in the treatment of adults with acute myeloid leukemia.  1, record 10, English, - idarubicin

Record 10,  Textual support,  French

Record 10,  Textual support,  Spanish

Record number: 10, Textual support number: 1 DEF

Fármaco antibiótico antineoplásico.  1, record 10, Spanish, - idarubicina

Record number: 10, Textual support number: 1 OBS

[...] utilizado en el tratamiento de la leucemia mielógena crónica, leucemia no linfocítica aguda y leucemia linfocítica aguda.  1, record 10, Spanish, - idarubicina

Record 11,  Textual support,  English

Record number: 11, Textual support number: 1 CONT

Multiparametric analysis including clinical, biochemical, morphological, immunological, and cytogenetic investigations were performed in 100 patients with primary acute myeloid leukemia(AML). Patients were treated according to the protocol of the German AML Cooperative Group. Patients over 60 years of age received a study protocol of our department(idarubicin plus cytarabin).  1, record 11, English, - cytarabin

Record 11,  Textual support,  French

Record number: 11, Textual support number: 1 OBS

La cytarabine est la seule molécule antitumorale d'origine marine actuellement commercialisée (sous le nom de Aracytine) dans le monde, isolée chez Thetya crypta (éponge) qui provient de la Mer des Caraïbes.  2, record 11, French, - cytarabine

Record 11,  Textual support,  Spanish

Record 12,  Textual support,  English

Record number: 12, Textual support number: 1 CONT

Mutations of CBP has recently been discovered to be responsible for cases of heritable Rubinstein-Taybi syndrome, an autosomal-dominant disorder which causes mental retardation and a predisposition to several forms of cancers. Further, transposition of CBP, which fuses the histone acetyl transferase domain of CBP to MOZ gene has been found in acute myeloid leukemia. The above two observations suggest that p300 and CBP may be tumor suppressor genes.  1, record 12, English, - MOZ%20gene

Record 12,  Textual support,  French

Record number: 12, Textual support number: 1 CONT

Le clonage positionnel du point de cassure de translocation a été réalisé de façon à rechercher les gènes impliqués dans le déterminisme de la maladie. Cela a mis en évidence l'existence au niveau du point de cassure d'un gène chimérique provenant de la fusion du gène codant pour le co-activateur de transcription CBP (CREB binding protein) en 16p13.3 avec un gène nouvellement identifié, MOZ (monocytic leukaemia zinc finger protein) sur le chromosome 8p11.  1, record 12, French, - g%C3%A8ne%20MOZ

Record 12,  Textual support,  Spanish

Record 13,  Textual support,  French

Record 13,  Textual support,  Spanish