TERMIUM Plus®
The Government of Canada’s terminology and linguistic data bank.
MYELOMA [23 records]
Record 1 - internal organization data 2021-10-18
Record 1, English
Record 1, Subject field(s)
- Pharmacology
Record 1, Main entry term, English
- repositioned drug
1, record 1, English, repositioned%20drug
correct
Record 1, Abbreviations, English
Record 1, Synonyms, English
- repurposed drug 2, record 1, English, repurposed%20drug
correct
- reprofiled drug 3, record 1, English, reprofiled%20drug
correct
Record 1, Textual support, English
Record number: 1, Textual support number: 1 CONT
So far, most successfully repositioned drugs have been identified through serendipitous observations..., such as the antiemetic thalidomide, which has gained new indications in leprosy and multiple myeloma 3, record 1, English, - repositioned%20drug
Record 1, French
Record 1, Domaine(s)
- Pharmacologie
Record 1, Main entry term, French
- médicament repositionné
1, record 1, French, m%C3%A9dicament%20repositionn%C3%A9
correct, masculine noun
Record 1, Abbreviations, French
Record 1, Synonyms, French
Record 1, Textual support, French
Record 1, Spanish
Record 1, Campo(s) temático(s)
- Farmacología
Record 1, Main entry term, Spanish
- medicamento reposicionado
1, record 1, Spanish, medicamento%20reposicionado
correct, masculine noun
Record 1, Abbreviations, Spanish
Record 1, Synonyms, Spanish
Record 1, Textual support, Spanish
Record number: 1, Textual support number: 1 CONT
El SOM1201 se corresponde a un medicamento reposicionado para el tratamiento de la adrenoleucodistrofia, una enfermedad huérfana pediátrica. 1, record 1, Spanish, - medicamento%20reposicionado
Record 2 - internal organization data 2017-01-04
Record 2, English
Record 2, Subject field(s)
- National Bodies and Committees (Canadian)
- Cancers and Oncology
- Blood
Record 2, Main entry term, English
- Myeloma Canada
1, record 2, English, Myeloma%20Canada
correct
Record 2, Abbreviations, English
Record 2, Synonyms, English
Record 2, Textual support, English
Record number: 2, Textual support number: 1 OBS
As a patient-driven, patient-focused organization, Myeloma Canada works with over a dozen local support groups across Canada, strengthening the voice of the Canadian myeloma community and improving the quality of life of myeloma patients, their caregivers and families. 2, record 2, English, - Myeloma%20Canada
Record number: 2, Textual support number: 2 OBS
By working together with Canadian support groups, the Scientific Advisory Board and the International Myeloma Foundation, Myeloma Canada aims to provide education and support, raise awareness of this devastating disease and help drive efforts towards improving access to clinical trials and new treatments. 3, record 2, English, - Myeloma%20Canada
Record 2, French
Record 2, Domaine(s)
- Organismes et comités nationaux canadiens
- Cancers et oncologie
- Sang
Record 2, Main entry term, French
- Myélome Canada
1, record 2, French, My%C3%A9lome%20Canada
correct
Record 2, Abbreviations, French
Record 2, Synonyms, French
Record 2, Textual support, French
Record number: 2, Textual support number: 1 OBS
Myélome Canada, un organisme axé sur les besoins des patients, travaille avec plus d'une douzaine de groupes de soutien régionaux à travers le Canada afin de fortifier la présence de la communauté canadienne du myélome et d'améliorer la qualité de vie des patients atteints de myélome, leurs soignants et leurs familles. 2, record 2, French, - My%C3%A9lome%20Canada
Record number: 2, Textual support number: 2 OBS
Myélome Canada, par son travail collaboratif avec les groupes de soutien canadiens, le conseil consultatif scientifique et l'International Myeloma Foundation, s'emploie à éduquer et à sensibiliser le public à cette maladie dévastatrice et à faire progresser les efforts déployés pour l'éradiquer. 3, record 2, French, - My%C3%A9lome%20Canada
Record 2, Spanish
Record 2, Textual support, Spanish
Record 3 - internal organization data 2014-10-15
Record 3, English
Record 3, Subject field(s)
- Medication
Record 3, Main entry term, English
- denosumab
1, record 3, English, denosumab
correct
Record 3, Abbreviations, English
Record 3, Synonyms, English
Record 3, Textual support, English
Record number: 3, Textual support number: 1 CONT
Denosumab is a fully human monoclonal antibody for the treatment of osteoporosis, treatment-induced bone loss, bone metastases, multiple myeloma, and giant cell tumor of bone... Denosumab is designed to inhibit RANKL(RANK ligand), a protein that acts as the primary signal for bone removal. In many bone loss conditions, RANKL overwhelms the body's natural defenses against bone destruction. 2, record 3, English, - denosumab
Record number: 3, Textual support number: 1 OBS
Active ingredient sold under a large number of commercial (trade) names, among which: Prolia, Xgeva. 3, record 3, English, - denosumab
Record 3, French
Record 3, Domaine(s)
- Médicaments
Record 3, Main entry term, French
- dénosumab
1, record 3, French, d%C3%A9nosumab
correct, masculine noun
Record 3, Abbreviations, French
Record 3, Synonyms, French
Record 3, Textual support, French
Record number: 3, Textual support number: 1 CONT
Le dénosumab est un anticorps monoclonal (IgG2) humain qui cible le RANKL, ligand du récepteur RANK. Le dénosumab se lie de façon spécifique au RANKL avec une forte affinité, empêchant l'activation du récepteur RANK situé à la surface des ostéoclastes et de leurs précurseurs. Le blocage de l'interaction RANK/RANKL inhibe la formation, la fonction et la survie des ostéoclastes et diminue ainsi la résorption osseuse dans l'os cortical et trabéculaire. 2, record 3, French, - d%C3%A9nosumab
Record number: 3, Textual support number: 2 CONT
Le dénosumab est un puissant inhibiteur de la résorption osseuse dont le mécanisme d’action diffère de celui des bisphosphonates. Il inhibe la formation des ostéoclastes et réduit le remodelage osseux ainsi que le risque de fracture. 3, record 3, French, - d%C3%A9nosumab
Record number: 3, Textual support number: 1 OBS
Principe actif commercialisé, entre autres, sous le nom de Prolia et Xgeva. 4, record 3, French, - d%C3%A9nosumab
Record 3, Spanish
Record 3, Textual support, Spanish
Record 4 - internal organization data 2014-04-28
Record 4, English
Record 4, Subject field(s)
- Human Diseases - Various
- Vertebrae and Bone Marrow
Record 4, Main entry term, English
- myeloma lesion
1, record 4, English, myeloma%20lesion
correct
Record 4, Abbreviations, English
Record 4, Synonyms, English
Record 4, French
Record 4, Domaine(s)
- Maladies humaines diverses
- Vertèbres et moelle
Record 4, Main entry term, French
- lésion myélomateuse
1, record 4, French, l%C3%A9sion%20my%C3%A9lomateuse
correct, feminine noun
Record 4, Abbreviations, French
Record 4, Synonyms, French
Record 4, Textual support, French
Record 4, Spanish
Record 4, Textual support, Spanish
Record 5 - internal organization data 2012-10-09
Record 5, English
Record 5, Subject field(s)
- Cytology
- Biotechnology
Record 5, Main entry term, English
- hybridoma
1, record 5, English, hybridoma
correct
Record 5, Abbreviations, English
Record 5, Synonyms, English
- hybridome 2, record 5, English, hybridome
correct
Record 5, Textual support, English
Record number: 5, Textual support number: 1 DEF
A hybrid cell, or chimera, produced by the fusion of a myeloma(antibody-producing tumour) cell and a plasma cell. 3, record 5, English, - hybridoma
Record number: 5, Textual support number: 1 CONT
... rabies-virus preparations were studied in immunoassays with rabies-specific monoclonal antibodies produced by hybridomas in tissue culture ... 4, record 5, English, - hybridoma
Record 5, French
Record 5, Domaine(s)
- Cytologie
- Biotechnologie
Record 5, Main entry term, French
- hybridome
1, record 5, French, hybridome
correct, masculine noun, standardized
Record 5, Abbreviations, French
Record 5, Synonyms, French
- immunome 2, record 5, French, immunome
correct, masculine noun
Record 5, Textual support, French
Record number: 5, Textual support number: 1 DEF
Cellule qui provient de l'hybridation entre des cellules lymphoïdes normales de mammifères et des cellules myélomateuses de tumeurs malignes du système immunitaire. [Définition normalisée par l'AFNOR et reproduite avec son autorisation.] 3, record 5, French, - hybridome
Record number: 5, Textual support number: 1 CONT
[...] on étudia les préparations de virus de la rage au cours de tests immunologiques (à l'aide d'anticorps monoclonaux spécifiques de la rage, issus d'hybridomes en culture) [...] 4, record 5, French, - hybridome
Record number: 5, Textual support number: 1 OBS
L'hybridome est stable en culture; il donne des lignées immortalisées. [Observation reproduite avec l'autorisation de l'AFNOR.] 3, record 5, French, - hybridome
Record number: 5, Textual support number: 2 OBS
hybridome : terme normalisé par l'AFNOR. 5, record 5, French, - hybridome
Record 5, Spanish
Record 5, Campo(s) temático(s)
- Citología
- Biotecnología
Record 5, Main entry term, Spanish
- hibridoma
1, record 5, Spanish, hibridoma
correct, masculine noun
Record 5, Abbreviations, Spanish
Record 5, Synonyms, Spanish
Record 5, Textual support, Spanish
Record number: 5, Textual support number: 1 DEF
Célula producida en laboratorio al combinar un leucito productor de anticuerpos y un leucocito canceroso. 2, record 5, Spanish, - hibridoma
Record 6 - internal organization data 2012-07-10
Record 6, English
Record 6, Subject field(s)
- Urinary Tract
Record 6, Main entry term, English
- diffuse glomerular mesangial sclerosis
1, record 6, English, diffuse%20glomerular%20mesangial%20sclerosis
correct
Record 6, Abbreviations, English
Record 6, Synonyms, English
Record 6, Textual support, English
Record number: 6, Textual support number: 1 CONT
A biopsy of normal sized kidneys showed diffuse glomerular mesangial sclerosis with cellular proliferation, exsudative lesions, large capillary plugs with hyaline material. Deposits were negative with the Congo red stain. There was a diffuse interstitial fibrosis with some patchy lymphocytic infiltrate and frequent arteriolar hyalinosis. No myeloma casts were seen. 1, record 6, English, - diffuse%20glomerular%20mesangial%20sclerosis
Record 6, French
Record 6, Domaine(s)
- Appareil urinaire
Record 6, Main entry term, French
- glomérulosclérose diffuse intercapillaire
1, record 6, French, glom%C3%A9ruloscl%C3%A9rose%20diffuse%20intercapillaire
correct, feminine noun
Record 6, Abbreviations, French
Record 6, Synonyms, French
- glomérulosclérose intercapillaire diffuse 2, record 6, French, glom%C3%A9ruloscl%C3%A9rose%20intercapillaire%20diffuse
correct, feminine noun
Record 6, Textual support, French
Record number: 6, Textual support number: 1 CONT
La glomérulosclérose diffuse intercapillaire. Elle précède dans le temps les lésions nodulaires auxquelles elle est constamment associée. Elle réalise une infiltration du tissu mésangial par des dépôts éosinophiles PAS positifs [coloration acide périodique de Schiff] qui entraînent une réduction progressive du calibre des capillaires glomérulaires. 1, record 6, French, - glom%C3%A9ruloscl%C3%A9rose%20diffuse%20intercapillaire
Record number: 6, Textual support number: 1 OBS
Le mésangium, ou espace intercapillaire, est formé de cellules mésangiales et d'une substance intercellulaire (de nature proche de la membrane basale glomérulaire). 3, record 6, French, - glom%C3%A9ruloscl%C3%A9rose%20diffuse%20intercapillaire
Record 6, Spanish
Record 6, Textual support, Spanish
Record 7 - internal organization data 2012-01-24
Record 7, English
Record 7, Subject field(s)
- Cancers and Oncology
- Bones and Joints
Record 7, Main entry term, English
- myeloma
1, record 7, English, myeloma
correct
Record 7, Abbreviations, English
Record 7, Synonyms, English
Record 7, Textual support, English
Record number: 7, Textual support number: 1 DEF
A neoplastic proliferation of plasma cells with bone tumors and pathogenic features. 2, record 7, English, - myeloma
Record 7, French
Record 7, Domaine(s)
- Cancers et oncologie
- Os et articulations
Record 7, Main entry term, French
- myélome
1, record 7, French, my%C3%A9lome
correct, masculine noun
Record 7, Abbreviations, French
Record 7, Synonyms, French
Record 7, Textual support, French
Record number: 7, Textual support number: 1 DEF
Tumeur primitive, ordinairement maligne, de la moelle osseuse, faite d'une prolifération plasmocytaire. 2, record 7, French, - my%C3%A9lome
Record 7, Spanish
Record 7, Campo(s) temático(s)
- Tipos de cáncer y oncología
- Huesos y articulaciones
Record 7, Main entry term, Spanish
- mieloma
1, record 7, Spanish, mieloma
correct, masculine noun
Record 7, Abbreviations, Spanish
Record 7, Synonyms, Spanish
Record 7, Textual support, Spanish
Record number: 7, Textual support number: 1 DEF
Cáncer derivado de las células plasmáticas de la médula ósea. 2, record 7, Spanish, - mieloma
Record number: 7, Textual support number: 1 OBS
Constituye el cáncer primario de determinadas enfermedades recogidas bajo el término genérico neoplasias de células plasmáticas. 2, record 7, Spanish, - mieloma
Record 8 - internal organization data 2011-08-17
Record 8, English
Record 8, Subject field(s)
- Lymphatic System
Record 8, Main entry term, English
- lymphoreticular disease
1, record 8, English, lymphoreticular%20disease
correct
Record 8, Abbreviations, English
Record 8, Synonyms, English
- lymphoreticular disorder 1, record 8, English, lymphoreticular%20disorder
- lymphoreticular syndrome 1, record 8, English, lymphoreticular%20syndrome
Record 8, Textual support, English
Record number: 8, Textual support number: 1 DEF
A group of malignant neoplasms arising from cells related to the common multipotential primitive lymphocellular cell that includes among others the lymphocytic, histocytic and monocytic leukemias, multiple myeloma, plastocytoma, Hodgkin's disease, all lymphocytic lymphomas and immunosecretory disorders associated with monoclonal gammapathy. 1, record 8, English, - lymphoreticular%20disease
Record 8, French
Record 8, Domaine(s)
- Système lymphatique
Record 8, Main entry term, French
- lymphoréticulopathie
1, record 8, French, lymphor%C3%A9ticulopathie
correct, feminine noun
Record 8, Abbreviations, French
Record 8, Synonyms, French
Record 8, Textual support, French
Record number: 8, Textual support number: 1 DEF
Maladie des systèmes lymphatique et réticulo-endothélial. 1, record 8, French, - lymphor%C3%A9ticulopathie
Record 8, Spanish
Record 8, Textual support, Spanish
Record 9 - internal organization data 2011-02-04
Record 9, English
Record 9, Subject field(s)
- Chemical Elements and Compounds
- Medication
- Biochemistry
Universal entry(ies) Record 9
Record 9, Main entry term, English
- N,N’-hexane-1,6-diyldiacetamide
1, record 9, English, N%2CN%26rsquo%3B%2Dhexane%2D1%2C6%2Ddiyldiacetamide
correct, see observation
Record 9, Abbreviations, English
Record 9, Synonyms, English
- hexamethylene bisacetamide 2, record 9, English, hexamethylene%20bisacetamide
correct, see observation
- HMBA 3, record 9, English, HMBA
avoid
- HMBA 3, record 9, English, HMBA
- N,N’-diacetylhexamethylenediamine 4, record 9, English, N%2CN%26rsquo%3B%2Ddiacetylhexamethylenediamine
avoid
- hexamethylenebisacetamide 4, record 9, English, hexamethylenebisacetamide
avoid
- N,N’-hexamethylenebisacetamide 4, record 9, English, N%2CN%26rsquo%3B%2Dhexamethylenebisacetamide
avoid
- N,N’-1,6-hexanediylbis acetamide 4, record 9, English, N%2CN%26rsquo%3B%2D1%2C6%2Dhexanediylbis%20acetamide
avoid
Record 9, Textual support, English
Record number: 9, Textual support number: 1 CONT
Hybrid polar compounds(HPCs) represent another kind of cyto-differentiating agent. Hexamethylene bisacetamide(HMBA), the prototype HPC, is an inducer of terminal differentiation and/or apoptosis in cultured transformed cells, including murine erythroleukemia(MEL) cells, human bladder carcinoma cells, and human myeloma cells. 5, record 9, English, - N%2CN%26rsquo%3B%2Dhexane%2D1%2C6%2Ddiyldiacetamide
Record number: 9, Textual support number: 1 OBS
N,N’-hexane-1,6-diyldiacetamide: form recommended by the IUPAC (International Union of Pure and Applied Chemistry). 1, record 9, English, - N%2CN%26rsquo%3B%2Dhexane%2D1%2C6%2Ddiyldiacetamide
Record number: 9, Textual support number: 2 OBS
hexamethylene bisacetamide: usual name. 1, record 9, English, - N%2CN%26rsquo%3B%2Dhexane%2D1%2C6%2Ddiyldiacetamide
Record number: 9, Textual support number: 3 OBS
Chemical formula: C10H20N2O2 6, record 9, English, - N%2CN%26rsquo%3B%2Dhexane%2D1%2C6%2Ddiyldiacetamide
Record 9, French
Record 9, Domaine(s)
- Éléments et composés chimiques
- Médicaments
- Biochimie
Entrée(s) universelle(s) Record 9
Record 9, Main entry term, French
- N,N'-hexane-1,6-diyldiacétamide
1, record 9, French, N%2CN%27%2Dhexane%2D1%2C6%2Ddiyldiac%C3%A9tamide
correct, see observation, masculine noun
Record 9, Abbreviations, French
Record 9, Synonyms, French
- hexaméthylène diacétamide 2, record 9, French, hexam%C3%A9thyl%C3%A8ne%20diac%C3%A9tamide
correct, see observation, masculine noun
Record 9, Textual support, French
Record number: 9, Textual support number: 1 OBS
N,N'-hexane-1,6-diyldiacétamide : forme recommandée par l'UICPA (Union internationale de chimie pure et appliquée). 1, record 9, French, - N%2CN%27%2Dhexane%2D1%2C6%2Ddiyldiac%C3%A9tamide
Record number: 9, Textual support number: 2 OBS
hexaméthylène diacétamide : nom usuel. 1, record 9, French, - N%2CN%27%2Dhexane%2D1%2C6%2Ddiyldiac%C3%A9tamide
Record number: 9, Textual support number: 3 OBS
Formule chimique : C10H20N2O2 3, record 9, French, - N%2CN%27%2Dhexane%2D1%2C6%2Ddiyldiac%C3%A9tamide
Record 9, Spanish
Record 9, Textual support, Spanish
Record 10 - internal organization data 2010-02-08
Record 10, English
Record 10, Subject field(s)
- Radiography (Medicine)
- Musculoskeletal System
Record 10, Main entry term, English
- geographic bone destruction
1, record 10, English, geographic%20bone%20destruction
correct
Record 10, Abbreviations, English
Record 10, Synonyms, English
Record 10, Textual support, English
Record number: 10, Textual support number: 1 CONT
Geographic bone destruction. The geographic pattern is the least aggressive pattern of bone destruction, as it is generally indicative of a slow-growing lesion. The margin of the lesion is well defined and easily separated from the surrounding normal bone. This margin may be smooth or irregular, but in either instance, it is usually clearly demarcated, with a short zone of transition from normal to abnormal bone. Benign bone tumors usually demonstrate geographic bone destruction. Malignant diseases(such as plasma cell myeloma and metastasis) and osteomyelitis(particularly granulomatous infections) can demonstrate a similar pattern of bone destruction, however. 1, record 10, English, - geographic%20bone%20destruction
Record 10, French
Record 10, Domaine(s)
- Radiographie (Médecine)
- Appareil locomoteur (Médecine)
Record 10, Main entry term, French
- ostéolyse géographique
1, record 10, French, ost%C3%A9olyse%20g%C3%A9ographique
correct, feminine noun
Record 10, Abbreviations, French
Record 10, Synonyms, French
Record 10, Textual support, French
Record number: 10, Textual support number: 1 CONT
L'ostéolyse géographique se traduit par une lacune à bords nets, à l'emporte-pièce, parfois polycyclique. La séparation entre os sain et os tumoral est nette. Le cortex peut être soit détruit, soit érodé et aminci, mais conservé; il peut être plus ou moins soufflé. Une ostéolyse de type géographique correspond à un processus d'évolution lente. [D'après EMSQU, 31520, A10, s.d., p. 2.] 2, record 10, French, - ost%C3%A9olyse%20g%C3%A9ographique
Record 10, Spanish
Record 10, Textual support, Spanish
Record 11 - internal organization data 2004-02-26
Record 11, English
Record 11, Subject field(s)
- Cancers and Oncology
- Blood
Record 11, Main entry term, English
- plasmacytoma
1, record 11, English, plasmacytoma
correct
Record 11, Abbreviations, English
Record 11, Synonyms, English
Record 11, Textual support, English
Record number: 11, Textual support number: 1 DEF
A malignant tumor of plasma cells. 2, record 11, English, - plasmacytoma
Record number: 11, Textual support number: 1 OBS
When there are multiple plasmacytomas in the body, it is called multiple myeloma. 2, record 11, English, - plasmacytoma
Record 11, French
Record 11, Domaine(s)
- Cancers et oncologie
- Sang
Record 11, Main entry term, French
- plasmocytome
1, record 11, French, plasmocytome
correct, masculine noun
Record 11, Abbreviations, French
Record 11, Synonyms, French
Record 11, Textual support, French
Record 11, Spanish
Record 11, Campo(s) temático(s)
- Tipos de cáncer y oncología
- Sangre
Record 11, Main entry term, Spanish
- plasmacitoma
1, record 11, Spanish, plasmacitoma
correct, masculine noun
Record 11, Abbreviations, Spanish
Record 11, Synonyms, Spanish
Record 11, Textual support, Spanish
Record number: 11, Textual support number: 1 DEF
Tumor maligno de las células plasmáticas. 1, record 11, Spanish, - plasmacitoma
Record number: 11, Textual support number: 1 OBS
[...] en el cual si existen varios plasmacitomas unidos se denomina mieloma múltiple. 1, record 11, Spanish, - plasmacitoma
Record 12 - internal organization data 2004-02-26
Record 12, English
Record 12, Subject field(s)
- Cancers and Oncology
- Vertebrae and Bone Marrow
Record 12, Main entry term, English
- multiple myeloma
1, record 12, English, multiple%20myeloma
correct
Record 12, Abbreviations, English
Record 12, Synonyms, English
Record 12, Textual support, English
Record number: 12, Textual support number: 1 DEF
A disseminated malignant neoplasma cells characterized by multiple bone marrow tumor loci and secretion of an M component (a monoclonal immunoglobulin or immunoglobulin fragment), associated with widespread osteolytic lesions ... 1, record 12, English, - multiple%20myeloma
Record 12, French
Record 12, Domaine(s)
- Cancers et oncologie
- Vertèbres et moelle
Record 12, Main entry term, French
- myélome multiple
1, record 12, French, my%C3%A9lome%20multiple
correct, masculine noun
Record 12, Abbreviations, French
Record 12, Synonyms, French
Record 12, Textual support, French
Record number: 12, Textual support number: 1 DEF
Tumeur maligne (cancer) résultant de la prolifération de plasmocytes malins. 2, record 12, French, - my%C3%A9lome%20multiple
Record number: 12, Textual support number: 1 OBS
Le plasmocyte normal est une variété mature d'un des deux types de cellules du système immunitaire, les lymphocytes B, et il sécrète des protéines appelées immunoglobulines ou anticorps. Lorsque les plasmocytes se multiplient de façon excessive, ils peuvent produire une tumeur appelée myélome. Les myélomes peuvent se développer dans plusieurs parties du corps, en particulier dans la moelle osseuse; lorsqu'il existe plusieurs sièges, on parle alors de myélome multiple. 1, record 12, French, - my%C3%A9lome%20multiple
Record 12, Spanish
Record 12, Campo(s) temático(s)
- Tipos de cáncer y oncología
- Vértebras y médula
Record 12, Main entry term, Spanish
- mieloma múltiple
1, record 12, Spanish, mieloma%20m%C3%BAltiple
correct, masculine noun
Record 12, Abbreviations, Spanish
Record 12, Synonyms, Spanish
Record 12, Textual support, Spanish
Record number: 12, Textual support number: 1 DEF
Cáncer originado en las células plasmáticas de la médula ósea. 1, record 12, Spanish, - mieloma%20m%C3%BAltiple
Record number: 12, Textual support number: 1 OBS
Representa el cáncer primario de las neoplasias de células plasmáticas. 1, record 12, Spanish, - mieloma%20m%C3%BAltiple
Record 13 - internal organization data 2004-02-24
Record 13, English
Record 13, Subject field(s)
- Symptoms (Medicine)
- Cancers and Oncology
Record 13, Main entry term, English
- Waldenström’s macroglobulinemia
1, record 13, English, Waldenstr%C3%B6m%26rsquo%3Bs%20macroglobulinemia
correct
Record 13, Abbreviations, English
Record 13, Synonyms, English
- lymphoplasmacytoid lymphoma 1, record 13, English, lymphoplasmacytoid%20lymphoma
Record 13, Textual support, English
Record number: 13, Textual support number: 1 CONT
Waldenström’s macroglobulinemia is included in the B-cell lymphoproliferative syndromes that have a low degree of malignancy. 1, record 13, English, - Waldenstr%C3%B6m%26rsquo%3Bs%20macroglobulinemia
Record number: 13, Textual support number: 1 OBS
The disease results from a malignant proliferation of lymphoplasmacellular elements. As in multiple myeloma, a paraproteinemia is found which is always type IgM. 1, record 13, English, - Waldenstr%C3%B6m%26rsquo%3Bs%20macroglobulinemia
Record 13, French
Record 13, Domaine(s)
- Symptômes (Médecine)
- Cancers et oncologie
Record 13, Main entry term, French
- maladie de Waldenström
1, record 13, French, maladie%20de%20Waldenstr%C3%B6m
correct, feminine noun
Record 13, Abbreviations, French
Record 13, Synonyms, French
- macroglobulinémie 1, record 13, French, macroglobulin%C3%A9mie
feminine noun
Record 13, Textual support, French
Record number: 13, Textual support number: 1 CONT
Syndromes lymphoprolifératifs [...] La macroglobulinémie (ou maladie de Waldenström) est caractérisée par l'association d'une prolifération lymphoïde généralement polymorphe et d'un pic d'IgM monoclonale sérique responsable d'une hyperviscosité sanguine. Les hémorragies sont fréquentes. 1, record 13, French, - maladie%20de%20Waldenstr%C3%B6m
Record 13, Spanish
Record 13, Campo(s) temático(s)
- Síntomas (Medicina)
- Tipos de cáncer y oncología
Record 13, Main entry term, Spanish
- macroglobulinemia de Waldenstrom
1, record 13, Spanish, macroglobulinemia%20de%20Waldenstrom
correct, feminine noun
Record 13, Abbreviations, Spanish
Record 13, Synonyms, Spanish
Record 13, Textual support, Spanish
Record number: 13, Textual support number: 1 DEF
Extraño tipo de trastorno linoproliferativo crónico que afecta a los linfocitos B y que presenta un crecimiento lento. En cierto modo, evolución como el mieloma, en el sentido de que se origina en una cavidad de la médula ósea y causa malformaciones óseas. 1, record 13, Spanish, - macroglobulinemia%20de%20Waldenstrom
Record number: 13, Textual support number: 1 CONT
La macroglobulinemia de Waldenstrom presenta una incidencia más alta en varones mayores de 60 años. 1, record 13, Spanish, - macroglobulinemia%20de%20Waldenstrom
Record 14 - internal organization data 2004-01-23
Record 14, English
Record 14, Subject field(s)
- Molecular Biology
- Cancers and Oncology
Record 14, Main entry term, English
- antiangiogenic
1, record 14, English, antiangiogenic
correct
Record 14, Abbreviations, English
Record 14, Synonyms, English
- anti-angiogenic 2, record 14, English, anti%2Dangiogenic
correct
Record 14, Textual support, English
Record number: 14, Textual support number: 1 CONT
In 1999, thalidomide was found to be a successful antiangiogenic treatment for Multiple Myeloma, a disease of mature proliferating B-cells, related to lymphoma. 1, record 14, English, - antiangiogenic
Record number: 14, Textual support number: 2 CONT
"The paradigm is emerging that the integrins responsible for angiogenesis are also responsible for stopping it," said Raghu Kalluri, Harvard Medical School associate professor at Beth Israel Deaconess Medical Center. To block integrins entirely would be to close off the body’s own anti-angiogenic efforts. 2, record 14, English, - antiangiogenic
Record 14, French
Record 14, Domaine(s)
- Biologie moléculaire
- Cancers et oncologie
Record 14, Main entry term, French
- antiangiogénique
1, record 14, French, antiangiog%C3%A9nique
correct
Record 14, Abbreviations, French
Record 14, Synonyms, French
Record 14, Textual support, French
Record number: 14, Textual support number: 1 CONT
Les Laboratoires AEterna inc. ont annoncé aujourd'hui la découverte d'une activité antiangiogénique chez une famille de molécules extraites du Neovastat. La Société a fait une demande de brevet auprès du Bureau des brevets et des marques de commerce des États-Unis (United States Patent and Trademark Office) reliée à cette découverte et qui couvre des compositions de matières ainsi que les méthodes d'utilisation du produit pour le traitement de maladies compliquées par l'angiogenèse. Plus d'une vingtaine de maladies sont reliées à l'angiogenèse, dont le cancer. 1, record 14, French, - antiangiog%C3%A9nique
Record 14, Spanish
Record 14, Textual support, Spanish
Record 15 - internal organization data 2003-05-30
Record 15, English
Record 15, Subject field(s)
- Histology
- Immunology
Record 15, Main entry term, English
- Bence-Jones protein 1, record 15, English, Bence%2DJones%20protein
Record 15, Abbreviations, English
Record 15, Synonyms, English
- Bence-Jones protein 1, record 15, English, Bence%2DJones%20protein
Record 15, Textual support, English
Record number: 15, Textual support number: 1 DEF
Free immunoglobulin light chain dimers found in the serum and urine of patients and animals with multiple myeloma. 2, record 15, English, - Bence%2DJones%20protein
Record 15, French
Record 15, Domaine(s)
- Histologie
- Immunologie
Record 15, Main entry term, French
- protéine de Bence-Jones
1, record 15, French, prot%C3%A9ine%20de%20Bence%2DJones
correct, feminine noun
Record 15, Abbreviations, French
Record 15, Synonyms, French
Record 15, Textual support, French
Record number: 15, Textual support number: 1 DEF
Chaînes légères [...] de globuline monoclonale, présentes dans le sang et les urines de malades atteints de myélome multiple ou de macroglobulinémie de Waldenström. 2, record 15, French, - prot%C3%A9ine%20de%20Bence%2DJones
Record 15, Spanish
Record 15, Campo(s) temático(s)
- Histología
- Inmunología
Record 15, Main entry term, Spanish
- proteína de Bence-Jones
1, record 15, Spanish, prote%C3%ADna%20de%20Bence%2DJones
correct, feminine noun
Record 15, Abbreviations, Spanish
Record 15, Synonyms, Spanish
Record 15, Textual support, Spanish
Record number: 15, Textual support number: 1 DEF
Proteína antigénica distinta a las otras proteínas de la sangre que se encuentra frecuentemente en la orina de los pacientes con mieloma múltiple. 1, record 15, Spanish, - prote%C3%ADna%20de%20Bence%2DJones
Record 16 - internal organization data 2002-04-24
Record 16, English
Record 16, Subject field(s)
- Immunology
Record 16, Main entry term, English
- paraprotein
1, record 16, English, paraprotein
correct
Record 16, Abbreviations, English
Record 16, Synonyms, English
Record 16, Textual support, English
Record number: 16, Textual support number: 1 CONT
The plasma cell disorders are characterized by the secretion of electrophoretically and immunologically homogeneous(monoclonal) proteins. Each monoclonal protein(M-protein, myeloma protein, or paraprotein) consists of two heavy(H) polypeptide chains of the same class and subclass and two light(L) polypeptide chains of the same type. 1, record 16, English, - paraprotein
Record 16, French
Record 16, Domaine(s)
- Immunologie
Record 16, Main entry term, French
- paraprotéine
1, record 16, French, paraprot%C3%A9ine
correct, feminine noun
Record 16, Abbreviations, French
Record 16, Synonyms, French
Record 16, Textual support, French
Record number: 16, Textual support number: 1 CONT
La paraprotéine est mise en évidence sur l'électrophorèse des protéines, son caractère monoclonal est reconnu grâce à l'immunoélectrophorèse. Parfois il s'agit d'une cryoglobuline, soit polyclonal (cryoglobuline mixte), soit monoclonal. Ces paraprotéines peuvent se rencontrer dans le cadre : d'une gammapathie monoclonale de cause inconnue [...] d'un myélome multiple [...] d'une macroglobulinémie de Waldenström [...] 1, record 16, French, - paraprot%C3%A9ine
Record 16, Spanish
Record 16, Campo(s) temático(s)
- Inmunología
Record 16, Main entry term, Spanish
- paraproteína
1, record 16, Spanish, paraprote%C3%ADna
correct, feminine noun
Record 16, Abbreviations, Spanish
Record 16, Synonyms, Spanish
Record 16, Textual support, Spanish
Record 17 - internal organization data 1998-06-01
Record 17, English
Record 17, Subject field(s)
- Immunology
Record 17, Main entry term, English
- Bence Jones myeloma
1, record 17, English, Bence%20Jones%20myeloma
correct
Record 17, Abbreviations, English
Record 17, Synonyms, English
- light chain disease 1, record 17, English, light%20chain%20disease
correct
- L-chain disease 1, record 17, English, L%2Dchain%20disease
correct
- L-chain myeloma 1, record 17, English, L%2Dchain%20myeloma
correct
Record 17, Textual support, English
Record number: 17, Textual support number: 1 DEF
Multiple myeloma in which the malignant plasma cells excrete only light chains of one type. 1, record 17, English, - Bence%20Jones%20myeloma
Record 17, French
Record 17, Domaine(s)
- Immunologie
Record 17, Main entry term, French
- myélome à chaîne légère
1, record 17, French, my%C3%A9lome%20%C3%A0%20cha%C3%AEne%20l%C3%A9g%C3%A8re
correct, masculine noun
Record 17, Abbreviations, French
Record 17, Synonyms, French
Record 17, Textual support, French
Record number: 17, Textual support number: 1 OBS
Il se définit par la sécrétion d'une chaîne légère. 1, record 17, French, - my%C3%A9lome%20%C3%A0%20cha%C3%AEne%20l%C3%A9g%C3%A8re
Record 17, Spanish
Record 17, Textual support, Spanish
Record 18 - internal organization data 1993-02-25
Record 18, English
Record 18, Subject field(s)
- Immunology
Record 18, Main entry term, English
- T15 idiotype 1, record 18, English, T15%20idiotype
Record 18, Abbreviations, English
Record 18, Synonyms, English
Record 18, Textual support, English
Record number: 18, Textual support number: 1 DEF
An idiotype associated with anti-phosphorylcholine antibodies, named after the TEPC15 myeloma prototype sequence. 1, record 18, English, - T15%20idiotype
Record 18, French
Record 18, Domaine(s)
- Immunologie
Record 18, Main entry term, French
- idiotype T15
1, record 18, French, idiotype%20T15
masculine noun
Record 18, Abbreviations, French
Record 18, Synonyms, French
Record 18, Textual support, French
Record number: 18, Textual support number: 1 DEF
T15 : Idiotype associé avec les anticorps anti-phosphorylcholine; le nom dérive de la protéine de myélome TEPC 15. 1, record 18, French, - idiotype%20T15
Record 18, Spanish
Record 18, Textual support, Spanish
Record 19 - internal organization data 1993-02-10
Record 19, English
Record 19, Subject field(s)
- Immunology
Record 19, Main entry term, English
- epidermolysis bullosa acquired 1, record 19, English, epidermolysis%20bullosa%20acquired
Record 19, Abbreviations, English
Record 19, Synonyms, English
- epidermolysis bullosa acquisita 1, record 19, English, epidermolysis%20bullosa%20acquisita
Record 19, Textual support, English
Record number: 19, Textual support number: 1 DEF
A form of epidermolysis bullosa presenting in adulthood with evidence of genetic transmission, and occurring in association with such diseases as diabetes mellitus, tuberculosis, amyloidosis, colitis, and multiple myeloma and with penicillamine therapy. The blisters, which occur most often on the pressure areas of the hands and feet but can occur anywhere on the body, heal leaving atrophic scars and milia; nail dystrophy and lesions of the oral mucosa are often seen. 1, record 19, English, - epidermolysis%20bullosa%20acquired
Record 19, French
Record 19, Domaine(s)
- Immunologie
Record 19, Main entry term, French
- épidermolyse bulleuse acquise
1, record 19, French, %C3%A9pidermolyse%20bulleuse%20acquise
feminine noun
Record 19, Abbreviations, French
Record 19, Synonyms, French
Record 19, Textual support, French
Record number: 19, Textual support number: 1 CONT
L'épidermolyse bulleuse acquise est une entité récemment individualisée au sein des pemphigoïdes. Les anticorps sont dirigés contre des antigènes de PM 145 kDa et 290 kDa situés sous la membrane basale. 1, record 19, French, - %C3%A9pidermolyse%20bulleuse%20acquise
Record 19, Spanish
Record 19, Textual support, Spanish
Record 20 - internal organization data 1992-09-16
Record 20, English
Record 20, Subject field(s)
- Radiography (Medicine)
- Musculoskeletal System
Record 20, Main entry term, English
- one-eyed vertebra sign
1, record 20, English, one%2Deyed%20vertebra%20sign
correct
Record 20, Abbreviations, English
Record 20, Synonyms, English
Record 20, Textual support, English
Record number: 20, Textual support number: 1 DEF
A vertebra in which one pedicle is destroyed and one pedicle is intact, as seen in metastases of the spine. [From GBONE 1980, p. 411.] 2, record 20, English, - one%2Deyed%20vertebra%20sign
Record number: 20, Textual support number: 1 OBS
The destruction or integrity of one or both pedicles of a vertebral body is a radiographic finding used to differentiate multiple myeloma from osteolytic metastases. It is referred to as the pedicle sign. Because myeloma primarily involves the red marrow, it frequently causes destruction of the vertebral bodies. Involvement of the vertebral pedicles, which lack red marrow, is much less frequent. Thus, isolated destruction of a pedicle without vertebral body involvement strongly suggests the diagnosis of metastatic carcinoma. [From EISER, 1984, p. 360. ] 2, record 20, English, - one%2Deyed%20vertebra%20sign
Record 20, French
Record 20, Domaine(s)
- Radiographie (Médecine)
- Appareil locomoteur (Médecine)
Record 20, Main entry term, French
- vertèbre borgne
1, record 20, French, vert%C3%A8bre%20borgne
correct, feminine noun
Record 20, Abbreviations, French
Record 20, Synonyms, French
Record 20, Textual support, French
Record number: 20, Textual support number: 1 DEF
Vertèbre caractérisée par une altération lytique d'un seul pédicule, observée dans les tumeurs secondaires du rachis. [D'après EMSQU, 31525, A10, 1976, p. 3.] 2, record 20, French, - vert%C3%A8bre%20borgne
Record number: 20, Textual support number: 1 OBS
Le pédicule est un site métastatique de prédilection des cancers ostéophiles. Les atteintes pédiculaires sont moins fréquentes au cours des myélomes qui intéressent préférentiellement le corps vertébral. [D'après TRIOS, 1983, vol. 12, p. 530.] 2, record 20, French, - vert%C3%A8bre%20borgne
Record number: 20, Textual support number: 2 OBS
On parle de vertèbre aveugle lorsque l'altération lytique touche les deux pédicules. [D'après EMSQU, 31525, A10, 1976, p. 3.]. 2, record 20, French, - vert%C3%A8bre%20borgne
Record number: 20, Textual support number: 3 OBS
source c : EMSQU, 31525, A10, 1976, p. 3. 2, record 20, French, - vert%C3%A8bre%20borgne
Record 20, Spanish
Record 20, Textual support, Spanish
Record 21 - internal organization data 1988-01-15
Record 21, English
Record 21, Subject field(s)
- Immunology
- Pharmacy
Record 21, Main entry term, English
- secondary resistance
1, record 21, English, secondary%20resistance
correct
Record 21, Abbreviations, English
Record 21, Synonyms, English
Record 21, Textual support, English
Record number: 21, Textual support number: 1 CONT
One-step or multiple-step secondary resistance to Canerten has developed during successive passages of Candida albicans ... 1, record 21, English, - secondary%20resistance
Record number: 21, Textual support number: 2 CONT
"Treatment of multiple myeloma chemotherapy in primary and secondary resistance to therapy and in renal insufficiency"(...). Patients with multiple myeloma who fail to respond to primary chemotherapy or suffering from renal insufficiency are known to have low response and short survival after subsequent salvage chemotherapy.(Source : BIOSIS database). 2, record 21, English, - secondary%20resistance
Record 21, French
Record 21, Domaine(s)
- Immunologie
- Pharmacie
Record 21, Main entry term, French
- résistance acquise
1, record 21, French, r%C3%A9sistance%20acquise
correct, feminine noun
Record 21, Abbreviations, French
Record 21, Synonyms, French
Record 21, Textual support, French
Record number: 21, Textual support number: 1 CONT
Du fait de la richesse en bacilles des cavernes tuberculeuses (...) et de la proportion élevée de mutants résistants aux antibiotiques au sein des souches de Mycobacterium tuberculosis, le risque de sélection des mutants résistants était très grand lorsque les malades étaient traités par un seul antibiotique. On voyait alors, très rapidement, s'installer la résistance acquise à l'antibiotique administré. 1, record 21, French, - r%C3%A9sistance%20acquise
Record 21, Spanish
Record 21, Textual support, Spanish
Record 22 - internal organization data 1980-09-01
Record 22, English
Record 22, Subject field(s)
- Microbiology and Parasitology
Record 22, Main entry term, English
- myeloma cell 1, record 22, English, myeloma%20cell
Record 22, Abbreviations, English
Record 22, Synonyms, English
Record 22, Textual support, English
Record number: 22, Textual support number: 1 OBS
After three or four days the spleen is removed and a suspension of mouse lymphocytes is fused in the presence of polyethylene glycol with mouse myeloma cells grown in culture and deficient in the enzyme hypoxanthine guanine ribosyltransferase. 1, record 22, English, - myeloma%20cell
Record 22, French
Record 22, Domaine(s)
- Microbiologie et parasitologie
Record 22, Main entry term, French
- cellule de myélome 1, record 22, French, cellule%20de%20my%C3%A9lome
Record 22, Abbreviations, French
Record 22, Synonyms, French
- cellule myélomateuse 1, record 22, French, cellule%20my%C3%A9lomateuse
Record 22, Textual support, French
Record number: 22, Textual support number: 1 OBS
Trois ou quatre jours après, on prélève la rate et on fait fusionner, en présence de polyéthylène glycol, une suspension de lymphocytes de souris avec des cellules de myélome de souris. (...) Les cellules fusionnées que l'on nomme hétérocaryons sont placées dans un milieu de culture qui inhibe la croissance des cellules myélomateuses. 1, record 22, French, - cellule%20de%20my%C3%A9lome
Record 22, Spanish
Record 22, Textual support, Spanish
Record 23 - internal organization data 1980-09-01
Record 23, English
Record 23, Subject field(s)
- Microbiology and Parasitology
Record 23, Main entry term, English
- hypoxanthine guanine ribosyltransferase 1, record 23, English, hypoxanthine%20guanine%20ribosyltransferase
Record 23, Abbreviations, English
Record 23, Synonyms, English
Record 23, Textual support, English
Record number: 23, Textual support number: 1 OBS
After three or four days the spleen is removed and a suspension of mouse lymphocytes is fused in the presence of polyethylene glycol with mouse myeloma cells grown in culture and deficient in the enzyme hypoxanthine guanine ribosyltransferase. 1, record 23, English, - hypoxanthine%20guanine%20ribosyltransferase
Record 23, French
Record 23, Domaine(s)
- Microbiologie et parasitologie
Record 23, Main entry term, French
- hypoxanthine guanine ribosyltranférase 1, record 23, French, hypoxanthine%20guanine%20ribosyltranf%C3%A9rase
Record 23, Abbreviations, French
Record 23, Synonyms, French
Record 23, Textual support, French
Record number: 23, Textual support number: 1 OBS
Ces [cellules de myélome], obtenues à partir de culture cellulaire, sont déficientes en une enzyme, l'hypoxanthine guanine ribosyltransférase. 1, record 23, French, - hypoxanthine%20guanine%20ribosyltranf%C3%A9rase
Record 23, Spanish
Record 23, Textual support, Spanish
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