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The Government of Canada’s terminology and linguistic data bank.
PATHOGENIC GENE [4 records]
Record 1 - internal organization data 2012-05-01
Record 1, English
Record 1, Subject field(s)
- Genetics
Record 1, Main entry term, English
- vpx gene
1, record 1, English, vpx%20gene
correct
Record 1, Abbreviations, English
Record 1, Synonyms, English
Record 1, Textual support, English
Record number: 1, Textual support number: 1 CONT
A real difference in pathogenicity between HIV-1 and HIV-2 could be significant, and it would be important to determine its molecular basis. The two viruses infect the same populations of cells, binding the same CD4 receptor, but there are some differences in their genetic material and therefore in proteins. One of the most obvious is the presence in HIV-1 of the vpu gene, which is absent in HIV-(and in SIV, for that matter). Perhaps the product of this gene, a small 16-kilodalton peptide, enpathogenicity. Similarly, HIV-2 and SIV contain the vpx gene; HIV-1 does not. If this gene's 12-kilodalton product somehow slows the proliferation or spread of the virus or reduces its ability cells, that too could help to explain why HIV-2 and SIV appear to be less regularly pathogenic than HIV-1. 1, record 1, English, - vpx%20gene
Record 1, French
Record 1, Domaine(s)
- Génétique
Record 1, Main entry term, French
- gène vpx
1, record 1, French, g%C3%A8ne%20vpx
correct, masculine noun
Record 1, Abbreviations, French
Record 1, Synonyms, French
- vpx 1, record 1, French, vpx
correct, masculine noun
Record 1, Textual support, French
Record number: 1, Textual support number: 1 CONT
L'organisation du génome du HIV est plus complexe que celle des autres rétrovirus. En plus des gènes dits de structure, gag, pol et env, qui produisent les constituants de la particule virale, on trouve plusieurs gènes, plus petits situés entre les gènes pol et env. Cette région comporte le gène vif, qui est le plus grand de cette partie du génome, le gène vpr, et le gène vpx chez HIV-2 et SIV, les premiers segments des gènes encodant les protéines régulatrices Tat et Rev ainsi que dans certains isolats, le gène vpu. Un autre gène unique au virus du groupe HIV, nef, est situé dans la partie terminale du génome, après le gène env chevauchant le LTR de droite. 2, record 1, French, - g%C3%A8ne%20vpx
Record 1, Spanish
Record 1, Textual support, Spanish
Record 2 - internal organization data 2004-09-08
Record 2, English
Record 2, Subject field(s)
- Biotechnology
- Microbiology and Parasitology
Record 2, Main entry term, English
- adeno-associated virus
1, record 2, English, adeno%2Dassociated%20virus
correct
Record 2, Abbreviations, English
- AAV 2, record 2, English, AAV
correct
Record 2, Synonyms, English
Record 2, Textual support, English
Record number: 2, Textual support number: 1 CONT
Adeno-associated virus(AAV) is unique in the viral world because it has never been shown to have any pathogenic effects in humans, and most of the population has been exposed to AAV early in life. This recommends it as a vehicle for gene therapy. And, during the past five years or so, interest has widened in the development of AAV vectors for gene delivery. 3, record 2, English, - adeno%2Dassociated%20virus
Record 2, French
Record 2, Domaine(s)
- Biotechnologie
- Microbiologie et parasitologie
Record 2, Main entry term, French
- virus associé aux adénovirus
1, record 2, French, virus%20associ%C3%A9%20aux%20ad%C3%A9novirus
correct, masculine noun
Record 2, Abbreviations, French
Record 2, Synonyms, French
- virus associé à l'adénovirus 2, record 2, French, virus%20associ%C3%A9%20%C3%A0%20l%27ad%C3%A9novirus
correct, masculine noun
- virus adéno-associé 2, record 2, French, virus%20ad%C3%A9no%2Dassoci%C3%A9
correct, masculine noun
- VAA 3, record 2, French, VAA
correct, masculine noun
- VAA 3, record 2, French, VAA
Record 2, Textual support, French
Record number: 2, Textual support number: 1 DEF
Virus icosaédrique [20 faces] d'un diamètre de 21,8 nm, dont la multiplication est dépendante de la présence d'adénovirus. 4, record 2, French, - virus%20associ%C3%A9%20aux%20ad%C3%A9novirus
Record number: 2, Textual support number: 1 CONT
Seul un groupe a rapporté l'utilisation des AAV (adeno-associated virus) : cela reflète le peu de travaux effectivement réalisés avec ces virus dont les possibilités d'intégration cellulaire et les propriétés ne sont pas encore bien connues. 1, record 2, French, - virus%20associ%C3%A9%20aux%20ad%C3%A9novirus
Record number: 2, Textual support number: 1 OBS
AAV : Bien que cette abréviation soit largement utilisée en français, on recommande l'abréviation «VAA» qui correspond au terme français «virus adéno-associé». 5, record 2, French, - virus%20associ%C3%A9%20aux%20ad%C3%A9novirus
Record 2, Spanish
Record 2, Textual support, Spanish
Record 3 - internal organization data 1994-04-13
Record 3, English
Record 3, Subject field(s)
- Genetics
Record 3, Main entry term, English
- pathogenic gene
1, record 3, English, pathogenic%20gene
correct
Record 3, Abbreviations, English
Record 3, Synonyms, English
Record 3, French
Record 3, Domaine(s)
- Génétique
Record 3, Main entry term, French
- gène anormal
1, record 3, French, g%C3%A8ne%20anormal
correct, masculine noun
Record 3, Abbreviations, French
Record 3, Synonyms, French
Record 3, Textual support, French
Record 3, Spanish
Record 3, Textual support, Spanish
Record 4 - internal organization data 1992-11-18
Record 4, English
Record 4, Subject field(s)
- Biochemistry
Record 4, Main entry term, English
- amyloid precursor protein
1, record 4, English, amyloid%20precursor%20protein
correct
Record 4, Abbreviations, English
- APP 2, record 4, English, APP
correct
Record 4, Synonyms, English
Record 4, Textual support, English
Record number: 4, Textual support number: 1 CONT
Direct sequencing of exon 17 of the amyloid precursor protein(APP) gene led to the identification of 3 different types of APP717 pathogenic mutations associated with familial Alzheimer's disease(FAD). 3, record 4, English, - amyloid%20precursor%20protein
Record number: 4, Textual support number: 1 OBS
Term and context extracted from PASCAL data base. 1, record 4, English, - amyloid%20precursor%20protein
Record 4, French
Record 4, Domaine(s)
- Biochimie
Record 4, Main entry term, French
- protéine précurseur amyloïde
1, record 4, French, prot%C3%A9ine%20pr%C3%A9curseur%20amylo%C3%AFde
correct, feminine noun
Record 4, Abbreviations, French
Record 4, Synonyms, French
Record 4, Textual support, French
Record number: 4, Textual support number: 1 OBS
Équivalent trouvé dans une liste de descripteurs français d'un article tiré de la base de données PASCAL. 1, record 4, French, - prot%C3%A9ine%20pr%C3%A9curseur%20amylo%C3%AFde
Record 4, Spanish
Record 4, Textual support, Spanish
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