TERMIUM Plus®

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POPULATION PHARMACOKINETICS [2 records]

Filter results by subject field Alphabetical list of terms

Filter results by subject field

Alphabetical list of terms

Record 1 2019-03-06

English

Subject field(s)
  • Toxicology
CONT

Another approach for linking biomonitoring data to health outcomes is to estimate external exposures that would be consistent with the measured biomonitoring data. Such approach is referred to as "reverse dosimetry." Similar to forward dosimetry, reverse dosimetry also uses pharmacokinetic models to link external exposure to biomarker concentration. The term "reverse," however, does not imply that the model input (i.e., administered dose or exposure) and output (i.e., internal tissue concentrations) are reversed. Instead, reverse dosimetry uses other statistical and computational tools to reverse the relationship of external-to-internal measure of exposures.

OBS

At the individual level, reverse dosimetry is referred to as dose or exposure reconstruction. At the population level, reverse dosimetry is incorporated with probabilistic data regarding exposure patterns and pharmacokinetics, it is referred to as "probabilistic reverse dosimetry. "

French

Domaine(s)
  • Toxicologie

Spanish

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Record 2 2019-02-26

English

Subject field(s)
  • Pharmacology
DEF

... the study of variability in the absorption, distribution, metabolism, and excretion (ADME) of a medicine between individuals (healthy volunteers or patients).

French

Domaine(s)
  • Pharmacologie
DEF

[...] étude de la variabilité de l'absorption, de la distribution, du métabolisme et de l'excrétion (ADME) d'un médicament entre individus (volontaires sains ou patients).

CONT

Afin de comprendre comment des individus d'une population diffèrent entre eux, il est nécessaire de procéder à une analyse de la pharmacocinétique des populations.

Spanish

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