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Record 1,  Textual support,  English

Record number: 1, Textual support number: 1 DEF

A recombinant alfa interferon consisting of 165 amino acids with lysine at position 23 and histidine at position 34. It is used extensively as an antiviral and antineoplastic agent.  1, record 1, English, - interferon%20alpha%2D2a

Record number: 1, Textual support number: 1 CONT

Interferons are substances that occur naturally in the body and that are secreted by certain cells in response to infection. Interferon alfa-2a, also known as Roferon-A, and interferon alfa-2b, also known as Intron A, are manmade interferons manufactured by recombinant DNA technology. These interferons belong to the class of drugs called biological response modifiers. This class of medicines stimulates the body's response to infection and disease. They also belong to the class of drugs called antineoplastics. Antineoplastics slow or stop the growth of cancer cells.  2, record 1, English, - interferon%20alpha%2D2a

Record number: 1, Textual support number: 1 OBS

Spelling "alfa" is commonly used for recombinant form.  1, record 1, English, - interferon%20alpha%2D2a

Record 1,  Textual support,  French

Record number: 1, Textual support number: 1 CONT

La pégylation est un procédé destiné à retarder l'élimination d'un produit dans l'organisme. Il consiste à associer à un produit, une molécule de polyéthylène-glycol (PEG) responsable d'une augmentation de son poids. Dans le cas de l'Interféron alfa-2b, la pégylation aboutit au Peginterféron alfa-2b et permet d'obtenir un taux constant de ce produit pendant une semaine, après une seule injection.  1, record 1, French, - interf%C3%A9ron%20alfa%2D2b

Record 1,  Textual support,  Spanish

Record 2,  Textual support,  English

Record number: 2, Textual support number: 1 CONT

One cellular protein, c-Rel, a member of the NF-KB/Rel family, actually hinders HIV transcription. But it is made more slowly than are the factors that stimulate transcription. Clearly, the virus succeeds in getting itself transcribed often enough to spread infection. At first, the provirus relies on NF-KB and other proteins present in the activated cell to initiate its transcription into RNA. This process, though slow to begin with, can be likened to the tumbling of a stone that sets more and more stones rolling until it creates an avalanche.  1, record 2, English, - c%2DRel%20protein

Record 2,  Textual support,  French

Record number: 2, Textual support number: 1 CONT

Une protéine cellulaire de la même famille que NF-KB/Rel, la protéine c-Rel, empêche la transcription de l'ADN viral. Malheureusement elle est produite plus lentement que les facteurs qui stimulent cette transcription, de sorte que l'infection continue à se propager. Le démarrage de la transcription virale dépend des protéines NF-KB/Rel et des autres protéines présentes dans la cellule infectée et activée. Cette transcription, lente au début, s'accélère comme une pierre qui roule, entraînant avec elle de plus en plus de pierres jusqu'à déclencher une avalanche.  1, record 2, French, - prot%C3%A9ine%20c%2DRel

Record 2,  Textual support,  Spanish

Record 3,  Textual support,  English

Record number: 3, Textual support number: 1 DEF

An infection in which there is a lengthy period of incubation and/or latency (months or years) followed by the appearance of illness, which may be severe and associated with life-threatening signs and symptoms.  2, record 3, English, - slow%20infection

Record 3,  Textual support,  French

Record number: 3, Textual support number: 1 DEF

Infection dont l'exposition et la durée d'incubation, fréquemment mal définies, s'étendent au-delà d'une année (limite arbitraire).  1, record 3, French, - infection%20lente

Record 3,  Textual support,  Spanish