TERMIUM Plus®
The Government of Canada’s terminology and linguistic data bank.
SLOW KINETICS [4 records]
Record 1 - internal organization data 2011-12-14
Record 1, English
Record 1, Subject field(s)
- Medication
Record 1, Main entry term, English
- multi-target drug
1, record 1, English, multi%2Dtarget%20drug
correct
Record 1, Abbreviations, English
Record 1, Synonyms, English
- dirty drug 2, record 1, English, dirty%20drug
correct, familiar, pejorative
- promiscuous drug 2, record 1, English, promiscuous%20drug
familiar, pejorative
Record 1, Textual support, English
Record number: 1, Textual support number: 1 CONT
Sutent (SU11248) is a relatively "dirty" drug (in that it hits multiple targets) and has some affinity for 74 different kinases. PTK787 was one of the "cleanest" drugs tested in this study ... Being a "dirty" drug is not necessarily a bad thing. … The trick is that most cancers have more than one target. They might have five or six targets and you have to knock out three to stop the cancer ... 3, record 1, English, - multi%2Dtarget%20drug
Record number: 1, Textual support number: 2 CONT
The rationale for multi-target drugs has been strengthened both on theoretical and empirical grounds. Serious diseases that are intractable to treatment were found to have multiple pathogenic factors and examples of successful drugs were shown to affect multiple disease targets. The salient features of multiple-target drugs, low target affinity and rapid binding kinetics, have been responsible for their late discovery and slow development. 4, record 1, English, - multi%2Dtarget%20drug
Record 1, French
Record 1, Domaine(s)
- Médicaments
Record 1, Main entry term, French
- médicament multicible
1, record 1, French, m%C3%A9dicament%20multicible
correct, masculine noun
Record 1, Abbreviations, French
Record 1, Synonyms, French
Record 1, Textual support, French
Record number: 1, Textual support number: 1 CONT
La première activité décrite du sorafénib était celle d'inhibiteur de sérine/thréonine kinase de la protéine Raf-1. Par la suite, les autres cibles ont été successivement identifiées. En bloquant plusieurs voies de transduction différentes, ces médicaments multicibles présentent donc l'intérêt d'avoir une action prédominante sur l'angiogenèse mais aussi sur la prolifération cellulaire et l'apoptose. 2, record 1, French, - m%C3%A9dicament%20multicible
Record 1, Spanish
Record 1, Textual support, Spanish
Record 2 - internal organization data 2009-09-18
Record 2, English
Record 2, Subject field(s)
- Atomic Physics
Record 2, Main entry term, English
- slow kinetics
1, record 2, English, slow%20kinetics
correct
Record 2, Abbreviations, English
Record 2, Synonyms, English
Record 2, Textual support, English
Record number: 2, Textual support number: 1 CONT
Slow kinetics : Determination of a proton exchange rate for thiamine hydrochloride by monitoring NMR intensity with time. 1, record 2, English, - slow%20kinetics
Record 2, French
Record 2, Domaine(s)
- Physique atomique
Record 2, Main entry term, French
- cinétique lente
1, record 2, French, cin%C3%A9tique%20lente
correct, feminine noun
Record 2, Abbreviations, French
Record 2, Synonyms, French
Record 2, Textual support, French
Record number: 2, Textual support number: 1 CONT
Modélisation des cinétiques lentes. Il s'agit de décrire l'évolution de la microstructure sur des durées allant jusqu'à la fin de vie des réacteurs. Il s'agit donc entre autres de décrire la germination et la croissance des amas de défauts ponctuels, amas d'atomes de solutés, bulles, cavités, etc. connaissant les interactions entre atomes, et leurs mécanismes de sauts (c'est-à-dire la thermodynamique et la diffusion), il est possible de construire des modèles cinétiques d'évolution microstructurale. 1, record 2, French, - cin%C3%A9tique%20lente
Record 2, Spanish
Record 2, Textual support, Spanish
Record 3 - external organization data 2004-03-15
Record 3, English
Record 3, Subject field(s)
- Physics
- Nuclear Fission Reactors
- Compartment - Canadian Nuclear Safety Commission
Record 3, Main entry term, English
- point kinetics method 1, record 3, English, point%20kinetics%20method
Record 3, Abbreviations, English
Record 3, Synonyms, English
Record 3, Textual support, English
Record number: 3, Textual support number: 1 CONT
Phase II is proposed to extend the review of the treatment of spatial effects and the current use of point reactor model and point kinetics method in trip coverage analysis of slow LORCA [loss of reactivity control] and LOF [loss of flow] events. 1, record 3, English, - point%20kinetics%20method
Record 3, French
Record 3, Domaine(s)
- Physique
- Réacteurs nucléaires de fission
- Tiroir - Commission canadienne de sûreté nucléaire
Record 3, Main entry term, French
- méthode ponctuelle de cinétique
1, record 3, French, m%C3%A9thode%20ponctuelle%20de%20cin%C3%A9tique
feminine noun
Record 3, Abbreviations, French
Record 3, Synonyms, French
Record 3, Textual support, French
Record number: 3, Textual support number: 1 CONT
La phase II portera sur un examen approfondi du traitement des effets spatiaux et de l'utilisation actuelle du modèle de réacteur ponctuel et de la méthode ponctuelle de cinétique dans l'analyse de la couverture du déclenchement en cas d'ACPR [absence de contrôle en cas de perte de réactivité] et de PD [perte de débit]. 1, record 3, French, - m%C3%A9thode%20ponctuelle%20de%20cin%C3%A9tique
Record 3, Spanish
Record 3, Textual support, Spanish
Record 4 - external organization data 2004-03-15
Record 4, English
Record 4, Subject field(s)
- Physics
- Nuclear Fission Reactors
- Compartment - Canadian Nuclear Safety Commission
Record 4, Main entry term, English
- point reactor model 1, record 4, English, point%20reactor%20model
Record 4, Abbreviations, English
Record 4, Synonyms, English
Record 4, Textual support, English
Record number: 4, Textual support number: 1 CONT
Phase II is proposed to extend the review of the treatment of spatial effects and the current use of point reactor model and point kinetics method in trip coverage analysis of slow LORCA [loss of reactivity control] and LOF [loss of flow] events. 1, record 4, English, - point%20reactor%20model
Record 4, French
Record 4, Domaine(s)
- Physique
- Réacteurs nucléaires de fission
- Tiroir - Commission canadienne de sûreté nucléaire
Record 4, Main entry term, French
- modèle de réacteur ponctuel
1, record 4, French, mod%C3%A8le%20de%20r%C3%A9acteur%20ponctuel
masculine noun
Record 4, Abbreviations, French
Record 4, Synonyms, French
Record 4, Textual support, French
Record number: 4, Textual support number: 1 CONT
La phase II portera sur un examen approfondi du traitement des effets spatiaux et de l'utilisation actuelle du modèle de réacteur ponctuel et de la méthode ponctuelle de cinétique dans l'analyse de la couverture du déclenchement en cas d'ACPR [absence de contrôle en cas de perte de réactivité] et de PD [perte de débit]. 1, record 4, French, - mod%C3%A8le%20de%20r%C3%A9acteur%20ponctuel
Record 4, Spanish
Record 4, Textual support, Spanish
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