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TARGET CHANGING [11 records]

Record 1 2022-09-09

English

Subject field(s)
  • Pharmacology
  • Biotechnology
CONT

For example, the concept of scaffold hopping, which could be considered a subset of the concept of bioisosterism..., might be applied during lead optimization to identify one or more new series of compounds having a fundamentally different core structure to improve, for example, its potency or selectivity profile, synthetic accessibility, intellectual property position, or pharmacokinetic properties. The goal of scaffold hopping is to attain novel structures by changing the central core framework(the scaffold) of active compounds without affecting its binding to the target receptor.

French

Domaine(s)
  • Pharmacologie
  • Biotechnologie

Spanish

Save record 1

Record 2 2022-08-10

English

Subject field(s)
  • Diagnostic Procedures (Medicine)
  • Endocrine System and Metabolism
CONT

SMBG works by having patients perform a number of glucose tests each day or each week. The test most commonly involves pricking a finger with a lancet device to obtain a small blood sample, applying a drop of blood onto a reagent strip, and determining the glucose concentration by inserting the strip into a reflectance photometer for an automated reading. Test results are then recorded in a logbook or stored in the glucose meter's electronic memory. People with diabetes can be taught to use their SMBG results to correct any deviations out of a desired target range by changing their carbohydrate intake, exercising, or using more or less insulin.

Key term(s)
  • glycaemia self-monitoring
  • self-monitoring of glycaemia

French

Domaine(s)
  • Méthodes diagnostiques (Médecine)
  • Systèmes endocrinien et métabolique

Spanish

Save record 2

Record 3 2017-01-30

English

Subject field(s)
  • Economic Doctrines, Systems and Policies
  • Economic Co-operation and Development
CONT

Institutional complementarity is said to exist when the presence or absence of one institution affects the efficiency of the other. This is seen to inhibit radical or fundamental socio-economic change and instead promote institutional reproduction.

CONT

Uncertainty about the future, then, is at the same time uncertainty about institutional complementarity, to the extent that complementarity is measured by economic performance... If we assume that world to be changing, in a direction on which we can make at best educated guesses, then complementarity is not just an uncertain but a moving target, one that we may pursue in bad times by either preserving or rebuilding our institutions, and by refining and upgrading them in good times, without ever knowing for sure, whether what we are doing will really make them more complementary, and with it more productive.

French

Domaine(s)
  • Doctrines, systèmes et politiques économiques
  • Coopération et développement économiques
CONT

L'analyse historique suggère qu'une stratégie que l'on peut qualifier d'américanisation se heurte au fait que les institutions de la nouvelle économie se sont forgées progressivement à travers un processus d'essais et d'erreurs, à l'issue duquel se manifeste une co-évolution qui peut être lue comme l'expression d'une complémentarité institutionnelle.

CONT

De nouveaux régimes économiques ont émergé ou sont en voie de le faire, mais qu'ils mettent en œuvre soit une complémentarité institutionnelle, soit une hiérarchie dans laquelle est impliquée la finance, plus qu'un déterminisme par les TIC [technologies de l'information et de la communication] en tant que telles.

Spanish

Save record 3

Record 4 2015-11-04

English

Subject field(s)
  • Advertising Media
CONT

Full vehicle wraps. No matter the type or colour of your vehicle, we can produce a complete car or van wrap to cover all surfaces, including windows. We produce specialist digitally printed films developed to conform to curves, contours and recesses that we then apply to your vehicle, completely changing its appearance to any design you desire. Turning cars and vans into eye-catching adverts is a fast and affordable way to communicate to your target market, whether out on the road, at an event or exhibition or even in a TV advert.

French

Domaine(s)
  • Supports publicitaires

Spanish

Save record 4

Record 5 2012-04-24

English

Subject field(s)
  • Explosives and Pyrotechnical Materials (Industries)
  • Weapon Systems
DEF

An explosive charge designed to propel a metal plate towards a target without changing its form.

OBS

platter charge: term and definition officially approved by the Joint Terminology Panel, the Army Terminology Panel and the Defence Terminology Standardization Board.

OBS

platter charge: term officially approved by the Engineering Terminology Working Group.

French

Domaine(s)
  • Explosifs et artifices (Industries)
  • Systèmes d'armes
DEF

Charge explosive conçue pour projeter une plaque de métal vers une cible sans en modifier la forme.

OBS

charge en crête : terme et définition uniformisés par le Groupe d’experts en terminologie interarmées et par le Conseil de normalisation de terminologie de la Défense.

OBS

charge en crête : terme uniformisé par le Groupe de travail de terminologie du génie et par le Comité de terminologie française du Conseil de doctrine et de tactique de l'Armée de terre.

Spanish

Save record 5

Record 6 2012-03-02

English

Subject field(s)
  • Fencing
  • Combined-Events Contests
DEF

A simple and direct offensive action.

OBS

The straight or direct thrust is the simplest form of attack; it is made by extending the sword arm and directing the tip of the blade to the target with a lunge but without changing the line of engagement.

French

Domaine(s)
  • Escrime
  • Compétitions à épreuves combinées
DEF

Mouvement offensif simple et direct.

OBS

Le coup droit est la forme la plus simple de l'attaque : la main armée dirige la pointe de la lame vers la cible par une extension du bras suivi d'une fente ou développement du corps sans changer la ligne d'engagement.

Spanish

Campo(s) temático(s)
  • Esgrima
  • Competiciones de pruebas combinadas
Save record 6

Record 7 2011-05-13

English

Subject field(s)
  • Shooting (Sports)
OBS

Technique/tactics.

French

Domaine(s)
  • Tir (Sports)
OBS

Technique/tactique.

Key term(s)
  • changement de la cible

Spanish

Campo(s) temático(s)
  • Tiro (Deportes)
Save record 7

Record 8 2010-04-27

English

Subject field(s)
  • Currency and Foreign Exchange
CONT

Since 1991, Canada's monetary policy framework has consisted of two main elements–an inflation target and a flexible exchange rate. This framework has allowed Canada to pursue an independent monetary policy–a policy suited to our own circumstances. The two main elements work together and reinforce each other. The result has been low and stable inflation, with less volatility in output and employment.... To summarize, our monetary policy framework has served us well in maintaining a domestic environment of growth and stability. Together with other domestic policies, it has helped Canada to adjust to some significant changes in the global economy.... Our monetary policy framework is helping the Canadian economy to absorb external shocks and to adjust to changing circumstances.

French

Domaine(s)
  • Politique monétaire et marché des changes
CONT

Depuis 1991, le cadre de conduite de la politique monétaire du Canada repose sur deux éléments principaux : une cible d'inflation et un régime de changes flexibles. Grâce à ce cadre, le Canada a pu mener une politique monétaire indépendante, adaptée à sa conjoncture propre. Ces deux éléments fonctionnent de concert et se renforcent mutuellement. Ils ont permis d'obtenir un taux d'inflation bas et stable, tout en réduisant la volatilité de la production et de l'emploi. [...] En résumé, notre cadre de conduite de la politique monétaire nous a bien servis, en nous permettant de maintenir un climat de croissance et de stabilité au pays. Conjugué aux autres politiques intérieures, il a aidé le Canada à s'adapter à de profondes transformations de l'économie mondiale. [...] Notre cadre de conduite de la politique monétaire aide l'économie canadienne à absorber les chocs externes et à s'ajuster aux conditions changeantes.

Spanish

Save record 8

Record 9 2007-01-31

English

Subject field(s)
  • Radar, Radio Guidance and Goniometry
  • Spacecraft
  • Remote Sensing
CONT

Depolarization occurs when the polarization state changes between the transmitted and received signal. For example, changing a HH to a HV response. There are four mechanisms known to cause depolarization : a quasi-specular reflection as a result of the difference between the Fresnel reflection coefficients for a two-dimensional, smoothly undulating surface [;] a multi-scattering due to target surface roughness [;] a multiple scattering due to volume scattering [;] anisotropic properties of the targets.

OBS

depolarization: term officially approved by the RADARSAT-2 Terminology Approval Group (RTAG).

French

Domaine(s)
  • Radar, radioguidage et radiogoniométrie
  • Engins spatiaux
  • Télédétection
CONT

L'onde polarisée circulairement a le désavantage, lorsque le faisceau radar pénètre la précipitation, de changer son état de polarisation de circulaire à elliptique. Ce changement d'état de polarisation, ou dépolarisation, est attribué aux effets de propagation dus à l'atténuation différentielle et au déphasage différentiel. Les mesures de radar se trouvent contaminées par ces effets et, par conséquent, rendent hasardeuse leur interprétation en termes des caractéristiques de polarisation propres à la précipitation ciblée.

OBS

dépolarisation : terme uniformisé par le Groupe de travail de la terminologie de RADARSAT-2 (GTTR).

PHR

Dépolarisation de l'onde.

Spanish

Campo(s) temático(s)
  • Guía radárica, radioguía y radiogoniometría
  • Naves espaciales
  • Teledetección
Save record 9

Record 10 2004-09-15

English

Subject field(s)
  • Titles of Conventions, Treaties and Agreements (Documents)
  • Informatics
  • Foreign Trade
OBS

Welcome to the Export Diagnostic! Answering the questions will give you a chance to test your export readiness and get feedback on priority activities to succeed in your target export market. Once you’ve completed the Diagnostic, you can try changing answers to run "what if" scenarios. Please be aware that the Diagnostic takes 30-60 minutes to complete. You can answer some of the questions now, save your scenario, and then return later to complete it.

French

Domaine(s)
  • Titres de conventions, de traités et d'accords (Documents)
  • Informatique
  • Commerce extérieur
OBS

Bienvenue à l'Évaluation de la capacité d'exportation! En répondant aux questions, vous pourrez vérifier à quel point vous êtes prêt à exporter et ainsi obtenir une rétroaction relative aux activités prioritaires qui favoriseront votre réussite sur les marchés extérieurs qui vous intéressent. Lorsque vous aurez terminé l'évaluation, vous pourrez modifier vos réponses de telle sorte à explorer d'autres «scénarios». Veuillez prendre note qu'il faut entre 30 et 60 minutes pour compléter le Diagnostique. Vous pouvez répondre à certaines questions maintenant, sauvegarder votre scénario, puis revenir le terminer un peu plus tard.

Spanish

Campo(s) temático(s)
  • Títulos de convenciones, tratados y acuerdos (Documentos)
  • Informática
  • Comercio exterior
Save record 10

Record 11 1997-09-23

English

Subject field(s)
  • Microbiology and Parasitology
CONT

Unlike drugs, to which HIV can develop resistance by genetically reshaping its component parts, the engineered (smart bomb) virus attacks a feature that HIV probably cannot alter without rendering itself harmless. In laboratory experiments, it reduced HIV to undetectable levels, raising the possibility of an entirely new kind of therapy for treating AIDS and maybe other viral diseases.

OBS

The virus doesn’t seem to infect any cells other than those infected with HIV. The method consists of reprogramming a virus, changing its natural target so that it kills another virus. However, the therapy based on injection of live viruses is unlikely to be approved easily.

CONT

The HIV-hunting virus has been designed by Dr. John Rose and his colleagues at Yale University School of Medicine this year. They worked with a well-understood virus that infects cattle, known as VSV, or vesicular stomatitis virus and stripped out the gene that makes its protein coat. In its place, they inserted human genes for the two proteins that constitutes the T-cell lack. This created a novel virus, coated with T-cell lock proteins avid to find HIV keys, a sort of HIV in reverse. When added to culture of infected human T-cells, the redesigned viruses sought out and killed them.

Key term(s)
  • lock protein
  • key and lock process
  • redesigned virus

French

Domaine(s)
  • Microbiologie et parasitologie

Spanish

Save record 11

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