TERMIUM Plus^®

Record 1,  Textual support,  English

Record number: 1, Textual support number: 1 CONT

Computer-aided drug discovery [involves] using computer algorithms to find the correct composition of a drug, develop the drug, and analyze its performance on a biological target.  5, record 1, English, - computer%2Daided%20drug%20discovery

Record 1,  Textual support,  French

Record 1,  Textual support,  Spanish

Record 2,  Textual support,  English

Record number: 2, Textual support number: 1 CONT

A biological target is a specific molecule or cellular component that is involved in a disease and is selected as the focus of a drug discovery project. Medicinal chemists design drugs that bind to this target in order to treat the disease.  3, record 2, English, - therapeutic%20target

Record 2,  Textual support,  French

Record number: 2, Textual support number: 1 DEF

Agent pathogène ou structure endogène qui, dans une situation pathologique, fait l'objet d'un traitement thérapeutique chez l'homme ou chez l'animal.  3, record 2, French, - cible%20th%C3%A9rapeutique

Record number: 2, Textual support number: 1 OBS

cible thérapeutique : désignation et définition publiées au Journal officiel de la République française le 5 janvier 2023.  4, record 2, French, - cible%20th%C3%A9rapeutique

Record 2,  Textual support,  Spanish

Record number: 2, Textual support number: 1 CONT

La enfermedad de Alzheimer está caracterizada por la aparición progresiva en el cerebro de unos depósitos o placas constituidas principalmente por péptido β amiloide. [...] Las enzimas β- g-secretasa, implicadas en la formación del péptido β amiloide, y la agregación de este péptido constituyen las principales dianas biológicas de muchas compañías farmacéuticas que pretenden desarrollar terapias modificadoras de esta enfermedad.  1, record 2, Spanish, - diana%20biol%C3%B3gica

Record 3,  Textual support,  English

Record number: 3, Textual support number: 1 CONT

Usually, the data is obtained by using drones or satellite reconnaissance means. Therefore, the acquired data is redundant and diverse. For the problem of camouflage detection, the traditional camouflage effect detection application personnel interpret the discovery probability of the target, which requires a lot of manpower and material resources.  3, record 3, English, - camouflage%20detection

Record number: 3, Textual support number: 1 OBS

camouflage detection; CD: designations standardized by NATO.  4, record 3, English, - camouflage%20detection

Record 3,  Textual support,  French

Record number: 3, Textual support number: 1 OBS

détection du camouflage; CD : désignations normalisées par l'OTAN.  3, record 3, French, - d%C3%A9tection%20du%20camouflage

Record 3,  Textual support,  Spanish

Record 4,  Textual support,  French

Record 4,  Textual support,  Spanish

Record 5,  Textual support,  English

Record number: 5, Textual support number: 1 CONT

Sutent (SU11248) is a relatively "dirty" drug (in that it hits multiple targets) and has some affinity for 74 different kinases. PTK787 was one of the "cleanest" drugs tested in this study ... Being a "dirty" drug is not necessarily a bad thing. … The trick is that most cancers have more than one target. They might have five or six targets and you have to knock out three to stop the cancer ...  3, record 5, English, - multi%2Dtarget%20drug

Record number: 5, Textual support number: 2 CONT

The rationale for multi-target drugs has been strengthened both on theoretical and empirical grounds. Serious diseases that are intractable to treatment were found to have multiple pathogenic factors and examples of successful drugs were shown to affect multiple disease targets. The salient features of multiple-target drugs, low target affinity and rapid binding kinetics, have been responsible for their late discovery and slow development.  4, record 5, English, - multi%2Dtarget%20drug

Record 5,  Textual support,  French

Record number: 5, Textual support number: 1 CONT

La première activité décrite du sorafénib était celle d'inhibiteur de sérine/thréonine kinase de la protéine Raf-1. Par la suite, les autres cibles ont été successivement identifiées. En bloquant plusieurs voies de transduction différentes, ces médicaments multicibles présentent donc l'intérêt d'avoir une action prédominante sur l'angiogenèse mais aussi sur la prolifération cellulaire et l'apoptose.  2, record 5, French, - m%C3%A9dicament%20multicible

Record 5,  Textual support,  Spanish

Record 6,  Textual support,  English

Record number: 6, Textual support number: 1 CONT

Nearly every drug molecule works through a structural interaction with a "target" or "receptor" molecule or protein that plays key roles in all biological processes. In the most common model for this interaction, the drug molecule inserts itself into a functionally important crevice of its target protein, like a key in a lock. The molecule then binds there and either induces or, more commonly, inhibits the protein's normal function. This universal drug-target scheme suggests a powerful alternative approach to drug discovery : if it were possible to identify, in advance, the appropriate protein target for a given therapeutic need and if enough were known about the distinguishing structure of that target protein, it ought to be feasible to design the structure of an ideal drug to interact with it.  2, record 6, English, - target%20protein

Record 6,  Textual support,  French

Record number: 6, Textual support number: 1 CONT

La discipline [...] «Bio-informatique du médicament» recouvre les activités suivantes : analyser et exploiter les génomes pour identifier les classes structurales et fonctionnelles d'intérêt thérapeutique; [...] modéliser les protéines-cibles dont la structure n'est pas accessible expérimentalement [...]  1, record 6, French, - prot%C3%A9ine%2Dcible

Record 6,  Textual support,  Spanish

Record 7,  Textual support,  English

Record number: 7, Textual support number: 1 CONT

Combinatorial chemistry is based on the simple premise that the greater the diversity of compounds tested, the better the chance of finding on that can be developed into a drug... Combinatorial chemistry can improve drug discovery by increasing the efficiency with which novel leads are generated; assisting the optimization of previously identified leads; generating molecules for target validation, independent in their value as potential drug candidates.  3, record 7, English, - combinatorial%20chemistry

Record 7,  Textual support,  French

Record number: 7, Textual support number: 1 CONT

La chimie combinatoire au service de la puissance et de la sélectivité des interactions intermoléculaires : la possibilité de recréer au laboratoire des mélanges de molécules pouvant contenir des milliers, voire des millions de molécules originales, grâce aux approches de synthèse combinatoire sur support solide, a bouleversé ces cinq dernières années les pratiques de nombreux laboratoires s'intéressant au développement de nouveaux composés doués d'activité biologique.  1, record 7, French, - chimie%20combinatoire

Record number: 7, Textual support number: 1 OBS

Ces approches ont pris un essor considérable dans le domaine de l'industrie pharmaceutique. Il y a lieu cependant de souligner que ces méthodes permettent d'aborder sous un nouvel angle les problèmes liés à la reconnaissance intermoléculaire. En effet, à la différence des démarches fondées sur le criblage de substances naturelles, la nature et la diversité des molécules synthétisées par les approches combinatoires peuvent être totalement contrôlées.  1, record 7, French, - chimie%20combinatoire

Record 7,  Textual support,  Spanish