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Record 1,  Textual support,  English

Record number: 1, Textual support number: 1 CONT

The human immunodeficiency virus(HIV) consists of a nucleoid core and the surrounding protein matrix, both enclosed in a lipid envelope. The nucleoid core contains the viral genetic material and the reverse transcriptase enzyme, which are used in viral replication. The transmembrane glycoprotein and the envelope glycoprotein are attached to the envelope; these proteins enable HIV to bind and fuse with a target host cell.  1, record 1, English, - envelope%20glycoprotein

Record 1,  Textual support,  French

Record number: 1, Textual support number: 1 CONT

Le VIH 1 se réplique dans les cellules exprimant le récepteur CD4, macrophages et lymphocytes T auxiliaires essentiellement. L'entrée du VIH 1 requiert la molécule CD4, sur laquelle s'attache la glycoprotéine d'enveloppe du virus.  1, record 1, French, - glycoprot%C3%A9ine%20d%27enveloppe

Record 1,  Textual support,  Spanish

Record 2,  Textual support,  English

Record number: 2, Textual support number: 1 CONT

The coat of the [HIV] virion bears numerous viral proteins "spikes" that project into the external medium. Each spike probably consists of four molecules of a protein called gp 120 on the outside and the same number of gp 41 embedded in the membrane. These envelope proteins play a crucial role when HIV binds to or enters target cells.  1, record 2, English, - envelope%20protein

Record number: 2, Textual support number: 1 OBS

(Gp stands for glycoprotein- the proteins are linked to sugars- and the number refers to the mass of the protein, in thousands of daltons).  1, record 2, English, - envelope%20protein

Record 2,  Textual support,  French

Record number: 2, Textual support number: 1 CONT

Les protéines du V.I.H.-1, toutes antigéniques, c'est-à-dire capables d'induire la production d'anticorps. Parmi les protéines identifiées on retrouve les protéines d'enveloppes chargées de sucres (glycoprotéines). La glycolylation d'une protéine de 90 kDa (produit par le gène env) aboutit à un précurseur de 160 kDa intracellulaire dont le clivage par une protéase cellulaire donne naissance à : une glycoprotéine de 110/120 kDa, d'où le sigle gp110/120, N-terminale, la plus externe (EGP), correspondant aux spicules d'attachement; une seconde de PM plus faible (41 kDa) ou gp41, C-terminale, qui est transmembranaire et dotée d'une région hydrophobe qui assure son ancrage à la membrane cellulaire phospholipidique.  1, record 2, French, - prot%C3%A9ine%20d%27enveloppe

Record 2,  Textual support,  Spanish

Record 3,  Textual support,  English

Record number: 3, Textual support number: 1 CONT

Treated with these two genomes, the packaging cell produces a crop of retroviruses with : the envelope protein needed to infect the human target cells; an RNA copy of the human ADA [adenosine deaminase] gene, complete with R sequences at each end; reverse transcriptase, needed to make a DNA copy of the ADA gene that can be inserted into the DNA of the target cell and none of the genes(gag, pol, env) that would enable the virus to replicate in its new host.  3, record 3, English, - packaging%20cell

Record number: 3, Textual support number: 2 CONT

To create the retroviral vectors that are used in gene therapy, the life-cycles of their naturally occurring counterparts are exploited. The transgene (in this case, the gene for factor IX) in a vector backbone is put into a packaging cell, which expresses the genes that are required for viral integration.  4, record 3, English, - packaging%20cell

Record 3,  Textual support,  French

Record number: 3, Textual support number: 1 CONT

Les différents modes de transfert sont : [...] Injection de cellules produisant le vecteur viral pour éviter son inactivation trop rapide par le complément. Ces cellules sont appelés cellules transcomplémentantes (ou cellules d'encapsidation).  3, record 3, French, - cellule%20d%27encapsidation

Record number: 3, Textual support number: 1 OBS

Il s'agit d'un type de cellules utilisées pour produire des virus non pathogènes en supprimant les gènes nécessaires à leur réplication et en les remplaçant par une séquence choisie et des éléments régulateurs.  4, record 3, French, - cellule%20d%27encapsidation

Record 3,  Textual support,  Spanish

Record 4,  Textual support,  English

Record number: 4, Textual support number: 1 CONT

The coat of the HIV virion bears numerous viral proteins "spikes" that project into the external medium. Each spike probably consists of four molecules of a protein called gp120 on the outside and the same number of gp41 embedded in the membrane. These envelope proteins play a crucial role when HIV binds to, and enters target cells. Underneath the envelope is a layer of matrix protein called p17, which in turn surrounds the core, or capsid. Gp stands for glycoprotein-the proteins are linked to sugars-and the number refers to the mass of the protein, in thousands of daltons. [From source a].  2, record 4, English, - p17

Record 4,  Textual support,  French

Record number: 4, Textual support number: 1 CONT

Le génome viral du VIH comprend 3 gènes principaux soit le gag, le pol et l'env. Les glycoprotéines 120 et gp41 sont codées par le gène env tandis que le gène gag code les protéines du noyau [core proteins] telles les p55, p40, p24,p17 et p7; le gène pol code les protéines p66 et p51 (transcriptase inverse), p11 (protéase), et p32 (intégrase).  1, record 4, French, - p17

Record 4,  Textual support,  Spanish

Record 5,  Textual support,  French

Record 5,  Textual support,  Spanish

Record 6,  Textual support,  English

Record number: 6, Textual support number: 1 DEF

A function which describes the complex envelope of the signal at the output for the radar receiver as a function of radar target range and radial velocity.  2, record 6, English, - ambiguity%20function

Record 6,  Textual support,  French

Record 6,  Textual support,  Spanish