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TARGET PROBLEM [19 records]
Record 1 - internal organization data 2026-01-08
Record 1, English
Record 1, Subject field(s)
- Artificial Intelligence
Record 1, Main entry term, English
- analogical problem solving
1, record 1, English, analogical%20problem%20solving
correct
Record 1, Abbreviations, English
Record 1, Synonyms, English
Record 1, Textual support, English
Record number: 1, Textual support number: 1 CONT
... analogical problem solving [is] the use of a solution to a known source problem to develop a solution to a novel target problem. 2, record 1, English, - analogical%20problem%20solving
Record 1, French
Record 1, Domaine(s)
- Intelligence artificielle
Record 1, Main entry term, French
- résolution de problèmes analogiques
1, record 1, French, r%C3%A9solution%20de%20probl%C3%A8mes%20analogiques
correct, feminine noun
Record 1, Abbreviations, French
Record 1, Synonyms, French
Record 1, Textual support, French
Record 1, Spanish
Record 1, Textual support, Spanish
Record 2 - internal organization data 2023-07-28
Record 2, English
Record 2, Subject field(s)
- Artificial Intelligence
Record 2, Main entry term, English
- bias-variance tradeoff
1, record 2, English, bias%2Dvariance%20tradeoff
correct
Record 2, Abbreviations, English
Record 2, Synonyms, English
- bias-variance trade-off 2, record 2, English, bias%2Dvariance%20trade%2Doff
correct
Record 2, Textual support, English
Record number: 2, Textual support number: 1 CONT
The bias-variance tradeoff is a fundamental problem in machine learning and statistics. It is the problem of finding a model that accurately predicts the target function while also minimizing the number of errors. The tradeoff is between the model' s ability to fit the data(bias) and the model' s ability to generalize to new data(variance). 3, record 2, English, - bias%2Dvariance%20tradeoff
Record 2, French
Record 2, Domaine(s)
- Intelligence artificielle
Record 2, Main entry term, French
- compromis biais-variance
1, record 2, French, compromis%20biais%2Dvariance
correct, masculine noun
Record 2, Abbreviations, French
Record 2, Synonyms, French
Record 2, Textual support, French
Record number: 2, Textual support number: 1 DEF
Problème qui consiste à minimiser simultanément la variance et le biais qui empêchent les algorithmes d'apprentissage supervisé de généraliser au-delà de leur échantillon d'apprentissage. 1, record 2, French, - compromis%20biais%2Dvariance
Record 2, Spanish
Record 2, Textual support, Spanish
Record 3 - internal organization data 2023-04-18
Record 3, English
Record 3, Subject field(s)
- Mental health and hygiene
Record 3, Main entry term, English
- evidence-based health intervention
1, record 3, English, evidence%2Dbased%20health%20intervention
correct
Record 3, Abbreviations, English
Record 3, Synonyms, English
Record 3, Textual support, English
Record number: 3, Textual support number: 1 CONT
Decision-makers must assess which evidence-based health interventions will best improve the health of a target population, a subgroup or a person, with respect to a specific health problem. 2, record 3, English, - evidence%2Dbased%20health%20intervention
Record 3, Key term(s)
- evidence based health intervention
Record 3, French
Record 3, Domaine(s)
- Hygiène et santé mentales
Record 3, Main entry term, French
- intervention en santé fondée sur des données probantes
1, record 3, French, intervention%20en%20sant%C3%A9%20fond%C3%A9e%20sur%20des%20donn%C3%A9es%20probantes
feminine noun
Record 3, Abbreviations, French
Record 3, Synonyms, French
- intervention de santé fondée sur des données probantes 2, record 3, French, intervention%20de%20sant%C3%A9%20fond%C3%A9e%20sur%20des%20donn%C3%A9es%20probantes
feminine noun
Record 3, Textual support, French
Record number: 3, Textual support number: 1 CONT
Le recours à des interventions en santé fondées sur des données probantes favorise des SSP [soins de santé primaires] pertinents, efficaces et sécuritaires. 1, record 3, French, - intervention%20en%20sant%C3%A9%20fond%C3%A9e%20sur%20des%20donn%C3%A9es%20probantes
Record 3, Spanish
Record 3, Textual support, Spanish
Record 4 - internal organization data 2021-06-23
Record 4, English
Record 4, Subject field(s)
- Counter-Measures (Military operations)
- Surveillance, Detection and Reconnaissance (Military)
Record 4, Main entry term, English
- camouflage detection
1, record 4, English, camouflage%20detection
correct, NATO, standardized
Record 4, Abbreviations, English
- CD 2, record 4, English, CD
correct, NATO, standardized
Record 4, Synonyms, English
Record 4, Textual support, English
Record number: 4, Textual support number: 1 CONT
Usually, the data is obtained by using drones or satellite reconnaissance means. Therefore, the acquired data is redundant and diverse. For the problem of camouflage detection, the traditional camouflage effect detection application personnel interpret the discovery probability of the target, which requires a lot of manpower and material resources. 3, record 4, English, - camouflage%20detection
Record number: 4, Textual support number: 1 OBS
camouflage detection; CD: designations standardized by NATO. 4, record 4, English, - camouflage%20detection
Record 4, French
Record 4, Domaine(s)
- Contre-mesures (Opérations militaires)
- Surveillance, détection et reconnaissance (Militaire)
Record 4, Main entry term, French
- détection du camouflage
1, record 4, French, d%C3%A9tection%20du%20camouflage
correct, feminine noun, NATO, standardized
Record 4, Abbreviations, French
- CD 2, record 4, French, CD
correct, feminine noun, NATO, standardized
Record 4, Synonyms, French
Record 4, Textual support, French
Record number: 4, Textual support number: 1 OBS
détection du camouflage; CD : désignations normalisées par l'OTAN. 3, record 4, French, - d%C3%A9tection%20du%20camouflage
Record 4, Spanish
Record 4, Textual support, Spanish
Record 5 - internal organization data 2020-11-18
Record 5, English
Record 5, Subject field(s)
- Various Military Titles
- Weapon Systems
Record 5, Main entry term, English
- Kerrison Predictor
1, record 5, English, Kerrison%20Predictor
correct
Record 5, Abbreviations, English
Record 5, Synonyms, English
Record 5, Textual support, English
Record number: 5, Textual support number: 1 OBS
The Kerrison Predictor was one of the first fully automated anti-aircraft fire-control systems. The Predictor solved the problem by doing all of the calculations mechanically through a complex system of gears. Inputs to its calculations included wind speed, ballistics of the gun and the rounds it fired, angle to the target in azimuth and altitude, and a user-input estimated target speed. Some of these inputs were fed in by dials, which turned gearing inside the Predictor to calculate the range(from the change in angle and estimated speed) and direction of motion. 1, record 5, English, - Kerrison%20Predictor
Record 5, French
Record 5, Domaine(s)
- Appellations militaires diverses
- Systèmes d'armes
Record 5, Main entry term, French
- Kerrison Predictor
1, record 5, French, Kerrison%20Predictor
correct, masculine noun
Record 5, Abbreviations, French
Record 5, Synonyms, French
- calculateur de tir Kerrison 2, record 5, French, calculateur%20de%20tir%20Kerrison
proposal, masculine noun
Record 5, Textual support, French
Record number: 5, Textual support number: 1 DEF
Ordinateur analogique créé à la fin des années 1930 [...] pour guider les tirs d'un canon antiaérien. 3, record 5, French, - Kerrison%20Predictor
Record 5, Spanish
Record 5, Textual support, Spanish
Record 6 - internal organization data 2014-01-24
Record 6, English
Record 6, Subject field(s)
- Scientific Research
- General Medicine, Hygiene and Health
Record 6, Main entry term, English
- moving target problem
1, record 6, English, moving%20target%20problem
correct, standardized
Record 6, Abbreviations, English
Record 6, Synonyms, English
Record 6, Textual support, English
Record number: 6, Textual support number: 1 DEF
Changes in health care that can render health technology assessments out-of-date, sometimes even before the recommendations that come out of them can be implemented. 1, record 6, English, - moving%20target%20problem
Record number: 6, Textual support number: 1 OBS
Included are changes in the mother technology, in one of its variants or in a complementary technology (used to treat a given health problem), emergence of new competing technologies, and changes in the application of a technology (e.g. to different patient populations or to different health problems). 1, record 6, English, - moving%20target%20problem
Record number: 6, Textual support number: 2 OBS
moving target problem : term and definition standardized by the Health Technology Assessment(HTA) Glossary English Editorial Board and the Translation Bureau. 2, record 6, English, - moving%20target%20problem
Record 6, Key term(s)
- moving-target problem
Record 6, French
Record 6, Domaine(s)
- Recherche scientifique
- Médecine générale, hygiène et santé
Record 6, Main entry term, French
- problème de l'évolution rapide des technologies
1, record 6, French, probl%C3%A8me%20de%20l%27%C3%A9volution%20rapide%20des%20technologies
correct, masculine noun, standardized
Record 6, Abbreviations, French
Record 6, Synonyms, French
Record 6, Textual support, French
Record number: 6, Textual support number: 1 DEF
Changements dans les soins de santé qui peuvent rendre les évaluations des technologies de la santé désuètes, parfois même avant que les recommandations qui en découlent puissent être appliquées. 1, record 6, French, - probl%C3%A8me%20de%20l%27%C3%A9volution%20rapide%20des%20technologies
Record number: 6, Textual support number: 1 OBS
Il peut s’agir de changements dans la technologie mère, dans une de ses variantes ou dans une technologie complémentaire (utilisée pour traiter un problème de santé donné), de l’émergence de nouvelles technologies concurrentes, ou de changements dans l’application d’une technologie (à différentes populations de patients ou à différents problèmes de santé, par exemple). 1, record 6, French, - probl%C3%A8me%20de%20l%27%C3%A9volution%20rapide%20des%20technologies
Record number: 6, Textual support number: 2 OBS
problème de l'évolution rapide des technologies : terme et définition normalisés par l'Institut national d'excellence en santé et en services sociaux (INESSS) et le Bureau de la traduction. 2, record 6, French, - probl%C3%A8me%20de%20l%27%C3%A9volution%20rapide%20des%20technologies
Record 6, Spanish
Record 6, Textual support, Spanish
Record 7 - internal organization data 2010-09-14
Record 7, English
Record 7, Subject field(s)
- Management Operations (General)
- Corporate Management (General)
- Artificial Intelligence
Record 7, Main entry term, English
- means-ends analysis
1, record 7, English, means%2Dends%20analysis
correct, standardized
Record 7, Abbreviations, English
Record 7, Synonyms, English
- means-end analysis 2, record 7, English, means%2Dend%20analysis
correct, standardized
Record 7, Textual support, English
Record number: 7, Textual support number: 1 DEF
The setting of goals at one level and determining what means are necessary to achieve them, then passing these means down to the next level where they become goals. 3, record 7, English, - means%2Dends%20analysis
Record number: 7, Textual support number: 1 CONT
The general heuristic called means-end analysis is related to specific task performing : the problem statement is transformed into a target or goal state that represents the solution to the problem. This state provides a means of identifying a proper solution to the problem. The program then identifies sequentially the operations that reduce the difference between the new present state and the goal state. 4, record 7, English, - means%2Dends%20analysis
Record number: 7, Textual support number: 1 OBS
means-ends analysis; means-end analysis: terms standardized by the International Organization for Standardization/International Electrotechnical Commission (ISO/IEC). 5, record 7, English, - means%2Dends%20analysis
Record 7, French
Record 7, Domaine(s)
- Opérations de la gestion (Généralités)
- Gestion de l'entreprise (Généralités)
- Intelligence artificielle
Record 7, Main entry term, French
- analyse moyens-fins
1, record 7, French, analyse%20moyens%2Dfins
correct, feminine noun, standardized
Record 7, Abbreviations, French
Record 7, Synonyms, French
- analyse moyens-fin 1, record 7, French, analyse%20moyens%2Dfin
correct, feminine noun, standardized
- analyse objectifs-moyens 2, record 7, French, analyse%20objectifs%2Dmoyens
correct, feminine noun
- analyse fins-moyens 3, record 7, French, analyse%20fins%2Dmoyens
correct, feminine noun
Record 7, Textual support, French
Record number: 7, Textual support number: 1 OBS
Technique qui consiste à déterminer une différence entre l'état souhaité (but) et la situation présente; chercher un opérateur qui réduise cette différence. Au cas où l'opérateur n'est pas immédiatement applicable, ses conditions d'applicabilité deviennent le nouveau but. 3, record 7, French, - analyse%20moyens%2Dfins
Record number: 7, Textual support number: 2 OBS
analyse moyens-fins; analyse moyens-fin : termes normalisés par l'Organisation internationale de normalisation/Commission électrotechnique internationale (ISO/CEI). 4, record 7, French, - analyse%20moyens%2Dfins
Record 7, Spanish
Record 7, Campo(s) temático(s)
- Operaciones de la gestión (Generalidades)
- Gestión de la empresa (Generalidades)
- Inteligencia artificial
Record 7, Main entry term, Spanish
- análisis de medios y fines
1, record 7, Spanish, an%C3%A1lisis%20de%20medios%20y%20fines
correct, masculine noun
Record 7, Abbreviations, Spanish
Record 7, Synonyms, Spanish
Record 7, Textual support, Spanish
Record number: 7, Textual support number: 1 DEF
Método de razonamiento que mira hacia atrás y hacia delante, desde el punto inicial a la meta, en un intento por reducir las diferencias. 2, record 7, Spanish, - an%C3%A1lisis%20de%20medios%20y%20fines
Record 8 - internal organization data 2010-06-08
Record 8, English
Record 8, Subject field(s)
- Social Problems
- Economic Co-operation and Development
- Special-Language Phraseology
Record 8, Main entry term, English
- problem of persistent hunger
1, record 8, English, problem%20of%20persistent%20hunger
correct
Record 8, Abbreviations, English
Record 8, Synonyms, English
- persistent hunger problem 2, record 8, English, persistent%20hunger%20problem
correct
Record 8, Textual support, English
Record number: 8, Textual support number: 1 CONT
The problem of persistent hunger is not limited to Nepal. The United Nations Food and Agriculture Organization(FAO) reports that more than 850 million people around the world suffer from hunger and that the millennium target of reducing that number by half by 2015 will not be met without stronger commitments and an accelerated pace. 1, record 8, English, - problem%20of%20persistent%20hunger
Record 8, French
Record 8, Domaine(s)
- Problèmes sociaux
- Coopération et développement économiques
- Phraséologie des langues de spécialité
Record 8, Main entry term, French
- problème de persistance de la faim
1, record 8, French, probl%C3%A8me%20de%20persistance%20de%20la%20faim
correct, masculine noun
Record 8, Abbreviations, French
Record 8, Synonyms, French
Record 8, Textual support, French
Record number: 8, Textual support number: 1 CONT
Le Népal n’est pas le seul pays aux prises avec le problème de la persistance de la faim. Selon l’Organisation des Nations Unies pour l’alimentation et l’agriculture (FAO), plus de 850 millions de personnes dans le monde souffrentde la faim et l’objectif du Millénaire, qui est de réduire ce nombre de moitié d’ici 2015, ne pourra être atteint si des engagements plus solides ne sont pas pris à un rythme plus soutenu. 1, record 8, French, - probl%C3%A8me%20de%20persistance%20de%20la%20faim
Record 8, Spanish
Record 8, Textual support, Spanish
Record 9 - internal organization data 2008-04-28
Record 9, English
Record 9, Subject field(s)
- Target Acquisition
- Missiles and Rockets
- Special-Language Phraseology
Record 9, Main entry term, English
- target update
1, record 9, English, target%20update
correct
Record 9, Abbreviations, English
Record 9, Synonyms, English
Record 9, Textual support, English
Record number: 9, Textual support number: 1 CONT
Several manufacturers have perceived the problem, including South Africa's Kentron. This company is now developing an infrared version of its Sahv which will enable the operator to fire the missile before the target has been acquired. The missile is fired "blind" in the general direction of the threat, then given target updates. 1, record 9, English, - target%20update
Record 9, French
Record 9, Domaine(s)
- Acquisition d'objectif
- Missiles et roquettes
- Phraséologie des langues de spécialité
Record 9, Main entry term, French
- recalage de cap
1, record 9, French, recalage%20de%20cap
masculine noun
Record 9, Abbreviations, French
Record 9, Synonyms, French
- recalage de la position de but 1, record 9, French, recalage%20de%20la%20position%20de%20but
masculine noun
Record 9, Textual support, French
Record number: 9, Textual support number: 1 CONT
Cette situation nouvelle n'a pas échappé aux constructeurs. C'est le cas de la firme sud-africaine Kentron qui développe une variante infrarouge de son missile Sahv qui peut être tirée "en aveugle" dans la direction générale de l'objectif et recevoir en vol un recalage de cap. 1, record 9, French, - recalage%20de%20cap
Record 9, Spanish
Record 9, Textual support, Spanish
Record 10 - internal organization data 2007-01-09
Record 10, English
Record 10, Subject field(s)
- Radar, Radio Guidance and Goniometry
- Target Acquisition
Record 10, Main entry term, English
- stationary target identification
1, record 10, English, stationary%20target%20identification
correct
Record 10, Abbreviations, English
- STI 2, record 10, English, STI
correct
Record 10, Synonyms, English
Record 10, Textual support, English
Record number: 10, Textual support number: 1 CONT
The stationary target identification(STI) problem can be divided into three distinct phases, namely :(1) detection,(2) discrimination, and(3) recognition. 3, record 10, English, - stationary%20target%20identification
Record 10, French
Record 10, Domaine(s)
- Radar, radioguidage et radiogoniométrie
- Acquisition d'objectif
Record 10, Main entry term, French
- identification de cibles fixes
1, record 10, French, identification%20de%20cibles%20fixes
feminine noun
Record 10, Abbreviations, French
Record 10, Synonyms, French
Record 10, Textual support, French
Record 10, Spanish
Record 10, Textual support, Spanish
Record 11 - internal organization data 2002-11-21
Record 11, English
Record 11, Subject field(s)
- Missiles and Rockets
Record 11, Main entry term, English
- fire blind
1, record 11, English, fire%20blind
correct, verb
Record 11, Abbreviations, English
Record 11, Synonyms, English
Record 11, Textual support, English
Record number: 11, Textual support number: 1 CONT
Several manufacturers have perceived the problem, including South Africa's Kentron. This company is now developing an infrared version of its Sahv which will enable the operator to fire the missile before the target has been acquired. The missile is fired "blind" in the general direction of the threat, then given target updates. 1, record 11, English, - fire%20blind
Record 11, French
Record 11, Domaine(s)
- Missiles et roquettes
Record 11, Main entry term, French
- tirer en aveugle
1, record 11, French, tirer%20en%20aveugle
correct
Record 11, Abbreviations, French
Record 11, Synonyms, French
Record 11, Textual support, French
Record number: 11, Textual support number: 1 CONT
Cette situation nouvelle n'a pas échappé aux constructeurs. C'est le cas de la firme sud-africaine Kentron qui développe une variante infrarouge de son missile Sahv qui peut être tirée «en aveugle» dans la direction générale de l'objectif et recevoir en vol un recalage de cap. 2, record 11, French, - tirer%20en%20aveugle
Record 11, Spanish
Record 11, Textual support, Spanish
Record 12 - internal organization data 2002-11-05
Record 12, English
Record 12, Subject field(s)
- Applications of Automation
- Astronautics
Record 12, Main entry term, English
- robotics technology experiment
1, record 12, English, robotics%20technology%20experiment
correct
Record 12, Abbreviations, English
- ROTEX 1, record 12, English, ROTEX
correct
Record 12, Synonyms, English
Record 12, Textual support, English
Record number: 12, Textual support number: 1 CONT
Even today, a geostationary satellite, whose useful life has ended, must be abandoned in space. The experimental servicing satellite ESS applies robotics to resolve the problem of servicing a non-cooperative target in or near to a geostationary orbit, a region of space still out of reach to manned spaceflight. A three-month demonstration flight of ESS has been planned and all phases of its mission have been defined. These include the acquisition, inspection and servicing of an orbiting satellite through to parking it in a "graveyard" orbit. The project builds on the experience gained with the robotics technology experiment Rotex, flown on the D2 Mission. 2, record 12, English, - robotics%20technology%20experiment
Record 12, French
Record 12, Domaine(s)
- Automatisation et applications
- Astronautique
Record 12, Main entry term, French
- expérience de technologie robotique
1, record 12, French, exp%C3%A9rience%20de%20technologie%20robotique
feminine noun
Record 12, Abbreviations, French
Record 12, Synonyms, French
Record 12, Textual support, French
Record 12, Spanish
Record 12, Textual support, Spanish
Record 13 - internal organization data 2002-04-23
Record 13, English
Record 13, Subject field(s)
- Flight Instruments and Equipment (Aeroindustry)
- Operations (Air Forces)
Record 13, Main entry term, English
- non-cooperative target recognition mode
1, record 13, English, non%2Dcooperative%20target%20recognition%20mode
correct
Record 13, Abbreviations, English
- NCTR mode 1, record 13, English, NCTR%20mode
correct
Record 13, Synonyms, English
Record 13, Textual support, English
Record number: 13, Textual support number: 1 CONT
When you do find yourself in the CAP, or over the target, what is available to do the deed? As in any depiction of a combat aircraft belonging to Uncle Sam, one has a multitude of radar modes and/or weapons to match the answer to the problem. The APG-73 radar in the Air to Air mode, give us all the usual suspects.... Also a nice job with the Non-Cooperative Target Recognition(NCTR) mode is used. 1, record 13, English, - non%2Dcooperative%20target%20recognition%20mode
Record 13, Key term(s)
- noncooperative target recognition
Record 13, French
Record 13, Domaine(s)
- Instruments et équipement de bord (Constructions aéronautiques)
- Opérations (Forces aériennes)
Record 13, Main entry term, French
- mode IFF basé sur la scintillation
1, record 13, French, mode%20IFF%20bas%C3%A9%20sur%20la%20scintillation
masculine noun
Record 13, Abbreviations, French
Record 13, Synonyms, French
Record 13, Textual support, French
Record 13, Spanish
Record 13, Textual support, Spanish
Record 14 - internal organization data 2001-04-01
Record 14, English
Record 14, Subject field(s)
- Spacecraft
Record 14, Main entry term, English
- experimental servicing satellite
1, record 14, English, experimental%20servicing%20satellite
correct
Record 14, Abbreviations, English
- ESS 1, record 14, English, ESS
correct
Record 14, Synonyms, English
Record 14, Textual support, English
Record number: 14, Textual support number: 1 CONT
Even today, a geostationary satellite, whose useful life has ended, must be abandoned in space. The experimental servicing satellite(ESS) applies robotics to resolve the problem of servicing a non-cooperative target in or near to a geostationary orbit, a region of space still out of reach to manned spaceflight. 2, record 14, English, - experimental%20servicing%20satellite
Record 14, French
Record 14, Domaine(s)
- Engins spatiaux
Record 14, Main entry term, French
- satellite expérimental de maintenance
1, record 14, French, satellite%20exp%C3%A9rimental%20de%20maintenance
correct, masculine noun
Record 14, Abbreviations, French
Record 14, Synonyms, French
Record 14, Textual support, French
Record 14, Spanish
Record 14, Textual support, Spanish
Record 15 - internal organization data 1997-05-14
Record 15, English
Record 15, Subject field(s)
- Genetics
Record 15, Main entry term, English
- therapeutic gene
1, record 15, English, therapeutic%20gene
correct
Record 15, Abbreviations, English
Record 15, Synonyms, English
Record 15, Textual support, English
Record number: 15, Textual support number: 1 CONT
For gene therapy to realize its clinical potential, there must be efficient and safe strategies of delivering therapeutic genes to somatic cells in vivo. Perhaps this problem simply represents a special case of drug delivery in which the therapeutic gene constitutes the drug. But the relevance of traditional drug development to technological developments in gene therapy is questionable. Recombinant genes that can independently express a therapeutic RNA or protein are extraordinarily large and polar molecules--10, 000 times larger than traditional pharmaceutical agents. Moreover, the administration of genes as therapy requires vehicles--so-called vectors--that encapsulate the gene and guide it to the target cell. The binding of the gene to the cell, its internalization, the transport of the administered genome to the nucleus, and the expression of the gene all constitute potential limitations of this process. 1, record 15, English, - therapeutic%20gene
Record 15, French
Record 15, Domaine(s)
- Génétique
Record 15, Main entry term, French
- gène à visée thérapeutique
1, record 15, French, g%C3%A8ne%20%C3%A0%20vis%C3%A9e%20th%C3%A9rapeutique
correct, masculine noun
Record 15, Abbreviations, French
Record 15, Synonyms, French
Record 15, Textual support, French
Record number: 15, Textual support number: 1 CONT
L'un des aspect essentiels du transfert de gènes à visée thérapeutique est la vectorisation de l'ADN par un transporteur jusqu'à la cellule cible [...] dans la plupart des cas, l'ADN doit être introduit dans la cellule, soit à l'aide d'une technique physique ou chimique fragilisant les membranes cellulaires, soit combiné à un vecteur. 1, record 15, French, - g%C3%A8ne%20%C3%A0%20vis%C3%A9e%20th%C3%A9rapeutique
Record 15, Spanish
Record 15, Textual support, Spanish
Record 16 - internal organization data 1997-03-20
Record 16, English
Record 16, Subject field(s)
- Genetics
Record 16, Main entry term, English
- therapeutic gene
1, record 16, English, therapeutic%20gene
correct
Record 16, Abbreviations, English
Record 16, Synonyms, English
Record 16, Textual support, English
Record number: 16, Textual support number: 1 CONT
For gene therapy to realize its clinical potential, there must be efficient and safe strategies of delivering therapeutic genes to somatic cells in vivo. Perhaps this problem simply represents a special case of drug delivery in which the therapeutic gene constitutes the drug. But the relevance of traditional drug development to technological developments in gene therapy is questionable. Recombinant genes that can independently express a therapeutic RNA or protein are extraordinarily large and polar molecules--10, 000 times larger than traditional pharmaceutical agents. Moreover, the administration of genes as therapy requires vehicles--so-called vectors--that encapsulate the gene and guide it to the target cell. The binding of the gene to the cell, its internalization, the transport of the administered genome to the nucleus, and the expression of the gene all constitute potential limitations of this process. 1, record 16, English, - therapeutic%20gene
Record 16, French
Record 16, Domaine(s)
- Génétique
Record 16, Main entry term, French
- gène considéré comme médicament
1, record 16, French, g%C3%A8ne%20consid%C3%A9r%C3%A9%20comme%20m%C3%A9dicament
correct, masculine noun
Record 16, Abbreviations, French
Record 16, Synonyms, French
- gène à visée thérapeutique 1, record 16, French, g%C3%A8ne%20%C3%A0%20vis%C3%A9e%20th%C3%A9rapeutique
correct, masculine noun
Record 16, Textual support, French
Record number: 16, Textual support number: 1 CONT
Mais surtout, à côté de la pathologie, un fantastique domaine s'ouvre au transfert et à la thérapie génique, c'est celui du gène considéré comme médicament. La médecine utilise en effet toute une série de molécules d'origine protéique, comme les facteurs antihémophilliques, l'insuline, l'hormone de croissance, pour ne citer que les plus importantes. Le futur pourrait être la fabrication directe par l'organisme des molécules actives après transfert de gènes dans les cellules permissives. Mieux encore, on pourra vraisemblablement dams l'avenir injecter directement par voie intramusculaire par exemple, l'ADN génique, les cellules de l'organisme se comportant ensuite comme de mini-usines de fabrication et de mini-unités de distribution. 1, record 16, French, - g%C3%A8ne%20consid%C3%A9r%C3%A9%20comme%20m%C3%A9dicament
Record number: 16, Textual support number: 2 CONT
Ceci ne saurait s'effectuer en dehors d'un contexte réglementaire adapté à la complexité des différents niveaux d'intervention que nécessite le transfert de gènes à visée thérapeutique. 1, record 16, French, - g%C3%A8ne%20consid%C3%A9r%C3%A9%20comme%20m%C3%A9dicament
Record 16, Spanish
Record 16, Textual support, Spanish
Record 17 - internal organization data 1993-07-20
Record 17, English
Record 17, Subject field(s)
- Wheeled Vehicles (Military)
Record 17, Main entry term, English
- Sahv
1, record 17, English, Sahv
correct
Record 17, Abbreviations, English
Record 17, Synonyms, English
Record 17, Textual support, English
Record number: 17, Textual support number: 1 CONT
Several manufacturers have perceived the problem, including South Africa's Kentron. This company is now developing an infrared version of its Sahv which will enable the operator to fire the missile before the target has been acquired. The missile is fired "blind" in the general direction of the threat, then given target updates. 1, record 17, English, - Sahv
Record 17, French
Record 17, Domaine(s)
- Véhicules à roues (Militaire)
Record 17, Main entry term, French
- missile Sahv
1, record 17, French, missile%20Sahv
correct, masculine noun
Record 17, Abbreviations, French
Record 17, Synonyms, French
Record 17, Textual support, French
Record number: 17, Textual support number: 1 CONT
Cette situation nouvelle n'a pas échappé aux constructeurs. C'est le cas de la firme sud-africaine Kentron qui développe une variante infrarouge de son missile Sahv qui peut être tirée "en aveugle" dans la direction générale de l'objectif et recevoir en vol un recalage de cap. 1, record 17, French, - missile%20Sahv
Record 17, Spanish
Record 17, Textual support, Spanish
Record 18 - internal organization data 1990-11-28
Record 18, English
Record 18, Subject field(s)
- Artificial Intelligence
Record 18, Main entry term, English
- target problem
1, record 18, English, target%20problem
correct
Record 18, Abbreviations, English
Record 18, Synonyms, English
Record 18, Textual support, English
Record number: 18, Textual support number: 1 DEF
The problem to be solved by the expert system. 1, record 18, English, - target%20problem
Record 18, French
Record 18, Domaine(s)
- Intelligence artificielle
Record 18, Main entry term, French
- problème cible
1, record 18, French, probl%C3%A8me%20cible
correct, masculine noun
Record 18, Abbreviations, French
Record 18, Synonyms, French
Record 18, Textual support, French
Record 18, Spanish
Record 18, Textual support, Spanish
Record 19 - internal organization data 1989-05-04
Record 19, English
Record 19, Subject field(s)
- Artificial Intelligence
Record 19, Main entry term, English
- inductive inference problem
1, record 19, English, inductive%20inference%20problem
correct
Record 19, Abbreviations, English
Record 19, Synonyms, English
Record 19, Textual support, English
Record number: 19, Textual support number: 1 DEF
Problem which has the five following components : a semantic domain, a syntactic domain, a mapping, a target object, and an oracle. 1, record 19, English, - inductive%20inference%20problem
Record 19, French
Record 19, Domaine(s)
- Intelligence artificielle
Record 19, Main entry term, French
- problème d'inférence déductive
1, record 19, French, probl%C3%A8me%20d%27inf%C3%A9rence%20d%C3%A9ductive
correct, masculine noun
Record 19, Abbreviations, French
Record 19, Synonyms, French
Record 19, Textual support, French
Record 19, Spanish
Record 19, Textual support, Spanish
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