TERMIUM Plus^®

Record 1,  Textual support,  English

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Stereotactic radiosurgery and radiotherapy are techniques to deliver high-dose radiation to a target with precise conformity to the target to create a desired radiobiological response and with minimal radiation dose to surrounding normal tissue. In this technique, the well-localised target volume is defined in three planes..., surrounding margins are minimal and very high doses are given over a short time period to ablate the tumour. The complication risks are reduced by decreasing or eliminating the margin of normal tissue from the tumour. When the total dose delivered stereotactically in a single session, it is called stereotactic radiosurgery(SRS), and if total dose of radiation is administered in more than one fraction, it is called stereotactic radiotherapy(SRT).  8, record 1, English, - stereotactic%20radiotherapy

Record number: 1, Textual support number: 1 OBS

stereotactic radiotherapy; stereotactic radiation therapy; stereotaxic radiotherapy; stereotaxic radiation therapy; SRT: While stereotactic radiotherapy can be used to treat both cranial or extracranial tumours, these designations can sometimes refer more specifically to therapy that targets cranial tumours.  9, record 1, English, - stereotactic%20radiotherapy

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stereotactic: Of or relating to precise localization of a tissue ...  10, record 1, English, - stereotactic%20radiotherapy

Record 1,  Textual support,  French

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La radiothérapie stéréotaxique est une forme de radiothérapie de haute précision qui utilise des microfaisceaux convergents. Cela permet d'irradier à haute dose de très petits volumes dans le corps du patient et ainsi de concentrer davantage de radiation sur la tumeur.  3, record 1, French, - radioth%C3%A9rapie%20en%20conditions%20st%C3%A9r%C3%A9otaxiques

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La dose d'irradiation peut soit être délivrée en une seule séance, on parle de radiochirurgie stéréotaxique, soit être délivrée en plusieurs fractions sur plusieurs jours : la radiothérapie en conditions stéréotaxiques.  4, record 1, French, - radioth%C3%A9rapie%20en%20conditions%20st%C3%A9r%C3%A9otaxiques

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radiothérapie en conditions stéréotaxiques; radiothérapie stéréotaxique : désignations publiées au Journal officiel de la République française le 16 décembre 2020.  5, record 1, French, - radioth%C3%A9rapie%20en%20conditions%20st%C3%A9r%C3%A9otaxiques

Record 1,  Textual support,  Spanish

Record 2,  Textual support,  English

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The ballistic impact of a high-speed bullet does not usually just punch a clean hole in a target, but rather shatters brittle material and disrupts soft tissue.  2, record 2, English, - high%2Dvelocity%20bullet

Record 2,  Textual support,  French

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Lors de raids dans les tranchées, les hommes utilisaient parfois des boucliers, puisque des combats corps à corps pouvaient avoir lieu. Néanmoins, ni les plastrons ni les boucliers ne pouvaient arrêter les balles à grande vélocité tirées de près.  2, record 2, French, - balle%20%C3%A0%20grande%20vitesse

Record 2,  Textual support,  Spanish

Record 3,  Textual support,  English

Record number: 3, Textual support number: 1 DEF

[The process by which] a drug molecule [accumulates] in the target organ or tissue selectively such that the concentration of the drug at the disease site is high, while its concentration in nontarget organs and tissues is low, preferably below a certain minimal level, so as to prevent any toxic effect.  2, record 3, English, - drug%20targeting

Record 3,  Textual support,  French

Record number: 3, Textual support number: 1 DEF

Action qui consiste à augmenter, à l'aide d'un vecteur, la concentration d'une substance pharmacologiquement active au sein d'un site particulier de l'organisme, l'organe cible, tout en réduisant ses concentrations au sein d'autres sites.  1, record 3, French, - ciblage%20pharmacologique

Record 3,  Textual support,  Spanish

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[…] entre las aplicaciones más importantes para el uso de las nanopartículas se encuentra la vectorización de medicamentos hacia el cerebro, […] lo cual puede ayudar en el tratamiento de enfermedades como el Alzheimer o el mal de Parkinson.  6, record 3, Spanish, - vectorizaci%C3%B3n%20de%20medicamentos

Record number: 3, Textual support number: 1 OBS

[…] tradicionalmente [la tarea de] llevar una substancia activa a su diana terapéutica se adjudica a un transportador como la sangre, que tiene [el inconveniente de distribuirla] por todas partes, [debido a que] no elige a sus destinatarios. La idea de la vectorización [consiste en utilizar] la sangre como transporte [e] incluir el fármaco en unas estructuras que, al alcanzar la diana terapéutica, liberan el fármaco que contienen […]  2, record 3, Spanish, - vectorizaci%C3%B3n%20de%20medicamentos

Record number: 3, Textual support number: 2 OBS

Diana terapéutica. Sustancia localizada en cualquier parte de la célula como la membrana celular, el citoplasma o el núcleo, capaz de reconocer un fármaco y producir una respuesta celular […]  7, record 3, Spanish, - vectorizaci%C3%B3n%20de%20medicamentos

Record number: 3, Textual support number: 3 OBS

La vectorización permite la liberación controlada del principio activo y con ello se mantiene una mayor duración de las concentraciones terapéuticas, disminución de sus efectos adversos y menor dosificación del fármaco […]  8, record 3, Spanish, - vectorizaci%C3%B3n%20de%20medicamentos

Record 4,  Textual support,  English

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Tamoxifen is a nonsteroidal agent which has demonstrated potent antiestrogenic properties in animal test systems. The antiestrogenic effects are related to its ability to compete with estrogen for binding sites in target tissues such as breast and uterus.  2, record 4, English, - target%20tissue

Record 4,  Textual support,  French

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Le tamoxifène est un produit non stéroïdien qui a montré une puissante action anti-œstrogénique chez des modèles animaux. Ses effets anti-œstrogéniques sont reliés à sa faculté d'entrer en compétition avec les œstrogènes pour se fixer sur les sites récepteurs de tissus-cibles tels que la glande mammaire et l'utérus.  2, record 4, French, - tissu%2Dcible

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Record 5,  Textual support,  English

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In recent years, the neodymium-YAG laser has gained popularity as a noninvasive method for discission of the posterior capsule. Pulses of laser energy cause small "explosions" in target tissue, creating a small hole in the posterior capsule in the pupillary axis. Complications of this technique include a transient rise in intraocular pressure...  1, record 5, English, - discission

Record 5,  Textual support,  French

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Chez le nourrisson, dans les cataractes congénitales, l'intervention prend le nom de discission et consiste à ouvrir largement la capsule à l'aide de deux aiguilles tranchantes et à fragmenter le cristallin et son noyau. Les masses se répandent dans la chambre antérieure et son digérées progressivement en trois ou quatre mois. L'œil ainsi opéré devient aphaque (sans cristallin), et il ne pourra voir correctement qu'à l'aide de verres convergents de forte puissance [...]  1, record 5, French, - discission

Record 5,  Textual support,  Spanish

Record 6,  Textual support,  English

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Muscarinic acetylcholine receptors are members of rhodopsin-like G-protein coupled receptor family. They play several important roles; they mediate many of the effects of acetylcholine in the central and peripheral nervous system and modulate a variety of physiological functions, such as airway, eye and intestinal smooth muscle contraction, heart rate and glandular secretions. The receptors have a widespread tissue distribution and are a major drug target in human disease. They may be effective therapeutic targets in Alzheimer's disease, schizophrenia, Parkinson's disease and chronic obstructive pulmonary disease.  1, record 6, English, - muscarinic%20receptor

Record 6,  Textual support,  French

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Il y a deux grands types de récepteurs (cholinergiques) de l'acétylcholine, les récepteurs muscariniques et nicotiniques qui ont été identifiés à partir des réponses à différents agents chimiques. Les récepteurs nicotiniques sont activés par la nicotine du tabac et les récepteurs muscariniques le sont par le poison d'un champignon, la muscarine [...] Les récepteurs muscariniques sont situés dans la membrane des cellules effectrices (muscle cardiaque, muscles lisses, glandes) et sont stimulés par la liaison de l'acétylcholine libérée par les fibres postganglionnaires du système parasympathique.  2, record 6, French, - r%C3%A9cepteur%20muscarinique

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Record 7,  Textual support,  English

Record number: 7, Textual support number: 1 DEF

A substance capable of preventing full expression of the biologic effects of androgenic hormones on responsive tissues, either by producing antagonistic effects on the target tissue, as estrogens do, or by merely inhibiting androgenic effects, such as by competing for binding sites at the cell surface.  3, record 7, English, - antiandrogen

Record 7,  Textual support,  French

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Les androgènes sont les hormones responsables des caractères masculins comme les poils sur la poitrine et sur le visage. L’androgène le plus connu et le plus présent chez l’homme est la testostérone [...] Les médicaments anti-androgènes bloquent le fonctionnement de la testostérone et empêchent son action.  2, record 7, French, - antiandrog%C3%A8ne

Record 7,  Textual support,  Spanish

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Agente hormonal [...] que bloquea las funciones de las hormonas masculinas.  2, record 7, Spanish, - antiandr%C3%B3geno

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[...] se utiliza en el tratamiento del cáncer de próstata. También aumenta la eficacia de otras terapias hormonales.  2, record 7, Spanish, - antiandr%C3%B3geno

Record 8,  Textual support,  English

Record number: 8, Textual support number: 1 DEF

[Referring to] a substance capable of preventing full expression of the biologic effects of androgenic hormones on responsive tissues, either by producing antagonistic effects on the target tissue, as estrogens do, or by merely inhibiting androgenic effects, such as by competing for binding sites at the cell surface.  2, record 8, English, - antiandrogenic

Record 8,  Textual support,  French

Record number: 8, Textual support number: 1 DEF

Qui s'oppose à l'action des androgènes, hormones stéroïdes qui favorisent le développement des organes génitaux externes chez l'homme, la formation du sperme et l'apparition des caractères sexuels secondaires masculins.  3, record 8, French, - antiandrog%C3%A8ne

Record 8,  Textual support,  Spanish

Record 9,  Textual support,  English

Record number: 9, Textual support number: 1 CONT

The observation that microglial cells in brain tissue are probably a major target for human immunodeficiency virus(HIV) infection has raised interest in the pathogenic role of this cell population for the development of neuro-AIDS.(In Virology :(New York. NY). 1993, 195(2) 561-568, cited in PASCAL data bank).  1, record 9, English, - neuro%2DAIDS

Record 9,  Textual support,  French

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neuro sida (Relevé dans Inst. Med. 1991, 62 (0003) 00029-0 0032, cité dans la base de données PASCAL.)  2, record 9, French, - neuro%2DSIDA

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Pathologie psychiatrique aiguë révélatrice d'une lésion sous-corticale au cours d'un neuro-SIDA. (Relevé dans Encéphale. 1991, 17 (2) 79-81, cité dans la base de données PASCAL.)  2, record 9, French, - neuro%2DSIDA

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[...] neuro-SIDA [...] figure dans un ouvrage du docteur Réjean Thomas, Le Sida, un nouveau défi médical. [...] le terme [...] décrit de façon générique et floue toute atteinte du SNC [système nerveux central] et du cerveau, ainsi que ses manifestations, dans le contexte de l'infection par le VIH.  3, record 9, French, - neuro%2DSIDA

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D'après l'ACIM (Association canadienne de l'industrie du médicament), le terme neuro-SIDA n'est usité qu'au Québec.  4, record 9, French, - neuro%2DSIDA

Record 9,  Textual support,  Spanish

Record 10,  Textual support,  English

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Erythema multiforme is an immunologic reaction in the skin and mucous membranes often mediated by circulating immune complexes that evolve in response to a number of antigenic stimulae(infections, drugs, connective tissue disease). As the name implies, the skin reaction is characterized by a variety of lesions, namely, erythematous plaques, blisters, and target or bull' s-eye lesions. The mucous membranes of the mouth and eye may also be involved, and this is referred to as Stevens-Johnson syndrome.  1, record 10, English, - Stevens%2DJohnson%20syndrome

Record 10,  Textual support,  French

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Forme grave d'érythème polymorphe caractérisée par des lésions cutanées maculo-vésiculeuses ou bulleuses, avec atteinte simultanée des muqueuses (conjonctivite, stomatite, urétrite) et symptômes généraux (fièvre, anorexie).  3, record 10, French, - syndrome%20de%20Stevens%2DJohnson

Record 10,  Textual support,  Spanish

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Forma de eritema multiforme que puede ser muy severo [...] y que se caracteriza por conjuntivitis que puede terminar en ceguera y por ulceraciones en los genitales y el ano.  1, record 10, Spanish, - s%C3%ADndrome%20de%20Stevens%20Johnson

Record 11,  Textual support,  English

Record number: 11, Textual support number: 1 DEF

A low-molecular weight polypeptide that mediates the action of growth hormone on skeletal tissue and produces insulin-like effects in various target tissues.  3, record 11, English, - somatomedin

Record number: 11, Textual support number: 2 DEF

Any of a group of peptides found in the liver and in plasma which mediate the effect of growth hormone (somatotropin) on cartilage; they are responsible for uptake of sulphate and increased synthesis of collagen and other proteins by cartilage.  4, record 11, English, - somatomedin

Record 11,  Textual support,  French

Record number: 11, Textual support number: 1 DEF

Type de facteurs de croissance servant de médiateurs à l'hormone osmatotrope. Ce sont des peptides, probablement au nombre de 3, d'un poids moléculaire de 4 000 à 7 000 et de structure inconnue, vraisemblablement synthétisés dans le foie, sous l'effet de l'hormone somatotrope. Ils stimulent les effets de l'insuline, l'incorporation d'acides aminés dans le muscle et l'oxydation du glucose dans le tissu adipeux.  2, record 11, French, - somatom%C3%A9dine

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Record 12,  Textual support,  English

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The overall aim of [the Proteases and Tissue Remodeling Unit] is to understand the function of matrix degrading proteolytic enzymes in physiological and pathological tissue remodeling processes, including cancer invasion and metastasis. An area of emphasis is the study of the biochemistry, biology, and pathology of the plasminogen activation system. Ongoing studies include the identification of the target substrates for plasmin during selected physiological and pathological tissue remodeling events...  1, record 12, English, - tissue%20remodeling

Record 12,  Textual support,  French

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[...] cette structure tridimensionnelle (une éponge ou un treillis de polymères, par exemple) sera colonisée après greffe par les cellules de l'hôte, et son architecture servira de guide au remodelage du tissu, pour que ce processus de cicatrisation conduise à un tissu fonctionnel plutôt qu'à un tissu fibreux non fonctionnel.  1, record 12, French, - remodelage%20de%20tissu

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Record 13,  Textual support,  English

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The method by which incident radiation interacts with the medium to cause ionization may be direct or indirect. Electromagnetic radiations(X rays and gamma photons) are indirectly ionizing; that is, they give up their energy in various interactions with cellular molecules, and the energy is then utilized to produce a fast-moving charged particle such as an electron. It is the electron that then secondarily may react with a target molecule. Charged particles, in contrast, strike the tissue or medium and directly react with target molecules, such as oxygen or water. These particulate radiations are directly ionizing radiations.  1, record 13, English, - gamma%20photon

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The third step is to fuse two tritium nuclei into one helium and two proton products. The end result of fusing four hydrogen nuclei (protons) is one helium nucleus, and two gamma ray photons, and two electron neutrinos, and kinetic heat energy.  2, record 13, English, - gamma%20photon

Record number: 13, Textual support number: 1 OBS

Gamma rays: A very penetrating electromagnetic radiation emitted from a nucleus of an atom during radioactive decay. Radiation: An emission of energy in the form of photons (gamma, x-rays) or particles (alpha, beta, positron, neutron radiation). Photon: A type of radiation in the form of an electromagnetic wave, having zero mass and zero charge.  3, record 13, English, - gamma%20photon

Record 13,  Textual support,  French

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Les photons gamma très pénétrants permettent de réaliser de véritables radiographies des matériaux les plus denses. Cette technique [gammamétrie] est appliquée depuis quelques années à la détermination de la densité et de l'humidité des sols.  1, record 13, French, - photon%20gamma

Record 13,  Textual support,  Spanish

Record 14,  Textual support,  English

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A secondary novel technology to which the Company has exclusive rights is that of antibody-targeted liposomes. This technology involves the incorporation of an antimyosin antibody into liposome membranes that serves to target the immunoliposome to cytoskeletal protein exposed by cellular membrane lesions. Upon anchoring the liposome to the cell via the antibody the liposome presumably fuses with the cell membrane and repairs the lesion. In vitro and animal model studies have shown that this methodology has been able to preserve cell and tissue viability under anoxic/ischemic conditions. This technology may be able to limit the extent of heart muscle damage during heart attacks and myocarditis.  1, record 14, English, - immunoliposome

Record 14,  Textual support,  French

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...Afin d'augmenter la quantité de molécules du médicament pouvant être associées aux anticorps, l'équipe de Pardridge a suggéré d'associer au complexe anticorps/médicament des vecteurs lipidiques, qu'elle a nommé «immunoliposomes». Chaque liposome de 100 nanomètres de diamètre peut acheminer au moins 10 000 petites molécules du médicament.(J. Huwyler et al. (1996) Proc.Natl. Acad. Sci. USA 93, 14164-14169.)  1, record 14, French, - immunoliposome

Record 14,  Textual support,  Spanish