TERMIUM Plus^®

Record 1,  Textual support,  English

Record number: 1, Textual support number: 1 CONT

Thinking about how cancer medicine has evolved, we’ve had surgery, chemotherapy, and radiation. CAR [chimeric antigen receptor] T cell therapy is a highly targeted immunotherapy, and is now being used worldwide to treat blood cancers.  1, record 1, English, - highly%20targeted%20immunotherapy

Record 1,  Textual support,  French

Record number: 1, Textual support number: 1 OBS

Cibler spécifiquement les cellules cancéreuses et les détruire sans endommager les cellules saines : telle est la promesse des nouvelles immunothérapies ultraciblées.  1, record 1, French, - immunoth%C3%A9rapie%20ultracibl%C3%A9e

Record 1,  Textual support,  Spanish

Record 2,  Textual support,  English

Record number: 2, Textual support number: 1 CONT

An antibody-drug conjugate(ADC) is cancer treatment that combines targeted therapy and chemotherapy.... ADCs deliver very powerful chemotherapy drugs to specific cancerous cells, damaging or destroying cancerous cells without harming nearby healthy cells.  1, record 2, English, - antibody%2Ddrug%20conjugate

Record 2,  Textual support,  French

Record number: 2, Textual support number: 1 CONT

Un conjugué anticorps-médicament ou ADC [...] est composé de deux éléments importants : une drogue cytotoxique [...] et un anticorps. Dans la majorité des cas, le médicament utilisé est trop toxique pour être utilisé seul, car il ferait plus de dommages au patient qu'au cancer.  3, record 2, French, - conjugu%C3%A9%20anticorps%2Dm%C3%A9dicament

Record 2,  Textual support,  Spanish

Record 3,  Textual support,  English

Record number: 3, Textual support number: 1 CONT

The overarching therapeutic process targeted in ACT [acceptance and commitment therapy] is psychological flexibility, the ability to fully experience the present moment and consciously choose values-consistent behaviors in response, regardless of what internal experiences are occurring … The word ’’flexibility’’ is used because emphasis is placed on adaptive responses to internal stimuli …  2, record 3, English, - psychological%20flexibility

Record 3,  Textual support,  French

Record number: 3, Textual support number: 1 CONT

L'objectif général de l'ACT [thérapie d'acceptation et d'engagement] est de favoriser la flexibilité psychologique, définie comme la capacité à persister ou à changer le cours d'une action, même en présence de pensées, sensations et émotions désagréables, afin d'avancer en direction de ce qui est important pour la personne, c'est-à-dire ses valeurs personnelles […]  2, record 3, French, - flexibilit%C3%A9%20psychologique

Record 3,  Textual support,  Spanish

Record 4,  Textual support,  English

Record number: 4, Textual support number: 1 CONT

Targeted alpha-particle therapy(or TAT) is an investigational method of targeted radionuclide therapy for various cancers and infectious diseases. It employs radioactive alpha-emitting substances which undergo decay to treat diseased tissue at close proximity. TAT has the potential to provide highly targeted treatment, especially to microscopic tumor cells. Targets include leukemias, lymphomas, gliomas, melanoma, peritoneal carcinomatosis and HIV.  2, record 4, English, - targeted%20alpha%20therapy

Record number: 4, Textual support number: 2 CONT

Targeted alpha therapy(TAT) delivers high-energy alpha particles to cancer cells and the tumour microenvironment to treat metastatic castration-resistant prostate cancer(mCRPC) and other cancers.  3, record 4, English, - targeted%20alpha%20therapy

Record 4,  Textual support,  French

Record number: 4, Textual support number: 1 CONT

Les thérapies alpha ciblées utilisent des isotopes médicaux liés à une biomolécule qui peut cibler les cellules cancéreuses avec précision sans endommager les zones environnantes.  1, record 4, French, - th%C3%A9rapie%20alpha%20cibl%C3%A9e

Record 4,  Textual support,  Spanish

Record 5,  Textual support,  English

Record number: 5, Textual support number: 1 DEF

An additional cancer treatment given after the primary treatment to lower the risk that the cancer will come back.  4, record 5, English, - adjuvant%20therapy

Record number: 5, Textual support number: 1 OBS

Adjuvant therapy may include chemotherapy, radiation therapy, hormone therapy, targeted therapy, or biological therapy.  4, record 5, English, - adjuvant%20therapy

Record 5,  Textual support,  French

Record number: 5, Textual support number: 1 DEF

Traitement administré en plus du traitement de première intention [...] pour aider à réduire le risque de [...] récidive [du] cancer.  3, record 5, French, - traitement%20adjuvant

Record 5,  Textual support,  Spanish

Record number: 5, Textual support number: 1 DEF

Tratamiento para el cáncer que se puede dar después del tratamiento primario para disminuir las probabilidades de que el cáncer vuelva a reproducirse.  1, record 5, Spanish, - terapia%20adyuvante

Record number: 5, Textual support number: 1 OBS

La terapia adyuvante puede incluir quimioterapia, radioterapia, terapia hormonal, terapia dirigida o terapia biológica. [...] El tratamiento adyuvante realizado antes del tratamiento principal se llama terapia neoadyuvante.  1, record 5, Spanish, - terapia%20adyuvante

Record 6,  Textual support,  English

Record number: 6, Textual support number: 1 CONT

There are several emerging agents in targeted alpha therapy. Targeted thorium conjugates are being investigated in several tumor types, including prostate cancer.  1, record 6, English, - targeted%20thorium%20conjugate

Record 6,  Textual support,  French

Record 6,  Textual support,  Spanish

Record 7,  Textual support,  English

Record number: 7, Textual support number: 1 CONT

Targeted therapy uses drugs to target specific molecules(for example, proteins) on the surface of or inside cancer cells. These molecules help send signals that tell cells to grow or divide. By targeting these molecules, the drugs stop the growth and spread of cancer cells while limiting harm to normal cells.  1, record 7, English, - targeted%20therapy

Record 7,  Textual support,  French

Record number: 7, Textual support number: 1 CONT

Le traitement ciblé a recours à des médicaments pour cibler des molécules spécifiques (des protéines par exemple) situées à la surface ou à l’intérieur des cellules cancéreuses. Ces molécules contribuent à l’envoi de signaux qui indiquent aux cellules de croître ou de se diviser. En ciblant ces molécules, les médicaments interrompent la croissance et la propagation des cellules cancéreuses tout en limitant les dommages aux cellules normales.  1, record 7, French, - traitement%20cibl%C3%A9

Record 7,  Textual support,  Spanish

Record 8,  Textual support,  English

Record number: 8, Textual support number: 1 CONT

Because of their potency in killing many types of eukaryotic cells, protein toxins have been engaged as killing moieties in the design of a novel group of molecules termed immunotoxins of chimeric proteins for targeted therapy of human diseases.  2, record 8, English, - protein%20toxin

Record 8,  Textual support,  French

Record number: 8, Textual support number: 1 CONT

Les toxines protéiques ressemblent aux enzymes : dénaturées par la chaleur, activité biologique (catalytique pour la plupart), spécificité d'action, substrat dans l'hôte : composants tissus, organes ou fluides ex entérotoxines (muqueuse intestinale), cytotoxines (tissus généraux), neurotoxines, hémolysines.  2, record 8, French, - toxine%20prot%C3%A9ique

Record 8,  Textual support,  Spanish

Record 9,  Textual support,  English

Record number: 9, Textual support number: 1 CONT

The idea of convergent combination therapy is to find particular combinations of drugs, all targeted against the reverse transcriptase enzyme, such that there is no combination of mutations which could convey resistance to all the drugs without also making the reverse transcriptase unable to function.  2, record 9, English, - convergent%20combination%20therapy

Record number: 9, Textual support number: 2 CONT

Specifically, we wanted to compare regimens inhibiting different steps in retroviral replication (conventional or divergent combination therapy) versus combinations that attack the same target (convergent combination therapy)...  3, record 9, English, - convergent%20combination%20therapy

Record 9,  Textual support,  French

Record number: 9, Textual support number: 1 CONT

Le cancer à l'heure des multithérapies ciblées.  1, record 9, French, - multith%C3%A9rapie%20cibl%C3%A9e

Record 9,  Textual support,  Spanish

Record 10,  Textual support,  English

Record number: 10, Textual support number: 1 CONT

Human artificial chromosomes(HAC) have been considered as a possible vector for human gene therapy. In our previous work a minichromosome(MC), isolated from a patient, was transformed with a selectable marker gene(neo) which was targeted into its centromere; the MC was then size reduced, by X-ray exposure, to be easily manipulated and further engineered. The method developed for gene targeting, based on the use of chromosome specific centromeric satellite DNA as transfection carrier, is highly efficient and reproducible.  1, record 10, English, - human%20artificial%20chromosome

Record 10,  Textual support,  French

Record number: 10, Textual support number: 1 CONT

En effet, les chromosomes artificiels humains (HAC) décrits constituent les premières constructions chromosomiques possédant tous les attributs (télomères, origines de réplication, centromère) d'un chromosome humain viable. [...] Les généticiens manquent encore d'informations précises sur les séquences qui, au niveau du centromère et des origines de réplications, sont nécessaires au fonctionnement du chromosome.  1, record 10, French, - chromosome%20artificiel%20humain

Record 10,  Textual support,  Spanish

Record number: 10, Textual support number: 1 DEF

Construcción análoga al cromosoma artificial de levadura, que consta de un centrómero y telómeros de origen humano, que permitiría la clonación de fragmentos de ADN muy grandes y su transferencia a las células humanas para aplicar la terapia génica.  1, record 10, Spanish, - cromosoma%20artificial%20humano

Record 11,  Textual support,  English

Record number: 11, Textual support number: 1 CONT

Virosome Vectors for gene therapy. The long term goal of this work is to develop a targeted, efficient, liposome-based vector for the delivery and insertion of the CFTR gene to lung cells. To do this, a combination of liposometechnology and molecular biology will be used. Three observations have led us to propose the outlined research :(i) The efficiency of liposome fusion to cells or organelles can be greatly enhanced by incorporating viral fusion proteins intovesicles.(ii) After liposome-cell fusion, the contents of the liposomes are released into the cell' s cytoplasm.(iii) By delivering DNA to nonlysosomal compartments of eukarvotic cells the efficiency of transfection can be greatly enhanced...  1, record 11, English, - virosome

Record number: 11, Textual support number: 1 OBS

Excerpt taken from Microsoft Internet Explorer.  1, record 11, English, - virosome

Record 11,  Textual support,  French

Record number: 11, Textual support number: 1 DEF

Liposome dans lequel des particules virales ont été introduites.  1, record 11, French, - virosome

Record 11,  Textual support,  Spanish