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TD 50 [2 records]

Record 1 2002-01-07

English

Subject field(s)
  • Environmental Studies and Analyses
  • Toxicology
  • Posology
DEF

The amount of an agent which will cause death.

CONT

A dose that results in the death of the organism is described as lethal (LD). A dose that results in an adverse toxic health effect other than death is often described as toxic (TD).

OBS

A subscript is often put beside lethal(LD) or toxic(TD) dose levels on dose-response curves, to show what percentage of the organisms experienced a toxic or lethal effect at specific dose levels. For example, a TD20</sub> is a dose level where 20% of the test organisms would have experienced adverse toxic effect(s) and the LD50</sub> is a dose level where 50% of the test organisms would have died(Williams and Burson, et al. 1985).

French

Domaine(s)
  • Études et analyses environnementales
  • Toxicologie
  • Posologie
CONT

Les lettres DL signifient dose létale. [Par exemple, la] DL50 est la quantité d'une substance qui, administrée d'un seul coup, entraîne la mort de la moitié (50 %) des animaux soumis au test. La DL50 peut être établie pour différentes voies d'exposition, dont les plus courantes sont la voie cutanée (par la peau) et la voie orale (par la bouche). La DL50 est une des façons qui existent pour déterminer le risque d'intoxication à court terme que présente une substance.

Spanish

Campo(s) temático(s)
  • Estudios y análisis del medio ambiente
  • Toxicología
  • Posología
DEF

[...] la cantidad de agente tóxico que causa la muerte cuando se la inyecta en el cuerpo.

OBS

Se expresa DL.

Save record 1

Record 2 2002-01-07

English

Subject field(s)
  • Pharmacodynamics

French

Domaine(s)
  • Pharmacodynamie
DEF

dose d'un médicament produisant un effet toxique chez 50 % des animaux d'expérience auxquels il est administré.

Spanish

Campo(s) temático(s)
  • Farmacodinámica
Save record 2

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