TERMIUM Plus^®

Record 1,  Textual support,  English

Record number: 1, Textual support number: 1 CONT

The protein called EGF-R sets off the chain reaction that activates the mucous gene. It binds with two molecules :transforming growth factor alpha and epidermal growth factor, which occur when tissues are inflamed by cigarette smoke, or some viruses and bacteria.  1, record 1, English, - epidermal%20growth%20factor%20receptor

Record 1,  Textual support,  French

Record number: 1, Textual support number: 1 CONT

[...] anticorps monoclonaux qui ciblent le récepteur du facteur de croissance épidermique (R-EGF) présent à la surface d’une cellule cancéreuse. Le R-EGF envoie des signaux qui favorisent la croissance et la survie des cellules cancéreuses.  1, record 1, French, - r%C3%A9cepteur%20du%20facteur%20de%20croissance%20%C3%A9pidermique

Record 1,  Textual support,  Spanish

Record number: 1, Textual support number: 1 CONT

Muchas células cancerosas tienen una proteína, conocida como receptor del factor de crecimiento epidérmico (EFGR), en su superficie, mientras que las células sanas no expresan esta proteína tan fuertemente. Conjugando, o uniendo las nanopartículas de oro a un anticuerpo contra el EFGR, llamado anti-EFGR, los investigadores pueden lograr que se unan a las células cancerígenas.  1, record 1, Spanish, - receptor%20de%20factor%20de%20crecimiento%20epid%C3%A9rmico

Record number: 1, Textual support number: 1 OBS

EFGR por sus siglas en inglés.  2, record 1, Spanish, - receptor%20de%20factor%20de%20crecimiento%20epid%C3%A9rmico

Record number: 1, Textual support number: 2 OBS

Ficha realizada en colaboración con los estudiantes del Certificado en Traducción español-inglés del Glendon College, York University, Toronto, Canada.  2, record 1, Spanish, - receptor%20de%20factor%20de%20crecimiento%20epid%C3%A9rmico

Record 2,  Textual support,  English

Record number: 2, Textual support number: 1 CONT

[Study on ] the complex hormonal regulation of casein and thrombospondine (TSP) genes in mouse mammary gland epithelial cells and ultimately in breast cancer cells ... a 5’ noncoding sequence element involved in the mammary specificity of casein gene transcription is shared with TSP gene ... The more difficult but conclusive tests of promoter function and trans acting factors are not proposed. The effects of hormone treatments on TSP MRNA stability will be evaluated by pulse chase experiments ....  1, record 2, English, - trans%20acting%20factor

Record number: 2, Textual support number: 2 CONT

A novel transforming growth factor-beta SUB 1 responsive cytoplasmic trans-acting factor binds selectively to the 3’-untranslated region of mammalian ribonucleotide reductase R2 mRNA... mRNA destabilization triggered by premature translational termination depends on at least three cis-acting sequence elements and one trans-acting factor... In vitro analysis of bovine growth hormone pre-mRNA alternative splicing involvement of exon sequences and trans-acting factor(s)... [Source : PASCAL database].  2, record 2, English, - trans%20acting%20factor

Record 2,  Textual support,  French

Record number: 2, Textual support number: 1 DEF

Protéine auxiliaire liant l’ADN et interagit avec les séquences cis-régulatrices d’ADN pour contrôler l’expression d’un gène.  3, record 2, French, - facteur%20trans%2Dactivateur

Record number: 2, Textual support number: 1 OBS

Facteur diffusible capable de moduler l'activité (en + ou en -) d'un ou de plusieurs gènes en interagissant avec leur(s) séquence(s) régulatrice(s).  1, record 2, French, - facteur%20trans%2Dactivateur

Record 2,  Textual support,  Spanish

Record number: 2, Textual support number: 1 DEF

Proteína auxiliar de unión con el ADN, que interacciona con las secuencias de ADN reguladas en cis para el control de la expresión génica.  1, record 2, Spanish, - factor%20de%20actuaci%C3%B3n%20en%20trans

Record 3,  Textual support,  English

Record number: 3, Textual support number: 1 DEF

A protein secreted by transformed cells that can stimulate growth of normal cells.  6, record 3, English, - transforming%20growth%20factor

Record number: 3, Textual support number: 1 CONT

A number of transforming growth factors have been isolated from media conditioned by tumor cells. Two of these were purified on the basis of their synergistic actions in stimulating the growth of fibroblasts in soft agar, an assay often used as an index of cell "transformation." Since cancer cells grow in soft agar, the growth factors were first thought to be mitogens involved in tumorigenesis and were called tumor growth factors. However their main role appear to be in embryonic development and in tissue repair.  7, record 3, English, - transforming%20growth%20factor

Record 3,  Textual support,  French

Record number: 3, Textual support number: 1 CONT

Or Todaro et coll. avaient observé que les fibroblastes en culture, transformés par certains rétrovirus porteurs d'oncogènes, secrétaient dans le milieu de culture des substances capables d'imprimer à des cellules normales un comportement phénotypique proche de cellules transformées. Ces facteurs que l'on a appelés facteur de croissance transformant (TGF) ont été isolés et caractérisés chimiquement.  1, record 3, French, - facteur%20de%20croissance%20transformant

Record 3,  Textual support,  Spanish

Record number: 3, Textual support number: 1 DEF

Proteína segregada por un tumor que estimula la multiplicación de las células cancerígenas.  1, record 3, Spanish, - factor%20de%20crecimiento%20transformante

Record 4,  Textual support,  English

Record number: 4, Textual support number: 1 DEF

A maternally expressed protein that by binding activin may interfere with activin-induced mesoderm formation.  1, record 4, English, - follistatin

Record number: 4, Textual support number: 1 OBS

Follistatin-deficient mice die within hours of birth because of multiple defects, indicating its requirement for several proteins of the transforming growth factor family.  1, record 4, English, - follistatin

Record 4,  Textual support,  French

Record number: 4, Textual support number: 1 CONT

La follistatine est encore une protéine de l'organisateur. La quatrième en date, elle a été découverte par hasard, suite à des expériences qui ne cherchaient pas à démontrer son existence. [Des scientifiques] cherchaient à évaluer l'importance de l'activine dans l'induction du mésoderme [...] Comme la follistatine est naturellement capable de se lier à l'activine (et à d'autres protéines apparentées) en d'en inhiber les effets, il se pouvait qu'il s'agisse là de l'un des facteurs sécrétés par l'organisateur.  1, record 4, French, - follistatine

Record 4,  Textual support,  Spanish

Record 5,  Textual support,  English

Record number: 5, Textual support number: 1 CONT

Activin, a member of the transforming growth factor-beta family of peptides, is implicated in the regulation of cell growth and differentiation in a variety of biological systems. We have sought to identify immediate early genes whose altered expression may provide a common nuclear event involved in activin-regulated phenotypic changes in many cell types. In both human K562 myelogenous leukemia and rat PC12 pheochromocytoma cells, activin treatment caused transient transcription-dependent and protein synthesis-independent increases of junB messenger RNA(mRNA) within 1 hour... [Source : PASCAL database].  1, record 5, English, - activin

Record number: 5, Textual support number: 1 OBS

Activin A not only stimulates the synthesis and release of pituitary follicle-stimulating hormones but exerts various effects on haematopoietic cells, embryos, and fibroblasts [Source: PASCAL database].  1, record 5, English, - activin

Record 5,  Textual support,  French

Record number: 5, Textual support number: 1 CONT

Les activines, des inducteurs du mésoderme axial chez le xénope et le poulet. Nous avons rapporté [...] que l'inducteur mésodermique XTC-MIF (mesoderm inducing factor dérivé de la lignée de xénope XTC), appartenant à la famille TGF B, était l'équivalent de l'activine chez Xenopus.  1, record 5, French, - activine

Record 5,  Textual support,  Spanish

Record 6,  Textual support,  English

Record number: 6, Textual support number: 1 CONT

Increased intraplatelet levels of platelet-derived growth factor and transforming growth factor-beta in patients with myelofibrosis with myeloid metaplasia.  3, record 6, English, - transforming%20growth%20factor%20beta

Record number: 6, Textual support number: 1 OBS

Tiré de: British Journal of Haematology, 1991, 77 (11), 80-86.  3, record 6, English, - transforming%20growth%20factor%20beta

Record 6,  Textual support,  French

Record number: 6, Textual support number: 1 CONT

Comme pour la régulation des chaînes A et B du PDGF, très peu de choses sont connues sur la régulation des sous-unités du récepteur. Le TGF-bêta (transforming growth factor beta) diminue l'expression des ARNm de la sous-unité alpha et augmente celle de la sous-unité Bêta sur des fibroblastes murins.  3, record 6, French, - facteur%20de%20croissance%20transformant%20b%C3%AAta

Record 6,  Textual support,  Spanish

Record 7,  Textual support,  English

Record number: 7, Textual support number: 1 CONT

Surgical biopsies from 10 head and neck squamous cell carcinomas were labeled in vitro with bromodeoxyuridine. In histological sections, bromodeoxyuridine-positive nuclei and beta-fibroblast growth factor(beta-FGF) were stained using immunohistochemistry. In clearly discernible clusters of tumor cells, the cytoplasm shows strong positive beta-FGF staining, whereas other tumor regions are completely beta-FGF negative... Three classes of mesoderm-inducing factor(MIF) that might be responsible for... interaction in vivo... These are members of the transforming growth factor type beta(TGF-beta), fibroblast growth factor(FGF) and Wnt families... Six well-characterized human growth factors were chosen for detailed investigation by topical application to standardized skin wounds in swine : epidermal growth factor(EGF), transforming growth factors alpha and beta(TGF-alpha and TGF-beta), fibroblast growth factor(FGF), insulin-like growth factor-1(IGF-l), and platelet-derived growth factor(PDGf). [Source : PASCAL database].  1, record 7, English, - beta%20fibroblast%20growth%20factor

Record 7,  Textual support,  French

Record number: 7, Textual support number: 1 OBS

Source : base de données PASCAL.  1, record 7, French, - facteur%20de%20croissance%20du%20fibroblaste%20b%C3%AAta

Record 7,  Textual support,  Spanish

Record 8,  Textual support,  English

Record number: 8, Textual support number: 1 CONT

Recently, several mesoderm-inducing factors(MIFs) have been discovered. These cause isolated Xenopus animal caps to form mesodermal cell types such as muscle, instead of their normal fate of epidermis. The MIFs fall into two classes. One comprises members of the fibroblast growth factor(FGF) family, and the other members of the transforming growth factor type beta(TGF-beta) family. Of the latter group, the most potent is XTC-MIF, a protein produced by Xenopus XTC cells. Here we show that XTC-MIF is the homologue of mammalian activin A.  3, record 8, English, - mesoderm%20inducing%20factor

Record number: 8, Textual support number: 1 OBS

Tiré du périodique londonien: Nature, 1990, 345 (6277), pp. 729-731.  3, record 8, English, - mesoderm%20inducing%20factor

Record 8,  Textual support,  French

Record number: 8, Textual support number: 1 CONT

Les activines, des inducteurs du mésoderme axial chez le xénope et le poulet. Nous avons rapporté, dans une brève récente, que l'inducteur mésodermique XTC-MIF (mesoderm inducing factor dérivé de la lignée de xénope XTC), appartenant à la famille TGF B, était l'équivalent de l'activine chez Xenopus.  1, record 8, French, - inducteur%20m%C3%A9sodermique

Record 8,  Textual support,  Spanish

Record 9,  Textual support,  English

Record number: 9, Textual support number: 1 CONT

Transforming growth factor alpha in arterioles : cell surface processing of its precursor by elastases.  3, record 9, English, - transforming%20growth%20factor%20alpha

Record number: 9, Textual support number: 1 OBS

Tiré de: Molecular and cellular biology, 1990, 10 (9), 4596-4602.  3, record 9, English, - transforming%20growth%20factor%20alpha

Record 9,  Textual support,  French

Record number: 9, Textual support number: 1 CONT

Le TGF a qui présente une forte homologie avec l'epidermal growth factor stimule l'angiogénèse in vivo et est mitogène pour les cellules endothéliales. Le TGF B entraîne in vivo, après injection sous-cutanée, une accumulation de macrophages, de fibroblastes et de collagène; et induit une néovascularisation. En revanche, in vitro, il inhibe la croissance des cellules endothéliales. Son activité angiogénique in vivo met donc probablement en jeu les macrophages.  2, record 9, French, - facteur%20de%20croissance%20transformant%20alpha

Record 9,  Textual support,  Spanish