TERMIUM Plus®

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TRANSFORMING GROWTH FACTOR ALPHA [3 records]

Record 1 2014-09-29

English

Subject field(s)
  • Cytology
CONT

The protein called EGF-R sets off the chain reaction that activates the mucous gene. It binds with two molecules :transforming growth factor alpha and epidermal growth factor, which occur when tissues are inflamed by cigarette smoke, or some viruses and bacteria.

French

Domaine(s)
  • Cytologie
CONT

[...] anticorps monoclonaux qui ciblent le récepteur du facteur de croissance épidermique (R-EGF) présent à la surface d’une cellule cancéreuse. Le R-EGF envoie des signaux qui favorisent la croissance et la survie des cellules cancéreuses.

Spanish

Campo(s) temático(s)
  • Citología
CONT

Muchas células cancerosas tienen una proteína, conocida como receptor del factor de crecimiento epidérmico (EFGR), en su superficie, mientras que las células sanas no expresan esta proteína tan fuertemente. Conjugando, o uniendo las nanopartículas de oro a un anticuerpo contra el EFGR, llamado anti-EFGR, los investigadores pueden lograr que se unan a las células cancerígenas.

OBS

EFGR por sus siglas en inglés.

OBS

Ficha realizada en colaboración con los estudiantes del Certificado en Traducción español-inglés del Glendon College, York University, Toronto, Canada.

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Record 2 1994-01-19

English

Subject field(s)
  • Biochemistry
CONT

Surgical biopsies from 10 head and neck squamous cell carcinomas were labeled in vitro with bromodeoxyuridine. In histological sections, bromodeoxyuridine-positive nuclei and beta-fibroblast growth factor(beta-FGF) were stained using immunohistochemistry. In clearly discernible clusters of tumor cells, the cytoplasm shows strong positive beta-FGF staining, whereas other tumor regions are completely beta-FGF negative... Three classes of mesoderm-inducing factor(MIF) that might be responsible for... interaction in vivo... These are members of the transforming growth factor type beta(TGF-beta), fibroblast growth factor(FGF) and Wnt families... Six well-characterized human growth factors were chosen for detailed investigation by topical application to standardized skin wounds in swine : epidermal growth factor(EGF), transforming growth factors alpha and beta(TGF-alpha and TGF-beta), fibroblast growth factor(FGF), insulin-like growth factor-1(IGF-l), and platelet-derived growth factor(PDGf). [Source : PASCAL database].

French

Domaine(s)
  • Biochimie
OBS

Source : base de données PASCAL.

Spanish

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Record 3 1991-07-01

English

Subject field(s)
  • Cytology
CONT

Transforming growth factor alpha in arterioles : cell surface processing of its precursor by elastases.

OBS

Tiré de: Molecular and cellular biology, 1990, 10 (9), 4596-4602.

French

Domaine(s)
  • Cytologie
CONT

Le TGF a qui présente une forte homologie avec l'epidermal growth factor stimule l'angiogénèse in vivo et est mitogène pour les cellules endothéliales. Le TGF B entraîne in vivo, après injection sous-cutanée, une accumulation de macrophages, de fibroblastes et de collagène; et induit une néovascularisation. En revanche, in vitro, il inhibe la croissance des cellules endothéliales. Son activité angiogénique in vivo met donc probablement en jeu les macrophages.

Spanish

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