TERMIUM Plus^®

Record 1,  Textual support,  English

Record number: 1, Textual support number: 1 CONT

Researchers first evaluate experimental vaccines in the laboratory and animal models. If a vaccine candidate is safe and appears promising in these preclinical experiments, it may go on to be carefully tested in people. Experimental vaccines undergo several phases of clinical testing to establish their safety and efficacy.  3, record 1, English, - experimental%20vaccine

Record 1,  Textual support,  French

Record number: 1, Textual support number: 1 CONT

Dans une première partie, le candidat-vaccin serait essayé sur quelques volontaires qui n'ont guère de risque de rencontrer le virus et sur lesquels il s'agirait simplement de vérifier si la vaccination provoque une montée d'anticorps.  4, record 1, French, - vaccin%20exp%C3%A9rimental

Record 1,  Textual support,  Spanish

Record 2,  Textual support,  English

Record number: 2, Textual support number: 1 DEF

A clinical trial in which participants are deliberately infected with a predetermined infectious agent under controlled conditions in order to test the safety and efficacy of a vaccine, drug, or other treatment.  4, record 2, English, - human%20challenge%20trial

Record number: 2, Textual support number: 1 OBS

A human challenge trial may be part of a controlled human infection model.  4, record 2, English, - human%20challenge%20trial

Record 2,  Textual support,  French

Record 2,  Textual support,  Spanish

Record 3,  Textual support,  English

Record number: 3, Textual support number: 1 DEF

... a clinical trial that aims at establishing the safety and efficacy of a vaccine prior to it being licensed.  3, record 3, English, - vaccine%20trial

Record 3,  Textual support,  French

Record number: 3, Textual support number: 1 CONT

En 1987, deux jeunes chercheurs en médecine [...] ont réalisé le premier essai clinique de vaccin contre le SIDA. Ils ont prélevé l'enveloppe qui entoure le virus et l'ont simplement injectée chez les participants d'une étude, en espérant déclencher une réponse immunitaire—une approche qui avait fonctionné pour l'hépatite B.  3, record 3, French, - essai%20clinique%20de%20vaccin

Record 3,  Textual support,  Spanish

Record 4,  Textual support,  English

Record number: 4, Textual support number: 1 CONT

A strain declared by WHO [World Health Organization] to represent the current threat [of a pandemic] has already been prepared as a manufacturing seed. This has already been used to produce the prototype vaccine used for the trial formulations.  2, record 4, English, - prototype%20vaccine

Record 4,  Textual support,  French

Record number: 4, Textual support number: 1 CONT

Une étude récente a démontré une bonne protection contre le H5N1 sur des souris suite à l'inoculation avec un vaccin contre le virus influenza H5 créé par génie génétique. La protection était atteinte malgré des différences antigéniques entre la souche du vaccin et le virus ciblé. [...] Une deuxième étude a suggéré que l'utilisation d'adjuvants dans le vaccin prototype pourrait favoriser le développement d'anticorps capable de neutraliser une souche pandémique jusqu'à ce qu'un vaccin adéquat soit disponible.  2, record 4, French, - vaccin%20prototype

Record 4,  Textual support,  Spanish

Record number: 4, Textual support number: 1 CONT

La virulencia asociada a las moléculas de hemaglutinina H5 en el lugar del péptido de unión ha sido eliminada. Como resultado presenta un virus atenuado en pollos y en huevos embrionados. Este virus inactivado con formalina se prepara en una emulsión oleosa y constituye una vacuna prototipo.  2, record 4, Spanish, - prototipo%20de%20vacuna

Record number: 4, Textual support number: 2 CONT

Las vacunas, fabricadas con virus inactivado, son eficaces en la prevención de la enfermedad y en la reducción de la mortalidad [...]. En la actualidad se está desarrollando un prototipo de vacuna frente al virus H5N1, responsable de los últimos brotes asiáticos, en el que se ha reducido su virulencia mediante técnicas de genética reversa.  1, record 4, Spanish, - prototipo%20de%20vacuna

Record 5,  Textual support,  English

Record number: 5, Textual support number: 1 CONT

Clinical trial of the conjugate vaccine of serogroup C meningococci and P64k as a protein carrier is planned for this year.  1, record 5, English, - protein%20carrier

Record 5,  Textual support,  French

Record number: 5, Textual support number: 1 CONT

Un nouveau vaccin, constitué d'un polysaccharide capsulaire du sérogroupe C conjugué à un support protéique, est immunogénique dès la petite enfance, induit une mémoire immunologique et protège contre l'infection à méningocoque du sérogroupe C.  1, record 5, French, - support%20prot%C3%A9ique

Record 5,  Textual support,  Spanish

Record 6,  Textual support,  English

Record number: 6, Textual support number: 1 CONT

Ockenhouse, C. F. [...] et al. Phase I/IIa safety, immunogenicity, and efficacy trial of NYVAC-Pf7, a pox-vectored, multiantigen, multistage vaccine candidate for Plasmodium falciparum Malaria. "Journal of Infectious Diseases, June 1998;177(6) : 1664-1673. According to the authors’ abstract of an article published in Journal of Infectious Diseases, "Candidate malaria vaccines have failed to elicit consistently protective immune responses against challenge with Plasmodium falciparum. NYVAC-Pf7, a highly attenuated vaccinia virus with 7 P. falciparum genes inserted into its genome, was tested in a Phase I/IIa safety, immunogenicity, and efficacy vaccine trial in human volunteers. Malaria genes inserted into the NYVAC genome encoded proteins from all stages of the parasite's life cycle.  1, record 6, English, - multiantigen%20vaccine

Record 6,  Textual support,  French

Record number: 6, Textual support number: 1 CONT

Grâce aux vaccins multi-antigènes, une piqûre «six-en-un» et le tour est joué.  1, record 6, French, - vaccin%20multi%2Dantig%C3%A8nes

Record 6,  Textual support,  Spanish

Record 7,  Textual support,  English

Record number: 7, Textual support number: 1 OBS

Part of a pre-marketing immunization trial of a vaccine.  2, record 7, English, - serological%20response

Record number: 7, Textual support number: 2 OBS

Canada Diseases Weekly Report.  2, record 7, English, - serological%20response

Record 7,  Textual support,  French

Record number: 7, Textual support number: 1 OBS

Rapport hebdomadaire des maladies au Canada.  2, record 7, French, - r%C3%A9ponse%20s%C3%A9rologique

Record 7,  Textual support,  Spanish