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ADENOSINE DEAMINASE DEFICIENCY [1 record]
Record 1 - internal organization data 2006-05-09
Record 1, English
Record 1, Subject field(s)
- Biochemistry
Record 1, Main entry term, English
- adenosine deaminase deficiency
1, record 1, English, adenosine%20deaminase%20deficiency
correct
Record 1, Abbreviations, English
- ADA deficiency 1, record 1, English, ADA%20deficiency
correct
Record 1, Synonyms, English
Record 1, Textual support, English
Record number: 1, Textual support number: 1 CONT
For example, one disease candidate for gene therapy is adenosine deaminase (ADA) deficiency which results in severe combined immunodeficiency disease (SCID). ADA deficient patients have little or no detectible enzyme in bone marrow cells. However, ADA deficiency has been cured by matched bone marrow transplantation. ADA normal cells have a selective advantage over ADA. 1, record 1, English, - adenosine%20deaminase%20deficiency
Record 1, French
Record 1, Domaine(s)
- Biochimie
Record 1, Main entry term, French
- déficit en adénosine désaminase
1, record 1, French, d%C3%A9ficit%20en%20ad%C3%A9nosine%20d%C3%A9saminase
correct, masculine noun
Record 1, Abbreviations, French
- déficit en ADA 2, record 1, French, d%C3%A9ficit%20en%20ADA
correct, masculine noun
Record 1, Synonyms, French
Record 1, Textual support, French
Record number: 1, Textual support number: 1 CONT
Les déficits immunitaires héréditaires sont considérés depuis longtemps comme un champ d'études privilégié de la thérapie génique. Ainsi le déficit en adénosine désaminase est la première maladie héréditaire à avoir fait l'objet d'un essai clinique de thérapie génique. Un bénéfice clinique n'a toutefois pas été observé. Plusieurs peuvent expliquer ces résultats décevants, notamment la perte au moins partielle de l'avantage sélectif escompté des cellules transduites du fait du traitement concomitant par PEG-ADA et les capacités limitées des vecteurs rétroviraux d'origine murine [...]. 1, record 1, French, - d%C3%A9ficit%20en%20ad%C3%A9nosine%20d%C3%A9saminase
Record 1, Spanish
Record 1, Campo(s) temático(s)
- Bioquímica
Record 1, Main entry term, Spanish
- déficit de adenosina-desaminasa
1, record 1, Spanish, d%C3%A9ficit%20de%20adenosina%2Ddesaminasa
correct, masculine noun
Record 1, Abbreviations, Spanish
Record 1, Synonyms, Spanish
Record 1, Textual support, Spanish
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