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ANTI-TNF ANTIBODY [1 record]

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Record 1 1993-01-23

English

Subject field(s)
  • Immunology
CONT

Endogenous tumour necrosis factor (cachectin) is essential to host resistance against Listeria monocytogenes infection ... When 1 mg of anti-TNF antibody was injected per mouse, all the mice died from listeriosis ... in vivo administration of anti-TNF antibody blocks antilisterial resistance.

French

Domaine(s)
  • Immunologie
CONT

Un anticorps dirigé contre le TNF (tumor necrosis factor) permet de prévenir le choc septique secondaire à une bactériémie expérimentale chez le babouin. (...) Injecté à l'animal, le TNF produit par recombinaison génétique provoque (...) un choc comparable à celui des septicémies. Le rôle du TNF comme intermédiaire du choc septique vient d'être illustré par le pouvoir protecteur contre ce dernier de l'injection préalable à des babouins d'anticorps anti-TNF.

Spanish

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