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AZACITIDINE [1 record]
Record 1 - internal organization data 2014-04-07
Record 1, English
Record 1, Subject field(s)
- Medication
Record 1, Main entry term, English
- azacitidine
1, record 1, English, azacitidine
correct
Record 1, Abbreviations, English
Record 1, Synonyms, English
Record 1, Textual support, English
Record number: 1, Textual support number: 1 CONT
Azacitidine is incorporated into DNA, where it reversibly inhibits DNA methyltransferase, thereby blocking DNA methylation. Hypomethylation of DNA by azacitidine may activate tumor suppressor genes silenced by hypermethylation, resulting in an antitumor effect. This agent is also incorporated into RNA, thereby disrupting normal RNA function and impairing tRNA cytosine-5-methyltransferase activity. 2, record 1, English, - azacitidine
Record number: 1, Textual support number: 1 OBS
A pyrimidine nucleoside analogue of cytidine with antineoplastic activity. 2, record 1, English, - azacitidine
Record number: 1, Textual support number: 2 OBS
Active ingredient sold under a number of commercial (trade) names, among which: Vidaza. 3, record 1, English, - azacitidine
Record 1, French
Record 1, Domaine(s)
- Médicaments
Record 1, Main entry term, French
- azacitidine
1, record 1, French, azacitidine
feminine noun
Record 1, Abbreviations, French
Record 1, Synonyms, French
Record 1, Textual support, French
Record number: 1, Textual support number: 1 CONT
L’azacitidine est un analogue pyrimidine. Elle possède deux principaux mécanismes d’action antinéoplasique : 1) cytotoxicité directe sur les cellules hématopoïétiques anormales dans la moelle osseuse et; 2) hypométhylation de l’ADN, permettant de rétablir le fonctionnement normal des gènes indispensables à la différenciation et à la prolifération des cellules de la moelle osseuse. 2, record 1, French, - azacitidine
Record number: 1, Textual support number: 1 OBS
Principe actif commercialisé, entre autres, sous le nom de Vidaza. 3, record 1, French, - azacitidine
Record 1, Spanish
Record 1, Campo(s) temático(s)
- Medicamentos
Record 1, Main entry term, Spanish
- azacitidina
1, record 1, Spanish, azacitidina
feminine noun
Record 1, Abbreviations, Spanish
Record 1, Synonyms, Spanish
Record 1, Textual support, Spanish
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