TERMIUM Plus®

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BONT [2 records]

Record 1 2011-10-31

English

Subject field(s)
  • Biochemistry
  • Genetics
OBS

With the increasing use of Botulinum toxin in the treatment of various neuromuscular disorders, it is very important that all who are involved be kept up with the latest developments and indications for the use of the toxin. The current literature reflects the potential uses of the toxin but at the same time discrepancies in the dosage of the toxin, and measurement of toxin activity are arising. In addition, basic scientists interested in the toxin for its elegant role as a molecular tool.

OBS

This article appeared in the following journal. Toxicon, Vol. 33, No. 2, pp. 21.

French

Domaine(s)
  • Biochimie
  • Génétique
CONT

Les neurotoxines tétaniques (TeTN) et botuliques (BoNT) sont responsables de deux maladies sévères : le tétanos et le botulisme. Le TnNT bloque la libération de GABA [acide 4-aminobutanoïque] et de glycine dans le système nerveux central alors que les BoNT agissent en périphérie en inhibant la libération d'acétylcholine.

Spanish

Campo(s) temático(s)
  • Bioquímica
  • Genética
DEF

[Neurotoxina] producida por la bacteria Clostridium botulinum como un complejo de proteínas que contiene la fracción neurotóxica asociada con componentes no tóxicos.

CONT

La NTBo se sintetiza como una cadena polipeptídica simple [...]. Existen siete serotipos de la NTBo (A, B, C1, D, E, F y G); todos ellos inhiben la liberación de acetilcolina aunque difieren considerablemente con respecto a sus proteínas diana intracelulares, las características de sus efectos y sus potencias.

CONT

La neurotoxina del tétanos [...] actúa principalmente en el sistema nervioso central, mientras que la neurotoxina del botulismo [...] actúa en la unión neuromuscular inhibiendo la liberación de acetilcolina del axón de la neurona afectada hacia la sinapsis, dando como resultado una parálisis fláccida localizada.

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Record 2 1996-05-14

English

Subject field(s)
  • Photoelectricity and Electron Optics
  • Optical Telecommunications
  • Video Technology
OBS

interactive video

French

Domaine(s)
  • Photo-électricité et optique électronique
  • Télécommunications optiques
  • Vidéotechnique

Spanish

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