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CLONAL SELECTION [1 record]
Record 1 - internal organization data 2012-08-01
Record 1, English
Record 1, Subject field(s)
- Genetics
Record 1, Main entry term, English
- clonal selection
1, record 1, English, clonal%20selection
correct
Record 1, Abbreviations, English
Record 1, Synonyms, English
Record 1, Textual support, English
Record number: 1, Textual support number: 1 CONT
The clonal selection theory is based on the proposition that during development each lymphocyte becomes committed to react with a particular antigen before ever being exposed to it. A cell expresses this commitment in the form of surface receptor proteins that specifically fit the antigen. The binding of antigen to the receptors activates the cell, causing it both to multiply and mature. Thus a foreign antigen selectively stimulates those cells that bear complementary antigen-specific receptors and are thus already committed to respond to it. This is what makes immune responses antigen-specific. The term "clonal" in clonal selection derives from the postulate that the immune system is composed of millions of different families, or clones, of cells, each consisting of T or B lymphocytes descended from a common ancestor. Since each ancestral cell is already committed to make one particular antigen-specific receptor protein, all cells in a clone have the same antigen specificity. 1, record 1, English, - clonal%20selection
Record 1, French
Record 1, Domaine(s)
- Génétique
Record 1, Main entry term, French
- sélection clonale
1, record 1, French, s%C3%A9lection%20clonale
correct, feminine noun
Record 1, Abbreviations, French
Record 1, Synonyms, French
Record 1, Textual support, French
Record number: 1, Textual support number: 1 CONT
Selon la théorie de la sélection clonale, les lymphocytes [sont] groupés en clones, un clone étant un ensemble de cellules identiques, descendantes d'une même cellule initiale, et exprimant les mêmes potentialités génétiques. Ainsi, chaque clone de lymphocyte B comporte-t-il un ensemble de cellules identiques, chacune synthétisant une espèce d'immunoglobuline, et une seule. Ce clone est sélectivement stimulé par l'antigène reconnu spécifiquement par l'immunoglobuline qu'il exprime. 1, record 1, French, - s%C3%A9lection%20clonale
Record 1, Spanish
Record 1, Campo(s) temático(s)
- Genética
Record 1, Main entry term, Spanish
- selección clonal
1, record 1, Spanish, selecci%C3%B3n%20clonal
correct, feminine noun
Record 1, Abbreviations, Spanish
Record 1, Synonyms, Spanish
- selección clónica 2, record 1, Spanish, selecci%C3%B3n%20cl%C3%B3nica
correct, feminine noun
Record 1, Textual support, Spanish
Record number: 1, Textual support number: 1 DEF
Producción de una población de células plasmáticas productoras de un mismo anticuerpo en respuesta a la interacción entre un linfocito B que produce el anticuerpo específico y el antígeno fijado por dicho anticuerpo. 2, record 1, Spanish, - selecci%C3%B3n%20clonal
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