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CYTOTOXIC ANTIBODY [1 record]

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Alphabetical list of terms

Record 1 2006-05-18

English

Subject field(s)
  • Immunology
DEF

An antibody which damages antigen-bearing cells, usually in the presence of complement.

DEF

Any specific antibody directed against cellular antigens, which when bound to the antigen, activates the complement pathway or activates killer cells, resulting in cell lysis.

French

Domaine(s)
  • Immunologie
CONT

Les anticorps cytotoxiques (IgM ou plus rarement IgG) entraînent la destruction de la cellule sur laquelle ils se sont fixés par activation locale du complément. Ce mécanisme [...] semble en fait assez peu intervenir en immunopathologie. Les anticorps cytotoxiques paraissent néanmoins jouer un rôle important dans les crises hémolytiques des anémies hémolytiques auto-immunes et dans le rejet hyperaigu des greffes d'organe.

Spanish

Campo(s) temático(s)
  • Inmunología
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