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DOLASTATIN [1 record]

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Record 1 1999-03-19

English

Subject field(s)
  • Animal Biology
CONT

Dolastatin-10 (D10) is a potent antimitotic peptide isolated from the marine mollusk Dolabella auricularia which inhibits tubulin polymerization.

OBS

D10 has been shown to cause peripheral neuropathy in a rat embryo dorsal root ganglion neurite model (Schumacher CP, Windebank AJ, Ann Neuro138:316, 1995.). We performed a phase I clinical trial to determine the MTD, pharmacokinetics, and biologic effects of escalating doses of D10 (65, 130, 217, 325, 400, 455 m g/m2) administered as an IV bolus every 21 days.

French

Domaine(s)
  • Biologie animale
OBS

Substance d'origine marine présentant des propriétés antitumorales,isolée chez Dolabella auricularia (aplypsie) qu'on retrouve dans l'Océan Indien.

Spanish

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