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HUMAN ARTIFICIAL CHROMOSOME [1 record]
Record 1 - internal organization data 2007-08-08
Record 1, English
Record 1, Subject field(s)
- Genetics
Record 1, Main entry term, English
- human artificial chromosome
1, record 1, English, human%20artificial%20chromosome
correct
Record 1, Abbreviations, English
- HAC 1, record 1, English, HAC
correct
Record 1, Synonyms, English
Record 1, Textual support, English
Record number: 1, Textual support number: 1 CONT
Human artificial chromosomes (HAC) have been considered as a possible vector for human gene therapy. In our previous work a minichromosome (MC), isolated from a patient, was transformed with a selectable marker gene (neo) which was targeted into its centromere; the MC was then size reduced, by X-ray exposure, to be easily manipulated and further engineered. The method developed for gene targeting, based on the use of chromosome specific centromeric satellite DNA as transfection carrier, is highly efficient and reproducible. 1, record 1, English, - human%20artificial%20chromosome
Record 1, French
Record 1, Domaine(s)
- Génétique
Record 1, Main entry term, French
- chromosome artificiel humain
1, record 1, French, chromosome%20artificiel%20humain
correct, masculine noun
Record 1, Abbreviations, French
- HAC 2, record 1, French, HAC
correct, masculine noun
Record 1, Synonyms, French
Record 1, Textual support, French
Record number: 1, Textual support number: 1 CONT
En effet, les chromosomes artificiels humains (HAC) décrits constituent les premières constructions chromosomiques possédant tous les attributs (télomères, origines de réplication, centromère) d'un chromosome humain viable. [...] Les généticiens manquent encore d'informations précises sur les séquences qui, au niveau du centromère et des origines de réplications, sont nécessaires au fonctionnement du chromosome. 1, record 1, French, - chromosome%20artificiel%20humain
Record 1, Spanish
Record 1, Campo(s) temático(s)
- Genética
Record 1, Main entry term, Spanish
- cromosoma artificial humano
1, record 1, Spanish, cromosoma%20artificial%20humano
correct, masculine noun
Record 1, Abbreviations, Spanish
- HAC 1, record 1, Spanish, HAC
correct, masculine noun
Record 1, Synonyms, Spanish
Record 1, Textual support, Spanish
Record number: 1, Textual support number: 1 DEF
Construcción análoga al cromosoma artificial de levadura, que consta de un centrómero y telómeros de origen humano, que permitiría la clonación de fragmentos de ADN muy grandes y su transferencia a las células humanas para aplicar la terapia génica. 1, record 1, Spanish, - cromosoma%20artificial%20humano
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