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LYON HYPOTHESIS [1 record]

Record 1 1996-05-15

English

Subject field(s)
  • Genetics
DEF

The theory that all X chromosomes in a cell in excess of one are inactivated (in the form of sex chromatin) on a random basis in all mammalian cells at an early stage of embryogenesis. In the normal human female the paternal X chromosome is inactivated in some cells and the maternal one in the remainder. During oogenesis, the inactive X is reactivated so that products of both Xs are represented in the mammalian egg.

OBS

also found in the adjectival form. Lyonized (ex.: a Lyonized haircell precursor).

French

Domaine(s)
  • Génétique
DEF

Hypothèse selon laquelle, lorsque le nombre des chromosomes X est supérieur à 1 (chez la femme normale, par exemple), un de ces chromosomes est inactivé, c'est-à-dire ne s'exprime pas génétiquement. Cette inactivation, qui se produirait à un stade précoce de l'embryogenèse, serait due au hasard et porterait donc dans 50 p. cent des cas sur le chromosome X paternel et dans 50 p. cent des cas sur le chromosome X maternel.

Spanish

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