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MALIGNANT HISTIOCYTOSIS [1 record]

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Record 1 2009-09-24

English

Subject field(s)
  • Cancers and Oncology
  • Blood
CONT

Malignant histiocytosis is a rare invasive proliferation of neoplastic histiocytes. ... A case of malignant histiocytosis is described, in which a patient presenting with symptoms suggestive of pneumonia suddenly deteriorated and died. ... Extensive infiltration by pleomorphic tumour cells and erythrophagocytosis by tumour cells were seen on histological examination of the spleen.

OBS

It usually affects children or young adults and has a poor prognosis.

French

Domaine(s)
  • Cancers et oncologie
  • Sang
CONT

L'histiocytose maligne (malignant histiocytosis) [...] est une prolifération systémique d'histiocytes atypiques, qui touche l'enfant ou l'adulte jeune. Les signes généraux dominent le tableau, avec une fièvre, une altération de l'état général, des adénopathies, une hépato-splénomégalie et une atteinte viscérale digestive, pulmonaire et rénale. [...] Il existe histologiquement un infiltrat périvasculaire histiocytaire atypique dépourvu de granules de Birbeck, avec des images d'érythrophagocytose. L'extension de la maladie, en particulier l'atteinte médullaire, est le facteur pronostique principal.

Spanish

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