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PARADOXICAL TOXICITY [1 record]

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Record 1 1988-01-29

English

Subject field(s)
  • Pharmacodynamics
CONT

No toxicity [due to cysteamine] was found in cells maintained at 5 degrees during treatment; however, at 37 degrees and 44 degrees, a paradoxical toxicity was observed, i.e., a substantial toxicity was observed at cysteamine concentrations of 0.2 - 1 mM but decreased at higher drug concentrations. (Source: Cancer Research, 1984, vo. 44, no. 9, pp. 3911-3915).

Key term(s)
  • paradoxal toxicity

French

Domaine(s)
  • Pharmacodynamie
CONT

La spécificité des effets radioprotecteurs et cytotoxiques de la cysteamine dans les cellules heal S(3) : Génération de peroxyde en tant que mécanisme de la toxicité paradoxale (...) : La cysteamine (0,5 - 5 mM) tue efficacement les cellules heal S(3), alors qu'elle est beaucoup moins toxique à une concentration plus élevée (30 mM). (Source : base de données PASCAL).

Spanish

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