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PEGYLATION [1 record]
Record 1 - internal organization data 2023-05-16
Record 1, English
Record 1, Subject field(s)
- Biochemistry
Record 1, Main entry term, English
- PEGylation
1, record 1, English, PEGylation
correct
Record 1, Abbreviations, English
Record 1, Synonyms, English
- pegylation 2, record 1, English, pegylation
correct
Record 1, Textual support, English
Record number: 1, Textual support number: 1 DEF
The process of covalent attachment of polyethylene glycol (PEG) polymer chains to another molecule, normally a drug or therapeutic protein. 3, record 1, English, - PEGylation
Record number: 1, Textual support number: 1 OBS
An appropriately sized and shaped nano-object decorated with polyethylene glycol (a process called PEGylation) can avoid detection. 4, record 1, English, - PEGylation
Record number: 1, Textual support number: 2 OBS
Many PEG-coupled biomolecules are reported to have increased plasma half-lives as well as improved solubility, increased resistance to proteolysis and reducedtoxicity and immunogenicity. 2, record 1, English, - PEGylation
Record number: 1, Textual support number: 3 OBS
"PEG" stands for "polyethylene glycol." 4, record 1, English, - PEGylation
Record 1, French
Record 1, Domaine(s)
- Biochimie
Record 1, Main entry term, French
- pégylation
1, record 1, French, p%C3%A9gylation
correct, feminine noun
Record 1, Abbreviations, French
Record 1, Synonyms, French
- Pegylation 2, record 1, French, Pegylation
feminine noun
- pegylation 3, record 1, French, pegylation
feminine noun
- PEGylation 2, record 1, French, PEGylation
feminine noun
Record 1, Textual support, French
Record number: 1, Textual support number: 1 DEF
Procédé [...] qui consiste à attacher (conjuguer) des chaînes de polyéthylène glycol à des molécules biologiquement actives [...] 2, record 1, French, - p%C3%A9gylation
Record number: 1, Textual support number: 1 OBS
[On entend par «molécules biologiquement actives»] des molécules telles que des protéines ou des médicaments peptidiques. [La pégylation] peut augmenter la masse moléculaire des protéines et des peptides et leur solubilité et ainsi mieux les protéger des enzymes protéolytiques. La pégylation d'une protéine peut aussi diminuer ses propriétés allergènes. Le procédé peut inactiver certaines enzymes face à un produit pégylé, mais il peut aussi allonger la durée de présence d'une enzyme si cette dernière est une molécule qui a été pégylée puis injectée dans l'organisme. 2, record 1, French, - p%C3%A9gylation
Record number: 1, Textual support number: 2 OBS
La pégylation de nano-objets de dimensions et de forme appropriées (par greffage avec du polyéthylène glycol) leur permet de ne pas être détectés. 3, record 1, French, - p%C3%A9gylation
Record number: 1, Textual support number: 3 OBS
pégylation : nom dérivé de l'abréviation anglaise «PEG», qui signifie «polyethylene glycol». 4, record 1, French, - p%C3%A9gylation
Record 1, Spanish
Record 1, Textual support, Spanish
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