TERMIUM Plus®

The Government of Canada’s terminology and linguistic data bank.

PTGS [2 records]

Filter results by subject field Alphabetical list of terms

Filter results by subject field

Alphabetical list of terms

Record 1 2011-08-31

English

Subject field(s)
  • Genetics
  • Biotechnology
CONT

Using this knowledge, an emerging use of PTGS and, in particular, RNA interference (RNAi), the initiating of PTGS by introducing small (21-25 nucleotides) double-stranded RNA (siRNA), as a tool to knock out the expression of specific genes in a variety of organisms can be observed.

OBS

Epigenic silencing of transgene and endogenous genes can occur at the transcriptional level (TGS) or at the post-transcriptional level (PTGS).

OBS

post-transcriptional silencing: Elliptical form of "post-transcriptional gene silencing." As the term "silencing" can only apply in this context to genes, the term "gene" can be removed.

Key term(s)
  • posttranscriptional gene silencing

French

Domaine(s)
  • Génétique
  • Biotechnologie
DEF

Phénomène ou mécanisme cytoplasmique de mise en sommeil des gènes qui peut être d'origine naturelle ou provoqué in vitro et qui induit une destruction sélective de l'ARNm [ARN messager] pour lequel correspondent au moins une centaine de nucléotides.

OBS

PTGS : Bien qu'issue de l'expression anglaise «Post Transcriptional Gene Silencing», cette abréviation est utilisée dans les textes français.

Spanish

Campo(s) temático(s)
  • Genética
  • Biotecnología
DEF

Degradación citoplasmática del ARNm [ácido ribonucleico mensajero] de un gen específico debido a la presencia de ARNbc [ácido ribonucleico bicatenario] complementarios a él.

Save record 1

Record 2 2006-10-03

English

Subject field(s)
  • Biochemistry
DEF

An enzyme protein complex present in most tissues that catalyses two steps in prostaglandin biosynthesis and produces prostaglandins and thromboxanes from arachidonic acid.

CONT

Prostaglandin endoperoxide synthases (PTGS), commonly referred to as cyclooxygenases (COX-1 and COX-2), catalyze the key step in the synthesis of biologically active prostaglandins (PGs), the conversion of arachidonic acid (AA) into prostaglandin H2 (PGH2).

OBS

The cyclooxygenase activity is inhibited by aspirin-like drugs, accounting for their anti-inflammatory effects.

French

Domaine(s)
  • Biochimie
DEF

Enzyme qui permet la formation de prostaglandines à partir de l'acide arachidonique [un acide gras qui contribue à la fabrication des parois cellulaires].

CONT

La cyclo-oxygénase existe sous deux isoformes : la Cox1, isoforme constitutive de la plupart des tissus et la Cox2, isoforme inductible (par les cytokines, l'endotoxine et les mitogènes). Tous les A.I.N.S. [anti-inflammatoires non stéroïdiens] actuels sont spécifiques de la Cox1 et le rôle ubiquitaire des prostaglandines dans l'organisme (coagulation, bronchomotricité, filtration rénale, contractions utérines, neurotransmission chimique) explique les indications très variées des A.I.N.S., ainsi que la richesse de leurs effets indésirables.

Spanish

Campo(s) temático(s)
  • Bioquímica
Save record 2

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