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TETRAHYDRO-IMIDAZO-BENZODIAZEPINE-2-ONE AND-THIONE [1 record]
Record 1 - internal organization data 2005-05-04
Record 1, English
Record 1, Subject field(s)
- Medication
Record 1, Main entry term, English
- tetrahydro-imidazo-benzodiazepine-2-one and-thione
1, record 1, English, tetrahydro%2Dimidazo%2Dbenzodiazepine%2D2%2Done%20and%2Dthione
correct
Record 1, Abbreviations, English
- TIBO 1, record 1, English, TIBO
correct
Record 1, Synonyms, English
Record 1, Textual support, English
Record number: 1, Textual support number: 1 CONT
TIBO: Tetrahydro-imidazo-benzodiazepine-2-one and-thione. TIBO derivatives are synthetic compounds found to have anti-HIV-1 activity and, to date, few toxic side effects. These compounds, under study currently, are reverse transcriptase inhibitors that interfere with replication of HIV. 1, record 1, English, - tetrahydro%2Dimidazo%2Dbenzodiazepine%2D2%2Done%20and%2Dthione
Record number: 1, Textual support number: 1 OBS
TIBO derivatives: New class of antivirals being developed by Jannsen Pharmaceuticals in Belgium. 2, record 1, English, - tetrahydro%2Dimidazo%2Dbenzodiazepine%2D2%2Done%20and%2Dthione
Record 1, Key term(s)
- TIBO derivative
Record 1, French
Record 1, Domaine(s)
- Médicaments
Record 1, Main entry term, French
- tétrahydro-imidazo-benzodiazepin-one
1, record 1, French, t%C3%A9trahydro%2Dimidazo%2Dbenzodiazepin%2Done
correct
Record 1, Abbreviations, French
- T.I.B.O. 1, record 1, French, T%2EI%2EB%2EO%2E
correct
Record 1, Synonyms, French
Record 1, Textual support, French
Record number: 1, Textual support number: 1 CONT
les T.I.B.O. (tétrahydro-imidazo-benzodiazepin-one) sont des inhibiteurs hautement spécifiques de la réplication du V.I.H.-1 mais pas de celle de V.I.H.-2 ou d'autres rétrovirus. Ces T.I.B.O. sont atoxiques en dehors d'un effet sédatif. Un de ces produits est le BI-RG-587 du laboratoire Boehringer Ingelheim. Après avoir été exclusivement administrés en perfusion intraveineuse, les premiers essais per os des T.I.B.O. ont eu lieu début 91. 1, record 1, French, - t%C3%A9trahydro%2Dimidazo%2Dbenzodiazepin%2Done
Record 1, Spanish
Record 1, Campo(s) temático(s)
- Medicamentos
Record 1, Main entry term, Spanish
- tetrahidro imidizol benzo diazepino
1, record 1, Spanish, tetrahidro%20imidizol%20benzo%20diazepino
masculine noun
Record 1, Abbreviations, Spanish
- TIBO 1, record 1, Spanish, TIBO
masculine noun
Record 1, Synonyms, Spanish
Record 1, Textual support, Spanish
Record number: 1, Textual support number: 1 CONT
Los compuestos derivados del TIBO son altamente selectivos contra la transcriptasa reversa del VIH ya que inhiben la transcripción del ARN del virus al ADN de la célula. 1, record 1, Spanish, - tetrahidro%20imidizol%20benzo%20diazepino
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