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TRIGGERED CONFORMATIONAL CHANGE [1 record]
Record 1 - internal organization data 2010-09-15
Record 1, English
Record 1, Subject field(s)
- Biological Sciences
Record 1, Main entry term, English
- triggered conformational change
1, record 1, English, triggered%20conformational%20change
correct
Record 1, Abbreviations, English
Record 1, Synonyms, English
Record 1, Textual support, English
Record number: 1, Textual support number: 1 CONT
Triggered conformational changes ... are the motions of groups of atoms (i.e. individual side-chains) or whole sections of a protein (i.e. loops of chain, domains of secondary and tertiary structure, or subunit), which occur as a response to a specific stimulus. The distance moved can be as much as 10 [angstrom unit] or more. The time scale can be estimated by studies of the rate of binding or turnover reactions. The energy for triggered conformational change comes from specific interactions, such as electrostatic attractions or hydrogen bonding interactions. The best-known example of a triggered conformational change is the transition in tertiary structure that occurs when ligands bind to the iron atoms of hemoglobin. 1, record 1, English, - triggered%20conformational%20change
Record number: 1, Textual support number: 1 OBS
The types of substances whose binding can trigger a specific conformational change include substrates (dihydroxyacetone phosphate in triose phosphate isomerase), coenzymes (NAD binding to lactate dehydrogenase), allosteric effectors (CTP and ATP in aspartic transcarbamylase), inhibitors (statine-containing polypeptide inhibitors of acid proteases) and even protons (the Bohr effect in hemoglobin; pH-dependent conformational changes in adenylate kinase). 1, record 1, English, - triggered%20conformational%20change
Record 1, French
Record 1, Domaine(s)
- Sciences biologiques
Record 1, Main entry term, French
- changement de conformation protéique induit
1, record 1, French, changement%20de%20conformation%20prot%C3%A9ique%20induit
correct, masculine noun
Record 1, Abbreviations, French
Record 1, Synonyms, French
Record 1, Textual support, French
Record number: 1, Textual support number: 1 DEF
Modification de la conformation des protéines provoquée par la fixation de ligands à leur surface. Parmi ces ligands, notons les substrats, activateurs, inhibiteurs et coenzymes. 2, record 1, French, - changement%20de%20conformation%20prot%C3%A9ique%20induit
Record 1, Spanish
Record 1, Textual support, Spanish
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