TERMIUM Plus®

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1 COMPARTMENT PK MODEL [1 record]

Record 1 2023-06-02

English

Subject field(s)
  • Pharmacology
CONT

The most basic mathematical description of drug distribution and elimination is the one-compartment model. ... One-compartment models utilize a single central compartment and assume that equilibrium is rapidly/instantaneously achieved with tissues. Although the drug in the body, as a single "compartment," cannot be measured, an assumption is made that the changes in blood (or other sampling compartment) reflect a proportional change in tissue drug concentrations. The rate of drug elimination from the central compartment in a one-compartment model is a first-order process. ... In the case of a one-compartment model, [clearance] is linear ... regardless of the mechanism of clearance.

Key term(s)
  • one compartment pharmacokinetic model
  • single compartment pharmacokinetic model
  • one compartment PK model
  • single compartment PK model
  • one compartment model
  • single compartment model
  • 1-compartment pharmacokinetic model
  • 1 compartment pharmacokinetic model
  • 1-compartment PK model
  • 1 compartment PK model
  • 1-compartment model
  • 1 compartment model

French

Domaine(s)
  • Pharmacologie
Key term(s)
  • modèle pharmaco-cinétique à un compartiment
  • modèle pharmaco-cinétique à compartiment unique
  • modèle pharmacocinétique à 1 compartiment
  • modèle pharmaco-cinétique à 1 compartiment
  • modèle à 1 compartiment

Spanish

Campo(s) temático(s)
  • Farmacología
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