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ANGIOTENSIN 2 RECEPTOR INHIBITOR [2 records]

Filter results by subject field Alphabetical list of terms

Filter results by subject field

Alphabetical list of terms

Record 1 2026-03-20

English

Subject field(s)
  • Medication
  • Cardiovascular System
CONT

ARNI, or an angiotensin receptor/neprilysin inhibitor, is made up of two drugs put together to treat heart failure. It contains an ARB (angiotensin II receptor blocker) and a neprilysin inhibitor.

CONT

Angiotensin II receptor–neprilysin inhibitors. Sacubitril-valsartan is a fixed dose combination of the angiotensin II receptor blocker valsartan and the neprilysin inhibitor sacubitril. ... Sacubitril/valsartan is a combination product. Sacubritil acts as a neprilysin inhibitor and works by blocking the action of neprilysin, inhibiting the breakdown of natriuretic peptides. This results in increased diuresis, vasodilation, reduction in blood pressure and work on the heart. Valsartan is an angiotensin receptor blocker and inhibits the RAAS [renin-angiotensin aldosterone system] ... to reduce the maladaptive response to cardiac failure. Neprilysin breaks down angiotensin II, so sacubitril given alone would result in an accumulation of angiotensin II. For this reason, it must be combined with an angiotensin receptor blocker to block the effect of excess angiotensin II.

Key term(s)
  • angiotensin 2 receptor and neprilysin inhibitor
  • angiotensin 2 receptor–neprilysin inhibitor
  • angiotensin 2 receptor/neprilysin inhibitor

French

Domaine(s)
  • Médicaments
  • Système cardio-vasculaire
OBS

Médicament composé de deux agents actifs qui est employé pour traiter l'insuffisance cardiaque.

Key term(s)
  • inhibiteur de la néprilysine/antagoniste des récepteurs de l'angiotensine 2

Spanish

Save record 1

Record 2 2026-02-06

English

Subject field(s)
  • Medication
  • Cardiovascular System
CONT

Angiotensin II receptor blockers do not inhibit ACE [angiotensin-converting enzymes]. Instead, they block the vasoconstricting and aldosterone-secreting effects of angiotensin II by selectively blocking the binding of angiotensin II to the angiotensin I receptors in many tissues, especially in the vascular smooth muscle and adrenal gland tissues.

Key term(s)
  • angiotensin 2 receptor blocker
  • angiotensin 2 receptor inhibitor
  • angiotensin 2 receptor antagonist

French

Domaine(s)
  • Médicaments
  • Système cardio-vasculaire
CONT

Les antagonistes des récepteurs de l'angiotensine II (ARA II) s'opposent à l'action de l'angiotensine II, puissant vasoconstricteur favorisant en outre la rétention hydrosodée et la sécrétion d'aldostérone.

Key term(s)
  • antagoniste des récepteurs de l'angiotensine 2
  • ARA 2
  • ARAII
  • ARA2

Spanish

Save record 2

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