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ANTIGENIC VARIANT [1 record]

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Record 1 2004-10-05

English

Subject field(s)
  • Immunology
CONT

The pathogenesis of AIDS is dependent on the biology of HIV, e.g: "Trojan horse" mechanism - virus escapes recognition by replication inside monocytes, from where it can spread to other tissues and other hosts. Latency - Lentiviruses do not show true latency (unlike Herpes viruses or lambda) but do have the capacity to control the expression of their genome by means of virus-encoded trans-acting regulatory proteins (tat and rev). Antigenic variation - new variants continually arise. In other Lentiviruses such as CAEV, each new antigenic variant results in a flare up of disease.

French

Domaine(s)
  • Immunologie
OBS

La variabilité est une stratégie classique des microorganismes persistants; du fait des délais de mise en route de la réponse immunitaire, l'organisme présente toujours un temps de retard sur les variants antigéniques présents dans l'organisme.

Spanish

Campo(s) temático(s)
  • Inmunología
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