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ANTIMICROBIAL PEPTIDE [3 records]

Record 1 2013-07-29

English

Subject field(s)
  • Biotechnology
  • Immunology
CONT

Some of the AMPs [antimicrobial peptides] may be useful for humans. Clinical mycoses are on the increase with the increased use of immunosuppressants in transplants and also in immunosuppressive diseases. Antimicrobial peptides or drugs based on their mode of action may have pharmacological value in the future against human fungal pathogens.

OBS

Antimicrobial peptide defenses: amino acid chains that generally disrupt the membranes of a target cell, causing the breakdown of the cell.

French

Domaine(s)
  • Biotechnologie
  • Immunologie
CONT

Recherche de molécules à activité biologique: les peptides antimicrobiens. Depuis la découverte par le Professeur Hans Boman en 1980 du premier peptide antimicrobien, plus de cinq cents autres molécules ont été caractérisées. Ces peptides, mis en évidence dans tous les phyla, présentent un large spectre d'activité contre les bactéries, les champignons filamenteux et les levures. De nombreux travaux montrent qu'ils jouent un rôle clé dans les mécanismes immunitaires innés puisqu'ils participent efficacement, et cela chez tous les métazoaires, à la lutte contre les microorganismes que ce soit au niveau cellulaire (destruction des bactéries phagocytées), au niveau humoral ou encore au niveau des épithélia et des muqueuses.

Spanish

Campo(s) temático(s)
  • Biotecnología
  • Inmunología
OBS

Proteínas de origen natural que tienen propiedades antibióticas [...]

Save record 1

Record 2 2013-07-18

English

Subject field(s)
  • Biotechnology
  • Immunology
CONT

Peptide antibiotics fall into two broad classes whose evolutionary biology is very different. The first is a large and heterogeneous category of peptides that are synthesized on very large, modular enzyme complexes by bacteria and fungi ... The second category is quite different. It comprises linear peptides consisting almost entirely of conventional amino acid residues that are produced by all major kinds of organisms (including microbes). These are translated using ribosomes in the usual fashion of protein synthesis, and we therefore call them RAMPs, for ribosomally synthesized antimicrobial peptides, to distinguish them from the non-RAMPs of the first category.

OBS

non-ribosomally synthesized antimicrobial peptide: term proposed by analogy with the terms "non-ribosomally synthesized peptide" and "ribosomally synthesized antimicrobial peptide."

French

Domaine(s)
  • Biotechnologie
  • Immunologie
OBS

La synthèse est essentiellement due à des gènes comprenant ceux des polykétides synthases et des peptides synthases (synthèse non ribosomique de peptides).

OBS

peptide antimicrobien produit par synthèse non ribosomique : expression proposée par analogie avec les termes «peptide antimicrobien», «synthèse non ribosomique de peptides» et «peptide produit par synthèse ribosomique».

Spanish

Campo(s) temático(s)
  • Biotecnología
  • Inmunología
Save record 2

Record 3 2012-10-25

English

Subject field(s)
  • Biotechnology
  • Immunology
  • Medication
CONT

Peptide antibiotics fall into two broad classes whose evolutionary biology is very different. The first is a large and heterogeneous category of peptides that are synthesized on very large, modular enzyme complexes by bacteria and fungi. ... The second category is quite different. It comprises linear peptides consisting almost entirely of conventional amino acid residues that are produced by all major kinds of organisms (including microbes). These are translated using ribosomes in the usual fashion of protein synthesis, and we therefore call them RAMPs, for "ribosomally synthesized antimicrobial peptides" to distinguish them from the non-RAMPs of the first category.

French

Domaine(s)
  • Biotechnologie
  • Immunologie
  • Médicaments
OBS

La nisine est un peptide produit par synthèse ribosomique et qui subit une modification par post-traduction enzymatique donnant la forme mature de la bactériocine nécessaire pour son activité biologique.

OBS

peptide antimicrobien produit par synthèse ribosomique : expression proposée par analogie avec «peptide produit par synthèse ribosomique».

Spanish

Campo(s) temático(s)
  • Biotecnología
  • Inmunología
  • Medicamentos
OBS

Las bacteriocinas son péptidos antimicrobianos de síntesis ribosomal.

Save record 3

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