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COLD AUTOANTIBODY [1 record]

Record 1 1993-01-23

English

Subject field(s)
  • Immunology
DEF

An autoantibody that is active only at temperature below 37 ° C.

CONT

Autoimmune haemolytic anemias. (...) Cold-reactive autoantibodies are often present in higher titres than the warm-reactive autoantibodies. The antibodies are primarily IgM and fix complement strongly. In most cases they are specific for the Ii blood group system.

French

Domaine(s)
  • Immunologie
CONT

La majorité des autoanticorps froids de classe IgM reconnaissent l'antigène public I. (...) Les autoanticorps anti-I de classe IgM ne se fixent sur les hématies qu'à basse température (4 ° C) et non à la température du corps. Cette particularité n'est pas liée à une modification de l'autoanticorps IgM par la température mais aux propriétés particulières de la membrane érythrocytaire au froid comme le démontre la réactivité identique de l'anticorps à 0 ° C et à 37 ° C avec l'antigène I purifié.

CONT

Anémie hémolytique à auto-anticorps "froids" (...)

Spanish

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