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CYSTIC FIBROSIS GENE [2 records]
Record 1 - internal organization data 1997-05-07
Record 1, English
Record 1, Subject field(s)
- Genetics
Record 1, Main entry term, English
- Cystic Fibrosis gene
1, record 1, English, Cystic%20Fibrosis%20gene
correct
Record 1, Abbreviations, English
Record 1, Synonyms, English
- CF gene 2, record 1, English, CF%20gene
correct
Record 1, Textual support, English
Record number: 1, Textual support number: 1 CONT
The Goal of Gene Therapy for Cystic Fibrosis...Gene therapy offers the best hope for a life-saving treatment which tackles the root cause of cystic fibrosis (CF), rather than only treating the symptoms... These early trials test the safety and efficiency of the adenovirus delivery system. Patients are monitored to detect whether the normal CF gene has turned on. If so, the gene will produce a normal protein that is vital to the health of cells lining the respiratory tract. 3, record 1, English, - Cystic%20Fibrosis%20gene
Record 1, French
Record 1, Domaine(s)
- Génétique
Record 1, Main entry term, French
- gène CF
1, record 1, French, g%C3%A8ne%20CF
correct, masculine noun
Record 1, Abbreviations, French
Record 1, Synonyms, French
- gène de la mucoviscidose 2, record 1, French, g%C3%A8ne%20de%20la%20mucoviscidose
proposal, masculine noun
- gène de la fibrose kystique du pancréas 2, record 1, French, g%C3%A8ne%20de%20la%20fibrose%20kystique%20du%20pancr%C3%A9as
proposal, masculine noun
Record 1, Textual support, French
Record number: 1, Textual support number: 1 DEF
Gène de la mucoviscidose localisé sur le bras du chromosome 7. 1, record 1, French, - g%C3%A8ne%20CF
Record number: 1, Textual support number: 1 CONT
Grâce aux "enzyme de restriction", ciseaux moléculaires permettant de découper l'ADN en fragments, et aux "marqueurs" courtes séquences de nucléotides servant de point d'attaque aux enzymes de restriction, l'équipe de Lap-Chee Tsui, de concert avec Collaborative Research Inc. de Boston, réussit d'abord à restreindre la recherche du gène, baptisé gène CF (pour cystic Fibrosis, dénomination anglaise de la mucoviscidose), à moins de 1% de tout le matériel génétique. C'était en octobre 1985. Un mois plus tard, la même équipe annonce que le gène CF est localisé dans le bras long du chromosome 7. La région en question est formée d'environ un million de bases nucléotidiques. 1, record 1, French, - g%C3%A8ne%20CF
Record number: 1, Textual support number: 1 OBS
La protéine du gène CF a été baptisée CFTR (Cystic Fibrosis Transmembrane Conductance Regulator). 2, record 1, French, - g%C3%A8ne%20CF
Record 1, Spanish
Record 1, Textual support, Spanish
Record 2 - internal organization data 1996-09-10
Record 2, English
Record 2, Subject field(s)
- Genetics
Record 2, Main entry term, English
- cystic fibrosis transmembrane conductance regulator gene
1, record 2, English, cystic%20fibrosis%20transmembrane%20conductance%20regulator%20gene
correct
Record 2, Abbreviations, English
Record 2, Synonyms, English
- CFTR gene 1, record 2, English, CFTR%20gene
correct
Record 2, Textual support, English
Record 2, French
Record 2, Domaine(s)
- Génétique
Record 2, Main entry term, French
- gène CFTR
1, record 2, French, g%C3%A8ne%20CFTR
correct, masculine noun
Record 2, Abbreviations, French
Record 2, Synonyms, French
Record 2, Textual support, French
Record number: 2, Textual support number: 1 CONT
Du fait de sa fréquence et de sa gravité, la muscovidose a été une des premières maladies héréditaires pour laquelle on ait envisagé la thérapie génique. Elle est caractérisée par l'inactivation de la protéine «cystic fibrosis transmembrane conductance regulator» (CFTR). 1, record 2, French, - g%C3%A8ne%20CFTR
Record 2, Spanish
Record 2, Textual support, Spanish
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