TERMIUM Plus^®

Record 1,  Textual support,  English

Record 1,  Textual support,  French

Record number: 1, Textual support number: 1 CONT

Une approche alternative pour augmenter la capacité destructrice d'anticorps envers des cibles tumorales est la conjugaison de molécules cytotoxiques. L'idée est alors de créer une «ogive» dont la spécificité de ciblage serait assurée par l'anticorps monoclonal et l'activité par l'agent cytotoxique conjugué.  2, record 1, French, - mol%C3%A9cule%20cytotoxique

Record 1,  Textual support,  Spanish

Record 2,  Textual support,  English

Record number: 2, Textual support number: 1 DEF

A differentiated T lymphocyte that can recognize and lyse target cells bearing specific antigens recognized by their antigen receptors.  5, record 2, English, - T%2Dkiller%20cell

Record 2,  Textual support,  French

Record number: 2, Textual support number: 1 CONT

Le lymphocyte T cytotoxique [...] tue les cellules infectées par les virus et les cellules cancéreuses grâce à son interaction avec le lymphocyte T auxiliaire qui provoque son activation et sa prolifération.  4, record 2, French, - cellule%20T%20tueuse

Record 2,  Textual support,  Spanish

Record number: 2, Textual support number: 1 DEF

[Tipo de] célula T que destruye aquellas células que presentan antígenos previamente reconocidos.  2, record 2, Spanish, - linfocito%20T%20citot%C3%B3xico

Record 3,  Textual support,  English

Record number: 3, Textual support number: 1 DEF

An antiserum produced by immunizing horses with human spleen and bone marrow cells.  2, record 3, English, - antireticular%20cytotoxic%20serum

Record 3,  Textual support,  French

Record number: 3, Textual support number: 1 DEF

Antisérum obtenu par l'injection au cheval d'un extrait de tissu réticulo-endothélial humain.  2, record 3, French, - s%C3%A9rum%20antir%C3%A9ticulaire%20cytotoxique

Record 3,  Textual support,  Spanish

Record 4,  Textual support,  English

Record number: 4, Textual support number: 1 DEF

A drug or enzyme that is administered to plants, animals or humans for the specific purpose of altering the metabolic process or possessing a specific destructive action on cells.  1, record 4, English, - cytotoxic%20drug

Record number: 4, Textual support number: 1 OBS

This group of compounds was developed for use in cancer chemotherapy.  3, record 4, English, - cytotoxic%20drug

Record number: 4, Textual support number: 2 OBS

It may be genotoxic, oncogenic, mutagenic, and teratogenic and includes most anti-cancer drugs.  1, record 4, English, - cytotoxic%20drug

Record 4,  Textual support,  French

Record number: 4, Textual support number: 1 DEF

Substance, habituellement un médicament, qui détruit les cellules cancéreuses.  2, record 4, French, - agent%20cytotoxique

Record 4,  Textual support,  Spanish

Record 5,  Textual support,  English

Record number: 5, Textual support number: 1 DEF

Chemical substance, produced by microorganisms, inhibiting or preventing the development of neoplasms.  2, record 5, English, - cytotoxic%20antibiotic

Record number: 5, Textual support number: 1 CONT

Gemtuzumab ozogamicin is targeted against CD33, a surface marker expressed by 90% of myeloid leukemic blasts but absent from stem cells, and is armed with calicheamicin, a potent cytotoxic antibiotic that inhibits DNA synthesis and induces apoptosis.  3, record 5, English, - cytotoxic%20antibiotic

Record 5,  Textual support,  French

Record number: 5, Textual support number: 1 CONT

La mithramycine, ou plicamycine, est un antibiotique cytotoxique, utilisé parfois comme agent antitumoral.  2, record 5, French, - antibiotique%20cytotoxique

Record number: 5, Textual support number: 2 CONT

La bléomycine est un antibiotique cytotoxique utilisé dans le traitement des lymphomes, des carcinomes épimerdoïdes et des tumeurs testiculaires.  3, record 5, French, - antibiotique%20cytotoxique

Record 5,  Textual support,  Spanish

Record 6,  Textual support,  English

Record number: 6, Textual support number: 1 DEF

An antibody which damages antigen-bearing cells, usually in the presence of complement.  2, record 6, English, - cytotoxic%20antibody

Record number: 6, Textual support number: 2 DEF

Any specific antibody directed against cellular antigens, which when bound to the antigen, activates the complement pathway or activates killer cells, resulting in cell lysis.  3, record 6, English, - cytotoxic%20antibody

Record 6,  Textual support,  French

Record number: 6, Textual support number: 1 CONT

Les anticorps cytotoxiques (IgM ou plus rarement IgG) entraînent la destruction de la cellule sur laquelle ils se sont fixés par activation locale du complément. Ce mécanisme [...] semble en fait assez peu intervenir en immunopathologie. Les anticorps cytotoxiques paraissent néanmoins jouer un rôle important dans les crises hémolytiques des anémies hémolytiques auto-immunes et dans le rejet hyperaigu des greffes d'organe.  1, record 6, French, - anticorps%20cytotoxique

Record 6,  Textual support,  Spanish

Record 7,  Textual support,  English

Record number: 7, Textual support number: 1 DEF

Cell of the immune system that inhibits or helps to terminate an immune response.  1, record 7, English, - suppressor%20cell

Record number: 7, Textual support number: 1 OBS

Related terms: suppressor macrophage; suppressor T cell.  2, record 7, English, - suppressor%20cell

Record 7,  Textual support,  French

Record number: 7, Textual support number: 1 DEF

Toute cellule qui contrôle, en la diminuant, la réponse d'autres cellules du système immunitaire.  1, record 7, French, - cellule%20suppressive

Record number: 7, Textual support number: 1 OBS

Terme connexe : cellule T suppressive.  2, record 7, French, - cellule%20suppressive

Record 7,  Textual support,  Spanish

Record 8,  Textual support,  English

Record number: 8, Textual support number: 1 DEF

pertaining to, resulting from, or having the action of a cytotoxin.  2, record 8, English, - cytotoxic

Record number: 8, Textual support number: 1 OBS

Cytotoxin: a toxin or antibody that has a specific toxic action upon cells of special organs; cytotoxins are named according to the special variety of cell for which they are specific, as "nephrotoxin".  2, record 8, English, - cytotoxic

Record 8,  Textual support,  French

Record number: 8, Textual support number: 1 DEF

Doué d'une activité agressive contre certaines cellules qui se trouvent ainsi lésées ou tuées.  2, record 8, French, - cytotoxique

Record 8,  Textual support,  Spanish

Record number: 8, Textual support number: 1 DEF

[Dícese del] agente o proceso que es tóxico a las células, lo cual significa que suprime las funciones de la célula o le provoca la muerte. Se refiere especialmente a células cancerosas o infectadas.  2, record 8, Spanish, - citot%C3%B3xico

Record 9,  Textual support,  English

Record number: 9, Textual support number: 1 CONT

Cytotoxic effects on tracheal tissue exposed to carbon/acid particles were greater than damage produced by either acid or carbon alone.  2, record 9, English, - cytotoxic%20effect

Record number: 9, Textual support number: 1 OBS

cytotoxic: pertaining to, resulting from, or having the action of a cytotoxin.  3, record 9, English, - cytotoxic%20effect

Record number: 9, Textual support number: 2 OBS

cytotoxin: a toxin or antibody that has a specific toxic action upon cells of special organs, ....  3, record 9, English, - cytotoxic%20effect

Record 9,  Textual support,  French

Record number: 9, Textual support number: 1 CONT

[Perturbation de l'épuration pulmonaire.] [...] l'utilisation du M.A. en culture est actuellement un procédé valable pour l'étude in vitro des effets cytotoxiques des polluants [...] atmosphériques [...].  2, record 9, French, - effet%20cytotoxique

Record 9,  Textual support,  Spanish

Record 10,  Textual support,  English

Record number: 10, Textual support number: 1 CONT

The development of influenza virus-specific CD8+ cytotoxic T lymphocyte precursors (CTLp) is diminished in H-2b mice that are homozygous (-/-) for disruption of the H-2IA b gene. Virus clearance was not obviously delayed when compared with the congenic H-2IAb (+/+) controls, and evidence of CTL activity was apparent for inflammatory cells recovered from the respiratory tract in both cases. However, the virus-specific CTLp that are normally present in the regional lymph nodes and in the infected lung were evidently being consumed at the peak of the host response to give the terminally differentiated CTL effectors.  1, record 10, English, - cytotoxic%20T%20lymphocyte%20precursor

Record 10,  Textual support,  French

Record 10,  Textual support,  Spanish

Record 11,  Textual support,  English

Record number: 11, Textual support number: 1 DEF

Hypersensitivity caused by antibody to cell surface antigens. These can sensitize the cells for antibody-dependent cell-mediated cytotoxicity by K cells, or complement mediated lysis. Type II hypersensitivity is seen in the destruction of red blood cells in transfusion reactions, and in haemolytic disease of the newborn. The destruction of tissue in auto-immune diseases such as myathenia gravis is partly antibody-mediated.  3, record 11, English, - type%20II%20hypersensitivity%20reaction

Record 11,  Textual support,  French

Record number: 11, Textual support number: 1 DEF

Réaction d'immunité humorale. La combinaison antigène-anticorps ou haptène-anticorps détruit la cellule sur laquelle elle se fixe. Les anticorps sont des IgG ou des IgM; le complément peut intervenir dans ce processus; la réaction est précoce. En clinique, certaines anémies hémolytiques, agranulocytoses, thrombopénies et glomérulonéphrites sont dues à la réaction de type II.  1, record 11, French, - r%C3%A9action%20immunitaire%20de%20type%20II

Record 11,  Textual support,  Spanish

Record 12,  Textual support,  English

Record 12,  Textual support,  French

Record number: 12, Textual support number: 1 CONT

(...) ont été isolés une série de clones correspondants à des "CTLA 1", ... "CTLA 5" (cytotoxic T lymphocyte antigens), protéines qui seraient contenues dans les granules.  1, record 12, French, - antig%C3%A8ne%20CTLA

Record 12,  Textual support,  Spanish

Record 13,  Textual support,  English

Record number: 13, Textual support number: 1 CONT

MHC-restricted cytotoxic T cells: studies on the biological role of polymorphic major transplantation antigens determining T-cell restriction-specificity, function and responsiveness. (Adv Immunol 1979; 27: 51-77).  1, record 13, English, - MHC%2Drestricted%20cytotoxic%20T%20cell

Record 13,  Textual support,  French

Record number: 13, Textual support number: 1 CONT

Les mécanismes de défense immunitaire anti-tumoraux de l'hôte aboutissant à la lyse de la cellule tumorale peuvent être grossièrement regroupés en deux systèmes. Un premier système de défense, qui est spécifique de l'antigène de la cellule cible, met en jeu les lymphocytes T cytotoxiques «CMH restreints» de l'hôte qui répondent à des antigènes de surface immunogènes.  1, record 13, French, - lymphocyte%20T%20cytotoxique%20CMH%20restreint

Record number: 13, Textual support number: 1 DEF

CMH restreints : c'est-à-dire spécifiques d'épitopes présentés par les mêmes molécules du CMH que celles exprimées par le lymphocyte lui-même.  1, record 13, French, - lymphocyte%20T%20cytotoxique%20CMH%20restreint

Record number: 13, Textual support number: 1 OBS

CMH est l'abréviation de complexe majeur d'histocompatibilité.  2, record 13, French, - lymphocyte%20T%20cytotoxique%20CMH%20restreint

Record 13,  Textual support,  Spanish

Record 14,  Textual support,  French

Record 14,  Textual support,  Spanish

Record 15,  Textual support,  French

Record 15,  Textual support,  Spanish

Record 16,  Textual support,  English

Record number: 16, Textual support number: 1 OBS

cytotoxicity: the quality of being capable of producing a specific toxic action upon cells of special organs.  2, record 16, English, - cytotoxic%20action

Record number: 16, Textual support number: 2 OBS

cytotoxin: a toxin or antibody that has a specific toxic action ....  2, record 16, English, - cytotoxic%20action

Record 16,  Textual support,  French

Record number: 16, Textual support number: 1 CONT

Perturbations de l'épuration [pulmonaire]. (...) La notion d'action cytotoxique d'un polluant est une notion classique qui exprime l'action métabolique sur les cellules de l'appareil respiratoire.  2, record 16, French, - action%20cytotoxique

Record 16,  Textual support,  Spanish