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HUMAN SOMATIC TRANSGENESIS [1 record]

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Record 1 2010-04-07

English

Subject field(s)
  • Biotechnology
  • Genetics
CONT

It was initially unknown whether human somatic transgenesis would be safe, whether the transduced genes would be (durably) expressed, and whether the transduction process would affect natural cell properties.

OBS

Excerpt from: Published clinical results of Institut Pasteur.

French

Domaine(s)
  • Biotechnologie
  • Génétique
CONT

Historiquement, ce sont les vecteurs rétroviraux qui ont ouvert la voie à la transgénèse somatique chez l'homme. Depuis le premier essai clinique autorisé à l'équipe de Rosenberg (USA) en 1989, les vecteurs rétroviraux, presque toujours fondés sur le virus de la leucémie murine de Moloney (Mo-MuLV), restent employés dans les trois-quarts des protocoles actuels.

Spanish

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