TERMIUM Plus^®

Record 1,  Textual support,  English

Record number: 1, Textual support number: 1 CONT

Cyclin-dependent kinase (Cdks) is a family of serine-threonine protein kinase which plays a pivotal role in the eucaryote cell cycle regulation.  1, record 1, English, - cyclin%2Ddependent%20kinase

Record number: 1, Textual support number: 1 OBS

The term "dependent," when used as an adjective as is the case here, is more frequently written with an "e." "Dependant" with an "a" represents the noun form.  4, record 1, English, - cyclin%2Ddependent%20kinase

Record 1,  Textual support,  French

Record number: 1, Textual support number: 1 CONT

Le déroulement correct des phases successives du cycle mitotique des cellules eucaryotes est assuré, en grande partie, par une famille de kinases sérine-thréonine, dites kinases dépendantes des cyclines (cyclin-dependent kinases, Cdks). Leur structure primaire montre une homologie entre les espèces tout au long de l'échelle de l'évolution.  1, record 1, French, - kinase%20d%C3%A9pendante%20des%20cyclines

Record number: 1, Textual support number: 1 OBS

La plus connue, la Cdk2, associée à la cycline B, est indispensable à la mitose.  2, record 1, French, - kinase%20d%C3%A9pendante%20des%20cyclines

Record 1,  Textual support,  Spanish

Record 2,  Textual support,  English

Record number: 2, Textual support number: 1 DEF

An enzyme which is induced in cells affected with DNA viruses and which catalyses the phosphorylation of thymidine to thymidylic acid, in the process of DNA synthesis.  3, record 2, English, - thymidine%20kinase

Record number: 2, Textual support number: 1 CONT

In papovavirus-infected cells the induced enzyme is cellular in origin, but the thymidine kinase induced by Herpesvirus is specified by the virus Genome, and differs in several properties from the cell enzyme.  3, record 2, English, - thymidine%20kinase

Record 2,  Textual support,  French

Record number: 2, Textual support number: 1 CONT

Cette enzyme virale, la thymidine kinase, n'est présente que dans les cellules infectées.  1, record 2, French, - thymidine%20kinase

Record 2,  Textual support,  Spanish

Record number: 2, Textual support number: 1 DEF

Enzima que permite a una célula utilizar una vía metabólica alternativa para incorporar timidina en el ADN.  1, record 2, Spanish, - timidina%20quinasa

Record number: 2, Textual support number: 1 OBS

Se utiliza como marcador seleccionable para identificar las células eucarióticas transfectadas.  1, record 2, Spanish, - timidina%20quinasa

Record 3,  Textual support,  English

Record number: 3, Textual support number: 1 DEF

Enzyme that catalyzes the transfer of the [gamma] -phosphate of ATP to a 5'-OH terminus in DNA or RNA.  2, record 3, English, - polynucleotide%20kinase

Record number: 3, Textual support number: 1 OBS

It is used for labeling 5' termini in DNA for sequencing by the Maxam-Gilbert technique.  2, record 3, English, - polynucleotide%20kinase

Record 3,  Textual support,  French

Record number: 3, Textual support number: 1 DEF

Enzyme phosphorylant la partie terminale d'un polynucléotide. [Définition normalisée par l'AFNOR et reproduite avec son autorisation.]  2, record 3, French, - polynucl%C3%A9otide%20kinase

Record number: 3, Textual support number: 1 OBS

polynucléotide kinase : terme normalisé par l'AFNOR et publié au Journal officiel de la République française le 22 septembre 2000.  3, record 3, French, - polynucl%C3%A9otide%20kinase

Record 3,  Textual support,  Spanish

Record 4,  Textual support,  English

Record number: 4, Textual support number: 1 DEF

Enzyme of skeletal muscle and the myocardium and of brain tissue that catalyzes the transfer of a phosphate group from phosphocreatine to ADP, producing creatine and ATP. It occurs as three isoenzymes each having two components labeled M and B: the form in brain tissue is BB, in skeletal muscle MM, and in myocardial tissue both MM and MB. The form normally found in serum is virtually all MM isoenzyme.  1, record 4, English, - creatine%20kinase

Record number: 4, Textual support number: 1 OBS

The recommended name of this enzyme, that normally used, is creatine kinase, and the systematic name, based on the reaction catalyzed, is ATP: creatine phosphotransferase.  4, record 4, English, - creatine%20kinase

Record 4,  Textual support,  French

Record number: 4, Textual support number: 1 DEF

Enzyme musculaire catalysant la phosphorylation de la créatine en présence d'ATP. La créatine phosphate ainsi formée possède une liaison riche en énergie et constitue la forme de stockage de l'énergie au niveau du muscle.  1, record 4, French, - cr%C3%A9atine%20kinase

Record 4,  Textual support,  Spanish

Record 5,  Textual support,  English

Record number: 5, Textual support number: 1 DEF

Enzyme which converts a zymogen to the active enzyme form.  2, record 5, English, - kinase

Record number: 5, Textual support number: 1 CONT

A somewhat different type of regulation of enzyme activity is the enzyme-catalyzed activation of inactive precursors of enzymes (zymogens) to yield the catalytically active forms. The classical examples are the digestive enzymes pepsin, trypsin, and chymotrypsin which are synthesized as the inactive zymogens pepsinogen, trypsinogen, and chymotrypsinogen, respectively. When these enzymes are secreted into the gastrointestinal tract, they are converted into their active forms by the selective hydrolytic cleavage of one or more specific peptide bonds in the zymogen molecule.... Trypsinogen is converted into active trypsin by removal of a hexapeptide from the N-terminal end, through the action of ... kinase.  3, record 5, English, - kinase

Record 5,  Textual support,  French

Record number: 5, Textual support number: 1 DEF

Nom d'ensemble des enzymes dont la présence est nécessaire pour rendre active une autre enzyme. Ex.: l'entérokinase pancréatique permet la transformation du trypsinogène en trypsine.  2, record 5, French, - kinase

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Record 7,  Textual support,  English

Record number: 7, Textual support number: 1 CONT

In another application of gene therapy we have used an adenoviral vector that carries the gene for herpes simplex virus thymidine kinase (HSV-tk). Cells expressing HSV-tk will convert the anti-viral drug ganciclovir (GCV) to a form that is toxic to rapidly dividing cells. Using this adenoviral vector we have repeatedly shown robust tumoricidal effects in a variety of animal models of CNS tumor and will soon take this treatment to phase I clinical trials. We are extending this work to the manipulation of the CNSs immune response to tumors using adenoviral vectors that carry several cytokine genes.  1, record 7, English, - herpes%20simplex%20virus%20thymidine%20kinase

Record 7,  Textual support,  French

Record number: 7, Textual support number: 1 CONT

Traitement du glioblastome multiforme - une tumeur létale du cerveau - par transduction tumorale in vivo du gène codant la thymidine kinase du virus herpès simplex (HSV-TK), suivie par l'administration de ganciclovir, tel est l'intitulé des essais cliniques de phase II qui ont débuté en juin dernier en Belgique.  1, record 7, French, - thimidine%20kinase%20du%20virus%20herp%C3%A8s%20simplex

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Record 8,  Textual support,  English

Record number: 8, Textual support number: 1 DEF

[An enzyme that] phosphorylates tyrosine residues in some proteins.  1, record 8, English, - protein%20tyrosine%20kinase

Record 8,  Textual support,  French

Record number: 8, Textual support number: 1 CONT

[L']activation se traduit souvent par la mise en jeu d'une activité protéine tyrosine kinase (c'est-à-dire une activité de phosphorylation de protéines sur une tyrosine) portée par le récepteur ou simplement couplée au récepteur.  1, record 8, French, - prot%C3%A9ine%20tyrosine%20kinase

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Record 9,  Textual support,  English

Record number: 9, Textual support number: 1 DEF

[A receptor that] binds protein tyrosine kinase enzymes such as the receptors for epidermal growth factor, insulin, insulin-like growth factor-1, platelet-derived growth factor, fibroblast growth factor...  1, record 9, English, - receptor%20tyrosine%20kinase

Record 9,  Textual support,  French

Record number: 9, Textual support number: 1 CONT

Le récepteur de l'insuline est un récepteur tyrosine kinase. C'est une protéine enzymatique, une protéine tyrosine kinase, sur laquelle se fixe l'insuline : cette enzyme a pour fonction de phosphoryler des résidus tyrosine spécifiques appartenant à d'autres protéines.  1, record 9, French, - r%C3%A9cepteur%20tyrosine%20kinase

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Record 10,  Textual support,  English

Record number: 10, Textual support number: 1 DEF

A protein kinase [that transduces] the cellular signals [promoting] lipid hydrolysis.  1, record 10, English, - protein%20kinase%20C

Record number: 10, Textual support number: 1 OBS

[Protein kinase C is a] 80kDa [kilodaltons] enzyme... recruited to the plasma membrane by diacylglycerol and, in many cases, by calcium. The enzyme is activated by diacylglycerol and phospholipid (usually PS [phosphatidylserine]) and is thought to undergo a conformational change upon binding to the membrane. PKC [protein kinase C] phosphorylates a variety of target proteins which control growth and cellular differentiation.  1, record 10, English, - protein%20kinase%20C

Record 10,  Textual support,  French

Record number: 10, Textual support number: 1 CONT

Après activation, la protéine kinase C est transférée du cytoplasme vers la membrane où elle phosphoryle des protéines sur les résidus sérine et thréonine.  1, record 10, French, - prot%C3%A9ine%20kinase%20C

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Record 11,  Textual support,  English

Record number: 11, Textual support number: 1 CONT

the EGF receptor tyrosine kinase is an enzyme commonly studied for functions it performs as an internal cell communicator.  2, record 11, English, - tyrosine%20kinase

Record 11,  Textual support,  French

Record number: 11, Textual support number: 1 CONT

Les récepteurs de croissance possédant une activité intrinsèque de tyrosine kinase s'associent au niveau de leur domaine cytoplasmique à d'autres protéines participant au transfert de signaux mitogéniques.  4, record 11, French, - tyrosine%2Dkinase

Record number: 11, Textual support number: 1 OBS

Tyrosine : acide aminé  5, record 11, French, - tyrosine%2Dkinase

Record number: 11, Textual support number: 2 OBS

terme français formulé d'après les règles généralement suivies dans la nomenclature des enzymes.  1, record 11, French, - tyrosine%2Dkinase

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Record 12,  Textual support,  English

Record number: 12, Textual support number: 1 CONT

The G-protein-coupled receptor kinases (GRKs) are protein kinases that phosphorylate only active G-protein-coupled receptors.  2, record 12, English, - G%20protein%2Dcoupled%20receptor%20kinase

Record 12,  Textual support,  French

Record number: 12, Textual support number: 1 CONT

La phosphorylation du récepteur intervient dès la fixation du ligand. Deux classes principales de protéines kinases sont impliquées dans ce phénomène : la PKA et les GRK.  1, record 12, French, - kinase%20associ%C3%A9e%20au%20r%C3%A9cepteur%20coupl%C3%A9%20%C3%A0%20une%20prot%C3%A9ine%20G

Record number: 12, Textual support number: 2 CONT

Les kinases associées aux récepteurs couplés aux protéines G (GRK) : Le rôle des GRK a été montré par un certain nombre de moyens comme la surexpression, ou l'utilisation d'anticorps inhibant leur fonction.  1, record 12, French, - kinase%20associ%C3%A9e%20au%20r%C3%A9cepteur%20coupl%C3%A9%20%C3%A0%20une%20prot%C3%A9ine%20G

Record 12,  Textual support,  Spanish

Record 13,  Textual support,  English

Record number: 13, Textual support number: 1 CONT

We hope to elucidate the role of adenosine kinase (ADK) and that of the adenine salvage pathway in plant systems by isolating and characterizing ADK-deficient mutants from Arabidopsis thaliana. To achieve this goal, both a direct selection, previously employed for mammalian systems, and gene silencing are being used.  2, record 13, English, - adenosine%20kinase

Record 13,  Textual support,  French

Record 13,  Textual support,  Spanish

Record 14,  Textual support,  English

Record number: 14, Textual support number: 1 DEF

An enzyme of the transferase class that catalyses the realteen ATP + protein = ADP + phosphoprotein.  2, record 14, English, - protein%20kinase

Record 14,  Textual support,  French

Record number: 14, Textual support number: 1 DEF

Enzyme qui assure le transfert d'une liaison phosphate riche en énergie, provenant de l'adénosine triphosphate (ATP), sur une protéine acceptrice qui est ainsi activée.  3, record 14, French, - prot%C3%A9ine%20kinase

Record number: 14, Textual support number: 1 CONT

L'analyse de la séquence en acides aminés n'a pas permis de déduire une quelconque activité de la protéine (protéine kinase, facteur de croissance, etc.). Grâce à leur homologie, l'ADNc murin a pu servir de sonde pour isoler l'ADNc humain.  4, record 14, French, - prot%C3%A9ine%20kinase

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Record 17,  Textual support,  English

Record number: 17, Textual support number: 1 CONT

Aspartate kinase (AK) catalyzes the first reaction of common biosynthetic pathway of threonine, lysine and methionine in plants and bacteria.  2, record 17, English, - aspartate%20kinase

Record 17,  Textual support,  French

Record number: 17, Textual support number: 1 OBS

L'aspartate kinase (AK) catalyse la première étape de la biosynthèse commune à la thréonine, à la lysine et à la méthionine chez les plantes et les bactéries.  3, record 17, French, - aspartate%20kinase

Record 17,  Textual support,  Spanish

Record 18,  Textual support,  English

Record number: 18, Textual support number: 1 CONT

The protein kinase PKR is a component of the interferon-induced anti-viral defense mechanism in mammalian cells. Upon activation by binding double-stranded RNA in infected cells, the kinase down-regulates the cellular translational apparatus, and thus impairs viral protein expression. To overcome the inhibitory effects of PKR, viruses have developed efficient methods to prevent the activation or function of the kinase. A potential site of therapeutic intervention is to block viral inhibition of PKR.  2, record 18, English, - protein%20kinase%20PKR

Record 18,  Textual support,  French

Record number: 18, Textual support number: 1 CONT

Récemment, Michael Lai et son équipe de l'université de Los Angeles ont décrit un mécanisme expliquant la plus grande résistance de certaines souches de VHC à l'interféron. Ces chercheurs travaillent sur une enzyme, la protéine kinase PKR, qui fait avorter les virus en inhibant leur synthèse protéique. L'interféron accélère la production de la PKR par les cellules.  1, record 18, French, - prot%C3%A9ine%20kinase%20PKR

Record 18,  Textual support,  Spanish

Record 19,  Textual support,  English

Record number: 19, Textual support number: 1 DEF

An enzyme that catalyzes the phosphorylation of glycerol to glycerophosphate during microbial fermentation of propionic acid.  1, record 19, English, - glycerokinase

Record 19,  Textual support,  French

Record number: 19, Textual support number: 1 CONT

Les taux de phosphorylation du glycérol et d'oxydation du glycérol-3-phosphate sont moins rapides chez les rats consommant de l'éthanol que chez les rats témoins, ce qui indique une diminution de l'activité de la glycérol kinase et de la glycérol-3-phosphate déshydrogénase, donc, une utilisation plus lente du glycérol. Le taux d'utilisation du glycérol est fonction de la dose de glycérol et de la concentration d'oxygène.  1, record 19, French, - glyc%C3%A9rol%2Dkinase

Record 19,  Textual support,  Spanish

Record 20,  Textual support,  French

Record 20,  Textual support,  Spanish

Record 21,  Textual support,  English

Record number: 21, Textual support number: 1 CONT

Activation of macrophages by bacterial lipopolysaccharide (LPS) induces transcription of genes that encode for proinflammatory regulators of the immune response. Previous work has suggested that activation of the transcription factor activator protein 1 (AP-1) is one LPS-induced event that mediates this response. Consistent with this notion, we found that LPS stimulated AP-1- mediated transcription of a transfected reporter gene in the murine macrophage cell line RAW 264.7. As AP-1 activity is regulated in part by activation of the c-Jun N-terminal kinase (JNK), which phosphorylates and subsequently increases the transcriptional activity of c-Jun, we examined whether LPS treatment of macrophages resulted in activation of this kinase.  3, record 21, English, - jun%20N%2Dterminal%20kinase

Record number: 21, Textual support number: 1 OBS

PNAS Activation of c-Jun N-terminal kinase in bacterial lipopolysaccharide-sti. Proceedings of the National Academy of Sciences Volume 93, Number 07; Pages: 2774-2778 Immunology.  4, record 21, English, - jun%20N%2Dterminal%20kinase

Record 21,  Textual support,  French

Record number: 21, Textual support number: 1 OBS

JNK  2, record 21, French, - prot%C3%A9ine%20JNK

Record 21,  Textual support,  Spanish

Record 22,  Textual support,  English

Record number: 22, Textual support number: 1 CONT

Rabbits immunized with a synthetic peptide corresponding to N- terminal amino acid residues 1-12 of rat p21-Activated Kinase (PAK) conjugated to KLH; sequence- MSNNGLDVQDKP-C (C-terminal cysteinyl residue added for conjugation).  3, record 22, English, - p21%2Dactivated%20kinase

Record number: 22, Textual support number: 1 OBS

Manser et al., Nature 367:40, 1994; Martin et al., EMBO J. 14:1971, 1995; Manser et al., J. Biol. Chem. 270:25070, 1995  4, record 22, English, - p21%2Dactivated%20kinase

Record 22,  Textual support,  French

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Record 23,  Textual support,  English

Record number: 23, Textual support number: 1 CONT

Insoluble peptidoglycan (PGN) from staphylococcal cell walls as well as soluble PGN (sPGN) secreted by staphylococci in the presence of beta-lactam antibiotics induced TNF- alpha mRNA and secretion of bioactive TNF-alpha in the murine RAW264.7 macrophage cell line. PGN and sPGN also induced rapid and dose-dependent tyrosine phosphorylation of several cellular proteins, including lyn and mitogen-activated protein kinases (extracellular signal-regulated kinases; but not hck, fgr, or vav) and increased the activities of mitogen-activated protein and rsk kinases. These PGN- and sPGN-induced effects were qualitatively similar to the effects induced by ReLPS, but higher concentrations of PGN and sPGN than ReLPS were required.  3, record 23, English, - extracellular%20signal%2Dregulated%20kinase

Record number: 23, Textual support number: 1 OBS

The Journal of Immunology: Volume: 155 Number: 05 Pages: 2620 - 2630 September 1, 1995.  4, record 23, English, - extracellular%20signal%2Dregulated%20kinase

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Record 24,  Textual support,  English

Record number: 24, Textual support number: 1 CONT

We describe here the cloning and characterization of a cDNA encoding a protein kinase that has high sequence homology to members of the mitogen-activated protein kinase (MAPK) kinase kinase (MAPKKK or MEKK) family; this cDNA is named cATMEKK1 (Arabidopsis thaliana MAP kinase or ERK kinase kinase 1).  4, record 24, English, - MAP%20kinase%2Fextracellular%20signal%2Dregulated%20kinase%2Fkinase

Record number: 24, Textual support number: 1 OBS

Proceedings of the National Academy of Sciences Volume 93, Number 02; Pages: 765-769 Plant Biology.  5, record 24, English, - MAP%20kinase%2Fextracellular%20signal%2Dregulated%20kinase%2Fkinase

Record 24,  Textual support,  French

Record 24,  Textual support,  Spanish

Record 25,  Textual support,  English

Record number: 25, Textual support number: 1 CONT

We describe here the cloning and characterization of a cDNA encoding a protein kinase that has high sequence homology to members of the mitogen-activated protein kinase (MAPK) kinase kinase (MAPKKK or MEKK) family; this cDNA is named cATMEKK1 Arabidopsis thaliana MAP kinase or ERK kinase kinase.  1, record 25, English, - mitogen%2Dactivated%20protein%20kinase%20kinase%20kinase

Record number: 25, Textual support number: 1 OBS

Proceedings of the National Academy of Sciences Volume 93, Number 02; Pages: 765-769 Plant Biology. A gene encoding a mitogen-activated protein kinase.  3, record 25, English, - mitogen%2Dactivated%20protein%20kinase%20kinase%20kinase

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Record 27,  Textual support,  English

Record number: 27, Textual support number: 1 CONT

Study of the recognition-sites of nucleotides on the contractile proteins myosin and actinomyosin as well as their associated kinases, arginine kinase and creatine kinase, involving a synthetic, photolabile derivative of ATP: ATPgamma -(p-azido-aniline). Study of the structure-activity relations of the globular heads of myosin by chemical and photochemical methods (synthesis and interaction of an ATP analogue, substituted on the gamma -phosphorus atom with an azide radical). (Cited in PASCAL data base.)  1, record 27, English, - arginine%20kinase

Record 27,  Textual support,  French

Record number: 27, Textual support number: 1 CONT

Étude des sites de reconnaissance des nucléotides au niveau des protéines contractiles, myosine [...] ainsi que des kinases qui leur sont associées : arginine kinase et créatine kinase, à l'aide d'un dérivé photolabile synthétique de l'ATP [...]. Étude des relations structure-activité au niveau des têtes globulaires de la myosine par approches chimique et photochimique (synthèse et interaction d'un analogue de l'ATP substitué sur l'atome de phosphore-gamma par le radical azide). (Cité dans la base de données PASCAL.)  1, record 27, French, - arginine%20kinase

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Record 28,  Textual support,  English

Record 28,  Textual support,  French

Record number: 28, Textual support number: 1 OBS

kinase : Enzyme assurant le transfert d'un phosphate provenant de l'adénosine triphosphate (ATP) sur un accepteur qui est ainsi activé (...).  2, record 28, French, - prot%C3%A9ine%2Dkinase%20intracellulaire

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Record 29,  Textual support,  French

Record 29,  Textual support,  Spanish

Record 30,  Textual support,  English

Record number: 30, Textual support number: 1 OBS

creatine kinase. Enzyme of skeletal muscle and the myocardium and of brain tissue that catalyzes the transfer of a phosphate group from phosphocreatine to ADP, producing creatine and ATP. It occurs as three isoenzymes each having two components labeled M and B: the form in brain tissue is BB, in skeletal muscle MM, and in myocardial tissue both MM, and in myocardial tissue both MM and MB. The form normally found in serum is virtually all MM isoenzyme.  3, record 30, English, - MB%20creatine%20kinase

Record 30,  Textual support,  French

Record number: 30, Textual support number: 1 CONT

Le taux sanguin de la créatine-kinase s'élève dans tous les cas d'atteinte musculaire : myopathies, ischémies aiguës des membres, infarctus du myocarde, dans ce dernier cas, l'élévation du taux sérique de la CK atteint son maximum vers la 20e heure. [...] Une variété de cette enzyme (isozyme), la créatine-kinase MB (CK-MB : M = muscle; B = brain, cerveau) n'apparaît dans le sérum qu'en cas de lésion du myocarde.  1, record 30, French, - cr%C3%A9atine%20%2D%20kinase%20MB

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Record 31,  Textual support,  French

Record 31,  Textual support,  Spanish