TERMIUM Plus^®

Record 1,  Textual support,  English

Record number: 1, Textual support number: 1 DEF

An altered sequence at a single base pair in DNA.  2, record 1, English, - single%20nucleotide%20variant

Record number: 1, Textual support number: 1 OBS

Single nucleotide variants may be rare or common in a population. Sometimes single nucleotide variants are referred to as single nucleotide polymorphisms if they are present in at least 1% of the population.  3, record 1, English, - single%20nucleotide%20variant

Record 1,  Textual support,  French

Record number: 1, Textual support number: 1 CONT

Les techniques [de séquençage de nouvelle génération] peuvent traiter des millions de réactions de séquençage en parallèle. Elles permettent théoriquement la détection de tous les types de variants génétiques, depuis les variants mononucléotidiques jusqu'aux grands variants structurels (comme les variations du nombre de copies ou CNV).  1, record 1, French, - variant%20monucl%C3%A9otidique

Record 1,  Textual support,  Spanish

Record 2,  Textual support,  English

Record number: 2, Textual support number: 1 OBS

D55.3: code used in the International Statistical Classification of Diseases and Related Health Problems.  3, record 2, English, - anemia%20due%20to%20disorders%20of%20nucleotide%20metabolism

Record 2,  Textual support,  French

Record number: 2, Textual support number: 1 OBS

D55.3 : code de la Classification statistique internationale des maladies et des problèmes de santé connexes.  2, record 2, French, - an%C3%A9mie%20due%20%C3%A0%20des%20anomalies%20du%20m%C3%A9tabolisme%20des%20nucl%C3%A9otides

Record 2,  Textual support,  Spanish

Record 3,  Textual support,  English

Record number: 3, Textual support number: 1 DEF

... a long-standing foundational initiative ... between DDBJ [DNA Data Bank of Japan], EMBL-EBI [European Molecular Biology Laboratory - European Bioinformatics Institute] and NCBI [National Center for Biotechnology Information][, which] covers the spectrum of data raw reads, through alignments and assemblies to functional annotation, enriched with contextual information relating to samples and experimental configurations.  1, record 3, English, - International%20Nucleotide%20Sequence%20Database%20Collaboration

Record 3,  Textual support,  French

Record 3,  Textual support,  Spanish

Record 4,  Textual support,  English

Record number: 4, Textual support number: 1 DEF

A compound consisting of a sugar (ribose or deoxyribose), joined to a phosphate group and one of the following bases: adenine, cytosine, guanine, thymine or uracil.  2, record 4, English, - nucleotide

Record number: 4, Textual support number: 1 OBS

Ribonucleotides and deoxyribonucleotides (collectively called nucleotides) are the building blocks of the nucleic acids, RNA and DNA, respectively.  3, record 4, English, - nucleotide

Record 4,  Textual support,  French

Record number: 4, Textual support number: 1 DEF

Nom générique du complexe formé par l'association d'un nucléoside avec l'acide phosphorique et entrant dans la constitution des acides nucléiques.  2, record 4, French, - nucl%C3%A9otide

Record number: 4, Textual support number: 1 OBS

Selon le nombre de nucléosides entrant dans la molécule on distingue les mono-, les di- et les polynucléotides [et selon le type de sucres on distingue les déoxyribonucléotides et les ribonucléotides].  2, record 4, French, - nucl%C3%A9otide

Record number: 4, Textual support number: 2 OBS

Les nucléotides portent le nom de la base qu'ils contiennent (adénine, guanine, cytosine, thymine ou uracile).  3, record 4, French, - nucl%C3%A9otide

Record 4,  Textual support,  Spanish

Record number: 4, Textual support number: 1 DEF

Nucleósido fosforilado, es decir que se le ha agregado un grupo fosfatado, consistente en fósforo más cuatro átomos de oxígeno. Un nucleósido necesita convertirse en nucleótido para poder ser integrado a la cadena genética.  3, record 4, Spanish, - nucle%C3%B3tido

Record 5,  Textual support,  English

Record number: 5, Textual support number: 1 DEF

The determination of the sequence of bases in a specific nucleic acid.  2, record 5, English, - nucleotide%20sequencing

Record 5,  Textual support,  French

Record number: 5, Textual support number: 1 DEF

Détermination de l'ordre linéaire de l'enchaînement des bases d'un acide nucléique.  2, record 5, French, - d%C3%A9termination%20des%20s%C3%A9quences%20nucl%C3%A9otidiques

Record 5,  Textual support,  Spanish

Record 6,  Textual support,  English

Record number: 6, Textual support number: 1 DEF

A difference in a single nucleotide at a particular DNA site [that is] used as [a] genomic [masker] for human (or other) populations.  1, record 6, English, - single%2Dnucleotide%20polymorphism

Record number: 6, Textual support number: 1 CONT

A tool is under way to catalogue genetic variations among single DNA bases, known as single nucleotide polymorphisms (SNPs, pronounced "snips"), which can be used in characterizing drug responses. The National Institutes of Health has launched a $36-million, three-year program to collect data on 50,000 to 100,000 SNPs, a new goal for its Human Genome Project.  3, record 6, English, - single%2Dnucleotide%20polymorphism

Record 6,  Textual support,  French

Record number: 6, Textual support number: 1 DEF

Différence génétique entre individus d'une même population, correspondant à la variation d'une seule base dans une séquence nucléotidique déterminée.  1, record 6, French, - polymorphisme%20mononucl%C3%A9otidique

Record number: 6, Textual support number: 1 CONT

Le but de cette coopération est de mettre au point par Nanogen une méthode pour cartographier les «polymorphismes de nucléotides simples» [...] Les SNP sont le type le plus fréquent de variations individuelles dans les séquences d'ADN humain.  2, record 6, French, - polymorphisme%20mononucl%C3%A9otidique

Record number: 6, Textual support number: 1 OBS

Il existe plus de trois millions de ces variations.  1, record 6, French, - polymorphisme%20mononucl%C3%A9otidique

Record number: 6, Textual support number: 2 OBS

polymorphisme mononucléotidique; snip : termes et définition publiés au Journal officiel de la République française le 6 septembre 2008.  6, record 6, French, - polymorphisme%20mononucl%C3%A9otidique

Record 6,  Textual support,  Spanish

Record number: 6, Textual support number: 1 DEF

Marcador genético resultante de la variación en una secuencia situada en una determinada posición dentro de una secuencia de ADN.  1, record 6, Spanish, - polimorfismo%20de%20un%20solo%20nucle%C3%B3tido

Record number: 6, Textual support number: 1 CONT

Los SNP provienen generalmente de cambios por transición (A [adenina] por G [guanina], T [timina] por C [citosina]), por transversión (G o A por T o C) o por deleción de una única base. Esta variación se encuentra en todos los genomas y tiene como ventaja específica el poder detectarla sin necesidad de emplear electroforesis en gel.  1, record 6, Spanish, - polimorfismo%20de%20un%20solo%20nucle%C3%B3tido

Record number: 6, Textual support number: 1 OBS

SNP por sus siglas en inglés.  2, record 6, Spanish, - polimorfismo%20de%20un%20solo%20nucle%C3%B3tido

Record 7,  Textual support,  French

Record 7,  Textual support,  Spanish

Record 8,  Textual support,  English

Record number: 8, Textual support number: 1 DEF

The specific order and identities of component nucleotides in a polynucleotide denoted by the purine and pyrimidine bases they contain and expressed by the single letter abbreviations used for the nucleotides.  3, record 8, English, - base%20sequence

Record number: 8, Textual support number: 1 CONT

Many base sequences for small RNA molecules are known. Base sequence for DNA species have been determined by various techniques.  3, record 8, English, - base%20sequence

Record 8,  Textual support,  French

Record number: 8, Textual support number: 1 DEF

Séquence des différents nucléotides au sein d'un acide nucléique.  3, record 8, French, - s%C3%A9quence%20des%20bases

Record 8,  Textual support,  Spanish

Record 9,  Textual support,  English

Record number: 9, Textual support number: 1 OBS

Term(s) taken from a Canadian laboratory-equipment company's catalogue.  1, record 9, English, - recovery%20of%20nucleotides

Record 9,  Textual support,  French

Record number: 9, Textual support number: 1 OBS

Terme(s) tiré(s) du catalogue d'une compagnie canadienne d'équipement de laboratoire.  1, record 9, French, - r%C3%A9cup%C3%A9ration%20de%20nucl%C3%A9otides

Record 9,  Textual support,  Spanish

Record 10,  Textual support,  English

Record number: 10, Textual support number: 1 CONT

Specifically, the technique utilized single nucleotide polymorphism chips, or SNP chips, to detect the presence of tens of thousands of SNPs in a genomic mixture.  1, record 10, English, - single%20nucleotide%20polymorphism%20chip

Record 10,  Textual support,  French

Record number: 10, Textual support number: 1 CONT

De nouvelles approches bio-informatiques de puces SNP [polymorphismes de nucléotides simples] sont en cours de développement pour analyser les profils génomiques complexes des [tumeurs héréditaires].  1, record 10, French, - puce%20SNP

Record 10,  Textual support,  Spanish

Record number: 10, Textual support number: 1 CONT

Entender la variación estructural es esencial para desarrollar nuevas tecnologías que permitan detectar las diferencias genéticas entre la gente. Por ejemplo, los llamados chips de SNP, ya sea utilizados en investigación o en aplicaciones clínicas, necesitan reflejar esta variabilidad estructural para poder asociar las variantes genéticas con enfermedades particulares.  1, record 10, Spanish, - chip%20de%20SNP

Record 11,  Textual support,  English

Record number: 11, Textual support number: 1 CONT

The sequence of nucleotide bases along the linear chain of the DNA molecule specifies the structure of the proteins that are the construction materials of the cell and the catalysts of its intricate biochemical reactions.  1, record 11, English, - nucleotide%20base

Record 11,  Textual support,  French

Record number: 11, Textual support number: 1 CONT

La séquence des bases nucléotidiques, le long de la chaîne linéaire des molécules d'ADN, détermine la structure des milliers de protéines. Ces protéines sont les matériaux de base de la cellule et les catalyseurs de réactions biochimiques complexes qui s'y déroulent.  1, record 11, French, - base%20nucl%C3%A9otidique

Record 11,  Textual support,  Spanish

Record number: 11, Textual support number: 1 OBS

Elementos que conforman un filamento de ADN: adenina, citosina guanina y timina.  1, record 11, Spanish, - base%20nucle%C3%B3tida

Record 12,  Textual support,  English

Record number: 12, Textual support number: 1 DEF

Alteration in DNA involving a change in a single base pair at a particular site.  1, record 12, English, - nucleotide%20substitution

Record 12,  Textual support,  French

Record number: 12, Textual support number: 1 DEF

Remplacement d'une base par une autre dans la molécule d'ADN pouvant conduire à une mutation dans le génome.  2, record 12, French, - substitution%20de%20bases

Record 12,  Textual support,  Spanish

Record 13,  Textual support,  French

Record 13,  Textual support,  Spanish

Record 14,  Textual support,  French

Record 14,  Textual support,  Spanish

Record 15,  Textual support,  French

Record 15,  Textual support,  Spanish

Record 16,  Textual support,  French

Record 16,  Textual support,  Spanish

Record 17,  Textual support,  French

Record 17,  Textual support,  Spanish

Record 18,  Textual support,  English

Record number: 18, Textual support number: 1 CONT

Chirality about the trigonal axis. The quenchers are 6-coordinate Co(III) complexes with the general stoichiometric formula Co(NH3)4(ndp) or Co(NH3)4(ntp), where ndp denotes a diphosphate nucleotide ligand and ntp denotes a triphosphate nucleotide ligand. In these complexes the nucleotide ligand is coordinated to Co(III) via bidentate chelation in which the donor moieties are oxygen atoms from adjacent phosphate groups (beta, alpha in ndp and gamma, beta in ntp nucleotides). The nucleotides used as ligands in Ln in this study are the following: adenosine diphosphate and triphosphate (adp and atp), guanosine diphosphate and triphosphate (gdp and gtp), inosine diphosphate and triphosphate (idp and itp), cytidine triphosphate (ctp), uridine triphosphate (utp), and deoxythymidine triphosphate (ttp). The Co(NH3)4(nucleotide) complexes have dissymmetric structures both within and external to the Co(NH3)4(phosphate) coordination unit, but under the conditions employed in this study, they exist as mixtures of diastereomers that are quasi-racemic with respect to chirality within the Co(NH3)4(phosphate) coordination units.  1, record 18, English, - diphosphate%20nucleotide

Record 18,  Textual support,  French

Record 18,  Textual support,  Spanish

Record 19,  Textual support,  English

Record number: 19, Textual support number: 1 CONT

This server allows to query general nucleotide sequence collections (EMBL and GenBank), as well a specialized data banks (NRSub and Hovergen). It uses a WWW version of the retrieval program Query with the sequence banks indexed by ACNUC tables. It is possible to make queries on every structured field of the sequence documentation (e.g., keywords, species, bibliographic references, etc.) It is also possible to save a list of selected sequences and to do some treatments on them.  1, record 19, English, - sequence%20bank

Record 19,  Textual support,  French

Record number: 19, Textual support number: 1 CONT

Les banques séquentielles contiennent des séquences d'ADN ou de protéines et des «annotations», c'est-à-dire des renseignements sur les fonctions des gènes ou des protéines, les modifications post-traductionnelles, les domaines d'interaction, les structures de ces dernières. Genbank est l'une des plus anciennes et volumineuses des bases de séquences d'ADN, avec celle de l'EMBL (Laboratoire européen de biologie moléculaire, Heideilber, Allemagne).  1, record 19, French, - banque%20s%C3%A9quentielle

Record 19,  Textual support,  Spanish

Record 20,  Textual support,  English

Record number: 20, Textual support number: 1 DEF

A grayish-white powder, soluble in water and methanol, that is a coenzyme in numerous dehydrogenasic reactions.  1, record 20, English, - nicotinamide%20adenine%20dinucleotide%20phosphate

Record 20,  Textual support,  French

Record number: 20, Textual support number: 1 DEF

Co-enzyme de certaines déhydrogénases, intervenant dans les réactions très voisin du NAD dont il ne diffère que par un résidu phosphate supplémentaire.  2, record 20, French, - nicotinamide%2Dad%C3%A9nine%2Ddinucl%C3%A9otide%2Dphosphate

Record 20,  Textual support,  Spanish

Record 21,  Textual support,  English

Record number: 21, Textual support number: 1 CONT

The enzyme lactate dehydrogenase, ... transfers electrons from lactate to the oxidized form of the coenzyme nicotinamide adenine dinucleotide, NAD⁺, to yield pyruvate, the reduced coenzyme NADH, and a proton.... The reduced form of the coenzyme, NADH, absorbs light in the ultraviolet at 340 nm; whereas the oxidized form NAD⁺, the lactate, and the pyruvate do not. Thus the progress of the reaction in the forward direction can be followed by measuring the increase in light absorption of the system at 340 nm in a spectrophotometer.  4, record 21, English, - nicotinamide%20adenine%20dinucleotide

Record 21,  Textual support,  French

Record number: 21, Textual support number: 1 DEF

Coenzyme essentiel au métabolisme cellulaire intervenant dans les mécanismes d'oxydo-réduction (glycolyse, oxydations respiratoires terminales, réductions de l'azote) en agissant comme agent de transfert d'hydrogène et d'électrons.  3, record 21, French, - nicotinamide%20ad%C3%A9nine%20dinucl%C3%A9otide

Record 21,  Textual support,  Spanish

Record 22,  Textual support,  English

Record number: 22, Textual support number: 1 OBS

By Jane F. Gentleman and Ronald C. Mullin. Ottawa : Statistics Canada, Analytical Studies Branch. Research Paper, 14.  1, record 22, English, - The%20Distribution%20of%20the%20Frequency%20of%20Occurrence%20of%20Nucleotide%20Subsequences%2C%20Based%20on%20Their%20Overlap%20Capability

Record 22,  Textual support,  French

Record number: 22, Textual support number: 1 OBS

Ottawa : Statistique Canada, Direction des études analytiques. Document de recherche, 14.  1, record 22, French, - Distribution%20de%20la%20fr%C3%A9quence%20d%27occurrence%20des%20sous%2Ds%C3%A9quences%20de%20nucl%C3%A9otides%2C%20d%27apr%C3%A8s%20leur%20capacit%C3%A9%20de%20chevauchement

Record 22,  Textual support,  Spanish

Record 23,  Textual support,  English

Record number: 23, Textual support number: 1 CONT

A cluster of cystic fibrosis mutations in the first nucleotide-binding fold of the cystic fibrosis conductance regulator protein.  3, record 23, English, - nucleotide%20binding%20fold

Record number: 23, Textual support number: 1 OBS

Tiré du périodique "nature", London, 1990, 346 (6282), pp. 366-369.  3, record 23, English, - nucleotide%20binding%20fold

Record 23,  Textual support,  French

Record number: 23, Textual support number: 1 CONT

L'analyse génétique a attiré l'attention sur l'une des deux régions potentielles de liaison de l'ATP située à proximité de l'extrémité N-terminale du CFTR (NBF1, nucleotide binding fold). En effet, celle-ci renferme en position 508 un résidu de phénylalanine dont la délétion est retrouvée chez 68% des patients ou des transmetteurs.  1, record 23, French, - NBF

Record 23,  Textual support,  Spanish

Record 24,  Textual support,  English

Record number: 24, Textual support number: 1 CONT

("Unusual" means a base other than A, G, C, or U.) Many of the unusual bases differ from normal bases by the presence of one or more methyl (-CH₃) groups. Most, if not all, of the methyl groups are enzymatically added after the nucleotides are linked together by 3'-5' phosphodiester linkages. Very probably, the other unusual bases also arise by the enzymatic modification of a preexisting polynucleotide. The function of the unusual bases is not yet clear. They are not limited to alanine tRNA but occur in varying proportions in all tRNA molecules. Our only hint of their role is the fact that several unusual bases cannot form conventional base pairs. Some of the unusual bases may thus have the function of disruption double-helical hairpin regions, thereby exposing free keto and amino groups which can then form secondary bonds. Depending upon the specific bases, the free groups may form secondary bonds to template RNA, to a ribosome, or to the enzyme needed to attach a specific amino acid to its specific tRNA molecule. [Examples of those rare nucleotides are: Inosine, 1-methylinosine, N²-dimethylguanosine, 1-methylguanosine, Ribothymidine, Dihydrouridine and Pseudouridine].  1, record 24, English, - unusual%20base

Record 24,  Textual support,  French

Record number: 24, Textual support number: 1 CONT

Les deux classes de bases trouvées dans tous les mononucléotides sont dérivées de corps aromatiques hétérocycliques appelés purine et pyrimidine. La purine dérive elle-même de la pyrimidine par la fusion d'un cycle pyrimidine et imidazole. Les trois bases pyrimidiques les plus communes sont : l'uracile, la thymine et la cytosine, désignées couramment par U, T et C respectivement. Les bases puriques intervenant le plus souvent comme composantes des mononucléotides sont l'adénine et la guanine, respectivement désignées par A et G. Il existe [aussi] de nombreuses bases rares, telles que la 5-méthylcytosine, ou la 5-hydroxyméthyl-cytosine, [l'ionosine, la pseudouridine, etc...] Le rôle de ces bases rares n'est pas clair pour l'instant. Elles (...) existent en proportions variables dans toutes les molécules de tARN. Seul indice connu sur leur rôle possible, ces bases rares ne peuvent pas s'apparier de la manière habituelle. Certaines de ces bases rares pourraient donc avoir pour fonction de provoquer l'ouverture de quelques régions en épingle à cheveux de la double hélice, exposant ainsi des groupements cétones et aminés libres susceptibles de former des liaisons secondaires. Selon la nature des bases exposées, ces groupements libres pourraient former des liaisons secondaires avec la matrice d'ARN, avec le ribosome ou avec l'enzyme qui attache l'acide aminé à son tARN spécifique.  1, record 24, French, - base%20rare

Record 24,  Textual support,  Spanish

Record 25,  Textual support,  English

Record 25,  Textual support,  French

Record number: 25, Textual support number: 1 CONT

En 1975 Sanger et Coulson conçoivent et élaborent une élégante méthode de détermination des séquences nucléotidiques de l'ADN, bien plus rapide que les méthodes utilisées précédemment pour le déchiffrement des séquences nucléotidiques de l'ARN. Le principe de la méthode, dite méthode plus et moins, est relativement simple. Il consiste à synthétiser un grand nombre de segments d'ADN, de longueurs différentes, et complémentaires à la séquence nucléotidique que l'on désire connaître. Chacun des segments synthétisés, les conditions de synthèse étant ce qu'elles sont, se termine soit par un nucléotide précis et identifiable, A, T, G ou C (système +), soit juste avant ce nucléotide (système -).  1, record 25, French, - d%C3%A9termination%20des%20s%C3%A9quences%20nucl%C3%A9otidiques

Record 25,  Textual support,  Spanish

Record 26,  Textual support,  English

Record number: 26, Textual support number: 1 CONT

Dietary and metabolic manipulations of the carcinogenic process: role of nucleotide pool imbalances in carcinogenesis. Perturbations in DNA and/or membranes are considered to be important for the carcinogenic process. A search for nutritional and metabolic means of disturbing the homeostasis of DNA and membranes revealed that nucleotide pools offer an exciting possibility. An imbalance in nucleotide pools can exert a two-pronged attack on both DNA and membranes.  1, record 26, English, - nucleotide%20pool%20imbalance

Record number: 26, Textual support number: 1 OBS

This context was excerpted from the "Index Medicus data base"  2, record 26, English, - nucleotide%20pool%20imbalance

Record 26,  Textual support,  French

Record 26,  Textual support,  Spanish