TERMIUM Plus®

The Government of Canada’s terminology and linguistic data bank.

PHARMACOKINETIC [9 records]

Filter results by subject field Alphabetical list of terms

Filter results by subject field

Alphabetical list of terms

Record 1 2023-06-02

English

Subject field(s)
  • Pharmacology
CONT

The most basic mathematical description of drug distribution and elimination is the one-compartment model. ... One-compartment models utilize a single central compartment and assume that equilibrium is rapidly/instantaneously achieved with tissues. Although the drug in the body, as a single "compartment," cannot be measured, an assumption is made that the changes in blood (or other sampling compartment) reflect a proportional change in tissue drug concentrations. The rate of drug elimination from the central compartment in a one-compartment model is a first-order process. ... In the case of a one-compartment model, [clearance] is linear ... regardless of the mechanism of clearance.

Key term(s)
  • one compartment pharmacokinetic model
  • single compartment pharmacokinetic model
  • one compartment PK model
  • single compartment PK model
  • one compartment model
  • single compartment model
  • 1-compartment pharmacokinetic model
  • 1 compartment pharmacokinetic model
  • 1-compartment PK model
  • 1 compartment PK model
  • 1-compartment model
  • 1 compartment model

French

Domaine(s)
  • Pharmacologie
Key term(s)
  • modèle pharmaco-cinétique à un compartiment
  • modèle pharmaco-cinétique à compartiment unique
  • modèle pharmacocinétique à 1 compartiment
  • modèle pharmaco-cinétique à 1 compartiment
  • modèle à 1 compartiment

Spanish

Campo(s) temático(s)
  • Farmacología
Save record 1

Record 2 2023-06-01

English

Subject field(s)
  • Pharmacodynamics
  • Drugs and Drug Addiction
PHR

pharmacokinetic analysis, pharmacokinetic equation, pharmacokinetic model, pharmacokinetic study

PHR

PK analysis, PK equation, PK model, PK study

French

Domaine(s)
  • Pharmacodynamie
  • Drogues et toxicomanie
PHR

analyse pharmacocinétique, étude pharmacocinétique, paramètre pharmacocinétique, profil pharmacocinétique

Key term(s)
  • pharmaco-cinétique

Spanish

Campo(s) temático(s)
  • Farmacodinámica
  • Drogas y toxicomanía
Save record 2

Record 3 2023-06-01

English

Subject field(s)
  • Pharmacology
CONT

As the name suggests, a multiple-compartment PK [pharmacokinetic] model consists of a central compartment and one or several peripheral compartments, though the compartments do not represent specific anatomical or physiological structures. In general, the central compartment represents plasma (or blood) with or without richly perfused tissues, such as heart, liver, brain, etc., ... and the peripheral compartments represent slowly or less perfused tissues, such as skin, muscle, bone and fat. ... In a two-compartment model ... upon administration, a substance is introduced into the central compartment that is followed by its distribution between the central and a peripheral compartment; however, equilibration of the concentration of the substance between the two compartments is not anticipated to be achieved instantaneously. Once equilibration is reached, the elimination of the substance is assumed to occur from the central compartment.

Key term(s)
  • two compartment pharmacokinetic model
  • two compartment PK model
  • two compartment model
  • 2-compartment pharmacokinetic model
  • 2 compartment pharmacokinetic model
  • 2-compartment PK model
  • 2 compartment PK model
  • 2-compartment model
  • 2 compartment model

French

Domaine(s)
  • Pharmacologie
Key term(s)
  • modèle pharma-cocinétique à deux compartiments
  • modèle pharmacocinétique à 2 compartiments
  • modèle pharmaco-cinétique à 2 compartiments
  • modèle à 2 compartiments

Spanish

Campo(s) temático(s)
  • Farmacología
Save record 3

Record 4 2023-06-01

English

Subject field(s)
  • Pharmacology
  • Drugs and Drug Addiction
CONT

Tolerance that develops over time is termed acquired tolerance. Three classes of mechanism govern the development of acquired tolerance: pharmacokinetic, pharmacodynamic, and learned. Pharmacokinetic tolerance develops when the ability to metabolize or excrete the drug increases over time.

French

Domaine(s)
  • Pharmacologie
  • Drogues et toxicomanie
Key term(s)
  • tolérance pharmaco-cinétique

Spanish

Save record 4

Record 5 2023-06-01

English

Subject field(s)
  • Pharmacology
CONT

The three-compartment pharmacokinetic model divides the body into theoretic volumes from which pharmacokinetic parameters are derived ... The initial volume into which a drug is introduced is referred to as the central volume of distribution ... and represents some fraction of the circulating volume. Two peripheral compartments, one representing rapidly equilibrating tissues ... and the other the slowly equilibrating tissues ... are linked to the central compartment.

Key term(s)
  • three compartment pharmacokinetic model
  • three compartment PK model
  • three compartment model
  • 3-compartment pharmacokinetic model
  • 3 compartment pharmacokinetic model
  • 3-compartment PK model
  • 3 compartment PK model
  • 3-compartment model
  • 3 compartment model

French

Domaine(s)
  • Pharmacologie
Key term(s)
  • modèle pharmaco-cinétique à trois compartiments
  • modèle pharmacocinétique à 3 compartiments
  • modèle pharmaco-cinétique à 3 compartiments
  • modèle à 3 compartiments

Spanish

Campo(s) temático(s)
  • Farmacología
Save record 5

Record 6 2023-06-01

English

Subject field(s)
  • Pharmacology
CONT

The pharmacokinetic behaviour of most drugs is best described using a two-compartment model, in which a central compartment (blood plus the extracellular spaces of well-perfused tissues) and a peripheral compartment (less well-perfused tissues into which the drug permeates more slowly) are defined.

Key term(s)
  • pharmacokinetic behavior
  • PK behavior

French

Domaine(s)
  • Pharmacologie
Key term(s)
  • comportement pharmaco-cinétique

Spanish

Save record 6

Record 7 2011-12-12

English

Subject field(s)
  • Pharmacodynamics
CONT

The totality of processes involved in the absorption, distribution metabolism and excretion of drugs in a living organism.

French

Domaine(s)
  • Pharmacodynamie
CONT

Tout processus jouant un rôle dans l'adsorption, la distribution, le métabolisme et l'élimination d'un médicament dans un être vivant.

Spanish

Save record 7

Record 8 1995-02-03

English

Subject field(s)
  • Pharmacodynamics
CONT

The rodent AUCs and metabolite profiles may be determined from separate steady-state pharmacokinetic studies, as part of the subchronic toxicity studies, or dose-ranging studies.

French

Domaine(s)
  • Pharmacodynamie
CONT

Lors d'une étude pharmacocinétique à l'état d'équilibre menée sur l'administration simultanée de furosémide et de fosinopril, l'aire sous la courbe et les concentrations maximales du fosinoprilate ont augmenté de 26% et de 25% respectivement.

Spanish

Save record 8

Record 9 1993-04-30

English

Subject field(s)
  • Medication

French

Domaine(s)
  • Médicaments

Spanish

Save record 9

Copyright notice for the TERMIUM Plus® data bank

© Public Services and Procurement Canada, 2025
TERMIUM Plus®, the Government of Canada's terminology and linguistic data bank
A product of the Translation Bureau

Display options

Change the order of display of the official languages of Canada
Option to display the non-official languages (Spanish or Portuguese)
Display definitions, contexts, etc., on records

Features

Language Portal of Canada

Access a collection of Canadian resources on all aspects of English and French, including quizzes.

Writing tools

The Language Portal’s writing tools have a new look! Easy to consult, they give you access to a wealth of information that will help you write better in English and French.

Glossaries and vocabularies

Access Translation Bureau glossaries and vocabularies.

Date Modified: