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THYMIDINE [5 records]

Filter results by subject field Alphabetical list of terms

Filter results by subject field

Alphabetical list of terms

Record 1 2012-09-21

English

Subject field(s)
  • Medication
DEF

An enzyme which is induced in cells affected with DNA viruses and which catalyses the phosphorylation of thymidine to thymidylic acid, in the process of DNA synthesis.

CONT

In papovavirus-infected cells the induced enzyme is cellular in origin, but the thymidine kinase induced by Herpesvirus is specified by the virus Genome, and differs in several properties from the cell enzyme.

French

Domaine(s)
  • Médicaments
CONT

Cette enzyme virale, la thymidine kinase, n'est présente que dans les cellules infectées.

Spanish

Campo(s) temático(s)
  • Medicamentos
DEF

Enzima que permite a una célula utilizar una vía metabólica alternativa para incorporar timidina en el ADN.

OBS

Se utiliza como marcador seleccionable para identificar las células eucarióticas transfectadas.

Save record 1

Record 2 2010-04-20

English

Subject field(s)
  • Biochemistry
  • Genetics
CONT

In another application of gene therapy we have used an adenoviral vector that carries the gene for herpes simplex virus thymidine kinase (HSV-tk). Cells expressing HSV-tk will convert the anti-viral drug ganciclovir (GCV) to a form that is toxic to rapidly dividing cells. Using this adenoviral vector we have repeatedly shown robust tumoricidal effects in a variety of animal models of CNS tumor and will soon take this treatment to phase I clinical trials. We are extending this work to the manipulation of the CNSs immune response to tumors using adenoviral vectors that carry several cytokine genes.

French

Domaine(s)
  • Biochimie
  • Génétique
CONT

Traitement du glioblastome multiforme - une tumeur létale du cerveau - par transduction tumorale in vivo du gène codant la thymidine kinase du virus herpès simplex (HSV-TK), suivie par l'administration de ganciclovir, tel est l'intitulé des essais cliniques de phase II qui ont débuté en juin dernier en Belgique.

Spanish

Save record 2

Record 3 2005-01-10

English

Subject field(s)
  • Genetics
DEF

A pyrimidine nucleoside, C5H9O3C5H4N2O2, in which the base is thymine and the sugar desoxyribose, and which is obtained by the partial hydrolysis of DNA.

French

Domaine(s)
  • Génétique
DEF

Désoxyribonucléoside qui contient comme base azotée la thymine spécifique de l'ADN.

Spanish

Campo(s) temático(s)
  • Genética
DEF

Una de las cuatro bases nitrogenadas que conforman el filamento ADN ó ARN.

Save record 3

Record 4 1997-01-01

English

Subject field(s)
  • Commercial Fishing
  • Aquaculture
  • Fish
Key term(s)
  • H thymidine
  • thymidine-H
  • thymidine H

French

Domaine(s)
  • Pêche commerciale
  • Aquaculture
  • Poissons
OBS

Source(s) : Pêches - avril 1995.

Spanish

Save record 4

Record 5 1993-03-24

English

Subject field(s)
  • Immunology
CONT

Blastogenesis of lymphocytes or thymidine incorporation following stimulation of a specific antigen are in vitro tests that can be performed in a patient with a negative skin test, when the antigen is known, to determine whether the defect is an inability of the skin to react to lymphokines or an inability of T cells to produce lymphokines.

French

Domaine(s)
  • Immunologie
CONT

Le test de transformation lymphoblastique ou la mesure de l'incorporation de thymidine par les lymphocytes après stimulation spécifique sont praticables in vitro lorsque le test cutané étant négatif et l'antigène connu, on veut déterminer si l'absence de réaction est due à l'impossibilité de la peau à réagir aux lymphokines ou une incapacité des cellules T à produire des lymphokines.

Spanish

Save record 5

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