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THYMIDINE KINASE [2 records]
Record 1 - internal organization data 2012-09-21
Record 1, English
Record 1, Subject field(s)
- Medication
Record 1, Main entry term, English
- thymidine kinase
1, record 1, English, thymidine%20kinase
correct
Record 1, Abbreviations, English
- TK 2, record 1, English, TK
correct
Record 1, Synonyms, English
Record 1, Textual support, English
Record number: 1, Textual support number: 1 DEF
An enzyme which is induced in cells affected with DNA viruses and which catalyses the phosphorylation of thymidine to thymidylic acid, in the process of DNA synthesis. 3, record 1, English, - thymidine%20kinase
Record number: 1, Textual support number: 1 CONT
In papovavirus-infected cells the induced enzyme is cellular in origin, but the thymidine kinase induced by Herpesvirus is specified by the virus Genome, and differs in several properties from the cell enzyme. 3, record 1, English, - thymidine%20kinase
Record 1, French
Record 1, Domaine(s)
- Médicaments
Record 1, Main entry term, French
- thymidine kinase
1, record 1, French, thymidine%20kinase
correct, feminine noun
Record 1, Abbreviations, French
Record 1, Synonyms, French
Record 1, Textual support, French
Record number: 1, Textual support number: 1 CONT
Cette enzyme virale, la thymidine kinase, n'est présente que dans les cellules infectées. 1, record 1, French, - thymidine%20kinase
Record 1, Spanish
Record 1, Campo(s) temático(s)
- Medicamentos
Record 1, Main entry term, Spanish
- timidina quinasa
1, record 1, Spanish, timidina%20quinasa
correct, feminine noun
Record 1, Abbreviations, Spanish
Record 1, Synonyms, Spanish
Record 1, Textual support, Spanish
Record number: 1, Textual support number: 1 DEF
Enzima que permite a una célula utilizar una vía metabólica alternativa para incorporar timidina en el ADN. 1, record 1, Spanish, - timidina%20quinasa
Record number: 1, Textual support number: 1 OBS
Se utiliza como marcador seleccionable para identificar las células eucarióticas transfectadas. 1, record 1, Spanish, - timidina%20quinasa
Record 2 - internal organization data 2010-04-20
Record 2, English
Record 2, Subject field(s)
- Biochemistry
- Genetics
Record 2, Main entry term, English
- herpes simplex virus thymidine kinase
1, record 2, English, herpes%20simplex%20virus%20thymidine%20kinase
correct
Record 2, Abbreviations, English
- HSV-TK 2, record 2, English, HSV%2DTK
correct
- HSV-tk 1, record 2, English, HSV%2Dtk
correct
Record 2, Synonyms, English
Record 2, Textual support, English
Record number: 2, Textual support number: 1 CONT
In another application of gene therapy we have used an adenoviral vector that carries the gene for herpes simplex virus thymidine kinase (HSV-tk). Cells expressing HSV-tk will convert the anti-viral drug ganciclovir (GCV) to a form that is toxic to rapidly dividing cells. Using this adenoviral vector we have repeatedly shown robust tumoricidal effects in a variety of animal models of CNS tumor and will soon take this treatment to phase I clinical trials. We are extending this work to the manipulation of the CNSs immune response to tumors using adenoviral vectors that carry several cytokine genes. 1, record 2, English, - herpes%20simplex%20virus%20thymidine%20kinase
Record 2, French
Record 2, Domaine(s)
- Biochimie
- Génétique
Record 2, Main entry term, French
- thimidine kinase du virus herpès simplex
1, record 2, French, thimidine%20kinase%20du%20virus%20herp%C3%A8s%20simplex
correct, feminine noun
Record 2, Abbreviations, French
- HSV-TK 2, record 2, French, HSV%2DTK
correct, feminine noun
Record 2, Synonyms, French
Record 2, Textual support, French
Record number: 2, Textual support number: 1 CONT
Traitement du glioblastome multiforme - une tumeur létale du cerveau - par transduction tumorale in vivo du gène codant la thymidine kinase du virus herpès simplex (HSV-TK), suivie par l'administration de ganciclovir, tel est l'intitulé des essais cliniques de phase II qui ont débuté en juin dernier en Belgique. 1, record 2, French, - thimidine%20kinase%20du%20virus%20herp%C3%A8s%20simplex
Record 2, Spanish
Record 2, Textual support, Spanish
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