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CENTROMERO [3 records]

Filter results by subject field Alphabetical list of terms

Filter results by subject field

Alphabetical list of terms

Record 1 2013-09-19

English

Subject field(s)
  • Genetics
DEF

An inversion that is entirely within one arm of a chromosome, does not include the centromere.

CONT

When the two breaks occur within the same arm, the break point more proximal to the centromere is specified first; for example, inv (2) (p 13 p 23) defines a paracentric inversion in the short arm of chromosome no 2 with break points in bands 2 p 13 and 2 p 23.

French

Domaine(s)
  • Génétique
DEF

Inversion qui touche un bras chromosomique au-delà du centromère.

CONT

Une aneusomie de recombinaison est le résultat d'un réarrangement lors de la méiose, à la suite d'un [crossing-over], dans un chromosome parental équilibré mais déjà porteur d'une malfaçon par inversion péricentrique, paracentrique ou insertion.

Spanish

Campo(s) temático(s)
  • Genética
DEF

Reajuste cromosómico que se produce cuando un segmento cromosómico, que excluye al centrómero, cambia de orientación.

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Record 2 2013-02-21

English

Subject field(s)
  • Genetics
OBS

In genetics, an inversion that involves the centromere.

French

Domaine(s)
  • Génétique
CONT

Quand le segment «retourné» intéresse les deux bras et inclut le centromère, l'inversion est dite péricentrique.

Spanish

Campo(s) temático(s)
  • Genética
DEF

Reajuste cromosómico que se produce cuando un segmento cromosómico, que incluye al centrómero, cambia de orientación.

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Record 3 2007-08-08

English

Subject field(s)
  • Genetics
CONT

Human artificial chromosomes (HAC) have been considered as a possible vector for human gene therapy. In our previous work a minichromosome (MC), isolated from a patient, was transformed with a selectable marker gene (neo) which was targeted into its centromere; the MC was then size reduced, by X-ray exposure, to be easily manipulated and further engineered. The method developed for gene targeting, based on the use of chromosome specific centromeric satellite DNA as transfection carrier, is highly efficient and reproducible.

French

Domaine(s)
  • Génétique
CONT

En effet, les chromosomes artificiels humains (HAC) décrits constituent les premières constructions chromosomiques possédant tous les attributs (télomères, origines de réplication, centromère) d'un chromosome humain viable. [...] Les généticiens manquent encore d'informations précises sur les séquences qui, au niveau du centromère et des origines de réplications, sont nécessaires au fonctionnement du chromosome.

Spanish

Campo(s) temático(s)
  • Genética
DEF

Construcción análoga al cromosoma artificial de levadura, que consta de un centrómero y telómeros de origen humano, que permitiría la clonación de fragmentos de ADN muy grandes y su transferencia a las células humanas para aplicar la terapia génica.

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