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CROMOSOMA ARTIFICIAL LEVADURA [2 records]

Filter results by subject field Alphabetical list of terms

Filter results by subject field

Alphabetical list of terms

Record 1 2007-08-08

English

Subject field(s)
  • Genetics
CONT

Human artificial chromosomes (HAC) have been considered as a possible vector for human gene therapy. In our previous work a minichromosome (MC), isolated from a patient, was transformed with a selectable marker gene (neo) which was targeted into its centromere; the MC was then size reduced, by X-ray exposure, to be easily manipulated and further engineered. The method developed for gene targeting, based on the use of chromosome specific centromeric satellite DNA as transfection carrier, is highly efficient and reproducible.

French

Domaine(s)
  • Génétique
CONT

En effet, les chromosomes artificiels humains (HAC) décrits constituent les premières constructions chromosomiques possédant tous les attributs (télomères, origines de réplication, centromère) d'un chromosome humain viable. [...] Les généticiens manquent encore d'informations précises sur les séquences qui, au niveau du centromère et des origines de réplications, sont nécessaires au fonctionnement du chromosome.

Spanish

Campo(s) temático(s)
  • Genética
DEF

Construcción análoga al cromosoma artificial de levadura, que consta de un centrómero y telómeros de origen humano, que permitiría la clonación de fragmentos de ADN muy grandes y su transferencia a las células humanas para aplicar la terapia génica.

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Record 2 2007-08-08

English

Subject field(s)
  • Genetics
CONT

A map of human chromosome 3 which integrates both physical and genetic data has been developed from the fusion of two large collections of markers and corresponding yeast artificial chromosome (YAC) clones.

French

Domaine(s)
  • Génétique
CONT

Clonage de grands fragments d'ADN sous forme de chromosomes artificiels de levure (YAC, Yeast Artificial Chromosomes). Le principe de ce système consiste à munir de grands fragments d'ADN exogène (humain par exemple) de tous les éléments qui permettent leur propagation dans la levure [...]. Ces constructions sont alors répliquées par la levure comme s'il s'agissait d'un chromosome endogène. On peut ainsi construire des banques dans lesquelles chaque clone de levure contient un segment d'ADN humain de grande taille propagé sous forme de chromosome artificiel.

Spanish

Campo(s) temático(s)
  • Genética
DEF

Cromosoma artificial que se emplea como vector de clonación de grandes fragmentos de ADN de otras especies en el genoma de la levadura.

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